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Biodegradable materials for bone defect repair 被引量:1
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作者 Shuai Wei Jian-Xiong Ma +2 位作者 Lai Xu Xiao-Song Gu Xin-Long Ma 《Military Medical Research》 SCIE CSCD 2021年第2期202-229,共28页
Compared with non-degradable materials,biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects,and have attracted extensive attention from researchers.In the treatment of... Compared with non-degradable materials,biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects,and have attracted extensive attention from researchers.In the treatment of bone defects,scaffolds made of biodegradable materials can provide a crawling bridge for new bone tissue in the gap and a platform for cells and growth factors to play a physiological role,which will eventually be degraded and absorbed in the body and be replaced by the new bone tissue.Traditional biodegradable materials include polymers,ceramics and metals,which have been used in bone defect repairing for many years.Although these materials have more or fewer shortcomings,they are still the cornerstone of our development of a new generation of degradable materials.With the rapid development of modern science and technology,in the 21 st century,more and more kinds of new biodegradable materials emerge in endlessly,such as new intelligent micro-nano materials and cell-based products.At the same time,there are many new fabrication technologies of improving biodegradable materials,such as modular fabrication,3 D and 4 D printing,interface reinforcement and nanotechnology.This review will introduce various kinds of biodegradable materials commonly used in bone defect repairing,especially the newly emerging materials and their fabrication technology in recent years,and look forward to the future research direction,hoping to provide researchers in the field with some inspiration and reference. 展开更多
关键词 biodegradable materials Bone defects Bone repair Intelligent material Modular fabrication
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Biodegradable materials as binders for IVth generation moulding sands
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作者 K.Major-Gabrys 《China Foundry》 SCIE CAS 2015年第5期375-381,共7页
This paper focuses on the possibility of using the biodegradable materials as binders(or parts of binders' compositions) for foundry moulding and core sands. Results showed that there is a great possibility of usi... This paper focuses on the possibility of using the biodegradable materials as binders(or parts of binders' compositions) for foundry moulding and core sands. Results showed that there is a great possibility of using available biodegradable materials as foundry moulding sand binders. Using biodegradable materials as partial content of new binders, or additives to moulding sands may not only decrease the toxicity and increase reclamation ability of tested moulding sands, but also accelerate the biodegradation rate of used binders, and the new biodegradable additive(PCL) did not decrease the strength and thermal properties. In addition, using polycaprolactone(PCL) as a biodegradable material may improve the flexibility of moulding sands with polymeric binder and reduce toxicity. 展开更多
关键词 foundry practice moulding sand BINDER RESIN biodegradable material TOXICITY RECLAMATION
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A review on biodegradable materials for cardiovascular stent application 被引量:5
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作者 Li-Da HOU Zhen LI +3 位作者 Yu PAN Muhammadlqbal SABIR Yu-Feng ZHENG Li LI 《Frontiers of Materials Science》 SCIE CSCD 2016年第3期238-259,共22页
A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researcher;~ and engineers diverted to investigate biodegradable mat... A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researcher;~ and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials. 展开更多
关键词 biodegradable materials magnesium alloy POLYMERS biodegradablestent cardiovascular stent
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Recent progress on biodegradable materials and transient electronics 被引量:8
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作者 Rongfeng Li Liu Wang +1 位作者 Deying Kong Lan Yin 《Bioactive Materials》 SCIE 2018年第3期322-333,共12页
