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The power spectrum and correlation of flow noise for an axisymmetric body in water 被引量:3
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作者 黎雪刚 杨坤德 汪勇 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第6期269-276,共8页
Understanding the physical features of the flow noise for an axisymmetric body is important for improving the performance of a sonar mounted on an underwater platform. Analytical calculation and numerical analysis of ... Understanding the physical features of the flow noise for an axisymmetric body is important for improving the performance of a sonar mounted on an underwater platform. Analytical calculation and numerical analysis of the physical features of the flow noise for an axisymmetric body are presented and a simulation scheme for the noise correlation on the hydrophones is given. It is shown that the numerical values of the flow noise coincide well with the analytical values. The main physical features of flow noise are obtained. The flow noises of two different models are compared and a model with a rather optimal fore-body shape is given. The flow noise in horizontal symmetry profile of the axisymmetric body is non-uniform, but it is omni-directional and has little difference in the cross section of the body. The loss of noise diffraction has a great effect on the flow noise from boundary layer transition. Meanwhile, based on the simulation, the noise power level increases with velocity to approximately the fifth power at high frequencies, which is consistent with the experiment data reported in the literature. Furthermore, the flow noise received by the acoustic array has lower correlation at a designed central frequency, which is important for sonar system design. 展开更多
关键词 flow noise correlation analysis power spectrum
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Space-Time Correlation Based Fast Regional Spectrum Sensing in Cognitive Radio 被引量:1
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作者 Sai Huang Yuanyuan Yao +2 位作者 Zhiyong Feng Ping Zhang Yifan Zhang 《China Communications》 SCIE CSCD 2017年第5期78-90,共13页
In this paper,a space-time correlation based fast regional spectrum sensing(RSS)scheme is proposed to reduce the time and energy consumption of traditional spatial spectrum sensing. The target region is divided into s... In this paper,a space-time correlation based fast regional spectrum sensing(RSS)scheme is proposed to reduce the time and energy consumption of traditional spatial spectrum sensing. The target region is divided into small meshes,and all meshes are clustered into highly related groups using the spatial correlation among them. In each group,some representative meshes are selected as detecting meshes(DMs)using a multi-center mesh(MCM)clustering algorithm,while other meshes(EMs)are estimated according to their correlations with DMs and the Markov modeled dependence on history by MAP principle. Thus,detecting fewer meshes saves the sensing consumption. Since two independent estimation processes may provide contradictory results,minimum entropy principle is adopted to merge the results. Tested with data acquired by radio environment mapping measurement conducted in the downtown Beijing,our scheme is capable to reduce the consumption of traditional sensing method with acceptable sensing performance. 展开更多
关键词 Cognitive radio Channel occupancy estimation Dynamic spectrum access Radio environment mapping Space-time correlation spectrum sensing
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NEW FAMILY OF BIPOLAR SEQUENCES AND ITS CORRELATION SPECTRUM
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作者 HuFei WenHong JinFan 《Journal of Electronics(China)》 2004年第2期140-144,共5页
