Severe burn injury triggers the body＇s nonspecific adaptive responses to acute insult, including the systemic inflammatory and stress responses, as well as the sympathetic response to immobilization. These responses ...Severe burn injury triggers the body＇s nonspecific adaptive responses to acute insult, including the systemic inflammatory and stress responses, as well as the sympathetic response to immobilization. These responses trigger inflammatory bone resorption followed by glucocorticoid-induced apoptosis of osteoblasts and probably osteocytes. Because these patients are catabolic, they suffer concomitant muscle wasting and negative nitrogen balance. The use of anabolic agents such as recombinant human growth hormone and oxandrolone results in improved bone mineral content and muscle strength after approximately I year. Use of bisphosphonates within the first 10 days of a severe burn completely blocks the resorptive bone loss and has the added advantage of appearing to preserve muscle protein from excessive breakdown. The mechanism for the protective effect on muscle is not currently known. However, if the effect of bisphosphonates on muscle can be confirmed, it raises the possibility that bone communicates with muscle.展开更多
Hominin-animal interactions at Pleistocene archaeological sites have been the main subject of research during human evolution. However, in contrast to that of ungulates, little is known about the evidence of human pro...Hominin-animal interactions at Pleistocene archaeological sites have been the main subject of research during human evolution. However, in contrast to that of ungulates, little is known about the evidence of human processing of carnivore species in this time interval of China. In this paper, we present the first case report of an interactive relationship between carnivore species and hunter-gathers in Pleistocene China, based mainly on a detailed taphonomic study of the faunal remains from Shuidonggou Locality 7. It seems highly probable that hominins butchered some individuals of carnivores and roasted bone elements with adhering meat at the site;whereas it’s equally feasible that these animals were exploited by hominins mainly for their pelt or fur. In either way, evidence from the site indicates novel strategies in adaptive behaviors adopted by Late Pleistocene foragers in harsh environments of Northwest China.展开更多
基金partial support from P50 GM60338 from the National Institutes of Health and several grants from Shriners Hospitals for Children
文摘Severe burn injury triggers the body＇s nonspecific adaptive responses to acute insult, including the systemic inflammatory and stress responses, as well as the sympathetic response to immobilization. These responses trigger inflammatory bone resorption followed by glucocorticoid-induced apoptosis of osteoblasts and probably osteocytes. Because these patients are catabolic, they suffer concomitant muscle wasting and negative nitrogen balance. The use of anabolic agents such as recombinant human growth hormone and oxandrolone results in improved bone mineral content and muscle strength after approximately I year. Use of bisphosphonates within the first 10 days of a severe burn completely blocks the resorptive bone loss and has the added advantage of appearing to preserve muscle protein from excessive breakdown. The mechanism for the protective effect on muscle is not currently known. However, if the effect of bisphosphonates on muscle can be confirmed, it raises the possibility that bone communicates with muscle.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41672023 & 41772025)
文摘Hominin-animal interactions at Pleistocene archaeological sites have been the main subject of research during human evolution. However, in contrast to that of ungulates, little is known about the evidence of human processing of carnivore species in this time interval of China. In this paper, we present the first case report of an interactive relationship between carnivore species and hunter-gathers in Pleistocene China, based mainly on a detailed taphonomic study of the faunal remains from Shuidonggou Locality 7. It seems highly probable that hominins butchered some individuals of carnivores and roasted bone elements with adhering meat at the site;whereas it’s equally feasible that these animals were exploited by hominins mainly for their pelt or fur. In either way, evidence from the site indicates novel strategies in adaptive behaviors adopted by Late Pleistocene foragers in harsh environments of Northwest China.
