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An animal model of cerebral palsy induced by prenatal exposure to lipopolysaccharide and hypoxia 被引量:4
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作者 Gang Chen Yanrong HU +8 位作者 Wei Liu Jiang Li Linbao Wen Jianxin Li Lihui Zhao Xiaopeng Yang Yi Zhu Zhenzhu Sun Guangming Chi 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第14期1100-1103,共4页
BACKGROUND: Neonatal cerebral palsy is mainly caused by prenatal factors. At present, an animal model of prenatal infection and early postnatal hypoxia does not exist. OBJECTIVE: To observe morphology and motor perf... BACKGROUND: Neonatal cerebral palsy is mainly caused by prenatal factors. At present, an animal model of prenatal infection and early postnatal hypoxia does not exist. OBJECTIVE: To observe morphology and motor performance following prenatal infection and hypoxic insult-induced brain damage of neonatal rats to verify the feasibility to establish a model of cerebral palsy. DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Laboratories of Xinjiang Center for Disease Control and Prevention from September 2007 to June 2008. MATERIALS: The hypoxic incubator was purchased from Shanghai Pediatric Medical Institute, China. Lipopolysaccharide (LPS, Escherichia coil, 055: B5) was purchased from Sigma-Aldrich (St. Louis, MO, USA). METHODS: A total of 27 Wistar rats, aged 7 days, were randomly assigned to sham-surgery group (n = 15) with no carotid artery incision or hypoxia treatment, hypoxia/ischemia (H/I) group (n = 12) undergoing ligature of the right common carotid artery followed by exposure to hypoxia at postnatal day 7 (P7), and LPS/H group (n = 19), in which pregnant rats were exposed in utero to LPS followed by prenatal hypoxia at embryonic day 16. MAIN OUTCOME MEASURES: Behavior, compound muscle action potential, and pathological changes were observed in 28-day-old rats. RESULTS: The footprint repeat space showed that left limb footprint repeatability in the H/I and LPS/H groups was lower than in the sham-surgery group (P 〈 0.05). The space between the footprints was larger and unstable. Hind limb quadricep compound muscle action potential in the H/I and LPS/H groups showed lower wave amplitude compared with the sham-surgery group (P〈 0.05) Hematoxylin and eosin staining showed irregular cells around the ventricle, as well as periventricular leukomalacia. CONCLUSION: An animal model of cerebral palsy was established, which simulated the human condition most likely associated with occurrence of this disease. This model could be used for experimental studies related to cerebral palsy. 展开更多
关键词 inflammation HYPOXIA animal model cerebral palsy periventricular leukomalacia brain injury neural regeneration
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Stem cell treatment and cerebral palsy: Systemic review and meta-analysis 被引量:9
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作者 Simone Eggenberger Céline Boucard +4 位作者 Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller 《World Journal of Stem Cells》 SCIE 2019年第10期891-903,共13页
BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 ... BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. 展开更多
关键词 cerebral palsy PERINATAL brain injury STEM CELLS Umbilical cord blood Mesenchymal stem/stromal CELLS Gross motor function META-ANALYSIS
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A rat pup model of cerebral palsy induced by prenatal inflammation and hypoxia 被引量:1
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作者 Yanrong Hu Gang Chen +9 位作者 Hong Wan Zhiyou Zhang Hong Zhi Wei Liu Xinwei Qian Mingzhao Chen Linbao Wen Feng Gao Jianxin Li Lihui Zhao 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第9期817-824,共8页