Based on a class of bipolar sequences with two-values autocorrelation functions, a new family of bipolar sequences is constructed and its correlation spectrum is calculated. It is shown that the new family is optimal ... Based on a class of bipolar sequences with two-values autocorrelation functions, a new family of bipolar sequences is constructed and its correlation spectrum is calculated. It is shown that the new family is optimal with respect to Welch's bound and is different from the small set of Kasami sequences, while both of them have the same correlation properties. 展开更多
关键词 Bipolar sequences correlation function spectrum
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Chrestenson Spectrum and Auto-Correlation Function of Inverse Permutations of Quick Trickle Permutations
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作者 WANG Jue LI Zhengchao ZHAO Yaqun 《Wuhan University Journal of Natural Sciences》 CAS 2008年第5期587-590,共4页
In this paper, a sufficient and necessary condition of quick trickle permutations is given from the point of inverse permutations. The bridge is built between quick trickle permutations and m-value logic functions. By... In this paper, a sufficient and necessary condition of quick trickle permutations is given from the point of inverse permutations. The bridge is built between quick trickle permutations and m-value logic functions. By the methods of the Chrestenson spectrum of m-value logic functions and the auto-correlation function of m-value logic functions to investigate the Chrestenson spectral characteristics and the auto-correlation function charac- teristics of inverse permutations of quick trickle permutations, a determinant arithmetic of quick trickle permutations is given. Using the results, it becomes easy to judge that a permutation is a quick trickle permutation or not by using computer. This gives a new pathway to study constructions and enumerations of quick trickle permutations. 展开更多
关键词 quick trickle permutation chrestenson spectrum auto-correlation function m-value logic function
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青少年孤独症谱系障碍样行为与心理韧性的关系
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作者 曾龙平 王慧 +9 位作者 汤欣舟 苏醒 赵荔阳 吉兆正 宫小云 尹婷妮 刘勤一 孙秉玺 李雪 刘靖 《中国心理卫生杂志》 北大核心 2025年第1期26-31,共6页
目的:探讨青少年孤独症谱系障碍样行为(ASD样行为)和心理韧性之间的关系。方法:选取7 063名初中生,使用孤独症谱系障碍筛查量表(ASSQ)以及青少年心理韧性量表(RSCA)评估青少年的ASD样行为与心理韧性。以ASSQ总分P5、P95为界分组,比较两... 目的:探讨青少年孤独症谱系障碍样行为(ASD样行为)和心理韧性之间的关系。方法:选取7 063名初中生,使用孤独症谱系障碍筛查量表(ASSQ)以及青少年心理韧性量表(RSCA)评估青少年的ASD样行为与心理韧性。以ASSQ总分P5、P95为界分组,比较两组RSCA得分;对全样本ASSQ得分和RSCA得分进行相关分析及多重线性回归分析。结果:ASSQ高分组的RSCA得分低于ASSQ低分组;全样本的ASSQ分与RSCA分呈负相关(均P<0.01);ASSQ的社交互动得分与RSCA五因子分呈负关联(β=-0.23、-0.27、-0.11、-0.23、-0.37,均P<0.05)。结论:青少年的孤独症谱系障碍样行为与心理韧性存在负向关联,社交互动症状越重,心理韧性越差。 展开更多
关键词 孤独症谱系障碍 心理韧性 青少年 相关
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A Spectrum Prediction-Based Frequency Band Pre-Selection over Deteriorating HF Electromagnetic Environment 被引量:2
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作者 Xi Chen Jian Yang 《China Communications》 SCIE CSCD 2018年第9期10-24,共15页
As the earliest invented and utilized communication approach, shortwave, known as high frequency(HF) communication now experience the deterioration of HF electromagnetic environment. Finding quality frequency in effic... As the earliest invented and utilized communication approach, shortwave, known as high frequency(HF) communication now experience the deterioration of HF electromagnetic environment. Finding quality frequency in efficient manner becomes one of the key challenges in HF communication. Spectrum prediction infers the future spectrum status from history spectrum data by exploring the inherent correlations and regularities. The investigation of HF electromagnetic environment data reveals the correlations and predictability of HF frequency band in both time and frequency domain. To solve this problem, we develop a Spectrum Prediction-based Frequency Band Pre-selection(SP-FBP) for HF communications. The pre-selection of HF frequency band mainly incorporated in prediction of HF spectrum occupancy and prediction of HF usable frequency, which provide the frequency band ranking of spectrum occupancy and alternative frequency for spectrum sensing, respectively. Performance evaluation via real-world HF spectrum data shows that SP-FBP significantly improves the efficiency of finding quality frequency in HF communications. 展开更多
