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Challenges to associate early onset epilepsy with COVID-19 autoimmune encephalitis:A case
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作者 Salma Zouari Mallouli Olfa Jallouli +3 位作者 Wafa Bouchaala Sihem Ben Nsir Fatma Kamoun Feki Chahnez Charfi Triki 《World Journal of Immunology》 2023年第1期1-10,共10页
BACKGROUND Diagnosis of coronavirus disease 2019(COVID-19)-related neurological events in the pediatric population is challenging.Overlapping clinical picture of children with altered neurological state and inborn err... BACKGROUND Diagnosis of coronavirus disease 2019(COVID-19)-related neurological events in the pediatric population is challenging.Overlapping clinical picture of children with altered neurological state and inborn errors of metabolism,in addition to the frequency of asymptomatic COVID-19 cases,pose the main challenges for diagnosis.Diagnostic approaches to the onset post-COVID 19 subacute encephalopathy are still troublesome as seronegative autoimmune encephalitis(AIE)is reported.CASE SUMMARY A 27-mo-old boy was admitted for stormy refractory seizure of polymorphic semiology and altered mental status followed by various neuropsychiatric features that were suggestive of AIE.Brain magnetic resonance imaging and cerebrospinal fluid analysis were normal.Neither the immunological assessment,including viral serologies,antinuclear antibodies,autoimmune antibodies(NMDA,AMPA,CASPR2,LG11,GABARB,Hu,Yo,Ri,CV2,PNMA2,SOX1,Titin,amphiphysin,Recoverin),nor the metabolic assessment for lactate and pyruvate showed significant anomaly.Both positive history of COVID-19 infection and the findings of characteristic repetitive extreme delta brush played a key role in the diagnosis of COVID-19-related AIE.A remarkable improvement in the state of the child was noted after two pulse doses of intravenous Veinoglobulin and high dose of intravenous Corticosteroid.CONCLUSION Diagnostic biomarkers for AIE might aid effective treatment. 展开更多
关键词 Post-COVID-19 Auto-immune encephalitis Diagnosis biomarkers Pediatric population Delta brush sign Autoimmune antibodies
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MRI图像上“常春藤征”和“刷子征”对烟雾病的诊断价值 被引量:5
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作者 赵文卓 黄波涛 +2 位作者 张得旺 孙建军 李欣 《现代医用影像学》 2015年第6期964-967,共4页
目的:探讨MRI常规图像上"常春藤征"和"刷子征"对烟雾病的诊断价值。材料与方法:回顾性分析经颅脑磁共振诊断的25例烟雾病的影像特点,对常春藤征和刷子征的分布及程度进行分析。结果:25例烟雾病患者中MRI常规序列图... 目的:探讨MRI常规图像上"常春藤征"和"刷子征"对烟雾病的诊断价值。材料与方法:回顾性分析经颅脑磁共振诊断的25例烟雾病的影像特点,对常春藤征和刷子征的分布及程度进行分析。结果:25例烟雾病患者中MRI常规序列图像显示34侧大脑半球可见常春藤征,其中合并刷子征24侧,常春藤表现为沿软脑膜分布的点状或条状高信号,刷子征表现为放射冠、半卵圆中心密集白质区呈垂直于侧脑室壁的刷子状高信号。结论:常春藤征和刷子征对烟雾病的诊断具有重要的价值,认识此征象有利于正确的诊断和判断患者病情的程度。 展开更多
关键词 烟雾病 磁共振成像 常春藤征 刷子征
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