AIM: To investigate if there is an association between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the risk of pancreatic cancer. METHODS: All relevant studies published before 11 October, 2012 we...AIM: To investigate if there is an association between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the risk of pancreatic cancer. METHODS: All relevant studies published before 11 October, 2012 were identified by a systematic search of MEDLINE, EMBASE, BIOSIS Previews and the Cochrane Library databases and with cross-referencing. The observational studies that reported RR or OR estimates with 95%CIs for the association between HBV or HCV and pancreatic cancer were included. A random-effects model was used to summarize meta-analytic estimates. The Newcastle-Ottawa quality assessment scale was applied to assess the quality of the methodology in the included studies. RESULTS: A total of 8 eligible studies were selected for meta-analysis. Overall, chronic hepatitis B and inactive hepatitis B surface antigen (HBsAg) carrier state (HBsAg positive) had a significantly increased risk of pancreatic cancer with OR of 1.20 (95%CI: 1.01-1.39), especially in the Chinese population (OR = 1.30, 95%CI: 1.05-1.56). Past exposure to HBV (possible occult HBV infection) had an increased OR of pancreatic cancer risk (OR = 1.24, 95%CI: 1.05-1.42), especially among those patients without natural immunity [anti hepatitis B core (HBc) positive/hepatitis B surface antibody (anti HBs) negative], with OR of 1.67 (95%CI: 1.13-2.22). However, past exposure to HBV with natural immunity (anti-HBc positive/anti-HBs positive) had no association with pancreatic cancer development, with OR 0.98 (95%CI: 0.80-1.16), nor did the HBV active replication (hepatitis B e antigen positive status), with OR 0.98 (95%CI: 0.27-1.68). The risk of pancreatic cancer among anti-HBs positive patients was significantly lower than among anti-HBs negative patients (OR = 0.54, 95%CI: 0.46-0.62). Past exposure to HCV also resulted in an increased risk of pancreatic cancer (OR = 1.26, 95%CI: 1.03-1.50). Significant between-study heterogeneity was observed. Evidence of publication bias for HBV/HCV infection-pancreatic cancer association was not found. CONCLUSION: Chronic HBV and HCV infection increases pancreatic cancer risk. Our findings underscore the need for more studies to confirm this potential relationship.展开更多
Cubic C3N4 compound in the C-N thin films on Si and NaCl substrates was prepared by ion beam sputtering of a pure graphite target with discharge gas of pure N2. X-ray photoelectron spectroscopy indicated that nitrogen...Cubic C3N4 compound in the C-N thin films on Si and NaCl substrates was prepared by ion beam sputtering of a pure graphite target with discharge gas of pure N2. X-ray photoelectron spectroscopy indicated that nitrogen atoms combined with sp2- and sp3- coordinated C atoms in the film, respectively. X-ray diffraction, selected area electron diffraction and high-resolution electron microscopy were used to identify the cubic C3N4 phase. The results reconfirm the ab initio calculations on metastable structure in C-N compounds展开更多
In 2018,China successfully launched three new Haiyang(which means ocean in Chinese,referred to as HY)satellites which are an ocean color observation satellite HY-1C(operational),an ocean dynamics environment satellite...In 2018,China successfully launched three new Haiyang(which means ocean in Chinese,referred to as HY)satellites which are an ocean color observation satellite HY-1C(operational),an ocean dynamics environment satellite HY-2B(operational)and the China-France ocean satellite CFOSAT(experimental).In 2019,all the three satellites had finished their commissioning phases and were declared operational.HY-2A satellite continues to operate in-orbit,and its operational status is basically normal.So in 2020,China has 4 Haiyang satellites in-orbit,China’s ocean satellites enter into a new operational application phase.The operation of the ground application system of Chinese ocean satellites is stable.In 2019,Beijing,Hainan,Mudanjiang,and Hangzhou ocean satellite ground stations had received the data of HY-1C,HY-2A,HY-2B,and CFOSAT 5012 orbits and 26.46 TB data had been distributed to both domestic and international users.Chinese ocean satellite data has played an important role in marine disaster prevention and mitigation,development and management of marine resources,maintenance of marine rights and interests,marine environment protection,scientific researches,and blue economy development.展开更多
Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted...Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted of a population-based cross-sectiona subsequent 1-year follow-up study of 171 subjects with the fasting cholesterol of 5.13-8.00 mmol/L. study of 456 plasma total Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol （LDL-c） had a significant and negative association with the erythrocyte membrane n-6：n-3 PUFAs ratio （P for trend=0.019） after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6：n-3 ratio in erythrocyte membrane （△=month 12-month 0）. In the top quartile whose ratios of n-6：n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6：n-3 decreased by an average of 1.13 （-1.07 mmol/L v.s. -0.32 mmol/L）. The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile （P for difference=0.052）. Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.展开更多
Recent developments in cutting-edge live microscopy and image analysis provide a unique opportunity to systematically investigate individual cell’s dynamics as well as simulation-based hypothesis testing. After a sum...Recent developments in cutting-edge live microscopy and image analysis provide a unique opportunity to systematically investigate individual cell’s dynamics as well as simulation-based hypothesis testing. After a summary of data generation and analysis in the observation and modeling efforts related to C. elegans embryogenesis, we develop a systematic approach to model the basic behaviors of individual cells. Next, we present our ideas to model cell fate, division, and movement using 3D time-lapse images within an agent-based modeling framework. Then, we summarize preliminary result and discuss efforts in cell fate, division, and movement modeling. Finally, we discuss the ongoing efforts and future directions for C. elegans embryo modeling, including an inferred developmental landscape for cell fate, a quasi-equilibrium model for cell division, and multi-agent, deep reinforcement learning for cell movement.展开更多
A massive iceberg, named A-68 by National Ice Center （NIC） officially, calved away from the Larsen C Ice Shelf in Antarctica on luly 12, 2017. The iceberg A-68 is about 5 800 km2, weighs more than a trillion tons an...A massive iceberg, named A-68 by National Ice Center （NIC） officially, calved away from the Larsen C Ice Shelf in Antarctica on luly 12, 2017. The iceberg A-68 is about 5 800 km2, weighs more than a trillion tons and it is one of the biggest ever recorded icebergs. Chinese satellites Gaofen-1 （GF-1） and Gaofen-3 （GF-3） data was used to monitoring the propagation of the rift and the iceberg by National Satellite Ocean Application Service （NSOAS）.展开更多
This paper presents a conception of an exponential observer for a class of linear distributed-parameter systems (DPSs), in which the dynamics are partially unknown. The given distributed-parameter observer ensures asy...This paper presents a conception of an exponential observer for a class of linear distributed-parameter systems (DPSs), in which the dynamics are partially unknown. The given distributed-parameter observer ensures asymptotic state estimator with exponentially decay error, based on the theory of C0-semigroups in a Hilbert space. The theoretical observer developed is applied to a chemical tubular reactor, namely the isothermal Plug-Flow reactor basic dynamical model for which measurements are available at the reactor output only. The process is described by Partial differential equations with unknown initial states. For this application, performance issues are illustrated in a simulation study.展开更多
The accuracy of the cloud-aerosol lidar with orthogonal polarization (CALIOP), moderate resolution imaging spectroradiometer (MODIS), Multi-Angle Implementation of Atmospheric Correction (MAIAC), and Geostationary Ope...The accuracy of the cloud-aerosol lidar with orthogonal polarization (CALIOP), moderate resolution imaging spectroradiometer (MODIS), Multi-Angle Implementation of Atmospheric Correction (MAIAC), and Geostationary Operational Environmental Satellite (GOES) aerosol optical depth (AOD) products for the Arctic north of 59.75°N was examined by means of 35 aerosol robotic network (AERONET) AOD sites. The assessment for June to October 2006 to 2020 showed MAIAC AOD agreed the best with AERONET AOD;CALIOP AOD differed the strongest from the AERONET AOD. Cross-correlations of CALIOP AOD along the satellite path indicated that AOD-values 40 km up-and-down the path often failed to represent the AERONET AOD-values within ±30 min of the overpass in this region dominated by easterly winds. Typically, CALIOP AOD was lower than AERONET AOD and MAIAC AOD at the sites, especially, at sites with mean AOD below 0.1. Generally, MODIS AOD values exceeded those of MAIAC. Comparison of CALIOP, MAIAC, and MODIS products resampled on a 0.25° × 0.25° grid revealed differences among the products caused by their temporal and spatial resolution, sample habit and size. Typically, the MODIS AOD-product showed the most details in AOD distribution. Despite differences in AOD-values, all products provided similar temporal evolution of elevated and lower AOD.展开更多
