Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconi...Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.展开更多
目的探究谷红注射液联合复方脑肽节苷脂注射液在腔隙性脑梗死患者治疗中的应用效果。方法选取2019年6月—2023年6月在江苏省盱眙县中医院老年病科接受相应治疗的80例腔隙性脑梗死患者为研究对象。按照入院时间排序,把1~40号患者作为对照...目的探究谷红注射液联合复方脑肽节苷脂注射液在腔隙性脑梗死患者治疗中的应用效果。方法选取2019年6月—2023年6月在江苏省盱眙县中医院老年病科接受相应治疗的80例腔隙性脑梗死患者为研究对象。按照入院时间排序,把1~40号患者作为对照组,施行谷红注射液+盐酸倍他司汀注射液治疗,41~80号患者作为观察组,施行谷红注射液+复方脑肽节苷脂注射液治疗。对比两组患者在卒中量表(National Institute of Heslth Stroke Scale,NIHSS)评分、活动能力量表(Activity of Daily Living,ADL)评分以及不良反应中的差异,比较分析谷红注射液与复方脑肽节苷脂注射液的联合应用可行性。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,相较于对照组,观察组NIHSS评分更低,ADL评分更高,差异有统计学意义(P<0.05);观察组不良反应发生率(7.50%)与对照组(12.50%)比较,差异无统计学意义(χ^(2)=0.556,P=0.456)。结论面对腔隙性脑梗死患者,临床运用谷红注射液与复方脑肽节苷脂注射液联合治疗,显著提高治疗效果,纠正神经功能状态,增强机体自理能力,且不会增加患者不良反应发生风险,安全价值高。展开更多
文摘Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.
文摘目的探究谷红注射液联合复方脑肽节苷脂注射液在腔隙性脑梗死患者治疗中的应用效果。方法选取2019年6月—2023年6月在江苏省盱眙县中医院老年病科接受相应治疗的80例腔隙性脑梗死患者为研究对象。按照入院时间排序,把1~40号患者作为对照组,施行谷红注射液+盐酸倍他司汀注射液治疗,41~80号患者作为观察组,施行谷红注射液+复方脑肽节苷脂注射液治疗。对比两组患者在卒中量表(National Institute of Heslth Stroke Scale,NIHSS)评分、活动能力量表(Activity of Daily Living,ADL)评分以及不良反应中的差异,比较分析谷红注射液与复方脑肽节苷脂注射液的联合应用可行性。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,相较于对照组,观察组NIHSS评分更低,ADL评分更高,差异有统计学意义(P<0.05);观察组不良反应发生率(7.50%)与对照组(12.50%)比较,差异无统计学意义(χ^(2)=0.556,P=0.456)。结论面对腔隙性脑梗死患者,临床运用谷红注射液与复方脑肽节苷脂注射液联合治疗,显著提高治疗效果,纠正神经功能状态,增强机体自理能力,且不会增加患者不良反应发生风险,安全价值高。
