Optimization of the extraction process of total flavonoids from Trichosanthis Fructus by Box-Behnken response surface method combined with differential spectrophotometry

Objective:To optimize the extraction process of total flavones in Trichosanthis Fructus(composed of Trichosanthis pericarpium and Trichosanthis semen in certain proportion).Methods:The effects of the mixture ratio of Trichosanthis pericarpium and Trichosanthis semen,ethanol concentration,ultrasonic extraction time and extraction temperature on the extraction rate of total flavonoids in Trichosanthis Fructus were investigated.The extraction process of total flavonoids in Trichosanthis Fructus was optimized by Box-Behnken response surface method combined with differential spectrophotometry.Results:The optimum extraction conditions of total flavonoids in Trichosanthis Fructus were as follows:The mixture ratio of Trichosanthis pericarpium and Trichosanthis semen was 4:6,the ethanol concentration was 70%,the ultrasonic extraction time was 60min and the extraction temperature was 40℃.Conclusion:Box-Behnken response surface method combined with differential spectrophotometry can optimize the extraction process of total flavonoids from Trichosanthis Fructus,which can provide reference for the extraction and application of total flavonoids in Trichosanthis Fructus.

Failure pressure calculation of fracturing well based on fluid-structure interaction

Failure pressure is a key parameter in reservoir hydrofracturing operation. Existing analytical methods for calculating the failure pressure are based on the assumption that borehole fluid is under two extreme conditions: non-infiltration or complete infiltration. The assumption is not suitable for the actual infiltration process, and this will cause a great error in practical calculation. It shows that during the injection process, the dynamic variation in effective stress-dependent permeability has an influence on the infiltration, and the influence also brings about calculation errors. Based on the fluid-structure interaction and finite element method (FEM), considering partial infiltration during injection process, a numerical model for calculating rock failure pressure is established. According to the analysis of permeability test results and response-surface method, a new variation rule of rock permeability with the change of effective stress is presented, and the relationships among the permeability, confining pressure and pore pressure are proposed. There are some differences between the dynamic value of permeability-effective-stress coefficient observed herein and the one obtained by the classical theory. Combining with the numerical model and the dynamic permeability, a coupling method for calculating failure pressure is developed. Comparison of field data and calculated values obtained by various methods shows that accurate values can be obtained by the coupling method. The coupling method can be widely applied to the calculation of failure pressure of reservoirs and complex wells to achieve effective fracturing operation.

A quick evaluation model for CO_2 flooding and sequestration

CO2 flooding not only triggers an increase in oil production,but also reduces the amount of CO2 released to the atmosphere （by storing it permanently in the formations）.It is one of the best ways to use and store CO2.This paper firstly selects the key factors after analyzing the factors influencing the CO2 storage potential in the formations and oil recovery,and then introduces a series of dimensionless variables to describe reservoir characteristics.All influencing factors with varying values are calculated through a Box-Behnken experimental design.The results are interpreted by a response surface method,and then a quick screening model is obtained to evaluate the oil recovery and CO2 storage potential for an oil reservoir.Based on the evaluation model,sensitivity analysis of each factor is carried out.Finally,research on CO2 sequestration and flooding in a typical reservoir indicates that the evaluation model fits well with the numerical simulation,which proves that the evaluation model can provide criteria for screening attractive candidate reservoirs for CO2 sequestration and flooding.

Parametric optimization of friction stir welding process of age hardenable aluminum alloys-ANFIS modeling

A comparative approach was performed between the response surface method(RSM) and the adaptive neuro-fuzzy inference system(ANFIS) to enhance the tensile properties, including the ultimate tensile strength and the tensile elongation, of friction stir welded age hardenable AA6061 and AA2024 aluminum alloys. The effects of the welding parameters, namely the tool rotational speed, welding speed, axial load and pin profile, on the ultimate tensile strength and the tensile elongation were analyzed using a three-level, four-factor Box-Behnken experimental design. The developed design was utilized to train the ANFIS models. The predictive capabilities of RSM and ANFIS were compared based on the root mean square error, the mean absolute error, and the correlation coefficient based on the obtained data set. The results demonstrate that the developed ANFIS models are more effective than the RSM model.