关键词 HF electromagnetic environment spectrum prediction frequency band pre-selection HF correlation HF predictability
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A Method for Incipient Fault Diagnosis of Roller Bearings Based on the Wavelet Transform Correlation Filter and Hilbert Transform 被引量:1
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作者 ZENG Qing-hu QIU Jing LIU Guan-jun 《International Journal of Plant Engineering and Management》 2007年第4期192-198,共7页
Noise is the biggest obstacle that makes the incipient fault diagnosis results of roller bearings uncorrected; a new method for diagnosing incipient fault of roller bearings based on the Wavelet Transform Correlation ... Noise is the biggest obstacle that makes the incipient fault diagnosis results of roller bearings uncorrected; a new method for diagnosing incipient fault of roller bearings based on the Wavelet Transform Correlation Filter and Hilbert Transform was proposed. First, the weak fault information features are picked up from the roller bearings fault vibration signals by use of a de-noising characteristic of the Wavelet Transform Correlation Filter as the preprocessing of the Hilbert Envelope Analysis. Then, in order to get fault features frequency, de-noised wavelet coefficients of high scales which represent high frequency signal were analyzed by Hilbert Envelope Spectrum Analysis. The simulation signals and diagnosing examples analysis results reveal that the proposed method is more effective than the method of direct wavelet coefficients-Hilbert Transform in de-noising and clarifying roller bearing incipient fault. 展开更多
关键词 wavelet correlation Filter Hilbert transform envelope spectrum fault diagnosis roller bearings
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TIME DOMAIN PROCESSING MODE SPREAD SPECTRUM SYSTEM
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作者 何世平 《Journal of Electronics(China)》 1995年第3期276-283,共8页
The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this sy... The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this system is provided. The formula for calculating the probability of error of the system is given. The experimental results agree with the theoretical analysis. 展开更多
关键词 Time DOMAIN processing SPREAD spectrum system STORAGE correlATOR
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Subspace decomposition-based correlation matrix multiplication
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作者 Cheng Hao Guo Wei Yu Jingdong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第2期241-245,共5页
The correlation matrix, which is widely used in eigenvalue decomposition (EVD) or singular value decomposition (SVD), usually can be denoted by R = E[yiy'i]. A novel method for constructing the correlation matrix... The correlation matrix, which is widely used in eigenvalue decomposition (EVD) or singular value decomposition (SVD), usually can be denoted by R = E[yiy'i]. A novel method for constructing the correlation matrix R is proposed. The proposed algorithm can improve the resolving power of the signal eigenvalues and overcomes the shortcomings of the traditional subspace methods, which cannot be applied to low SNR. Then the proposed method is applied to the direct sequence spread spectrum (DSSS) signal's signature sequence estimation. The performance of the proposed algorithm is analyzed, and some illustrative simulation results are presented. 展开更多
关键词 subspace theory correlation matrix eigenvalue decomposition direct sequence spread spectrum signal
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Optical encryption scheme based on spread spectrum ghost imaging
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作者 刘进芬 董玥 +1 位作者 王乐 赵生妹 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期375-381,共7页
