The functional brain network using blood-oxygen-level-dependent(BOLD) functional magnetic resonance imaging(fMRI) has revealed the potentials for probing brain architecture,as well as for identifying clinical biom...The functional brain network using blood-oxygen-level-dependent(BOLD) functional magnetic resonance imaging(fMRI) has revealed the potentials for probing brain architecture,as well as for identifying clinical biomarkers for brain diseases.In the general context of Brainnetome,this review focuses on the development of approaches for modeling and analyzing functional brain networks with BOLD fMRI.The prospects for these approaches are also discussed.展开更多
Impaired cognitive function,along with positive and negative symptoms,is a core clinical feature of schizophrenia.Earlier studies suggest that impaired cognitive functioning should be assessed from the perspective of ...Impaired cognitive function,along with positive and negative symptoms,is a core clinical feature of schizophrenia.Earlier studies suggest that impaired cognitive functioning should be assessed from the perspective of brain networks.The recently developed brainnetome approach to evaluating brain networks-an approach that was initially developed by Chinese scientists-provides a new methodology for studying this issue.In this paper we first introduce the concept of brainnetome.We then review recent progress in developing a brainnetome of impaired cognitive function in people with schizophrenia.The models of the relevant brain networks considered were created using data obtained from functional and anatomical brain imaging technologies at different levels of analysis:networks centered on regions of interest,networks related to specific cognitive functions,whole brain networks,and the attributes of brain networks.Finally,we discuss the current challenges and potential new directions for research about brainnetome.展开更多
Attention deficit and hyperactivity disorder(ADHD) is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influen...Attention deficit and hyperactivity disorder(ADHD) is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored.We explored age-related brain network differences between ADHD patients and typically developing(TD) subjects using resting state f MRI(rs-f MRI) for three age groups of children,adolescents,and adults.We collected rs-f MRI data from 184 individuals(27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults).The Brainnetome Atlas was used to define nodes in the network analysis.We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal centrality.The left middle temporal gyrus showed significant interaction effects between disease status(i.e.,ADHD or TD) and age(i.e.,child,adolescent,or adult)(P 0.001).Additional regions were identified at a relaxed threshold(P 0.05).Many of the identified regions(the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus) were related to cognitive function.The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients.These findings contribute to better understand how brain function influences the symptoms of ADHD.展开更多
Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders ...Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders of consciousness. Here, we aim to review neuroimaging studies in chronic disorders of consciousness from the viewpoint of the brain network, focusing on positron emission tomogra- phy, functional MRI, functional near-infrared spectroscopy, electrophysiology, and diffusion MRI. To accelerate basic research on disorders of consciousness and provide a panoramic view of unconsciousness, we propose that it is urgent to integrate different techniques at various spatiotemporal scales, and to merge fragmented findings into a uniform "Brainnetome" (Brain-net-ome) research framework.展开更多
基金supported by the National Basic Research Development Program(973) of China(2011CB707800)the National Natural Science Foundation of China(91132301 and 81101040)
文摘The functional brain network using blood-oxygen-level-dependent(BOLD) functional magnetic resonance imaging(fMRI) has revealed the potentials for probing brain architecture,as well as for identifying clinical biomarkers for brain diseases.In the general context of Brainnetome,this review focuses on the development of approaches for modeling and analyzing functional brain networks with BOLD fMRI.The prospects for these approaches are also discussed.
基金Supported by the National Key Basic Research Program of China (2011CB707800)the Young Program from the National Natural Science Foundation of China (30900487)the Open Project of National Laboratory of Pattern Recognition
文摘Impaired cognitive function,along with positive and negative symptoms,is a core clinical feature of schizophrenia.Earlier studies suggest that impaired cognitive functioning should be assessed from the perspective of brain networks.The recently developed brainnetome approach to evaluating brain networks-an approach that was initially developed by Chinese scientists-provides a new methodology for studying this issue.In this paper we first introduce the concept of brainnetome.We then review recent progress in developing a brainnetome of impaired cognitive function in people with schizophrenia.The models of the relevant brain networks considered were created using data obtained from functional and anatomical brain imaging technologies at different levels of analysis:networks centered on regions of interest,networks related to specific cognitive functions,whole brain networks,and the attributes of brain networks.Finally,we discuss the current challenges and potential new directions for research about brainnetome.
基金supported by the Institute for Basic Science[grant No.IBS-R015-D1]the National Research Foundation of Korea(grant No.NRF-2016R1A2B4008545)
文摘Attention deficit and hyperactivity disorder(ADHD) is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored.We explored age-related brain network differences between ADHD patients and typically developing(TD) subjects using resting state f MRI(rs-f MRI) for three age groups of children,adolescents,and adults.We collected rs-f MRI data from 184 individuals(27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults).The Brainnetome Atlas was used to define nodes in the network analysis.We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal centrality.The left middle temporal gyrus showed significant interaction effects between disease status(i.e.,ADHD or TD) and age(i.e.,child,adolescent,or adult)(P 0.001).Additional regions were identified at a relaxed threshold(P 0.05).Many of the identified regions(the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus) were related to cognitive function.The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients.These findings contribute to better understand how brain function influences the symptoms of ADHD.
基金supported by the National Natural Science Foundation of China(81471380,31771076,81501550,91432302,31620103905,and 81501179)the Science Frontier Program of the Chinese Academy of Sciences(QYZDJSSW-SMC019)+4 种基金National Key R&D Program of China(2017YFA0105203,2017YFB1002502)Beijing Municipal Science and Technology Commission(Z161100000216152,Z161100000216139,Z171100000117002,and Z161100000516165)the Shenzhen Peacock Plan(KQTD2015033016104926)the Guangdong Pearl River Talents Plan(2016ZT06S220)Youth Innovation Promotion Association,CAS,China
文摘Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders of consciousness. Here, we aim to review neuroimaging studies in chronic disorders of consciousness from the viewpoint of the brain network, focusing on positron emission tomogra- phy, functional MRI, functional near-infrared spectroscopy, electrophysiology, and diffusion MRI. To accelerate basic research on disorders of consciousness and provide a panoramic view of unconsciousness, we propose that it is urgent to integrate different techniques at various spatiotemporal scales, and to merge fragmented findings into a uniform "Brainnetome" (Brain-net-ome) research framework.