Animal models of cerebral palsy established by simple infection or the hypoxia/ischemia method cannot effectively simulate the brain injury of a premature infant. Healthy 17-day-pregnant Wistar rats were intraperitone... Animal models of cerebral palsy established by simple infection or the hypoxia/ischemia method cannot effectively simulate the brain injury of a premature infant. Healthy 17-day-pregnant Wistar rats were intraperitoneally injected with lipopolysaccharide then subjected to hypoxia. The pups were used for this study at 4 weeks of age. Simultaneously, a hypoxia/ischemia group and a control group were used for comparison. The results of the footprint test, the balance beam test, the water maze test, neuroelectrophysiological examination and neuropathological examination demonstrated that, at 4 weeks after birth, footprint repeat space became larger between the forelimbs and hindlimbs of the rats, the latency period on the balance beam and in the Morris water maze was longer, place navigation and ability were poorer, and the stimulus intensity that induced the maximal wave amplitude of the compound muscle action potential was greater in the lipopolysaccharide/hypoxia and hypoxia/ischemia groups than in the control group. We observed irregular cells around the periventricular area, periventricular leukomalacia and breakage of the nuclear membrane in the lipopolysacchadde/hypexia and hypoxia/ischemia groups. These results indicate that we successfully established a Wistar rat pup model of cerebral palsy by intraperitoneal injection of lipopolysaccharide and hypoxia. 展开更多
关键词 neural regeneration brain injury HYPOXIA lipopolysaccharide animal models cerebral palsy watermaze test neuroelectrophysiology histopathology grants-supported paper photographs-containing paper neuroregeneration
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Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia:effects on neurobehavioral phenotypes
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作者 Xiaowen Xu Xinxin Wang +5 位作者 Li Zhang Yiming Jin Lili Li Meifang Jin Lianyong Li Hong Ni 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2760-2772,共13页
Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy.Currently,there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury.Here,we i... Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy.Currently,there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury.Here,we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide,which can protect against hypoxic injury in adulthood,in a mouse model of neonatal hypoxic-ischemic brain injury.In this study,nicotinamide adenine dinucleotide(5 mg/kg)was intraperitoneally administered 30 minutes befo re surgery and every 24 hours thereafter.The results showed that nicotinamide adenine dinucleotide treatment improved body weight,brain structure,adenosine triphosphate levels,oxidative damage,neurobehavioral test outcomes,and seizure threshold in experimental mice.Tandem mass tag proteomics revealed that numerous proteins were altered after nicotinamide adenine dinucleotide treatment in hypoxic-ischemic brain injury mice.Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine(or cysteine)peptidase inhibitor,clade A,member 3N,fibronectin 1,5'-nucleotidase,cytosolic IA,microtubule associated protein 2,and complexin 2.Proteomics analyses showed that nicotinamide adenine dinucleotide ameliorated hypoxic-ischemic injury through inflammation-related signaling pathways(e.g.,nuclear factor-kappa B,mitogen-activated protein kinase,and phosphatidylinositol 3 kinase/protein kinase B).These findings suggest that nicotinamide adenine dinucleotide treatment can improve neurobehavioral phenotypes in hypoxic-ischemic brain injury mice through inflammation-related pathways. 展开更多
