<strong>Background:</strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">First described in 1908, TAK has now been recognized as a non...<strong>Background:</strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">First described in 1908, TAK has now been recognized as a non-specific inflammatory disease of unknown etiology, predominantly affecting young females. Sometimes, it progresses into relatively rare and potentially fatal scenarios such heart failure.</span><b><span style="font-family:Verdana;"> Case Presentation: </span></b><span style="font-family:Verdana;">Here, we present the case of a 50-year sub-saharan</span></span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">female suffering from acute heart failure related to TAK.</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">Despite constitutional symptoms (fever, malaise, weight loss) and more characteristic features such claudication of lower extremities, carotydinia, and pulseless syndrome, diagnosis of TAK was delayed since main presentation was heart failure.</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">Immunosuppressive and anticoagulant therapies have induced improvement in cardiac manifestations.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">Early diagnosis and proper treatment can protect the patient from dangerous complications such heart failure.</span></span>展开更多
Aim: To determine the epidemiological findings of acute rheumatic fever (ARF) and relationship with acute rheumatic heart disease (RHD). Patients and method: This cross sectional study was conducted from January 2012 ...Aim: To determine the epidemiological findings of acute rheumatic fever (ARF) and relationship with acute rheumatic heart disease (RHD). Patients and method: This cross sectional study was conducted from January 2012 to December 2016 (5 years) in the Department of Pediatrics. We had included patients aged from 5 to15 years old, admitted for ARF. Results: Twenty-nine black African children, 15 boys (51.7%) were included. The incidence was 5.8 cases/year. The mean age was 10.4 ± 2.7 years. The mean age of parents was 34.5 ± 6.9 years (range: 24-48) for mother and 41.2 ± 6.9 years (range: 28 - 56) for father. Parents were low-income 10 (34.5%), the delay of consultation was 17.7 ± 19.5 days. The medical history was: frequent pharyngitis 22 (76%), previous ARF 17 (58.6%), previous hospitalization 11 (38%). Signs were: polyarthralgia (n = 28, 96.6%), fever (n = 24, 82.8%), asthenia (n = 18, 62%), migratory polyarthritis (n = 12, 41.4%). Organic heart murmur has been reported in 13 cases (44.8%), and heart failure in 7 cases. The anomalies of blood analysis were inflammatory syndrome (100%), elevation of streptococcal enzymes (n = 27, 93%), and anemia (n = 16, 55.2%). In cardiac ultrasound, anomalies were: thickened valve (n = 13, 44.8%), mitral regurgitation (n = 13, 44.8%), dilatation of left ventricle (n = 9, 31%), aortic regurgitation (n = 5, 17.2%). The nosology of pathology was acute RHD (n = 15, 51.7%), ARF only (n = 14, 48.3%). Associated factors of acute RHD were: female sex (OR 1.52, 95%CI 0.35 - 6.6), low-income (OR 1.33, 95%CI 0.24 - 7.4), previous hospitalization (OR 2.7, 95%CI 0.58 - 13) and migratory polyarthritis (OR 1.12, 95%CI 0.25 - 4.9). Conclusion: The ARF remains prevalent in our countries. Its complications lead to sequelae that are difficult to treat, because of the lack of cardiac surgery centers in many sub-Saharan African countries including Congo. Prevention and effective treatment of angina should be applied by practitioners.展开更多
【目的】组建铁心杉优良杂交组合,为铁心杉种质资源圃构建及种子园配置提供数据支撑和科学依据。【方法】选取铁心杉优良母树3576个半同胞子代中表现优良的幼苗优株以及403个候选父本、10个母本作为研究对象,筛选15个EST-SSR标记,采用AB...【目的】组建铁心杉优良杂交组合,为铁心杉种质资源圃构建及种子园配置提供数据支撑和科学依据。【方法】选取铁心杉优良母树3576个半同胞子代中表现优良的幼苗优株以及403个候选父本、10个母本作为研究对象,筛选15个EST-SSR标记,采用ABI 370XL毛细管电泳检测PCR扩增产物,利用软件GeneMarker 2.20进行基因分型、软件PIC_CALC Version 0.6计算多态信息含量(PIC),GenALex6.5估算各个SSR位点的等位基因数目(NA)、期望杂合度(HE)、观测杂合度(HO);以等位基因分布频率为基础,CERVUS3.0.7软件和最大似然值法计算LOD值进行父本鉴定,计算NE-1P、NE-2P和NE-PP。【结果】共计选出50株铁心杉半同胞优株;15个SSR位点在所有样本中的平均等位基因数、平均观测杂合度和平均期望杂合度分别为9.867、0.475和0.679;15个SSR位点的多态信息含量PIC值在0.356~0.876,平均为0.634;平均NE-1P、NE-2P和NE-PP为0.872、0.802、0.702;50个半同胞子代在403个疑似父本中检测出的最似父本LOD值均大于0,其中TXS-14的繁殖贡献率最高为6%,TXS-20、TXS-201、TXS-204、TXS-399、TXS-5的繁殖贡献率次之,为4%,其余均为2%,共鉴定出42个真实父本,选出高配合力亲本杂交组合50对。【结论】已发表的SSR标记能够用来对铁心杉半同胞子代优株进行父本鉴定,研究结果将为铁心杉种质资源圃的构建提供理论依据和进一步开展铁心杉分子辅助杂交育种奠定基础。展开更多