An optical encryption(OE) scheme based on the spread spectrum ghost imaging(SSGI), named as SSGI-OE, is proposed to obtain a high security with a smaller key. In the scheme, the randomly selected row number of a Hadam... An optical encryption(OE) scheme based on the spread spectrum ghost imaging(SSGI), named as SSGI-OE, is proposed to obtain a high security with a smaller key. In the scheme, the randomly selected row number of a Hadamard matrix of order N is used as the secure key, and shared with the authorized user, Bob, through a private channel. Each corresponding row vector of the order-N Hadamard matrix is then used as the direct sequence code to modulate a speckle pattern for the ghost imaging system, and an image is encrypted with the help of the SSGI. The measurement results from the bucket detector, named as ciphertext, are then transmitted to Bob through a public channel. The illuminating speckle patterns are also shared with Bob by the public channel. With the correct secure key, Bob could reconstruct the image with the aid of the SSGI system, whereas the unauthorized user, Eve, could not obtain any useful information of the encrypted image. The numerical simulations and experimental results show that the proposed scheme is feasible with a higher security and a smaller key. For the 32 × 32 pixels image, the number of bits sent from Alice to Bob by using SSGIOE(M = 1024, N = 2048) scheme is only 0.0107 times over a computational ghost imaging optical encryption scheme.When the eavesdropping ratio(ER) is less than 40%, the eavesdropper cannot acquire any information of the encrypted image. The extreme circumstance for the proposed SSGI-OE scheme is also discussed, where the eavesdropper begins to extract the information when ER is up to 15%. 展开更多
关键词 optical encryption ghost imaging spread spectrum correlated imaging
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Frequency and Correlation Characteristic of the Hopf Bifurcation Chemical Oscillatory Patterns
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《Journal of Chemistry and Chemical Engineering》 2012年第3期284-291,共8页
The Belousov-Zhabotinski type of chemical reactions was studied. Dynamics of the unperturbed oscillating chemical system and subject to the external perturbations is considered. The system response to the external per... The Belousov-Zhabotinski type of chemical reactions was studied. Dynamics of the unperturbed oscillating chemical system and subject to the external perturbations is considered. The system response to the external periodic perturbation near the Hopf bifurcation point has been monitored. As a response to the external periodic perturbation of system, one obtains the synchronization oscillations, two-, three-and multiperiodic ones as well as obtain two types of chaos. The kinetic of such reactions is analyzed by time series. The Fourier transforms were used to analyze the frequency characteristics of the synchronized and chaotic states giving the different harmonic spectra. As further statistical characteristics the winding numbers and variation values of trajectories are calculated using a rotational model of processes in relation to the coherence parameter joint with perturbation period. For chaotic states the autocorrelation functions and correlation dimensions, which form an approximation of a fractal dimension D, have been calculated. Additionally, Lyapunov exponents were computed. Their positive values confirmed chaotic behavior. 展开更多
关键词 OSCILLATIONS Fourier spectrum circle map correlation dimension Lyapunov spectrum.
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Determination of Fourier Components of Spatial Correlation Function of Dielectric Susceptibility of Random Medium
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作者 Ning Mu Wanrong Gao 《Journal of Modern Physics》 2019年第4期443-451,共9页