关键词 brain injury cerebral palsy HYPOXIA hypoxic-ischemic brain injury inflammation NEUROPROTECTION nicotinamide adenine dinucleotide NEONATE nicotinamide adenine dinucleotide PROTEOMICS
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Establishing a rat model of spastic cerebral palsy by targeted ethanol injection 被引量:5
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作者 Yadong Yu Liang Li +2 位作者 Xinzhong Shao Fangtao Tian Qinglu Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第34期3255-3262,共8页
Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxi... Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxic instrument under intraperitoneal anesthesia. Based on the rat brain stereotaxic map, a 1-mm hole was made 10 mm posterior to bregma and 0.8 mm left of sagittal suture. A microsyringe was inserted perpendicularly to the surface of the brain to a depth of 9.7 mm, and 15 wL of ethanol was slowly injected to establish a rat model of spastic cerebral palsy. After modeling, the rats appeared to have necrotic voids in the pyramidal tract and exhibited typical signs and symptoms of flexion spasms that lasted for a long period of time. These findings indicate that this is an effective and easy method of establishing a rat model of spastic cerebral palsy with good reproducibility. Ethanol as a chemical ablation agent specifically and thoroughly damages the py- ramidal tract, and therefore, the animals display flexion spasms, which are a typical symptom of the disease. 展开更多
关键词 neural regeneration brain injury spastic cerebral palsy animal models ETHANOL pyramidal tractstereotaxic instrument targeted injection modeling methods NEUROREGENERATION
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Therapies for children with cerebral palsy A Web of Science-based literature analysis 被引量:2
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作者 Yaping Mu Na Li Lijun Guan Chunnan Wang Shuyun Shang Yan Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第33期2632-2639,共8页
OBJECTIVE: To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL: We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2... OBJECTIVE: To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL: We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA: Inclusion criteria: (a) peer-reviewed published articles on botulinum toxin, constraint-induced movement therapy, or acupuncture for children with cerebral palsy indexed in Web of Science; (b) original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items; and (c) publication between 2002 and 2011. Exclusion criteria: (a) articles that required manual searching or telephone access; (b) documents that were not published in the public domain; and (c) a number of corrected papers from the total number of articles. MAIN OUTCOME MEASURES: (1) Number of publications on the three therapies; (2) annual publication output, distribution by journals, distribution by institution, and top-cited articles on botulinum toxin; (3) annual publication output, distribution by journal, distribution by institution, and top-cited articles on constraint-induced movement therapy; (4) annual publication, distribution by journal, distribution by institution, and top-cited articles on acupuncture. RESULTS: This analysis, based on Web of Science articles, identified several research trends in studies published over the past 10 years of three therapies for children with cerebral palsy. More articles on botulinum toxin for treating children with cerebral palsy were published than the articles regarding constraint-induced movement therapy or acupuncture. The numbers of publications increased over the 10-year study period. Most papers appeared in journals with