Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a treatment.Methods: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evalua...Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a treatment.Methods: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evaluated. The treatment dosage was three million IU three times a week for one year. All the patients underwent bone mass density detection at lumbar spine and femoral neck before and after the interferon-a treatment. All the necessary information such as age,sex, and laboratory test, history of occurrence of fractures, lifestyle, and menopause status was collected by interviewers face-to-face from participants at the research visit. Smoking was categorized by whether participants were nonsmokers or smokers. Menopause was designated if there had been complete cessation of menses for more than 12 months. All statistical analyses were performed by SPSS version 14(SPSS, Inc., Chicago, IL, USA).Results: Among 70 patients, 52% were male, 48% were female and the mean age was(57.0 ± 9.6) years(range: 24–79). Twenty-nine percent of the patients had a history of smoking. The mean body mass index was(24.4 ± 3.6) kg/m^2(range: 18.4–35.3). Of the70 cases, 21 had high fibrosis-4. The prevalence of overall fracture history was 2.9%(two patients).Conclusions: Chronic hepatitis C virus infection did increase the risk of development of metabolic bone disease in this cohort. Indeed, greater reduction of bone mass density occurs in advanced liver fibrosis. The bone loss in earlier stages of chronic hepatitis C infection is likely to result from increased bone reduction rather than decreased bone formation. Overall, these observations suggest an important role for chronic hepatitis C virus infection in increased bone turnover in osteodystrophy pathogenesis.展开更多
目的通过8955例长春市汉族人群骨密度测量,提供本地区骨密度正常参考值及峰值骨量,分析骨质疏松发生的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂尺桡骨中远端三分之一处骨密度（...目的通过8955例长春市汉族人群骨密度测量,提供本地区骨密度正常参考值及峰值骨量,分析骨质疏松发生的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂尺桡骨中远端三分之一处骨密度（BMD）。将8955例检测结果按不同性别每10岁分为一年龄组统计分析骨密度均值,T评分及骨量丢失百分率。结果长春市区男女BMD峰值分别为0.6244±0.098、0.5050±0.064,其BMD峰值出现在30岁年龄段,50岁以后开始缓慢下降。50～59岁男性OP发生率为6.95%,女性为8.52%;60～69岁男性OP发生率为19.66%,女性为35.44%;70～79岁男性OP发生率为38.39%,女性为60.64%;80岁以上男性OP发生率为58.17%,女性为72.73%。结论不同年龄组及同年龄组两性间比较BMD测定值差异显著（P〈0.01）,50岁以后各年龄段女性OP发生率明显高于男性（P〈0.01）。不同地域、不同民族、不同仪器检测的BMD数据存在差异。展开更多
基金Supported by Iran National Science Foundation(Grant No.91002993)
文摘Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a treatment.Methods: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evaluated. The treatment dosage was three million IU three times a week for one year. All the patients underwent bone mass density detection at lumbar spine and femoral neck before and after the interferon-a treatment. All the necessary information such as age,sex, and laboratory test, history of occurrence of fractures, lifestyle, and menopause status was collected by interviewers face-to-face from participants at the research visit. Smoking was categorized by whether participants were nonsmokers or smokers. Menopause was designated if there had been complete cessation of menses for more than 12 months. All statistical analyses were performed by SPSS version 14(SPSS, Inc., Chicago, IL, USA).Results: Among 70 patients, 52% were male, 48% were female and the mean age was(57.0 ± 9.6) years(range: 24–79). Twenty-nine percent of the patients had a history of smoking. The mean body mass index was(24.4 ± 3.6) kg/m^2(range: 18.4–35.3). Of the70 cases, 21 had high fibrosis-4. The prevalence of overall fracture history was 2.9%(two patients).Conclusions: Chronic hepatitis C virus infection did increase the risk of development of metabolic bone disease in this cohort. Indeed, greater reduction of bone mass density occurs in advanced liver fibrosis. The bone loss in earlier stages of chronic hepatitis C infection is likely to result from increased bone reduction rather than decreased bone formation. Overall, these observations suggest an important role for chronic hepatitis C virus infection in increased bone turnover in osteodystrophy pathogenesis.
文摘目的通过8955例长春市汉族人群骨密度测量,提供本地区骨密度正常参考值及峰值骨量,分析骨质疏松发生的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂尺桡骨中远端三分之一处骨密度（BMD）。将8955例检测结果按不同性别每10岁分为一年龄组统计分析骨密度均值,T评分及骨量丢失百分率。结果长春市区男女BMD峰值分别为0.6244±0.098、0.5050±0.064,其BMD峰值出现在30岁年龄段,50岁以后开始缓慢下降。50～59岁男性OP发生率为6.95%,女性为8.52%;60～69岁男性OP发生率为19.66%,女性为35.44%;70～79岁男性OP发生率为38.39%,女性为60.64%;80岁以上男性OP发生率为58.17%,女性为72.73%。结论不同年龄组及同年龄组两性间比较BMD测定值差异显著（P〈0.01）,50岁以后各年龄段女性OP发生率明显高于男性（P〈0.01）。不同地域、不同民族、不同仪器检测的BMD数据存在差异。