In this work, we present a new method of directly determining Fourier components of the spatial correlation function of the dielectric susceptibility of random medium. The method is based on the analysis of the ratio ... In this work, we present a new method of directly determining Fourier components of the spatial correlation function of the dielectric susceptibility of random medium. The method is based on the analysis of the ratio of the spectrum of the light scattered by the spatial correlation components of the dielectric susceptibility of tissue to the spectrum of light scattered by the randomly distributed scatterers which are independent on the value of the spectrum of the incident light and the direction of the observation. The results may find wide applications in areas such as in biomedical diagnosis. 展开更多
关键词 Spatial correlATION of Refractive Index spectrum of the Light SCATTERED DIELECTRIC SUSCEPTIBILITY FOURIER Components
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Harmonicity Spectrum
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作者 Lintao Liu Guocheng Wang +3 位作者 Xiaoqing Su Xuepeng Sun Huiwen Hu Xiaowen Luo 《Open Journal of Statistics》 2023年第5期761-768,共8页
Perceiving harmonic information (especially weak harmonic information) in time series has important scientific and engineering significance. Fourier spectrum and time-frequency spectrum are commonly used tools for per... Perceiving harmonic information (especially weak harmonic information) in time series has important scientific and engineering significance. Fourier spectrum and time-frequency spectrum are commonly used tools for perceiving harmonic information, but they are often ineffective in perceiving weak harmonic signals because they are based on energy or amplitude analysis. Based on the theory of Normal time-frequency transform (NTFT) and complex correlation coefficient, a new type of spectrum, the Harmonicity Spectrum (HS), is developed to perceive harmonic information in time series. HS is based on the degree of signal harmony rather than energy or amplitude analysis, and can therefore perceive very weak harmonic information in signals sensitively. Simulation examples show that HS can detect harmonic information that cannot be detected by Fourier spectrum or time-frequency spectrum. Acoustic data analysis shows that HS has better resolution than traditional LOFAR spectrum. 展开更多
关键词 Normal Time-Frequency Transform Complex correlation Coefficient Harmonicity spectrum Weak Harmonic Signal Detection
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Short-tim e spectrum discrim ination between transientevoked otoacoustic em ission and stim ulus artifact
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作者 LILi-ming LINJin-sen ZHANGZheng-guo 《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第2期1-8,共8页
Transient Evoked Otoacoustic Emission(TEOAE) has been widely researched and applied in auditory field during these years.Correctly indentifying TEOAE is the basis of study and application.Aiming at the limitations of ... Transient Evoked Otoacoustic Emission(TEOAE) has been widely researched and applied in auditory field during these years.Correctly indentifying TEOAE is the basis of study and application.Aiming at the limitations of the traditional TEOAE identification methods,this study put forward a new discrimination criterion between TEOAE and residual stimulus artifact in time frequency domain according to their different features.This method has been demonstrated to improve the correctness of identification,and will help the accurate diagnosis of cochlear function. 展开更多
关键词 TEOAE identification correlation coefficient SHORT time spectrum
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Improved Circular Correlation Methods for Acquisition in Software GPS Receiver
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作者 Vandana Patel Pankaj Shukla Mithilesh Kumar 《Computer Technology and Application》 2011年第5期389-395,共7页
