Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconi...Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.展开更多
目的：建立同时测定注射用复方甘草酸苷中盐酸半胱氨酸和甘氨酸含量的高效液相色谱法。方法：采用Phenomenex Luna C18（2）色谱柱（4.6mm×25cm,5μm）,流动相A：乙腈-水（50∶50）;流动相B：0.014mol·L^-1磷酸氢二钾溶液（...目的：建立同时测定注射用复方甘草酸苷中盐酸半胱氨酸和甘氨酸含量的高效液相色谱法。方法：采用Phenomenex Luna C18（2）色谱柱（4.6mm×25cm,5μm）,流动相A：乙腈-水（50∶50）;流动相B：0.014mol·L^-1磷酸氢二钾溶液（磷酸调节pH值至8.2）,梯度洗脱,流速1.0mL·min^-1,柱温：30℃,检测波长：360nm。结果：盐酸半胱氨酸、甘氨酸浓度分别在7.931-71.379μg·ml^-1和0.1632-1.4684mg·ml^-1范围内与峰面积呈良好的线性关系;平均回收率分别为99.19%和99.18%,RSD分别为0.64%和0.99%（n=9）。结论：本法可用于同时测定注射用复方甘草酸苷中盐酸半胱氨酸和甘氨酸的含量,方法简便、结果准确。展开更多
目的观察复方苦参注射液联合盐酸羟考酮治疗肺癌疼痛的近期疗效。方法将60例中晚期肺癌疼痛患者随机分为治疗组和对照组各30例。对照组给予最佳对症支持治疗联合盐酸羟考酮,治疗组在对照组基础上给予复方苦参注射液20 m L加入0.9%氯化...目的观察复方苦参注射液联合盐酸羟考酮治疗肺癌疼痛的近期疗效。方法将60例中晚期肺癌疼痛患者随机分为治疗组和对照组各30例。对照组给予最佳对症支持治疗联合盐酸羟考酮,治疗组在对照组基础上给予复方苦参注射液20 m L加入0.9%氯化钠注射液250 m L中静脉滴注,每日1次,连用14 d。观察2组患者治疗前后卡氏评分、疼痛程度及不良反应。结果治疗组治疗后疼痛得到明显缓解(P<0.01),对照组疼痛程度治疗前后比较差异无统计学意义(P>0.05),治疗后组间比较差异无统计学意义(P>0.05)。治疗组治疗后卡氏评分明显高于治疗前及对照组,差异均有统计学意义(P<0.05);对照组治疗前后卡氏评分差异无统计学意义(P>0.05)。结论复方苦参注射液联合盐酸羟考酮能明显缓解中晚期肺癌患者疼痛,提高生活质量,且无明显不良反应。展开更多
文摘Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.
文摘目的：建立同时测定注射用复方甘草酸苷中盐酸半胱氨酸和甘氨酸含量的高效液相色谱法。方法：采用Phenomenex Luna C18（2）色谱柱（4.6mm×25cm,5μm）,流动相A：乙腈-水（50∶50）;流动相B：0.014mol·L^-1磷酸氢二钾溶液（磷酸调节pH值至8.2）,梯度洗脱,流速1.0mL·min^-1,柱温：30℃,检测波长：360nm。结果：盐酸半胱氨酸、甘氨酸浓度分别在7.931-71.379μg·ml^-1和0.1632-1.4684mg·ml^-1范围内与峰面积呈良好的线性关系;平均回收率分别为99.19%和99.18%,RSD分别为0.64%和0.99%（n=9）。结论：本法可用于同时测定注射用复方甘草酸苷中盐酸半胱氨酸和甘氨酸的含量,方法简便、结果准确。
文摘目的观察复方苦参注射液联合盐酸羟考酮治疗肺癌疼痛的近期疗效。方法将60例中晚期肺癌疼痛患者随机分为治疗组和对照组各30例。对照组给予最佳对症支持治疗联合盐酸羟考酮,治疗组在对照组基础上给予复方苦参注射液20 m L加入0.9%氯化钠注射液250 m L中静脉滴注,每日1次,连用14 d。观察2组患者治疗前后卡氏评分、疼痛程度及不良反应。结果治疗组治疗后疼痛得到明显缓解(P<0.01),对照组疼痛程度治疗前后比较差异无统计学意义(P>0.05),治疗后组间比较差异无统计学意义(P>0.05)。治疗组治疗后卡氏评分明显高于治疗前及对照组,差异均有统计学意义(P<0.05);对照组治疗前后卡氏评分差异无统计学意义(P>0.05)。结论复方苦参注射液联合盐酸羟考酮能明显缓解中晚期肺癌患者疼痛,提高生活质量,且无明显不良反应。