a focus on neurology, such as Developmental Medicine and Child Neurology and Journal of Child Neurology.Research institutes publishing on botulinum toxin treatments for this population are mostly in the Netherlands, the United States of America, and Australia; those publishing on constraint-induced movement therapy are mostly in Australia and the United States of America; and those publishing on acupuncture are mostly in China, Sweden and the United States of America.CONCLUSION: Analysis of literature and research trends indicated that there was no one specific therapy to cure cerebral palsy. Further studies are still necessary. 展开更多
关键词 constraint-induced movement therapy botulinum toxin ACUPUNCTURE cerebral palsy nerve injury INFANT children brain Web of Science BIBLIOMETRIC neural regeneration
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Vojta and Bobath combined treatment for high risk infants with brain damage at early period 被引量:1
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作者 Chunyan Wu Xiaohui Peng +3 位作者 Xuesong Li Qingling Niu Hong Guo Huitao Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第2期121-125,共5页
BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage, the occasion and choosing methods of interventions and the combined application of different interventions are s... BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage, the occasion and choosing methods of interventions and the combined application of different interventions are still at the exploratory phase. OBJECTIVE: To observe the efficacy of early intervention using Vojta and Bobath combined treatment in high risk infants with brain damage, and investigate the effect of early rehabilitation on the prognosis. DESIGN: A randomized controlled comparative observation. SETTING: Daqing Oil Field General Hospital of Heilongjiang Province. PARTICIPANTS: Eighty-four high risk infants younger than l year were selected from the Department of Pediatrics, Daqing Oil Field General Hospital of Heilongjiang Province from October 2005 to October 2006, including 52 boys (62%) and 32 girls (38%). The treatment started at the age of 0 - 3 months in II cases (13%), 4 - 6 months in 28 cases (33%), 7 - 9 months in 35 cases (42%), and 10 - 12 months in 10 cases (1 2%). Infants with at least two of the followings were enrolled, including 7 Vojta abnormal postural reflexes, slow or disorder of motor development, increase of muscular tension, postural abnormality, primary reflection residual and CT/MRI abnormalities. Informed consents were obtained from their guardians. The 84 infants were randomly divided into treatment group (n =42) and control group (n =42). METHODS: All the children were intravenously injected with cerebroprotein hydrolysate injection or cattle encephalon glycoside and ignotin injection, 10 times as a course for 2 - 5 courses; Besides, the infants in the treatment group also received early rehabilitative training of Vojta and Bobath combined treatment, once a day, 40 minutes per time, 5 times a week followed by a 2-day rest, 1 month as a course, and totally 2 - 5 courses. The Vojta method was to facilitate the automatic regulation by reflexlocomotion. Bobath method was to inhibit abnormal posture but facilitate the normal one, thus it is also called neurodevelopmental therapy realized by reflex inhibition and facilitation. The rehabilitation was evaluated clinically using Gesell Development Schedules (GDS) after the courses when the infants were 1 year old. GDS included five aspects of adaptive behavior, gross motor, refine motor, speech, individual-social behavior. The developmental quotient (DQ) could be calculated according to their development. DQ=developmental age/actual age × 100, 〈 85 points was