In this paper the authors explore the Global Positioning System (GPS) signal acquisition and tracking algorithms used in software GPS receiver. Acquisition time is the most important parameter in evaluating the perf... In this paper the authors explore the Global Positioning System (GPS) signal acquisition and tracking algorithms used in software GPS receiver. Acquisition time is the most important parameter in evaluating the performance of a software GPS receiver in terms of its speed. A trade-off study is done to seek a good balance between the acquisition accuracy and the processing time. The frequency-domain acquisition method by circular correlation, used in a software GPS receiver, has been improved by studying the power spectrum of the Coarse Acquisition (C/A) code alone. The analysis of C/A code reveals that its power spectrum is symmetrical; hence only half the points are required to perform circular correlation. Besides, either half of the spectrum is asymmetrical where a larger amount of power is concentrated in almost one-quarter of the spectrum on its either sides. This further reduces the number of points used to perform correlation. Comparative results of MATLAB simulation of full-size, half-size and quarter-size circular correlation done on actual data stored on hard disk are provided, and they agree with those obtained using GPS receiver. Further reduction in acquisition time has been achieved by investigating the effect of length of the noncoherent pre-integration period. The improved acquisition methods pave way for further development of new algorithms to enhance software GPS receiver performance. 展开更多
关键词 Global positioning system (GPS) software GPS receiver coarse acquisition (C/A) code signal acquisition circular correlation signal power spectrum.
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Measurement of Particle Velocity, Particle Size Distribution and Concentration in Particulate Suspension by Transmission Fluctuation Correlation Spectrometry
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作者 Peng Gong 《International Journal of Clean Coal and Energy》 2022年第2期13-23,共11页
In coal-fired power generation industry, parameters such as particle size affect combustion efficiency. Especially in the application of two-phase flow clean energy, the parameters such as particle velocity, particle ... In coal-fired power generation industry, parameters such as particle size affect combustion efficiency. Especially in the application of two-phase flow clean energy, the parameters such as particle velocity, particle size distribution and concentration are very important, because the coal particle velocity, concentration or size range have an impact on the whole combustion process. This paper introduces an optical measurement setup based on the transmission fluctuation correlation spectrum measurement technique, which realizes the simultaneous measurement of particle velocity, particle size distribution and concentration. Compared with image method, ultrasonic spectrum method and other methods, the experimental device is simple and low-cost. 展开更多
关键词 On-Line Measurement Two-Phase Flow Transmission Fluctuation correlation spectrum Energy and Power
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Application of the Double-difference Relocation Method Combined with Waveform Cross-correlation on the Three Gorges Reservoir Seismicity
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作者 Luo Jiahong Ma Wentao Li Chunzheng 《Earthquake Research in China》 CSCD 2017年第3期368-380,共13页