Transient electronics(or biodegradable electronics)is an emerging technology whose key characteristic is an ability to dissolve,resorb,or physically disappear in physiological environments in a controlled manner.Poten... Transient electronics(or biodegradable electronics)is an emerging technology whose key characteristic is an ability to dissolve,resorb,or physically disappear in physiological environments in a controlled manner.Potential applications include eco-friendly sensors,temporary biomedical implants,and datasecure hardware.Biodegradable electronics built with water-soluble,biocompatible active and passive materials can provide multifunctional operations for diagnostic and therapeutic purposes,such as monitoring intracranial pressure,identifying neural networks,assisting wound healing process,etc.This review summarizes the up-to-date materials strategies,manufacturing schemes,and device layouts for biodegradable electronics,and the outlook is discussed at the end.It is expected that the translation of these materials and technologies into clinical settings could potentially provide vital tools that are beneficial for human healthcare. 展开更多
关键词 biodegradable electronics Transient electronics biodegradable materials Silicon METALS
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Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review 被引量:2
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作者 Chowdhury Ahmed Shahed Faiz Ahmad +4 位作者 Ebru Günister Farhana Mohd Foudzi Saad Ali Khurshid Malik Wan Sharuzi Wan Harun 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第9期3038-3058,共21页
Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial p... Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver(Ag), copper(Cu), lithium(Li), and gallium(Ga). Copper ions(Cu^(2+)) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion(Ag^(+)) kills bacteria by creating bonds with the thiol group. Gallium ion(Ga^(3+)) inhibits ferric ion(Fe^(3+)) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species(ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions. 展开更多
关键词 biodegradable materials Biomedical implants Antibacterial mechanism CYTOTOXICITY Reactive oxygen species
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Magnesium as Biodegradable Implant Material
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作者 Wang Hao1,2 Shi Zhiming2 Yang Ke3 (1.Faculty of Engineering and Surveying, University of Southern Queensland2.School of Engineering, The University of Queensland3.Institute of Metal Research, Chinese Academy of Sciences) 《特种铸造及有色合金》 CAS CSCD 北大核心 2008年第S1期213-215,共3页
Drawbacks associated with permanent metallic implants lead to the search for degradable metallic biomaterials. Magnesium alloys have been highly considered as Mg has a high biocorrosion potential and is essential to b... Drawbacks associated with permanent metallic implants lead to the search for degradable metallic biomaterials. Magnesium alloys have been highly considered as Mg has a high biocorrosion potential and is essential to bodies. In this study, corrosion behaviour of pure magnesium and magnesium alloy AZ31 in both static and dynamic physiological conditions (Hank's solution) has been investigated. It is found that the materials degrade fast at beginning, then stabilize after 5 days of immersion. High purity in the materials reduces the corrosion rate while the dynamic condition accelerates the degradation process. In order to slow down the degradation process to meet the requirement for their bio-applications, an anodized coating is applied and is proved as effective in controlling the biodegradation rate. 展开更多
关键词 biodegradable materials BIOmaterialS magnesium alloys biocorrosion behaviour.
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A review on in vitro corrosion performance test of biodegradable metallic materials 被引量:10
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作者 甄珍 奚廷斐 郑玉峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第8期2283-2293,共11页
Extensive in vitro corrosion test systems have been carried out to simulate the in vivo corrosion behavior of biodegradable metallic materials. Various methods have their own unique benefits and limitations. The corro... Extensive in vitro corrosion test systems have been carried out to simulate the in vivo corrosion behavior of biodegradable metallic materials. Various methods have their own unique benefits and limitations. The corrosion mechanism of biodegradable alloys and in vitro corrosion test systems on biodegradable metallic materials are reviewed, to build a reasonable simulated in vitro test system for mimicking the in vivo animal test from the aspects of electrolyte solution selection, surface roughness influence, test methods and evaluation methodology of corrosion rate. Buffered simulated body fluid containing similar components to human blood plasma should be applied as electrolyte solution, such as simulated body fluid (SBF) and culture medium with serum. Surface roughness of samples and ratio of solution volume to sample surface area should be adopted based on the real implant situation, and the dynamic corrosion is preferred. As to the evaluation methodology of corrosion rate, different methods may complement one another. 展开更多
关键词 biodegradable metallic material in vitro corrosion test Mg FE
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Structural and corrosion characterization of biodegradable Mg-RE (RE=Gd, Y, Nd) alloys 被引量:18
