BACKGROUND Bladder metastasis from lung cancer with epidermal growth factor receptor(EGFR)mutation is extremely rare.Here,we report a case of bladder metastasis from lung adenocarcinoma with EGFR mutation.CASE SUMMARY...BACKGROUND Bladder metastasis from lung cancer with epidermal growth factor receptor(EGFR)mutation is extremely rare.Here,we report a case of bladder metastasis from lung adenocarcinoma with EGFR mutation.CASE SUMMARY A 53-year-old female patient was diagnosed with advanced lung adenocarcinoma with EGFR exon 19 deletion.Multiple nodules on the bladder wall were found by regular examination of the pelvic cavity through computed tomography during targeted therapy.Further cystoscopy and histological examination of bladder biopsy tissues confirmed the bladder metastasis from lung adenocarcinoma.In addition,genetic analysis of the bladder metastasis revealed EGFR T790M mutation.The patient achieved a good response to a third-generation EGFR tyrosine kinase inhibitor.CONCLUSION During routine follow-up of lung cancer patients,imaging examination of the pelvic cavity should be performed to avoid missing bladder metastasis.The ultimate diagnosis of bladder metastasis sill depends on the pathological result of biopsy tissues.展开更多
Renal cell carcinoma(RCC)is well known for its metastatic potential and predilection for unusual sites of metastasis.Metastasis to the bladder is rare and has been reported predominantly from clear cell RCC.We report ...Renal cell carcinoma(RCC)is well known for its metastatic potential and predilection for unusual sites of metastasis.Metastasis to the bladder is rare and has been reported predominantly from clear cell RCC.We report a case of a 72-year-old male presenting with a bladder tumor which on histopathological evaluation was found to be a metastasis from papillary RCC,7 years after radical nephrectomy.This case highlights the need to maintain a high index of suspicion to diagnose bladder metastasis in a patient with a history of RCC presenting with a bladder lesion.展开更多
Bladder tumor is the most common malignant tumor in urinary system and always com- panied with lymph node metastasis. The accurate staging plays a significant role in treatment for bladder tumor and prognostic evaluat...Bladder tumor is the most common malignant tumor in urinary system and always com- panied with lymph node metastasis. The accurate staging plays a significant role in treatment for bladder tumor and prognostic evaluation, and the distant metastasis predicts worse prognosis. The objective of this study was to assess the clinical significance of 18F-FDG PET/CT imaging in diagnosing bladder tumor metastasis lesions. A retrospective analysis of 60 patients with bladder tumor from October 2008 to May 2010 was done. The patients were stratified based on the imaging technique. Among all 60 cases, besides the primary lesion, 81 suspected lesions were spotted and 73 confirmed as metastasis, including 50 lymph node metastases, 22 distant metastases, and 1 bone metastasis. For PET/CT imaging, its sensitivity was 94.5%, specificity 87.5%, positive predictive value 98.6%, negative predictive value 63.6% and accuracy 93.8% respectively. For CT, its sensitivity was 82.2%, specificity 50%, positive predictive value 93.8%, negative predictive value 23.5% and accuracy 79% respectively. PET/CT im- aging was superior to CT in sensitivity, specificity and accuracy. In conclusion, 18F-FDG PET/CT imaging is more significant in diagnosing bladder tumor metastasis lesions.展开更多
文摘BACKGROUND Bladder metastasis from lung cancer with epidermal growth factor receptor(EGFR)mutation is extremely rare.Here,we report a case of bladder metastasis from lung adenocarcinoma with EGFR mutation.CASE SUMMARY A 53-year-old female patient was diagnosed with advanced lung adenocarcinoma with EGFR exon 19 deletion.Multiple nodules on the bladder wall were found by regular examination of the pelvic cavity through computed tomography during targeted therapy.Further cystoscopy and histological examination of bladder biopsy tissues confirmed the bladder metastasis from lung adenocarcinoma.In addition,genetic analysis of the bladder metastasis revealed EGFR T790M mutation.The patient achieved a good response to a third-generation EGFR tyrosine kinase inhibitor.CONCLUSION During routine follow-up of lung cancer patients,imaging examination of the pelvic cavity should be performed to avoid missing bladder metastasis.The ultimate diagnosis of bladder metastasis sill depends on the pathological result of biopsy tissues.
文摘Renal cell carcinoma(RCC)is well known for its metastatic potential and predilection for unusual sites of metastasis.Metastasis to the bladder is rare and has been reported predominantly from clear cell RCC.We report a case of a 72-year-old male presenting with a bladder tumor which on histopathological evaluation was found to be a metastasis from papillary RCC,7 years after radical nephrectomy.This case highlights the need to maintain a high index of suspicion to diagnose bladder metastasis in a patient with a history of RCC presenting with a bladder lesion.
文摘Bladder tumor is the most common malignant tumor in urinary system and always com- panied with lymph node metastasis. The accurate staging plays a significant role in treatment for bladder tumor and prognostic evaluation, and the distant metastasis predicts worse prognosis. The objective of this study was to assess the clinical significance of 18F-FDG PET/CT imaging in diagnosing bladder tumor metastasis lesions. A retrospective analysis of 60 patients with bladder tumor from October 2008 to May 2010 was done. The patients were stratified based on the imaging technique. Among all 60 cases, besides the primary lesion, 81 suspected lesions were spotted and 73 confirmed as metastasis, including 50 lymph node metastases, 22 distant metastases, and 1 bone metastasis. For PET/CT imaging, its sensitivity was 94.5%, specificity 87.5%, positive predictive value 98.6%, negative predictive value 63.6% and accuracy 93.8% respectively. For CT, its sensitivity was 82.2%, specificity 50%, positive predictive value 93.8%, negative predictive value 23.5% and accuracy 79% respectively. PET/CT im- aging was superior to CT in sensitivity, specificity and accuracy. In conclusion, 18F-FDG PET/CT imaging is more significant in diagnosing bladder tumor metastasis lesions.
