Cell biomechanics and its applications in human disease diagnosis

Certain diseases are known to cause changes in the physical and biomechanical properties of cells.These include cancer,malaria,and sickle cell anemia among others.Typically,such physical property changes can result in several fold increases or decreases in cell stiffness,which are significant and can result in severe pathology and eventual catastrophic breakdown of the bodily functions.While there are developed biochemical and biological assays to detect the onset or presence of diseases,there is always a need to develop more rapid,precise,and sensitive methods to detect and diagnose diseases.Biomechanical property changes can play a significant role in this regard.As such,research into disease biomechanics can not only give us an in-depth knowledge of the mechanisms underlying disease progression,but can also serve as a powerful tool for detection and diagnosis.This article provides some insights into opportunities for how significant changes in cellular mechanical properties during onset or progression of a disease can be utilized as useful means for detection and diagnosis.We will also showcase several technologies that have already been developed to perform such detection and diagnosis.

Stabilized composition of 26 mg/mL of high molecular weight HA for subcutaneous injection to improve skin quality

Aim:Skin firmness is one of the key parameters to define skin quality and facial aging.Among the minimally invasive anti-aging strategies,hyaluronic acid(HA)injection is widely accepted to improve skin quality.While most of the available HA injectables are designed and intended for intradermal injection,a novel HA/sorbitol composition containing 2.6% high molecular weight hyaluronic acid stabilized by sorbitol was recently developed to be specifically injected into the adipose tissue to improve the quality of all skin layers,especially the skin firmness.Methods:The HA/sorbitol composition was investigated versus product comparators in terms of biophysical properties,tolerance in subcutaneous tissue with in vivo implantation study,and skin firmness assessment on human skin explants.Results:The HA/sorbitol composition was characterized by unique and differentiated biophysical properties,proper distribution and high tolerance of the gel composition into the adipose tissue,and the ability to efficiently improve skin firmness.Conclusion:The HA/sorbitol composition represents a new attractive solution to treat facial skin aging with an injection strategy specifically targeting the adipose tissue instead of the dermis,to improve the quality of the skin.