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作者 J.KUBSEK D.VOJTěCH 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第5期1215-1225,共11页
Binary Mg-Gd (up to 5% Gd in mass fraction), Mg-Nd (up to 9% Nd in mass fraction) and ternary Mg-Gd-Y (up to 5% Gd, 1% Y) alloys with precisely determined contents of cathodic impurities (Fe, Ni, Cu, Co) were ... Binary Mg-Gd (up to 5% Gd in mass fraction), Mg-Nd (up to 9% Nd in mass fraction) and ternary Mg-Gd-Y (up to 5% Gd, 1% Y) alloys with precisely determined contents of cathodic impurities (Fe, Ni, Cu, Co) were studied. The alloys were studied in the as-cast state (cooling rate of 500 K/min) and after solution heat treatment (T4). Structures were investigated by optical and scanning electron microscopy, energy dispersive spectrometry, X-ray diffraction and glow discharge spectrometry. Structural investigation was completed by Vickers hardness measurements. Corrosion behavior in the simulated physiological solution (9 g/L NaCl) was assessed by immersion tests and potentiodynamic measurements. It was found that the structures of the as-cast alloys were dominated by fine a-Mg dendrites and eutectic Mg-RE phases. The dendrites exhibited RE-concentration gradients which were most pronounced in the Mg-Gd alloys. For this reason, the T4 heat treatment of the Mg-Gd alloy led to the formation of a new cuboidal Mg5Gd phase. The corrosion resistance was significantly improved by Gd. The effect of Nd was weak and the addition of Y to Mg-Gd alloys had harmful effect on the corrosion resistance. The T4 heat treatment strongly accelerated the corrosion of Mg-Gd alloys. Its effect on the corrosion of Mg-Nd alloys was not significant. The observed corrosion behavior of the alloys was discussed in relation to their structural states and contents of cathodic impurities. 展开更多
关键词 biodegradable material MAGNESIUM rare earths Mg-RE alloy structure CORROSION
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Fabrication of a Knitted Biodegradable Stents for Tracheal Regeneration 被引量:3
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作者 李毅 张佩华 冯勋伟 《Journal of Donghua University(English Edition)》 EI CAS 2004年第2期98-101,共4页
Endoluminal stents for reinforcement and regeneration of human trachea have been developed by weft-knitting method on a small-diameter circular knitting machine. The constituent materials of the stent are Polyglactin,... Endoluminal stents for reinforcement and regeneration of human trachea have been developed by weft-knitting method on a small-diameter circular knitting machine. The constituent materials of the stent are Polyglactin, Polypropylene and Chitosan with Polyglactin and Polypropylene plate-stitched fabric acting as backbone while chitosan as matrix, respectively. The fabrication procedures including knitting and coating are described in this paper. Mechanical and animal tests have been carried out to evaluate the mechanical properties of the stents. 展开更多
关键词 medical stent weft knitting biodegradable material mechanical properties
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Characterization of Potential Cellulose from Hylocereus Polyrhizus(Dragon Fruit)peel:A Study on Physicochemical and Thermal Properties
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作者 Nurul Hanan Taharuddin Ridhwan Jumaidin +2 位作者 Muhd Ridzuan Mansor Fahmi Asyadi Md Yusof Roziela Hanim Alamjuri 《Journal of Renewable Materials》 SCIE EI 2023年第1期131-145,共15页
The strict environmental regulations to overcome the drawbacks of consumption and disposal of non-renewable synthetic materials have motivated this investigation.The physical,chemical,morphological,and thermal propert... The strict environmental regulations to overcome the drawbacks of consumption and disposal of non-renewable synthetic materials have motivated this investigation.The physical,chemical,morphological,and thermal properties of Hylocereus Polyrhizus peel(HPP)powder obtained from the raw materials were examined in this study.The physical properties analyzes of Hylocereus Polyrhizus peel(HPP)powder discovered that the moisture content,density,and water holding capacity were 9.70%,0.45 g/cm^(3),and 98.60%,respectively.Meanwhile,the chemical composition analysis of Hylocereus Polyrhizus peel(HPP)powder revealed that the powder was significantly high in cellulose contents(34.35%)from other bio-peel wastes.The crystallinity index of Hylocereus Polyrhizus peel(HPP)powder was 32.76%,according to further X-ray diffraction(XRD)analysis.The thermal stability of Hylocereus Polyrhizus peel(HPP)powder was examined using thermogravimetric analysis(TGA)and found thermally stable at 204℃.The morphological study via scanning electron microscopy(SEM)showed a shriveled and irregular geometry surface.Hylocereus Polyrhizus peel(HPP)powder demonstrated the peak in the range representing the major functional groups responsible for pectin’s properties.Thus,the findings revealed that the Hylocereus Polyrhizus peel(HPP)powder has the potential for the development of biodegradable and renewable materials. 展开更多
