Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and hyperglycemia.The management of T1D primarily focuses on exogenous insu...Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and hyperglycemia.The management of T1D primarily focuses on exogenous insulin replacement to control blood glucose levels.However,this approach does not address the underlying autoimmune process or prevent the progressive loss of beta cells.Recent research has explored the potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)as a novel intervention to modify the disease course and delay the onset of T1D.GLP-1RAs are medications initially developed for treating type 2 diabetes.They exert their effects by enhancing glucose-dependent insulin secretion,suppressing glucagon secretion,and slowing gastric emptying.Emerging evidence suggests that GLP-1RAs may also benefit the treatment of newly diagnosed patients with T1D.This article aims to highlight the potential of GLP-1RAs as an intervention to delay the onset of T1D,possibly through their potential immunomodulatory and anti-inflammatory effects and preservation of beta-cells.This article aims to explore the potential of shifting the paradigm of T1D management from reactive insulin replacement to proactive disease modification,which should open new avenues for preventing and treating T1D,improving the quality of life and long-term outcomes for individuals at risk of T1D.展开更多
目的:探讨动态血糖监测系统联合心理疏导对2型糖尿病患者的血糖控制、负性情绪及生活质量的影响。方法:选取我院2019年6月至2020年6月收治的2型糖尿病患者200例为研究对象,按照随机数表法将200例研究对象分为对照组(n=100)和观察组(n=1...目的:探讨动态血糖监测系统联合心理疏导对2型糖尿病患者的血糖控制、负性情绪及生活质量的影响。方法:选取我院2019年6月至2020年6月收治的2型糖尿病患者200例为研究对象,按照随机数表法将200例研究对象分为对照组(n=100)和观察组(n=100)。分析比较两组干预前和干预后空腹血糖(fasting plasmaglucose,FPG)、餐后2 h血糖(2 hours plasmaglucose,2hPG)及糖化血红蛋白(HbA1c)水平,焦虑自评量表(Self-rating anxiety scale,SAS)和抑郁自量表(Self-rating depression scale,SDS)评分、2型糖尿病患者生活质量评定量表(quality of life scale for patients with Type 2 diabetes mellitus,DMQLS)各维度评分。结果:干预后,观察组FPG、2hPG和HbA1c水平明显低于对照组,差异均有统计学意义(t=-7.988,-8.120,-5.811;P<0.001);干预后,观察组患者SAS和SDS评分降低程度较对照组高,差异均有统计学意义(t=-8.978,-7.359;P<0.001);干预后,观察组患者DMQLS各维度评分均明显低于对照组,差异有统计学意义(t=-6.088,-4.456,-4.399,-5.930,-3.900;P<0.001)。结论:动态血糖监测联合心理疏导能明显控制2型糖尿病患者的血糖水平,改善患者的不良情绪,提高其生活质量。展开更多
文摘Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and hyperglycemia.The management of T1D primarily focuses on exogenous insulin replacement to control blood glucose levels.However,this approach does not address the underlying autoimmune process or prevent the progressive loss of beta cells.Recent research has explored the potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)as a novel intervention to modify the disease course and delay the onset of T1D.GLP-1RAs are medications initially developed for treating type 2 diabetes.They exert their effects by enhancing glucose-dependent insulin secretion,suppressing glucagon secretion,and slowing gastric emptying.Emerging evidence suggests that GLP-1RAs may also benefit the treatment of newly diagnosed patients with T1D.This article aims to highlight the potential of GLP-1RAs as an intervention to delay the onset of T1D,possibly through their potential immunomodulatory and anti-inflammatory effects and preservation of beta-cells.This article aims to explore the potential of shifting the paradigm of T1D management from reactive insulin replacement to proactive disease modification,which should open new avenues for preventing and treating T1D,improving the quality of life and long-term outcomes for individuals at risk of T1D.
文摘目的:探讨动态血糖监测系统联合心理疏导对2型糖尿病患者的血糖控制、负性情绪及生活质量的影响。方法:选取我院2019年6月至2020年6月收治的2型糖尿病患者200例为研究对象,按照随机数表法将200例研究对象分为对照组(n=100)和观察组(n=100)。分析比较两组干预前和干预后空腹血糖(fasting plasmaglucose,FPG)、餐后2 h血糖(2 hours plasmaglucose,2hPG)及糖化血红蛋白(HbA1c)水平,焦虑自评量表(Self-rating anxiety scale,SAS)和抑郁自量表(Self-rating depression scale,SDS)评分、2型糖尿病患者生活质量评定量表(quality of life scale for patients with Type 2 diabetes mellitus,DMQLS)各维度评分。结果:干预后,观察组FPG、2hPG和HbA1c水平明显低于对照组,差异均有统计学意义(t=-7.988,-8.120,-5.811;P<0.001);干预后,观察组患者SAS和SDS评分降低程度较对照组高,差异均有统计学意义(t=-8.978,-7.359;P<0.001);干预后,观察组患者DMQLS各维度评分均明显低于对照组,差异有统计学意义(t=-6.088,-4.456,-4.399,-5.930,-3.900;P<0.001)。结论:动态血糖监测联合心理疏导能明显控制2型糖尿病患者的血糖水平,改善患者的不良情绪,提高其生活质量。