文摘<strong>Background:</strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">First described in 1908, TAK has now been recognized as a non-specific inflammatory disease of unknown etiology, predominantly affecting young females. Sometimes, it progresses into relatively rare and potentially fatal scenarios such heart failure.</span><b><span style="font-family:Verdana;"> Case Presentation: </span></b><span style="font-family:Verdana;">Here, we present the case of a 50-year sub-saharan</span></span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">female suffering from acute heart failure related to TAK.</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">Despite constitutional symptoms (fever, malaise, weight loss) and more characteristic features such claudication of lower extremities, carotydinia, and pulseless syndrome, diagnosis of TAK was delayed since main presentation was heart failure.</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">Immunosuppressive and anticoagulant therapies have induced improvement in cardiac manifestations.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">Early diagnosis and proper treatment can protect the patient from dangerous complications such heart failure.</span></span>
文摘Aim: To determine the epidemiological findings of acute rheumatic fever (ARF) and relationship with acute rheumatic heart disease (RHD). Patients and method: This cross sectional study was conducted from January 2012 to December 2016 (5 years) in the Department of Pediatrics. We had included patients aged from 5 to15 years old, admitted for ARF. Results: Twenty-nine black African children, 15 boys (51.7%) were included. The incidence was 5.8 cases/year. The mean age was 10.4 ± 2.7 years. The mean age of parents was 34.5 ± 6.9 years (range: 24-48) for mother and 41.2 ± 6.9 years (range: 28 - 56) for father. Parents were low-income 10 (34.5%), the delay of consultation was 17.7 ± 19.5 days. The medical history was: frequent pharyngitis 22 (76%), previous ARF 17 (58.6%), previous hospitalization 11 (38%). Signs were: polyarthralgia (n = 28, 96.6%), fever (n = 24, 82.8%), asthenia (n = 18, 62%), migratory polyarthritis (n = 12, 41.4%). Organic heart murmur has been reported in 13 cases (44.8%), and heart failure in 7 cases. The anomalies of blood analysis were inflammatory syndrome (100%), elevation of streptococcal enzymes (n = 27, 93%), and anemia (n = 16, 55.2%). In cardiac ultrasound, anomalies were: thickened valve (n = 13, 44.8%), mitral regurgitation (n = 13, 44.8%), dilatation of left ventricle (n = 9, 31%), aortic regurgitation (n = 5, 17.2%). The nosology of pathology was acute RHD (n = 15, 51.7%), ARF only (n = 14, 48.3%). Associated factors of acute RHD were: female sex (OR 1.52, 95%CI 0.35 - 6.6), low-income (OR 1.33, 95%CI 0.24 - 7.4), previous hospitalization (OR 2.7, 95%CI 0.58 - 13) and migratory polyarthritis (OR 1.12, 95%CI 0.25 - 4.9). Conclusion: The ARF remains prevalent in our countries. Its complications lead to sequelae that are difficult to treat, because of the lack of cardiac surgery centers in many sub-Saharan African countries including Congo. Prevention and effective treatment of angina should be applied by practitioners.
文摘【目的】组建铁心杉优良杂交组合,为铁心杉种质资源圃构建及种子园配置提供数据支撑和科学依据。【方法】选取铁心杉优良母树3576个半同胞子代中表现优良的幼苗优株以及403个候选父本、10个母本作为研究对象,筛选15个EST-SSR标记,采用ABI 370XL毛细管电泳检测PCR扩增产物,利用软件GeneMarker 2.20进行基因分型、软件PIC_CALC Version 0.6计算多态信息含量(PIC),GenALex6.5估算各个SSR位点的等位基因数目(NA)、期望杂合度(HE)、观测杂合度(HO);以等位基因分布频率为基础,CERVUS3.0.7软件和最大似然值法计算LOD值进行父本鉴定,计算NE-1P、NE-2P和NE-PP。【结果】共计选出50株铁心杉半同胞优株;15个SSR位点在所有样本中的平均等位基因数、平均观测杂合度和平均期望杂合度分别为9.867、0.475和0.679;15个SSR位点的多态信息含量PIC值在0.356~0.876,平均为0.634;平均NE-1P、NE-2P和NE-PP为0.872、0.802、0.702;50个半同胞子代在403个疑似父本中检测出的最似父本LOD值均大于0,其中TXS-14的繁殖贡献率最高为6%,TXS-20、TXS-201、TXS-204、TXS-399、TXS-5的繁殖贡献率次之,为4%,其余均为2%,共鉴定出42个真实父本,选出高配合力亲本杂交组合50对。【结论】已发表的SSR标记能够用来对铁心杉半同胞子代优株进行父本鉴定,研究结果将为铁心杉种质资源圃的构建提供理论依据和进一步开展铁心杉分子辅助杂交育种奠定基础。
