The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in China’s mainland recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order ...The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in China’s mainland recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order to evaluate the safety profile for postmarketing Chinese medicines. A registry study on ten Chinese medicine injections for postmarketing surveillance has come to the end. From such a study observing more than 300,000 patients for more than 4 years, a theoretical research question emerges, that is, how to identify and evaluate safety evidence systematically. We put forward a brand new research paradigm on the theory level, which is to establish a body of evidence on safety evaluation for postmarketing Chinese medicine. Therefore, multiple information sources were explored and extracted from preclinical experiments for toxicity, postmarketing clinical trials for efficacy and safety evaluation, registry study for surveillance, retrospective data analysis from hospital information system and spontaneous response system, and case reports and systematic review from literature. Greater efforts for this idea and cooperation with experts in this field both in China and abroad are urgently needed.展开更多
Two-dimensional internal waves generated by a moving flat body in a continuous- ly stratified fluid are investigated by using three kinds of flow-visualization methods:electrolytic precipitation,hydrogen bubbles,and d...Two-dimensional internal waves generated by a moving flat body in a continuous- ly stratified fluid are investigated by using three kinds of flow-visualization methods:electrolytic precipitation,hydrogen bubbles,and dye streaks.Attentions are paid mainly to the generation and propagation process in the upstream region under low internal Froude number(1/10π<F_r<1/2π).The features of the upstream disturbances as well as their relationship with stratification number K (K=1/F_r) are illustrated.The corresponding theoretical analysis is briefly presented,and by comparison,the experimental and theoretical results agree well.展开更多
Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regu...Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regulation,which was published in PNAS(2017,114:2042—2047).展开更多
基金Supported by the Ninth-Science Foundation of Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences(No.Z0406)the Seventh Science Foundation of China Academy of Chinese Medical Sciences(No.ZZ070817)+1 种基金National Natural Science Foundation of China(General Program,No.81202776)China Postdoctoral Science Foundation project(No.2014T70202)
文摘The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in China’s mainland recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order to evaluate the safety profile for postmarketing Chinese medicines. A registry study on ten Chinese medicine injections for postmarketing surveillance has come to the end. From such a study observing more than 300,000 patients for more than 4 years, a theoretical research question emerges, that is, how to identify and evaluate safety evidence systematically. We put forward a brand new research paradigm on the theory level, which is to establish a body of evidence on safety evaluation for postmarketing Chinese medicine. Therefore, multiple information sources were explored and extracted from preclinical experiments for toxicity, postmarketing clinical trials for efficacy and safety evaluation, registry study for surveillance, retrospective data analysis from hospital information system and spontaneous response system, and case reports and systematic review from literature. Greater efforts for this idea and cooperation with experts in this field both in China and abroad are urgently needed.
基金The project supported by National Natural Science Foundation of China.
文摘Two-dimensional internal waves generated by a moving flat body in a continuous- ly stratified fluid are investigated by using three kinds of flow-visualization methods:electrolytic precipitation,hydrogen bubbles,and dye streaks.Attentions are paid mainly to the generation and propagation process in the upstream region under low internal Froude number(1/10π<F_r<1/2π).The features of the upstream disturbances as well as their relationship with stratification number K (K=1/F_r) are illustrated.The corresponding theoretical analysis is briefly presented,and by comparison,the experimental and theoretical results agree well.
文摘Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regulation,which was published in PNAS(2017,114:2042—2047).