taken as abnormal; The higher the DQ value, the better the development. (2) Evaluation of efficacy: Cured: Developmental order reached normal or generally normal, abnormal posture disappeared, muscular tension ameliorated, symmetric limbs' motor function, free movement, normal intelligence, powerful reaction, and clear speech. Significant effect: Developmental order tended to normal, abnormal posture disappeared incompletely, muscular tension ameliorated incompletely, transient pause in the flexion and extension of limbs, good reaction, and improved intelligence. Effective: Developmental order improved to a certain degree, muscular tension ameliorated, limbs' motor function and posture improved as compared with before treatment, but still under control, intelligence improved a little. Invalid: No obvious changes before and after treatment. Total significant effective rate=(cured cases+cases of significant effect)/total cases × 100%. (3) The enumeration data and measurement data were compared with chi-square test and t test respectively. MAIN OUTCOME MEASURES: Clinical efficacy and GDS results at 1 year old in both groups. RESUTLS: All the 84 infants were involved in the analysis of results. (1) Efficacy: The total significant effective rate in the treatment group was higher than that in the control group (93%, 74%, x^2=4.2, P 〈 0.05). (2) Results of GDS evaluation: The DQ values of individual intercourse and social adaptation in the treatment group (93.57±11.23, 95.13±9.32) were higher than those in the control group (88.27±10.18, 90.10±10.67, t =2.267, 2.301, P 〈 0.05); The DQ values of gross motor, fine motor and speech in the treatment group (90.78±10.20, 98.63±9.23, 93.69±11.31) were higher than those in the control group (84.32± 11.33, 87.80±8.61, 85.52±10.61, t =2.746, 5.560, 2.746, P 〈 0.01). The interventional effects on each functional area were significant, especially the gross motor, fine motor and speech. CONCLUSION: The Vojta and Bobath combined treatment on the basis of drug therapy can improve the general developments of abilities in motor, intelligence, social intercourse, social adaptation and speech of high risk infants with brain damage, also can improve the curative efficacy. 展开更多
关键词 brain injuries cerebral palsy REHABILITATION
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Unmasking the responses of the stem cells and progenitors in the subventricular zone after neonatal and pediatric brain injuries
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作者 Mariano Guardia Clausi Ekta Kumari Steven W.Levison 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第1期45-48,共4页
There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the subventricular zone(SVZ). However, a comprehensive understanding of SVZ cell responses to brain injuri... There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the subventricular zone(SVZ). However, a comprehensive understanding of SVZ cell responses to brain injuries has been hindered by the lack of sensitive approaches to study the cellular composition of this niche. Here we review progress being made in deciphering the cells of the SVZ gleaned from the use of a recently designed flow cytometry panel that allows SVZ cells to be parsed into multiple subsets of progenitors as well as putative stem cells. We review how this approach has begun to unmask both the heterogeneity of SVZ cells as well as the dynamic shifts in cell populations with neonatal and pediatric brain injuries. We also discuss how flow cytometric analyses also have begun to reveal how specific cytokines, such as Leukemia inhibitory factor are coordinating SVZ responses to injury. 展开更多
关键词 CNS regeneration cytokines glial progenitors gliogenesis inflammation cerebral palsy traumatic brain injury stroke