关键词 Hylocereus Polyrhizus dragon fruit PEEL natural fiber biodegradable materials
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An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects
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作者 Jialian Xu Guo Bao +11 位作者 Bo Jia Minqi Wang Peng Wen Tianyou Kan Shutao Zhang Aobo Liu Haozheng Tang Hongtao Yang Bing Yue Kerong Dai Yufeng Zheng Xinhua Qu 《Bioactive Materials》 SCIE CSCD 2024年第8期207-224,共18页
Healing of fractures or bone defects is significantly hindered by overactivated osteoclasts and inhibited osteogenesis in patients with abnormal bone metabolism.Current clinical approaches using titanium alloys or sta... Healing of fractures or bone defects is significantly hindered by overactivated osteoclasts and inhibited osteogenesis in patients with abnormal bone metabolism.Current clinical approaches using titanium alloys or stainless steel provide mechanical support but have no biological effects on bone regeneration.Therefore,designing and fabricating degradable metal materials with sufficient mechanical strength and bidirectional regulation of both osteoblasts and osteoclasts is a substantial challenge.Here,this study first reported an adaptive biodegradable Zn-0.8 Mg alloy with bidirectional regulation of bone homeostasis,which promotes osteogenic differentiation by activating the Pi3k/Akt pathway and inhibits osteoclast differentiation by inhibiting the GRB2/ERK pathway.The anti-osteolytic ability of the Zn-0.8 Mg alloy was verified in a mouse calvarial osteolysis model and its suitability for internal fracture fixation with high-strength screws was confirmed in the rabbit femoral condyle fracture model.Furthermore,in an aged postmenopausal rat femoral condyle defect model,3D printed Zn-0.8 Mg scaffolds promoted excellent bone regeneration through adaptive structures with good mechanical properties and bidirectionally regulated bone metabolism,enabling personalized bone defect repair.These findings demonstrate the substantial potential of the Zn-0.8 Mg alloy for treating fractures or bone defects in patients with aberrant bone metabolism. 展开更多
关键词 Aberrant bone metabolism Bone healing biodegradable materials Zn-0.8 Mg alloy Bidirectional regulation
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Recent advances in immobilized enzymes on nanocarriers 被引量:12
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作者 曹诗林 徐培 +5 位作者 马永正 姚潇晓 姚远 宗敏华 李雪辉 娄文勇 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第11期1814-1823,共10页
Recent progress in nanotechnology has provided high-performance nanomaterials for enzyme immobilization.Nanobiocatalysts combining enzymes and nanocarriers are drawing increasing attention because of their high cataly... Recent progress in nanotechnology has provided high-performance nanomaterials for enzyme immobilization.Nanobiocatalysts combining enzymes and nanocarriers are drawing increasing attention because of their high catalytic performance,enhanced stabilities,improved enzyme-substrate affinities,and reusabilities.Many studies have been performed to investigate the efficient use of cellulose nanocrystals,polydopamine-based nanomaterials,and synthetic polymer nanogels for enzyme immobilization.Various nanobiocatalysts are highlighted in this review,with the emphasis on the design,preparation,properties,and potential applications of nanoscale enzyme carriers and nanobiocatalysts. 展开更多
关键词 Enzyme immobilization Cellulose nanocrystal POLYDOPAMINE biodegradable material
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Opportunities and challenges for the biodegradable magnesium alloys as next-generation biomaterials 被引量:36
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作者 Wenjiang Ding 《Regenerative Biomaterials》 SCIE 2016年第2期79-86,共8页
In recent years,biodegradable magnesium alloys emerge as a new class of biomaterials for tissue engineering and medical devices.Deploying biodegradable magnesium-based materials not only avoids a second surgical inter... In recent years,biodegradable magnesium alloys emerge as a new class of biomaterials for tissue engineering and medical devices.Deploying biodegradable magnesium-based materials not only avoids a second surgical intervention for implant removal but also circumvents the long-term foreign body effect of permanent implants.However,these materials are often subjected to an uncontrolled and fast degradation,acute toxic responses and rapid structural failure presumably due to a localized,too rapid corrosion process.The patented Mg-Nd-Zn-based alloys(JiaoDa BioMg[JDBM])have been developed in Shanghai Jiao Tong University in recent years.The alloy series exhibit lower