This study identifies a decadal shift of summer surface air temperature （SAT） over Northeast Asia,including southeastern parts of Russia,Mongolia and northern China,around the mid-1990s.The results suggest that the ...This study identifies a decadal shift of summer surface air temperature （SAT） over Northeast Asia,including southeastern parts of Russia,Mongolia and northern China,around the mid-1990s.The results suggest that the SAT over the Northeast Asia experienced a significant warming after 1994 relative to that before 1993.This decadal shift also extends to northern China,and leads to a warmer summer over Northeast China and North China after the mid-1990s.The decadal warming over Northeast Asia is found to concur with the enhancement of South China rainfall around the mid-1990s.On the one hand,both the Northeast Asian SAT and South China rainfall exhibit this mid-1990s decadal shift only in summer,but not in other seasons.On the other hand,both the Northeast Asian SAT and South China rainfall exhibit this mid-1990s decadal shift not only in the summer seasonal mean,but also in each month of summer （June,July and August）.Furthermore,the decadal warming is found to result from an anticyclonic anomaly over Northeast Asia,which can be interpreted as the response to the increased precipitation over South China,according to previous numerical results.Thus,we conclude that the warming shift of summer Northeast Asian SAT around the mid-1990s was a remote response to the increased precipitation over South China.展开更多
Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
Introduction：Alzheimer’s disease（AD）begins to develop decades prior to its clinical manifestation（Sperling et al.,2011）,and while it is the most common form of dementia,as of yet there is no cure.Two of the most...Introduction：Alzheimer’s disease（AD）begins to develop decades prior to its clinical manifestation（Sperling et al.,2011）,and while it is the most common form of dementia,as of yet there is no cure.Two of the most researched pathological features contributing to disease development are the extracellular amyloid plaques composed of amyloid-beta proteins（Aβ）and neurofibrillary tangles of tau proteins.Another feature of AD is the progression of early neuronal excitability/hyperactivity to silencing/hypoactivity（Palop and Mucke,2010）,展开更多
With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cin...With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cinema to attract the attention of larger audiences.With regard to the box office performance of Chinese Women’s Cinema,there seems to be a gap in research in finding an association between women’s status and the relevant films’box office performance.The purpose of this research is to outline the underlying reasons for the changes in gender roles and gender representation in the Chinese film industry over the past few decades in order to better understand this expansive social change in the 21st century.This study provides a comprehensive analysis through the use of questionnaires to better understand society’s attitude towards gender representation within the film industry.The questionnaire findings indicate that there is a direct correlation between people’s awareness of women’s changing status and gender equality and their acceptance of materials produced by Chinese Women’s Cinema.At the some time,it highlights that the Chinese government’s support and initiatives for gender equality have had a significant impact on the general popularity of Chinese Women’s Cinema.The significance of this research is to effectively popularize Chinese Women’s Cinema culture and the box office growth by understanding the social attitude towards gender representation in the Chinese film industry and to provide relevant information about the development direction and trend of Chinese Women’s Cinema.Furthermore,this research aims to provide foundational support for gender equality and help to understand the underlying factors that society needs to promote gender equality.展开更多
<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle...<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. <strong>Objective: </strong>The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. <strong>Methods:</strong> We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. <strong>Results:</strong> A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. <strong>Conclusion: </strong>Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.展开更多
Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent amo...Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent among them.This study is a discussion of the elevation-dependent warming(EDW),snowfall shift,and precipitation variability over Sikkim Himalaya using a high-resolution ERA5-land dataset.Furthermore,the findings show that the Sikkim Himalaya region is experiencing a warming trend from south to north.The majority of the Sikkim Himalayan region shows a declining trend in snowfall.A positive advancement in snowfall trend(at a rate of 1 mm per decade)has been noticed above 4500 meters.The S/P ratio indicates a shift in snowfall patterns,moving from lower elevations to much higher regions.This suggests that snowfall has also transitioned from Lachung and Lachen(3600 m)to higher elevated areas.Moreover,the seasonal shifting of snowfall in the recent decade is seen from January-March(JFM)to February-April(FMA).Subsequently,the preceding 21 years are being marked by a significant spatiotemporal change in temperature,precipitation,and snowfall.The potent negative correlation coefficient between temperature and snowfall(–0.9),temperature and S/P ratio(–0.5)suggested the changing nature of snowfall from solid to liquid,which further resulted in increased lower elevation precipitation.The entire Sikkim region is transitioning from a cold-dry to a warm-wet weather pattern.In the climate change scenario,a drop in the S/P ratio with altitude will continue to explain the rise in temperature over mountainous regions.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 41105046)the National Basic Research Program of China (Grant No. 2010CB950403)the Chinese Academy of Sciences (Grant No. XDA05090000)