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早期康复治疗联合家庭康复训练在小儿脑损伤及脑瘫患儿中的应用效果
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作者 安春梅 《中国医药科学》 2024年第13期108-110,146,共4页
目的探讨早期康复治疗联合家庭康复训练干预对小儿脑损伤及脑瘫患儿的临床效果。方法选取2020年2月至2022年9月泰安市妇幼保健院收治的52例小儿脑损伤及脑瘫患儿为研究对象,采用投掷硬币法将其分为参照组(n=26)和研究组(n=26)。参照组... 目的探讨早期康复治疗联合家庭康复训练干预对小儿脑损伤及脑瘫患儿的临床效果。方法选取2020年2月至2022年9月泰安市妇幼保健院收治的52例小儿脑损伤及脑瘫患儿为研究对象,采用投掷硬币法将其分为参照组(n=26)和研究组(n=26)。参照组采用家庭康复训练方式;研究组采用早期康复治疗联合家庭康复训练方式,两组均保持为期2周的干预。比较两组小儿脑损伤及脑瘫患儿的护理总有效率、生存质量评分(社交功能评分、情感功能评分及生理功能评分)、日常生活能力量表(ADL)评分及肢体运动功能评定量表(FMA)评分。结果研究组小儿脑损伤及脑瘫患儿护理总有效率高于参照组,差异有统计学意义(P<0.05)。护理后,两组小儿脑损伤及脑瘫患儿社交功能评分、情感功能评分及生理功能评分高于护理前,且研究组高于参照组,差异有统计学意义(P<0.05)。护理后,两组小儿脑损伤及脑瘫患儿ADL评分及FMA评分高于护理前,且研究组高于参照组,差异有统计学意义(P<0.05)。结论临床给予小儿脑损伤及脑瘫患儿早期康复治疗联合家庭康复训练干预,对于患儿护理效果、生存质量、日常生活能力及肢体运动功能的提升具有显著效果。 展开更多
关键词 小儿脑损伤 脑瘫 早期康复治疗 家庭康复训练 护理效果 生存质量 日常生活能力 肢体运动功能
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舒筋健脑方对缺血缺氧脑瘫模型大鼠细胞凋亡的影响
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作者 姜煜 徐林 +6 位作者 赵亚林 刘港 张亚奇 白惠中 任敬佩 曾杰 穆晓红 《中国组织工程研究》 CAS 北大核心 2024年第28期4477-4483,共7页
背景:围产期缺血缺氧性脑损伤是脑性瘫痪发生的最常见原因之一。舒筋健脑方是北京中医药大学东直门医院骨科治疗脑瘫、改善脑部供血的经验方剂。目的:探讨舒筋健脑方改善脑性瘫痪缺血缺氧的作用机制。方法:采用64只新生7 d龄SD大鼠,随... 背景:围产期缺血缺氧性脑损伤是脑性瘫痪发生的最常见原因之一。舒筋健脑方是北京中医药大学东直门医院骨科治疗脑瘫、改善脑部供血的经验方剂。目的:探讨舒筋健脑方改善脑性瘫痪缺血缺氧的作用机制。方法:采用64只新生7 d龄SD大鼠,随机分为6组,对照组、模型组各12只,米诺环素组、舒筋健脑方低、中、高剂量组各10只。除对照组外,其余各组建立新生大鼠缺血缺氧脑瘫模型。造模成功后的药物组大鼠分别进行米诺环素、舒筋健脑方各剂量[4,8,16 g/(kg·d)]灌胃,每日1次,持续1周。给药前后测量各组大鼠的体质量,检测行为学变化,苏木精-伊红染色观察大鼠脑组织海马CA1区组织形态,免疫组化和Western Blot检测大鼠脑组织Bcl-2、Bax、Caspase-3的表达水平。结果与结论:①体质量:与模型组比较,舒筋健脑方中、高剂量组大鼠体质量得到显著增加(P<0.05);②行为学:与模型组比较,米诺环素组大鼠有效延长了悬吊时间(P<0.05),舒筋健脑方中、高剂量组大鼠有效延长了悬吊时间、缩短了倾斜板实验时间、提升了Longa评分(P<0.05);③组织形态:药物组大鼠脑组织仅少量神经细胞坏死形成,细胞排列较整齐,细胞结构较为完整,只部分细胞核变小;④免疫组化和Western Blot结果:与模型组比较,米诺环素组、舒筋健脑方中、高剂量组Bax和Caspase-3的表达减少(P<0.05),舒筋健脑方中、高剂量组Bcl-2表达增加(P<0.05),米诺环素组、舒筋健脑方各剂量组Bcl-2/Bax蛋白表达增加(P<0.05),蛋白表达量随舒筋健脑方的剂量增加而增加,且舒筋健脑方高剂量组与米诺环素组作用差异无显著性意义(P>0.05);⑤结果说明,舒筋健脑方治疗缺血缺氧脑瘫大鼠的机制可能是提升抗凋亡蛋白Bcl-2表达,抑制促凋亡蛋白Bax的表达,降低Caspase-3的蛋白表达,最终抑制脑瘫大鼠海马组织细胞凋亡;舒筋健脑方在一定范围内,剂量越高治疗效果越好,且高剂量使用疗效不亚于米诺环素。 展开更多
关键词 脑性瘫痪 舒筋健脑方 细胞凋亡 缺血缺氧脑损伤 大鼠
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早期康复治疗联合家庭康复训练治疗小儿脑损伤及脑瘫的价值探究
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作者 陈关粉 《中外医药研究》 2024年第27期6-8,共3页
目的:分析早期康复治疗联合家庭康复训练在小儿脑损伤及脑瘫治疗中的应用效果。方法:选取2021年4月—2023年1月昆明市儿童福利院收治的80例脑损伤及脑瘫患儿作为研究对象,按照随机数字表法分为对照组(家庭康复训练)和观察组(早期康复治... 目的:分析早期康复治疗联合家庭康复训练在小儿脑损伤及脑瘫治疗中的应用效果。方法:选取2021年4月—2023年1月昆明市儿童福利院收治的80例脑损伤及脑瘫患儿作为研究对象,按照随机数字表法分为对照组(家庭康复训练)和观察组(早期康复治疗联合家庭康复训练),各40例。比较两组临床治疗效果。结果:观察组治疗总有效率高于对照组(P=0.045);干预后,两组Fugl-Meyer运动功能评定量表、生活活动能力量表评分升高,美国国立卫生研究院卒中量表评分降低,观察组优于对照组(P<0.05);干预后,两组社交行为、适应能力、精细动作、大动作、语言评分升高,观察组高于对照组(P<0.05)。结论:早期康复治疗联合家庭康复训练在小儿脑损伤及脑瘫治疗中的应用效果显著,可以提高患儿的发育商水平,改善肢体运动能力和神经损伤程度,提高其日常生活能力。 展开更多
关键词 家庭康复训练 早期康复治疗 脑损伤 脑瘫
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Physiological Markers and Reflex Pattern Progression in Individuals with Neurodevelopmental Deficits Utilizing the MNRI Method
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作者 Trina Deiss Rebekah Meyers +4 位作者 Jordan Whitney Clayton Bell Тatiana Tatarinova Lorri Franckle Susan Beaven 《Neuroscience & Medicine》 2019年第1期30-54,共25页
The physiological markers of 310 individuals aged 2 through 19 were evaluated for the effects of the Masgutova Neurosensorimotor Reflex Integration Method on their four body systems: respiratory, cardiovascular, diges... The physiological markers of 310 individuals aged 2 through 19 were evaluated for the effects of the Masgutova Neurosensorimotor Reflex Integration Method on their four body systems: respiratory, cardiovascular, digestive, and nervous systems of individuals with neurodevelopmental deficits—cerebral palsy (CP), seizures, traumatic and acute brain injury, attention