biodegradation rate and homogeneous nanophasic degradation patterns as compared with other biodegradable Mg alloys.The in vitro cytotoxicity tests using various types of cells indicate excellent biocompatibility of JDBM.Finally,bone implants using JDBM-1 alloy and cardiovascular stents using JDBM-2 alloy have been successfully fabricated and in vivo long-term assessment via implantation in animal model have been performed.The results confirmed the reduced degradation rate in vivo,excellent tissue compatibility and long-term structural and mechanical durability.Thus,this novel Mg-alloy series with highly uniform nanophasic biodegradation represent a major breakthrough in the field and a promising candidate for manufacturing the next generation biodegradable implants. 展开更多
关键词 biodegradable material magnesium alloys uniform corrosion orthopaedic implants cardiovascular stents
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Experimental Study on the Mechanical Properties of Novel Plate-knitted Composite Tracheal Stents 被引量:1
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作者 李毅 张佩华 +1 位作者 王文祖 冯勋伟 《Journal of Donghua University(English Edition)》 EI CAS 2003年第4期8-11,共4页
A new knitted composite artificial tracheal stent made of polyglactin(PGLA) and polypropylene (PP) filaments for reinforcement and regeneration of human trachea has been developed by plated-knitting technique on a sma... A new knitted composite artificial tracheal stent made of polyglactin(PGLA) and polypropylene (PP) filaments for reinforcement and regeneration of human trachea has been developed by plated-knitting technique on a small-diameter circular knitting machine.Both tensile and compressive tests were carried out to determine the Young's modulus and the critical pressure corresponding to crushing of the stent.The experimental results confirmed that the new type of knitted composite artificial stent is mechanically feasible. 展开更多
关键词 medical stent KNITTING biodegradable materials mechanicl properties
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RING-OPENING POLYMERIZATION OF ε-CAPROLACTONE BY LANTHANOCENE CATALYSIS
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作者 孙俊全 潘智达 杨士林 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1998年第4期297-303,共7页
Ring-opening polymerization of ε-caprolactone (CL) catalyzed bylanthanocenes, O(C_2H_4C_5H_3CH_3)_2YCl (Cat-YCl) and Me_2Si[(CH_3)_3SiC_5H_3]_2NdCl(Cat-NdCl) has been carried out for the first time. It has been found... Ring-opening polymerization of ε-caprolactone (CL) catalyzed bylanthanocenes, O(C_2H_4C_5H_3CH_3)_2YCl (Cat-YCl) and Me_2Si[(CH_3)_3SiC_5H_3]_2NdCl(Cat-NdCl) has been carried out for the first time. It has been found that both yttroceneand neodymocene are very efficient to catalyze the polymerization of CL, giving high molec-ular weight poly (ε-caprolactone) (PCL ). The effects of [cat] / [ε- CL] molar ratio, polymeriza-tion temperature and time, as well as solvents were investigated and polymerization tem-perature is found to be the most important factor affecting the polymerization. The bulkpolymerization gives higher molecular weight PCL and higher conversion than that in solu-tion polymerization. NaBPh_4 was found to promote the polymerization of ε-caprolactone,and thus to increase both the polymerization conversion and MW of poly (ε- caprolactone ). 展开更多
关键词 Ring-opening polymerization Ε-CAPROLACTONE Lanthanocene catalyst Rare-earth catalysts biodegradable material
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Improvement of Plant Growing Techniques in Drying up and Water Scarcity Conditions
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作者 Georgi Mitev Krasimir Bratoev Jivko Demirev 《Journal of Environmental Science and Engineering(A)》 2013年第10期593-605,共13页
Due to its specificity, seasonality and location of large areas, the crops are exposed to the greatest degree of risks posed by climate change. To maintain stability and increase yields, it is imperative to implement ... Due to its specificity, seasonality and location of large areas, the crops are exposed to the greatest degree of risks posed by climate change. To maintain stability and increase yields, it is imperative to implement an innovative approach by which to optimize certain processes such as tillage, sowing and irrigation. The main tasks of innovative solutions are proposed to increase the soil water holding capacities in the root layer over a prolonged period of time, and improve the accuracy of the drilling process for row crops and vegetables by using biodegradable materials, and on this basis to optimize the irrigation by use of specialized software products to determine irrigation scheduling and irrigation requirements. 展开更多
关键词 PLANT climate change innovative technologies soil water holding properties accurate drilling with biodegradable materials watering schedules and rates.