Study on the Effect of Preparation Parameters of K₂CO₃/Al₂O₃Sorbent on CO₂Capture Capacity at Flue Gas Operating Conditions

In this paper, study on the effect of preparation conditions of K2CO3/Al2O3 sorbent was done. Box-Behnken design was applied to study the influence of four parameters involve initial solution concentration, impregnation time and calcination step temperature and time. A quadratic model was used to correlate the sorbent capture capacity. The model was used to calculate the optimum conditions for preparing sorbent. From the analysis of variance (ANOVA), the most influential factor on each experimental design response was identified. The potassium-based sorbents used in this study were prepared by impregnating K2CO3 on Al2O3 support. The CO2 capture capacity was measured in the presence of H2O in a fixed-bed reactor at CO2 capture temperature of 60°C using breakthrough curves. The optimum sorbent prepared by this method showed CO2 capture capacity of 77.21 mg CO2/g sorbent. It was observed that the experimental values obtained were in good agreement with the values predicted by the model, with relatively small errors between the predicted and the actual values. The results obtained in this study can be used as basic data for study on design and operating condition optimization of CO2 capture process using these sorbents.

The Effects of Stochastic Characteristics of Materials on the Reliability of a Composite Ship Hull

The effects of stochastic characteristics of materials on the reliability of ship hulls made of composite materials under longitudinal moment were extensively studied using reliability and sensitivity calculations of a composite ship hull which was sagging.The reliability indices and failure probabilities of the ship in three kinds of failure modes (buckling,material failure,and ultimate collapse) were calculated by the surface response method and JC method.The importance factors of random variables in stochastic models,such as the model errors in predicting the ultimate longitudinal strength of ship and the longitudinal bending moment that the ship withstands,as well as the stochastic characteristics of materials in the models used,were calculated.Then,the effects of these random variables,including the stochastic characteristics of materials on the reliability index and the failure probability of ships which were sagging,were discussed with their importance factors.The results show that the effects of stochastic characteristics of materials on the reliability of ship hulls made of composite materials should be considered during the reliability assessment of composite ships.Finally,some conclusions and recommendations were given for high-speed ship design and safety assessment.

Crashworthiness uncertainty analysis of typical civil aircraft based on Box–Behnken method

The crashworthiness is an important design factor of civil aircraft related with the safety of occupant during impact accident. It is a highly nonlinear transient dynamic problem and may be greatly influenced by the uncertainty factors. Crashworthiness uncertainty analysis is conducted to investigate the effects of initial conditions, structural dimensions and material properties. Simplified finite element model is built based on the geometrical model and basic physics phenomenon. Box-Behnken sampling and response surface methods are adopted to obtain gradient information. Results show that the proposed methods are effective for crashworthiness uncertainty analysis. Yield stress, frame thickness, impact velocity and angle have great influence on the failure behavior, and yield stress and frame thickness dominate the uncertainty of internal energy. Failure strain and tangent modulus have the smallest influence on the initial peak acceleration, and gradients of mean acceleration increase because the appearance of material plastic deformation and element failure.

Uncertainty quantification of stability and damage detection parameters of coupled hydrodynamic-ground motion in concrete gravity dams

In this paper, models of the global system of the Koyna dam have been created using ABAQUS software considering the dam-reservoir-fbundation interaction. Non coupled models and the coupled models were compared regarding the horizontal displacement of the dam crest and the differential settlement of the dam base in clay foundation. Meta models were constructed and uncertainty quantification process was adopted by the support of Sobol's sensitivity in dices considering five un certain parameters by exploiting Box-Behnken experimental method. The non coupled models results determined overestimated predicted stability and damage detection in the dam. The rational effects of the reservoir height were very sensitive in the variation of the horizontal displacement of the dam crest with a small interaction effect with the beta viscous damping coefficient of the clay fbundation. The modulus of elasticity of the clay foundation was the decisive parameter regarding the variation of the differential settlement of the dam base. The XFEM approach has been used for damage detection in relation with both minimum and maximum values of each uncertain parameter. Finally the effects of clay and rock foundations were determined regarding the resistance against the propagation of cracks in the dam, where the rock fbundation was the best.