deficit and hyperactive disorders (ADD, ADHD), autism spectrum disorders, anxiety, post-trauma and post-traumatic stress disorders. We found that 53.33% of physiological markers and 66.67% of reflex patterns on the pre-test demonstrated to be poorly functioning. Both evaluation results showed statistically significant improvements after 8-days of intensive training using the Masgutova Neurosensorimotor Reflex Integration Method. Improvements according to 60.0% of the physiological markers positively correlated with functionality gains in 77.5% of reflex patterns in all four study groups compared to the control group, which did not receive the Reflex Integration training program (p-value < 0.05). The magnitude of improvement depended upon the severity of symptoms indicating the essentiality for individualized training in accordance with the diagnosis and individual neurological deficits. Results of this study show that reflex integrative techniques can lead to a reduction of stress and other negative factors blocking health homeostasis, limiting perception, and causing dysregulation in behavior and emotions, especially following traumatic events. Positive changes in physiological markers and reflex pattern functions indicate potential benefits for survival and stress resiliency through supporting neuro-physiological and neuro-psychological aspects of overall health and well-being in individuals with neurological deficits. 展开更多
关键词 PHYSIOLOGICAL MARKERS cerebral palsy Autism brain injury Trauma PTSD Masgutova Neurosensorimotor REFLEX Integration METHOD (MNRI)
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补阳还五汤联合西药治疗脑梗死恢复期气虚血瘀证临床研究 被引量:1
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作者 王立功 寇绍杰 +2 位作者 苏惠娟 郑春欢 吴茜 《新中医》 CAS 2023年第24期41-45,共5页
目的:观察补阳还五汤联合西药治疗脑梗死(CI)恢复期气虚血瘀证的临床疗效。方法:选取62例CI恢复期气虚血瘀证患者,按照随机数字表法分为观察组和对照组各31例。对照组给予西药(阿司匹林肠溶片、硫酸氢氯吡格雷片)治疗,观察组在对照组基... 目的:观察补阳还五汤联合西药治疗脑梗死(CI)恢复期气虚血瘀证的临床疗效。方法:选取62例CI恢复期气虚血瘀证患者,按照随机数字表法分为观察组和对照组各31例。对照组给予西药(阿司匹林肠溶片、硫酸氢氯吡格雷片)治疗,观察组在对照组基础上给予补阳还五汤治疗,2组均治疗14 d。比较2组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、血液流变学指标水平、脑损伤标志物水平及不良反应发生率。结果:治疗后,观察组总有效率93.55%,高于对照组74.19%(P<0.05)。2组NIHSS评分均较治疗前降低(P<0.05),观察组NIHSS评分低于对照组(P<0.05)。2组全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)及红细胞压积(HCT)水平均较治疗前降低(P<0.05),观察组HSV、LSV、PSV及HCT水平均低于对照组(P<0.05)。2组血清脑源性神经营养因子(BDNF)水平均较治疗前升高(P<0.05),血清神经元特异性烯醇化酶(NSE)及中枢神经特异性蛋白(S100-β)水平均较治疗前降低(P<0.05);观察组血清BDNF水平高于对照组(P<0.05),血清NSE、S100-β水平均低于对照组(P<0.05)。治疗期间,观察组不良反应发生率9.68%,与对照组6.45%比较,差异无统计学意义(P>0.05)。结论:补阳还五汤联合西药治疗CI恢复期气虚血瘀证疗效确切,可有效改善血液流变学指标,调节脑损伤标志物水平,促进神经功能恢复,安全性较好。 展开更多
关键词 脑梗死 恢复期 气虚血瘀证 补阳还五汤 神经功能 血液流变学 脑损伤标志物
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创伤性脑疝后双侧枕叶脑梗死伴Anton综合征一例报道 被引量:8
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作者 陈二涛 杨西涛 +1 位作者 楚胜华 冯东福 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2010年第12期1494-1495,共2页
文章报道1例创伤性脑疝后双侧枕叶脑梗死伴Anton综合征病例。术后早期因患者无视物障碍主诉而未予视觉功能情况检查,术后3周余查体发现眼球固定、双眼上视,颅脑CT及MRI确诊为双侧枕叶脑梗死。予脱水、营养神经及高压氧等治疗,效果欠佳... 文章报道1例创伤性脑疝后双侧枕叶脑梗死伴Anton综合征病例。术后早期因患者无视物障碍主诉而未予视觉功能情况检查,术后3周余查体发现眼球固定、双眼上视,颅脑CT及MRI确诊为双侧枕叶脑梗死。予脱水、营养神经及高压氧等治疗,效果欠佳。文章结合文献,对该病例的相关问题进行探讨。 展开更多
关键词 颅脑创伤 脑疝 双侧枕叶脑梗死 Anton综合征
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颅脑损伤后低钠血症的临床特点分析及诊治 被引量:17
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作者 张荣军 王晓峰 +8 位作者 唐宗椿 罗文颖 王军 王保江 陈勃勃 张洋 李孝伟 李虎 高飞 《中华神经外科疾病研究杂志》 CAS 2017年第2期124-127,共4页
目的研究颅脑损伤后低钠血症的病因、发病机制、临床特点及治疗。方法回顾性分析我科近5年收治的137例颅脑损伤后低钠血症的临床表现、实验室检查,分析其临床特点,总结其诊治经验。结果颅脑损伤后低钠血症主要分为脑性盐耗综合征(CSWS)... 目的研究颅脑损伤后低钠血症的病因、发病机制、临床特点及治疗。方法回顾性分析我科近5年收治的137例颅脑损伤后低钠血症的临床表现、实验室检查,分析其临床特点,总结其诊治经验。结果颅脑损伤后低钠血症主要分为脑性盐耗综合征(CSWS)和抗利尿激素分泌异常综合征(SIADH),均具有低钠血症、意识障碍、头痛头晕及恶心呕吐等特点,但CSWS患者血容量不足,中心静脉压降低,SIADH患者血容量升高,中心静脉压升高。本组患者治愈123例,死亡14例。结论颅脑损伤低钠血症发病机制与治疗措施有所不同,中心静脉压监测可鉴别CSWS和SIADH,限水补钠等诊断性治疗措施是鉴别CSWS和SIADH最简捷有效的方法,早期诊治能降低颅脑损伤患者的病残率和死亡率。 展开更多
