STUDY OF A DIVICE ON THE WATCH FOR PARAMETER OF BLOOD PRESSURE AND ITS FLOW BY UNDAMAGED METHOD

ＳＴＵＤＹＯＦＡＤＩＶＩＣＥＯＮＴＨＥＷＡＴＣＨＦＯＲＰＡＲＡＭＥＴＥＲＯＦＢＬＯＯＤＰＲＥＳＳＵＲＥＡＮＤＩＴＳＦＬＯＷＢＹＵＮＤＡＭＡＧＥＤＭＥＴＨＯＤＳＴＵＤＹＯＦＡＤＩＶＩＣＥＯＮＴＨＥＷＡＴＣＨＦＯＲＰＡＲＡＭＥＴＥＲＯＦＢＬＯＯＤＰＲＥＳ...

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios alone or combined with prostate-specific antigen for the diagnosis of prostate cancer and clinically significant prostate cancer

Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our hospital.Methods:This study included patients with increased prostate-specific antigen(PSA)up to 20 ng/mL.The associations of neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR)alone or with PSA with PCa and clinically significant PCa were analyzed.Results:We included 365 patients,of whom 52.9%(193)had PCa including 66.8%(129)with GS of≥7.PSA density(PSAD)and PSA had better the area under the curve(AUC)of 0.722 and 0.585,respectively with pZ0.001 for detecting PCa compared with other blood parameters.PSA combined with PLR(PsPLR)and PSA with NLR(PsNLR)had better AUC of 0.608 and 0.610,respectively with p<0.05,for diagnosing GS≥7 population,compared with PSA,free/total PSA,NLR,PLR,and PsNPLR(PSA combined with NLR and PLR).NLR and PLR did not predict PCa on multivariate analysis.For GS≥7 cancer detection,in the multivariate analysis,separate models with PSA and NLR(Model 1:PsNLRþbaseline parameters)or PSA and PLR(Moder 2:PsPLRþbaseline parameters)were made.Baseline parameters comprised age,digital rectal exam-positive lesions,PSA density,free/total PSA,and magnetic resonance imaging.Model 2 containing PsPLR was statistically significant(odds ratio:2.862,95% confidence interval:1.174-6.975,p=0.021)in finding aggressive PCa.The predictive accuracy of Model 2 was increased(AUC:0.734,p<0.001)than that when only baseline parameters were used(AUC:0.693,p<0.001).Conclusion:NLR or PLR,either alone or combined with PSA,did not detect PCa.However,the combined use of PSA with PLR could find the differences between clinically significant and insignificant PCa in our retrospective study limited by the small number of samples.

Effects of stocking density on growth performance, blood parameters and immunity of growing pigs

This study was conducted to evaluate the effects of different stocking densities on growth performance,blood parameters,intestinal morphology and intestinal immunity of growing pigs.A total of288 male pigs(44.35±0.50 kg)were randomly assigned to groups with stocking densities of 2.46,1.23 and 0.82 m2/pig for a month.The results showed that there was no significant difference on growth performance among groups.Pigs in the stocking density of 0.82 m2/pig had the lowest backfat thickness and spleen weight index among groups(P<0.05).With increasing stocking density,the serum concentrations of blood urea nitrogen(BUN),transglutaminase(TGG),alkaline phosphatase(AKP)and immunoglobulin A(Ig A)were increased,and albumin(ALB),albumin-to-globulin ratio(ALB:GLO),insulin-like growth factor-1(IGF-1)and immunoglobulin(Ig M)were decreased(P<0.05),and cortisol tended to increase and glucose tended to decrease(0.05<P<0.1).Compared with the stocking density of 2.46 m2/pig,the ileal villus height and jejunal villus width decreased in stocking densities of 1.23 and 0.82 m2/pig(P<0.05).The duodenal villus height and ileal villus width in the stocking density of 0.82 m2/pig were the lowest among 3 groups(P<0.05).The content of immunoglobulin A in duodenum,jejunum and ileum mucosa increased along with increasing density(P<0.05).The contents of interleukin(IL)-2 in the spleen or liver and IL-10 in the spleen were higher in the stocking density of 0.82 m2/pig than in other 2 groups.These results showed that stocking density could affect the metabolism,intestinal morphology,and immunity of growing pigs and 1.23 m2/pig may be the suitable stocking density for the growing pigs in the present study.