【目的】探讨免疫联合化疗对多发性骨髓瘤（MM）患者外周血T、B淋巴细胞及调节性T细胞（Tregs）水平的影响。【方法】本院收治的MM患者60例，采用数字随机对照表分为两组，每组各30例；对照组给予DC-CIK免疫治疗＋化疗，对照组仅给予化...【目的】探讨免疫联合化疗对多发性骨髓瘤（MM）患者外周血T、B淋巴细胞及调节性T细胞（Tregs）水平的影响。【方法】本院收治的MM患者60例，采用数字随机对照表分为两组，每组各30例；对照组给予DC-CIK免疫治疗＋化疗，对照组仅给予化疗，评估两组临床疗效，观察两组T淋巴细胞、Tregs水平、B细胞、浆细胞比例水平变化；随访1年，比较两组复发率。【结果】观察组治疗有效率为53．33％（i6／30）显著高于对照组26．67％（8／30），1年复发率为6．67％（2／30）显著低于对照组30．0％（9／30），且差异有显著性（P〈0．05）。观察组治疗后CD4＋T淋巴细胞比例、CD4＋／CD8＋T淋巴比值显著高于对照组，CD8＋T淋巴细胞比例显著低于对照组，且差异有显著性（P〈0．05）。观察组治疗后CD4＋CD25＋Tregs、CD4＋CD25 high Tregs显著低于对照组，且差异有显著性（P〈0．05）。观察组治疗后B细胞比例高于对照组，浆细胞比例低于对照组，且差异有显著性（P〈0．05）。【结论】DCcIK免疫治疗＋化疗能够改善MM患者免疫功能紊乱症状，降低浆细胞比例，提高临床疗效。展开更多
【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受...【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受戈舍瑞林联合比卡鲁胺连续性治疗。比较治疗前及治疗后3、6、9、12个月时两组前列腺抗原、血管内皮生长因子（VEGF）、免疫功能变化及不良反应。【结果】治疗后3、6、9、12个月时，两组患者血清前列腺特异性抗原（PSA）、游离前列腺特异抗原（F-PSA）含量均明显低于治疗前（P〈0．05），VEGF含量显著低于治疗前（P〈0．05），外周血中CD3＋、CD4＋、CD4／CD8淋巴细胞的含量明显高于治疗前，CD8＋淋巴细胞亚群的含量明显低于治疗前（P〈0．05），但两组间上述各指标比较差异无显著性（P〉0．05）；两组不良反应发生率比较差异无显著性（6．98％ vs 11．90％）（P〉0．05）。【结论】戈舍瑞林联合比卡鲁胺间歇性治疗的疗效与连续性治疗相当，均能有效降低PSA含量并调节患者免疫功能。展开更多
A mixture of deuterium (D) and tritium (T) is the most likely fuel for laser-driven inertial confinement fusion (ICF) reactors and hence DD and DT are the fusion reactions that will fire these reactors in the future. ...A mixture of deuterium (D) and tritium (T) is the most likely fuel for laser-driven inertial confinement fusion (ICF) reactors and hence DD and DT are the fusion reactions that will fire these reactors in the future. Neutrons produced from the two reactions will escape from the burning plasma, in the reactor core, and they are the only products possible to be measured directly. DT/DD neutron ratio is crucial for evaluation of T/D fuel ratio, burn control, tritium cycle and alpha particle self-heating power. To measure this ratio experimentally, the neutron spectra of DD and DT reactions have to be measured separately and simultaneously under high neutron counting with sufficient statistics (typically within 10% error) in a very short time and these issues are mutually contradicted. That is why it is not plausible to measure this high priority ratio for reactor performance accurately. Precise calculations of the DT/DD neutron ratio are needed. Here, we introduce such calculations using a three dimensional (3-D) Monte Carlo code at energies up to 40 MeV (the predicted maximum ion acceleration energy with the available laser systems). In addition, the fusion power ratio of DD and DT reactions is calculated for the same energy range. The study indicates that for a mixture of 50% deuterium and 50% triton, with taking into account the reactions D(d,n)<sup>3</sup>He and T(d,n)<sup>4</sup>He, the optimum energy value for achieving the most efficient laser-driven ICF is 0.08 MeV.展开更多