关键词 颅脑损伤 低钠血症 脑性盐耗综合征 抗利尿激素分泌异常综合征
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重型颅脑损伤后中枢性低钠血症的诊治分析 被引量:23
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作者 彭玉峰 朱寿松 +3 位作者 丁之明 杨春盛 钟和生 陈硕朗 《中国煤炭工业医学杂志》 2004年第10期914-915,共2页
目的 重点探讨重型颅脑损伤患者并发脑性盐耗综合征的病因、发病机制及诊治方法。方法 根据患者临床表现及实验室检查指标 ,回顾性分析重型颅脑损伤后 1 4 2例低钠血症患者 ,其中 1 2例确诊为脑性盐耗综合征并进行治疗。结果  1 1例... 目的 重点探讨重型颅脑损伤患者并发脑性盐耗综合征的病因、发病机制及诊治方法。方法 根据患者临床表现及实验室检查指标 ,回顾性分析重型颅脑损伤后 1 4 2例低钠血症患者 ,其中 1 2例确诊为脑性盐耗综合征并进行治疗。结果  1 1例治愈 ,1例未能坚持治疗死于低血钠症。结论 低血钠、高尿钠、低血容量及意识状态改变是脑性盐耗综合征的诊断依据 ,补充钠盐和血容量是安全有效的。 展开更多
关键词 脑损伤 低钠血症 脑性盐耗综合征 抗利尿激素不适当分泌综合征
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早期干预对新生儿脑损伤神经心理发育的影响 被引量:28
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作者 杜开先 贾天明 +1 位作者 栾斌 蔡春玲 《中国实用神经疾病杂志》 2007年第5期5-7,共3页
目的探讨早期干预对脑损伤患儿存活后神经心理发育的影响。方法将124例脑损伤患儿分为有系统干预的甲组96例和未干预乙组28例,2组基本情况比较无显著性差异;另设正常足月儿30例丙组为对照组。均进行体格发育及神经系统检查;0~6岁小儿... 目的探讨早期干预对脑损伤患儿存活后神经心理发育的影响。方法将124例脑损伤患儿分为有系统干预的甲组96例和未干预乙组28例,2组基本情况比较无显著性差异;另设正常足月儿30例丙组为对照组。均进行体格发育及神经系统检查;0~6岁小儿神经心理发育量表测定。早期干预即予丰富环境、语言、视、听、触觉刺激、药物治疗及物理治疗等综合疗法。结果体格发育:乙组低于甲、丙组(P<0.01),甲与丙组无显著性差异;发育商:丙组高于甲、乙组各5分及27分;甲组高于乙组22分(P<0.01)。结论早期干预可提高脑损伤患儿神经心理发育,降低脑瘫、智障发生率。 展开更多
关键词 早期干预 新生儿 脑损伤 神经心理 脑瘫
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奥拉西坦和吡拉西坦治疗脑器质性综合症临床疗效的系统评价 被引量:15
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作者 王敬 张杰 周杰 《中国循证心血管医学杂志》 2016年第2期160-163,171,共4页
目的系统评价奥拉西坦和吡拉西坦治疗脑器质性综合症的临床疗效和安全性。方法计算机检索相关数据库:万方数据库、中国知识网(CNKI)、VIP、Pub Med、EMbase、迈特思创数据库(外文医学信息资源检索平台、Cochrane、Library、ACP Journal ... 目的系统评价奥拉西坦和吡拉西坦治疗脑器质性综合症的临床疗效和安全性。方法计算机检索相关数据库:万方数据库、中国知识网(CNKI)、VIP、Pub Med、EMbase、迈特思创数据库(外文医学信息资源检索平台、Cochrane、Library、ACP Journal Club等),辅以文献追溯、网上查询等方法,检索建库至2014年12月31日国内、外公开发表的奥拉西坦与吡拉西坦治疗脑器质性综合症的随机对照研究。对纳入的对照研究进行提取资料和评价质量后,采用Rev Man5.0统计软件进行Meta分析。结果最终纳入9篇随机对照研究(共计1347例患者),其中奥拉西坦组675例,吡拉西坦组672例。结果显示:简易精神状态评价量表(MMSE)评分改善情况奥拉西坦优于吡拉西坦(WMD=3.89,95%CI:3.32~4.45,P<0.01);格拉斯哥昏迷评分法(GCS)评分改善情况奥拉西坦优于吡拉西坦(WMD=1.83,95%CI:1.28~2.39,P<0.01);美国国立卫生院卒中量表(NIHSS评分)改善情况奥拉西坦优于吡拉西坦(WMD=-3.75,95%CI:-7.70^-4.18,P<0.01);不良事件发生情况奥拉西坦与吡拉西坦差异无统计学意义(OR=0.71,95%CI:0.37~1.37,P>0.05)。结论奥拉西坦在治疗脑器质性综合症患者的临床疗效(MMSE评分、GCS评分、NIHSS评分)方面优于吡拉西坦,不良事件发生率两者无明显差异。 展开更多
关键词 奥拉西坦 吡拉西坦 脑器质性综合症 脑损伤 系统评价
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重度颅脑损伤合并脑性耗盐综合征、抗利尿激素分泌异常综合征的早期临床诊断意义及预后分析 被引量:8
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作者 贺龙 王莎 +5 位作者 常祥平 李欣 袁世君 代巧英 贺恒旺 智孔亮 《脑与神经疾病杂志》 2017年第4期216-220,共5页
目的探讨重度颅脑损伤合并脑性耗盐综合征、抗利尿激素分泌异常综合征早期诊断的临床意义及预后分析。方法将47例重度颅脑损伤患者按照脑性耗盐(CSWS)、抗利尿激素分泌异常综合征(SIADH)的诊断标准分为CSWS组和SIADH组,比较两组实验室... 目的探讨重度颅脑损伤合并脑性耗盐综合征、抗利尿激素分泌异常综合征早期诊断的临床意义及预后分析。方法将47例重度颅脑损伤患者按照脑性耗盐(CSWS)、抗利尿激素分泌异常综合征(SIADH)的诊断标准分为CSWS组和SIADH组,比较两组实验室检查并采用Cox风险比例分析预后影响因素。结果 (1)CSWS组在治疗后心钠肽(ANP)、脑钠肽(BNP)降低,与治疗时比较有显著性差异(P<0.05或P<0.01);(2)治疗结束后,CSWS、SIADH患者格拉斯哥预后(GCS)评分3分以下、5分患者明显低于4分组(P<0.05);(4)Cox风险比例模型分析显示,颅底骨折、脑血肿、血渗透压、血钠、皮质醇(HC)、醛固酮(AL)为CSWS、SIADH患者预后危险因素,CSWS与ANP、BNP具有明显的相关性。结论重度颅脑损伤CSWS、SIADH可以通过CVP、ADH以及ANP、BNP变化进行鉴别,同时对预后有重要影响。 展开更多
关键词 重度颅脑损伤 脑性耗盐综合征 抗利尿激素不适当分泌综合征 诊断 预后
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体感音乐疗法降低痉挛型脑性瘫痪患儿肌张力临床观察 被引量:9
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作者 刘振寰 张丽红 +2 位作者 尹鲜桃 李志林 冯淑琴 《中国中西医结合儿科学》 2010年第1期27-29,共3页
目的观察体感音乐疗法对降低痉挛型脑性瘫痪(简称脑瘫)患儿肌张力的疗效。方法将36例痉挛型脑瘫患儿置于体感音乐床聆听中医五行音乐中角音30min,分别于治疗前后测量3次内收肌角度、双侧腘窝角度、足背屈角度,取其平均值,评估肌张力,计... 目的观察体感音乐疗法对降低痉挛型脑性瘫痪(简称脑瘫)患儿肌张力的疗效。方法将36例痉挛型脑瘫患儿置于体感音乐床聆听中医五行音乐中角音30min,分别于治疗前后测量3次内收肌角度、双侧腘窝角度、足背屈角度,取其平均值,评估肌张力,计算综合痉挛量表(CSS)评分。结果体感音乐治疗后,受试患儿内收肌角度和腘窝角度明显大于治疗前,治疗后足背屈角度均小于治疗前,其关节活动度改善明显,治疗后肌张力、CSS评分均比治疗前改善,经统计学处理,差异有统计学意义(P<0.05);治疗期间所有患儿均无不良反应。结论体感音乐治疗能降低痉挛型脑瘫患儿肌张力,缓解肌肉痉挛,改善肢体运动功能。 展开更多
关键词 痉挛型脑性瘫痪 脑损伤 体感音乐疗法 肌痉挛 肌张力 儿童
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