In this paper,we use the double difference location method based on waveform crosscorrelation algorithm for precise positioning of the Three Gorges Reservoir( TGR)earthquakes and analysis of seismic activity. First,we... In this paper,we use the double difference location method based on waveform crosscorrelation algorithm for precise positioning of the Three Gorges Reservoir( TGR)earthquakes and analysis of seismic activity. First,we use the bi-spectrum cross-correlation method to analyze the seismic waveform data of TGR encrypted networks from March,2009 to December,2010,and evaluate the quality of waveform cross-correlation analysis.Combined with the waveform cross-correlation of data obtained, we use the double difference method to relocate the earthquake position. The results show that location precision using bi-spectrum verified waveform cross-correlation data is higher than that by using other types of data,and the mean 2 sig-error in EW,NS and UD are 3.2 m,3.9 m and 6.2 m,respectively. For the relocation of the Three Gorges Reservoir earthquakes,the results show that the micro-earthquakes along the Shenlongxi river in the Badong reservoir area obviously show the characteristics of three linear zones with nearly east-west direction,which is in accordance with the small faults and carbonate strata line of the neotectonic period,revealing the reservoir water main along the underground rivers or caves permeated and induced seismic activity. The stronger earthquakes may have resulted from small earthquakes through the active layers. 展开更多
关键词 Bi-spectrum verification WAVEFORM CROSS-correlATION Double-difference LOCATION The Three Gorges RESERVOIR
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基于多模态神经网络的微地震事件检测
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作者 张岩 刘小秋 +2 位作者 王海潮 宋利伟 董宏丽 《石油物探》 CSCD 北大核心 2024年第4期790-806,共17页
针对微地震有效信号时序特征存在的局限导致微地震事件识别准确率不高的问题,提出了一种基于多模态学习的神经网络微地震事件检测方法。首先,利用道集数据的相关性以目标道为轴对称制作多道时域模态,对目标道进行时频分析得到S域模态特... 针对微地震有效信号时序特征存在的局限导致微地震事件识别准确率不高的问题,提出了一种基于多模态学习的神经网络微地震事件检测方法。首先,利用道集数据的相关性以目标道为轴对称制作多道时域模态,对目标道进行时频分析得到S域模态特征;然后,联合时域模态和S域模态设计微地震事件检测神经网络,综合多模态的特征进行训练学习,提高微地震事件识别的精度;最后,为验证方法的有效性,对合成微地震信号进行低信噪比数据分析、小幅值数据分析以及实际油井微地震监测信号事件分析。结果表明,该方法可以有效检测低信噪比及微弱的微地震事件;与支持向量机、卷积神经网络、基于监督机器学习方法的对比实验结果表明该方法具有更高的抗噪性与准确率。 展开更多
关键词 微地震 事件检测 拉普拉斯变换 多模态网络 时频谱 道集数据相关性
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孤独症谱系障碍患儿父母心理适应与心理弹性及自我效能的关系
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作者 张丽军 徐海萍 +3 位作者 徐瑞 李正华 鲁兴凤 王瑞霞 《海南医学》 CAS 2024年第16期2366-2370,共5页
目的探讨孤独症谱系障碍(ASD)患儿父母心理适应与心理弹性及自我效能的关系。方法通过随机取样法选取2021年10月至2022年4月期间在郑州大学第三附属医院接受治疗的316例ASD患儿及其父亲或母亲316名作为研究对象。采用一般资料调查问卷... 目的探讨孤独症谱系障碍(ASD)患儿父母心理适应与心理弹性及自我效能的关系。方法通过随机取样法选取2021年10月至2022年4月期间在郑州大学第三附属医院接受治疗的316例ASD患儿及其父亲或母亲316名作为研究对象。采用一般资料调查问卷、心理适应量表(PAS)、心理弹性量表(CD-RISC)以及一般自我效能感量表(GSES)对所有ASD患儿父亲或母亲进行调查,应用Spearman相关性分析法评价ASD患儿父亲或母亲心理适应与心理弹性及自我效能的关系,采用多元线性回归分析ASD患儿父亲或母亲心理适应的影响因素。结果ASD患儿父亲或母亲PAS量表总分为(59.71±6.38)分、CD-RISC量表总分为(62.44±5.87)分、GSES量表总分为(20.45±4.16)分;Spearman相关性分析法分析结果显示,ASD患儿父亲或母亲PAS量表各维度得分及总分与CD-RISC量表各维度得分及总分、GSES量表总分均呈正相关(P<0.05);多元线性回归分析结果显示,心理弹性、自我效能、与患儿关系、父亲或母亲年龄均是ASD患儿父亲或母亲心理适应的影响因素(P<0.05)。结论ASD患儿父亲或母亲心理适应、心理弹性、自我效能处于中等水平,心理弹性、自我效能、与患儿关系、父亲或母亲年龄是ASD患儿父亲或母亲心理适应的影响因素,临床应加强对影响因素的关注并采取有效干预,提升ASD患儿父亲或母亲心理适应水平。 展开更多
关键词 孤独症谱系障碍患儿 父母 心理适应 心理弹性 自我效能 相关性
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盐益智仁-盐小茴香药对止泻活性部位筛选及“谱效”关系研究
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作者 李红伟 徐若颖 +4 位作者 周宁 曹彦刚 田连起 石延榜 李凯 《中国比较医学杂志》 CAS 北大核心 2024年第7期48-59,共12页
目的筛选盐益智仁-盐小茴香药对(YZYH)止泻活性部位,并通过“谱效”关系研究推测其药效物质基础和质量标志物。方法制备大鼠脾肾阳虚泄泻模型,测定盐益智仁-盐小茴香药对石油醚(YZYH⁃L)、乙酸乙酯(YZYH⁃M)、水(YZYH⁃H)3部位药效指标,包... 目的筛选盐益智仁-盐小茴香药对(YZYH)止泻活性部位,并通过“谱效”关系研究推测其药效物质基础和质量标志物。方法制备大鼠脾肾阳虚泄泻模型,测定盐益智仁-盐小茴香药对石油醚(YZYH⁃L)、乙酸乙酯(YZYH⁃M)、水(YZYH⁃H)3部位药效指标,包括体重、肛温、腹泻潜伏期(diarrhea incubation period,DIP)、腹泻指数(diarrheal index,DI)等行为学指标及一氧化氮合成酶(nitric oxide synthetase,NOS)、环磷酸鸟苷(cyclic guanosine monophosphate,cGMP)、磷酸肌酸激酶(creatine phosphate kinase,CPK)等生化指标;建立不同部位高效液相色谱(high performance liquid chromatography,HPLC)图谱,采用灰色关联法分析各部位化学成分与止泻药效指标间的“谱效”关系。结果与空白对照组大鼠相比,15 d后,模型组大鼠出现泄泻证主症关键病理指标—水样便,同时,伴随食后腹胀、食欲不振和弓背等脾阳和肾阳虚泄泻的次症典型特征;给与治疗药物后,泄泻主症和次症均有不同程度的改善,其中阳性药、YZYH⁃M部位第28天后泄泻模型大鼠关键指标DIP极显著延长(P<0.01)、DI极显著降低(P<0.01),以及脾、肾阳虚泄泻的次症典型特征代表性指标体重、24 h摄食、饮水量、肛温和血清生化指标NOS、cGMP、CPK等活性的调节作用均较其它给药组好;“谱效”关系研究表明茴香醛、4号色谱峰等成分与DIP、DI、NOS、cGMP、CPK 5个药效指标的关联度重要。结论YZYH⁃M部位为药对止泻活性部位,其作用机制与抑制胃肠功能亢进和调节机体能量代谢与免疫相关;茴香醛及4号峰作为药对的质量标志物。 展开更多
关键词 盐益智仁-盐小茴香药对 止泻作用 活性部位 “谱效”关系 灰色关联法 茴香醛
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