文摘This study identifies a decadal shift of summer surface air temperature （SAT） over Northeast Asia,including southeastern parts of Russia,Mongolia and northern China,around the mid-1990s.The results suggest that the SAT over the Northeast Asia experienced a significant warming after 1994 relative to that before 1993.This decadal shift also extends to northern China,and leads to a warmer summer over Northeast China and North China after the mid-1990s.The decadal warming over Northeast Asia is found to concur with the enhancement of South China rainfall around the mid-1990s.On the one hand,both the Northeast Asian SAT and South China rainfall exhibit this mid-1990s decadal shift only in summer,but not in other seasons.On the other hand,both the Northeast Asian SAT and South China rainfall exhibit this mid-1990s decadal shift not only in the summer seasonal mean,but also in each month of summer （June,July and August）.Furthermore,the decadal warming is found to result from an anticyclonic anomaly over Northeast Asia,which can be interpreted as the response to the increased precipitation over South China,according to previous numerical results.Thus,we conclude that the warming shift of summer Northeast Asian SAT around the mid-1990s was a remote response to the increased precipitation over South China.
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
文摘Introduction：Alzheimer’s disease（AD）begins to develop decades prior to its clinical manifestation（Sperling et al.,2011）,and while it is the most common form of dementia,as of yet there is no cure.Two of the most researched pathological features contributing to disease development are the extracellular amyloid plaques composed of amyloid-beta proteins（Aβ）and neurofibrillary tangles of tau proteins.Another feature of AD is the progression of early neuronal excitability/hyperactivity to silencing/hypoactivity（Palop and Mucke,2010）,
文摘With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cinema to attract the attention of larger audiences.With regard to the box office performance of Chinese Women’s Cinema,there seems to be a gap in research in finding an association between women’s status and the relevant films’box office performance.The purpose of this research is to outline the underlying reasons for the changes in gender roles and gender representation in the Chinese film industry over the past few decades in order to better understand this expansive social change in the 21st century.This study provides a comprehensive analysis through the use of questionnaires to better understand society’s attitude towards gender representation within the film industry.The questionnaire findings indicate that there is a direct correlation between people’s awareness of women’s changing status and gender equality and their acceptance of materials produced by Chinese Women’s Cinema.At the some time,it highlights that the Chinese government’s support and initiatives for gender equality have had a significant impact on the general popularity of Chinese Women’s Cinema.The significance of this research is to effectively popularize Chinese Women’s Cinema culture and the box office growth by understanding the social attitude towards gender representation in the Chinese film industry and to provide relevant information about the development direction and trend of Chinese Women’s Cinema.Furthermore,this research aims to provide foundational support for gender equality and help to understand the underlying factors that society needs to promote gender equality.
文摘<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. <strong>Objective: </strong>The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. <strong>Methods:</strong> We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. <strong>Results:</strong> A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. <strong>Conclusion: </strong>Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.
文摘Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent among them.This study is a discussion of the elevation-dependent warming(EDW),snowfall shift,and precipitation variability over Sikkim Himalaya using a high-resolution ERA5-land dataset.Furthermore,the findings show that the Sikkim Himalaya region is experiencing a warming trend from south to north.The majority of the Sikkim Himalayan region shows a declining trend in snowfall.A positive advancement in snowfall trend(at a rate of 1 mm per decade)has been noticed above 4500 meters.The S/P ratio indicates a shift in snowfall patterns,moving from lower elevations to much higher regions.This suggests that snowfall has also transitioned from Lachung and Lachen(3600 m)to higher elevated areas.Moreover,the seasonal shifting of snowfall in the recent decade is seen from January-March(JFM)to February-April(FMA).Subsequently,the preceding 21 years are being marked by a significant spatiotemporal change in temperature,precipitation,and snowfall.The potent negative correlation coefficient between temperature and snowfall(–0.9),temperature and S/P ratio(–0.5)suggested the changing nature of snowfall from solid to liquid,which further resulted in increased lower elevation precipitation.The entire Sikkim region is transitioning from a cold-dry to a warm-wet weather pattern.In the climate change scenario,a drop in the S/P ratio with altitude will continue to explain the rise in temperature over mountainous regions.