基金Supported by International Cooperation Project of the Guangzhou Science and Technology Bureau, No. 2011J5200017Guangdong Provincial Science and Technology Development Program, No. 2011B031800207
文摘AIM: To investigate if there is an association between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the risk of pancreatic cancer. METHODS: All relevant studies published before 11 October, 2012 were identified by a systematic search of MEDLINE, EMBASE, BIOSIS Previews and the Cochrane Library databases and with cross-referencing. The observational studies that reported RR or OR estimates with 95%CIs for the association between HBV or HCV and pancreatic cancer were included. A random-effects model was used to summarize meta-analytic estimates. The Newcastle-Ottawa quality assessment scale was applied to assess the quality of the methodology in the included studies. RESULTS: A total of 8 eligible studies were selected for meta-analysis. Overall, chronic hepatitis B and inactive hepatitis B surface antigen (HBsAg) carrier state (HBsAg positive) had a significantly increased risk of pancreatic cancer with OR of 1.20 (95%CI: 1.01-1.39), especially in the Chinese population (OR = 1.30, 95%CI: 1.05-1.56). Past exposure to HBV (possible occult HBV infection) had an increased OR of pancreatic cancer risk (OR = 1.24, 95%CI: 1.05-1.42), especially among those patients without natural immunity [anti hepatitis B core (HBc) positive/hepatitis B surface antibody (anti HBs) negative], with OR of 1.67 (95%CI: 1.13-2.22). However, past exposure to HBV with natural immunity (anti-HBc positive/anti-HBs positive) had no association with pancreatic cancer development, with OR 0.98 (95%CI: 0.80-1.16), nor did the HBV active replication (hepatitis B e antigen positive status), with OR 0.98 (95%CI: 0.27-1.68). The risk of pancreatic cancer among anti-HBs positive patients was significantly lower than among anti-HBs negative patients (OR = 0.54, 95%CI: 0.46-0.62). Past exposure to HCV also resulted in an increased risk of pancreatic cancer (OR = 1.26, 95%CI: 1.03-1.50). Significant between-study heterogeneity was observed. Evidence of publication bias for HBV/HCV infection-pancreatic cancer association was not found. CONCLUSION: Chronic HBV and HCV infection increases pancreatic cancer risk. Our findings underscore the need for more studies to confirm this potential relationship.
文摘Cubic C3N4 compound in the C-N thin films on Si and NaCl substrates was prepared by ion beam sputtering of a pure graphite target with discharge gas of pure N2. X-ray photoelectron spectroscopy indicated that nitrogen atoms combined with sp2- and sp3- coordinated C atoms in the film, respectively. X-ray diffraction, selected area electron diffraction and high-resolution electron microscopy were used to identify the cubic C3N4 phase. The results reconfirm the ab initio calculations on metastable structure in C-N compounds
文摘In 2018,China successfully launched three new Haiyang(which means ocean in Chinese,referred to as HY)satellites which are an ocean color observation satellite HY-1C(operational),an ocean dynamics environment satellite HY-2B(operational)and the China-France ocean satellite CFOSAT(experimental).In 2019,all the three satellites had finished their commissioning phases and were declared operational.HY-2A satellite continues to operate in-orbit,and its operational status is basically normal.So in 2020,China has 4 Haiyang satellites in-orbit,China’s ocean satellites enter into a new operational application phase.The operation of the ground application system of Chinese ocean satellites is stable.In 2019,Beijing,Hainan,Mudanjiang,and Hangzhou ocean satellite ground stations had received the data of HY-1C,HY-2A,HY-2B,and CFOSAT 5012 orbits and 26.46 TB data had been distributed to both domestic and international users.Chinese ocean satellite data has played an important role in marine disaster prevention and mitigation,development and management of marine resources,maintenance of marine rights and interests,marine environment protection,scientific researches,and blue economy development.