Enhancement of the electrocatalytic oxidation of antibiotic wastewater over the conductive black carbon-PbO2 electrode prepared using novel green approach

The secondary pollution caused by modification of an electrode due to doping of harmful materials has long been a big concern.In this study,an environmentally friendly material,conductive carbon black,was adopted for modification of lead dioxide electrode(Pb02).It was observed that the as-prepared conductive carbon black modified electrode(C-PbO2)exhibited an enhanced electrocatalytical performance and more stable structure than a pristine Pb02 electrode,and the removal efficiency of metronidazole(MNZ)and COD by a 1.0%C-Pb02 electrode at optimal conditions was increased by 24.66%and 7.01%,respectively.Results revealed that the electrochemical degradation of MNZ wastewater followed pseudo-first-order kinetics.This intimates that the presence of conductive carbon black could improve the current efficiency,promote the generation of hydroxyl radicals,and accelerate the removal of MNZ through oxidation.In addition,MNZ degradation pathways through a C-Pb02 electrode were proposed based on the identified intermediates.To promote the electrode to treat antibiotic wastewater,optimal experimental conditions were predicted through the Box-Behnken design(BBD)method.The results of this study suggest that a C-Pb02 electrode may represent a promising functional material to pretreat antibiotic wastewaters.

Control efficiency optimization and Sobol＇s sensitivity indices of MTMDs design parameters for buffeting and flutter vibrations in a cable stayed bridge

This paper studies optimization of three design parameters （mass ratio, frequency ratio and damping ratio） of multiple tuned mass dampers MTMDs that are applied in a cable stayed bridge excited by a strong wind using minimax optimization technique. ABAQUS finite element program is utilized to run numerical simulations with the support of MATLAB codes and Fast Fourier Transform FFT technique. The optimum values of these three parameters are validated with two benchmarks from the literature, first with Wang and coauthors and then with Lin and coauthors. The validation procedure detected a good agreement between the results. Box-Behnken experimental method is dedicated to formulate the surrogate models to represent the control efficiency of the vertical and torsional vibrations. Sobol＇s sensitivity indices are calculated for the design parameters in addition to their interaction orders. The optimization results revealed better performance of the MTMDs in controlling the vertical and the torsional vibrations for higher mode shapes. Furthermore, the calculated rational effects of each design parameter facilitate to increase the control efficiency of the MTMDs in conjunction with the support of the surrogate models.

β-Cyclodextrin inclusion complex： preparation, characterization, and its aspirin release in vitro

In this work, the optimal clathration condition was investigated for the preparation of aspirin-β-cyclodextrin （Asp-β-CD） inclusion complex using design of experiment （DOE） methodology. A 3-level, 3-factor Box-Behnken design with a total of 17 experimental runs was used. The Asp-β-CD inclusion complex was prepared by saturated solution method. The influence on the embedding rate was investigated, including molar ratio of β-CD to Asp, clathration temperature and clathration time, and the optimum values of such three test variables were found to be 0.82, 49C and 2.0 h, respectively. The embedding rate could be up to 61.19%. The formation of the bonding between -COOH group of Asp and O-H group of β-CD might play an important role in the process of clathration according to FT-IR spectra. Release kinetics of Asp from inclusion complex was studied for the evaluation of drug release mechanism and diffusion coefficients. The results showed that the drug release from matrix occurred through Fickian diffusion mechanism. The cumulative release of Asp reached only 40% over 24 h, so the inclusion complex could potentially be applied as a long-acting delivery system.

Optimization of Solid-Phase Extraction Conditions for Perfluorooctanoic Acid in Leachate

In order to optimize the solid phase extraction(SPE)conditions of perfluorooctanoic acid(PFOA)in the raw leachate and treated leachate,the effects of activator properties,SPE cartridge,p H value,ionic strength,and eluent properties were studied through single factor experiments.The optimal results of each single factor were obtained.Considering that the concentration of PFOA in the treated leachate is lower than that of the raw leachate,the SPE conditions of the treated leachate have been further optimized.Based on the above single-factor experiment,the main influencing factors were screened out as the volume of activator,ionic strength,and volume of eluent,and the three-factor threelevel response surface methodology(RSM)was optimized.The optimum SPE conditions of PFOA from treated landfill leachate were as follows:Activation of weak anion exchange(WAX)cartridge with 10 mL methanol,dosage of 600 mg KCl,6 m L 1%ammonia methanol eluted PFOA,the theory recovery rate is over95.67%.It has been verified that the error between the predicted value and the actual extraction recovery is small and has good repeatability.