文摘【目的】探讨免疫联合化疗对多发性骨髓瘤（MM）患者外周血T、B淋巴细胞及调节性T细胞（Tregs）水平的影响。【方法】本院收治的MM患者60例，采用数字随机对照表分为两组，每组各30例；对照组给予DC-CIK免疫治疗＋化疗，对照组仅给予化疗，评估两组临床疗效，观察两组T淋巴细胞、Tregs水平、B细胞、浆细胞比例水平变化；随访1年，比较两组复发率。【结果】观察组治疗有效率为53．33％（i6／30）显著高于对照组26．67％（8／30），1年复发率为6．67％（2／30）显著低于对照组30．0％（9／30），且差异有显著性（P〈0．05）。观察组治疗后CD4＋T淋巴细胞比例、CD4＋／CD8＋T淋巴比值显著高于对照组，CD8＋T淋巴细胞比例显著低于对照组，且差异有显著性（P〈0．05）。观察组治疗后CD4＋CD25＋Tregs、CD4＋CD25 high Tregs显著低于对照组，且差异有显著性（P〈0．05）。观察组治疗后B细胞比例高于对照组，浆细胞比例低于对照组，且差异有显著性（P〈0．05）。【结论】DCcIK免疫治疗＋化疗能够改善MM患者免疫功能紊乱症状，降低浆细胞比例，提高临床疗效。
文摘【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受戈舍瑞林联合比卡鲁胺连续性治疗。比较治疗前及治疗后3、6、9、12个月时两组前列腺抗原、血管内皮生长因子（VEGF）、免疫功能变化及不良反应。【结果】治疗后3、6、9、12个月时，两组患者血清前列腺特异性抗原（PSA）、游离前列腺特异抗原（F-PSA）含量均明显低于治疗前（P〈0．05），VEGF含量显著低于治疗前（P〈0．05），外周血中CD3＋、CD4＋、CD4／CD8淋巴细胞的含量明显高于治疗前，CD8＋淋巴细胞亚群的含量明显低于治疗前（P〈0．05），但两组间上述各指标比较差异无显著性（P〉0．05）；两组不良反应发生率比较差异无显著性（6．98％ vs 11．90％）（P〉0．05）。【结论】戈舍瑞林联合比卡鲁胺间歇性治疗的疗效与连续性治疗相当，均能有效降低PSA含量并调节患者免疫功能。
文摘A mixture of deuterium (D) and tritium (T) is the most likely fuel for laser-driven inertial confinement fusion (ICF) reactors and hence DD and DT are the fusion reactions that will fire these reactors in the future. Neutrons produced from the two reactions will escape from the burning plasma, in the reactor core, and they are the only products possible to be measured directly. DT/DD neutron ratio is crucial for evaluation of T/D fuel ratio, burn control, tritium cycle and alpha particle self-heating power. To measure this ratio experimentally, the neutron spectra of DD and DT reactions have to be measured separately and simultaneously under high neutron counting with sufficient statistics (typically within 10% error) in a very short time and these issues are mutually contradicted. That is why it is not plausible to measure this high priority ratio for reactor performance accurately. Precise calculations of the DT/DD neutron ratio are needed. Here, we introduce such calculations using a three dimensional (3-D) Monte Carlo code at energies up to 40 MeV (the predicted maximum ion acceleration energy with the available laser systems). In addition, the fusion power ratio of DD and DT reactions is calculated for the same energy range. The study indicates that for a mixture of 50% deuterium and 50% triton, with taking into account the reactions D(d,n)<sup>3</sup>He and T(d,n)<sup>4</sup>He, the optimum energy value for achieving the most efficient laser-driven ICF is 0.08 MeV.