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Investigation of Mg–Zn–Y–Nd alloy for potential application of biodegradable esophageal stent material 被引量:9
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作者 Shuo Wang Xueqi Zhang +2 位作者 Jingan Li Changsheng Liu Shaokang Guan 《Bioactive Materials》 SCIE 2020年第1期1-8,共8页
In recent years,due to unhealthy dietary habits and other reasons,advanced esophageal cancer patients are on the rise,threatening human health and life safety at all times.Stents implantation as an important complemen... In recent years,due to unhealthy dietary habits and other reasons,advanced esophageal cancer patients are on the rise,threatening human health and life safety at all times.Stents implantation as an important complementary or alternative method for chemotherapy has been widely applied in clinics.However,the adhesion and proliferation of pathological cells,such as tumor cells,fibroblasts and epithelial cells,may interfere the efficacy of stents.Further multiple implantation due to restenosis may also bring pain to patients.In this contribution,we preferred a biodegradable material Mg–Zn–Y–Nd alloy for potential application of esophageal stent.The hardness testing showed that Mg–Zn–Y–Nd alloy owned less mechanical properties compared with the commercial esophageal stents material,317L stainless steel(317L SS),while Mg–Zn–Y–Nd displayed significantly better biodegradation than 317L SS.Cell apoptosis assay indicated Mg–Zn–Y–Nd inhibited adhesion and proliferation of tumor cells,fibroblasts and epithelial cells.Our research suggested potential application of Mg–Zn–Y–Nd alloy as a novel material for biodegradable esophageal stent. 展开更多
关键词 Esophageal stent biodegradable metal material Mg-Zn-Y-Nd alloy Hardness BIOCOMPATIBILITY
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Effects of external stress on biodegradable orthopedic materials: A review 被引量:6
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作者 Xuan Li Chenglin Chu Paul K.Chu 《Bioactive Materials》 SCIE 2016年第1期77-84,共8页
Biodegradable orthopedic materials(BOMs)are used in rehabilitation and reconstruction of fractured tissues.The response of BOMs to the combined action of physiological stress and corrosion is an important issue in viv... Biodegradable orthopedic materials(BOMs)are used in rehabilitation and reconstruction of fractured tissues.The response of BOMs to the combined action of physiological stress and corrosion is an important issue in vivo since stress-assisted degradation and cracking are common.Although the degradation behavior and kinetics of BOMs have been investigated under static conditions,stress effects can be very serious and even fatal in the dynamic physiological environment.Since stress is unavoidable in biomedical applications of BOMs,recent work has focused on the evaluation and prediction of the properties of BOMs under stress in corrosive media.This article reviews recent progress in this important area focusing on biodegradable metals,polymers,and ceramics. 展开更多
关键词 biodegradable orthopedic materials External stress Stress mode Degradation rate MECHANOCHEMISTRY
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On the material dependency of peri-implant morphology and stability in healing bone
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作者 Stefan Bruns Diana Krüger +7 位作者 Silvia Galli D.C.Florian Wieland Jorg U.Hammel Felix Beckmann Ann Wennerberg Regine Willumeit-Romer Berit Zeller-Plumhoff Julian Moosmann 《Bioactive Materials》 SCIE CSCD 2023年第10期155-166,共12页
The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability.We present a study in which screw implants ... The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability.We present a study in which screw implants made from titanium,polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four,eight and twelve weeks after implantation.Screws were 4 mm in length and with an M2 thread.The loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5μm resolution.Bone deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image sequences.Implant stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical stabilization.Peri-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial utilized.Titanium implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain transfer.Correlations in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial utilized.This leaves the choice of biomaterial as situational depending on local tissue properties. 展开更多
关键词 biodegradable implant materials Bone mechanical testing Implant stability Synchrotron micro-computed tomography imaging Digital volume correlation
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Biomaterials for spinal cord repair 被引量:10
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作者 Agnes E. Haggerty Martin oudega 《Neuroscience Bulletin》 SCIE CAS CSCD 2013年第4期445-459,共15页
Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regener... Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCI. 展开更多
关键词 spinal cord injury axon regeneration biodegradable materials extracellular matrix proteins functionalrecovery growth factor guidance injury and repair spinal motor neuron
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