基金supported by research grants from the National Natural Science Foundation of China (30872102)the Diet Nutrition Research & Communication Grant of Danone Institute China (DIC2008‐12)
文摘Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted of a population-based cross-sectiona subsequent 1-year follow-up study of 171 subjects with the fasting cholesterol of 5.13-8.00 mmol/L. study of 456 plasma total Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol （LDL-c） had a significant and negative association with the erythrocyte membrane n-6：n-3 PUFAs ratio （P for trend=0.019） after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6：n-3 ratio in erythrocyte membrane （△=month 12-month 0）. In the top quartile whose ratios of n-6：n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6：n-3 decreased by an average of 1.13 （-1.07 mmol/L v.s. -0.32 mmol/L）. The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile （P for difference=0.052）. Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.
文摘Recent developments in cutting-edge live microscopy and image analysis provide a unique opportunity to systematically investigate individual cell’s dynamics as well as simulation-based hypothesis testing. After a summary of data generation and analysis in the observation and modeling efforts related to C. elegans embryogenesis, we develop a systematic approach to model the basic behaviors of individual cells. Next, we present our ideas to model cell fate, division, and movement using 3D time-lapse images within an agent-based modeling framework. Then, we summarize preliminary result and discuss efforts in cell fate, division, and movement modeling. Finally, we discuss the ongoing efforts and future directions for C. elegans embryo modeling, including an inferred developmental landscape for cell fate, a quasi-equilibrium model for cell division, and multi-agent, deep reinforcement learning for cell movement.
基金The National Key Research and Development Program of China under contract Nos 2016YFC1402704 and2016YFC1401007the International Science and Technology Cooperation Project of China under contract No.2011DFA22260
文摘A massive iceberg, named A-68 by National Ice Center （NIC） officially, calved away from the Larsen C Ice Shelf in Antarctica on luly 12, 2017. The iceberg A-68 is about 5 800 km2, weighs more than a trillion tons and it is one of the biggest ever recorded icebergs. Chinese satellites Gaofen-1 （GF-1） and Gaofen-3 （GF-3） data was used to monitoring the propagation of the rift and the iceberg by National Satellite Ocean Application Service （NSOAS）.
文摘This paper presents a conception of an exponential observer for a class of linear distributed-parameter systems (DPSs), in which the dynamics are partially unknown. The given distributed-parameter observer ensures asymptotic state estimator with exponentially decay error, based on the theory of C0-semigroups in a Hilbert space. The theoretical observer developed is applied to a chemical tubular reactor, namely the isothermal Plug-Flow reactor basic dynamical model for which measurements are available at the reactor output only. The process is described by Partial differential equations with unknown initial states. For this application, performance issues are illustrated in a simulation study.
文摘The accuracy of the cloud-aerosol lidar with orthogonal polarization (CALIOP), moderate resolution imaging spectroradiometer (MODIS), Multi-Angle Implementation of Atmospheric Correction (MAIAC), and Geostationary Operational Environmental Satellite (GOES) aerosol optical depth (AOD) products for the Arctic north of 59.75°N was examined by means of 35 aerosol robotic network (AERONET) AOD sites. The assessment for June to October 2006 to 2020 showed MAIAC AOD agreed the best with AERONET AOD;CALIOP AOD differed the strongest from the AERONET AOD. Cross-correlations of CALIOP AOD along the satellite path indicated that AOD-values 40 km up-and-down the path often failed to represent the AERONET AOD-values within ±30 min of the overpass in this region dominated by easterly winds. Typically, CALIOP AOD was lower than AERONET AOD and MAIAC AOD at the sites, especially, at sites with mean AOD below 0.1. Generally, MODIS AOD values exceeded those of MAIAC. Comparison of CALIOP, MAIAC, and MODIS products resampled on a 0.25° × 0.25° grid revealed differences among the products caused by their temporal and spatial resolution, sample habit and size. Typically, the MODIS AOD-product showed the most details in AOD distribution. Despite differences in AOD-values, all products provided similar temporal evolution of elevated and lower AOD.
