目的探讨C反应蛋白(CRP)基因-717A/G多态性与老年缺血性脑卒中的关系。方法选择年龄≥60岁的缺血性脑卒中患者196例为脑卒中组,同期健康体检者197例为对照组,PCR-RFLP方法检测CRP基因型,并测血清高敏CRP(hs-CRP),logistic回归分析CRP与...目的探讨C反应蛋白(CRP)基因-717A/G多态性与老年缺血性脑卒中的关系。方法选择年龄≥60岁的缺血性脑卒中患者196例为脑卒中组,同期健康体检者197例为对照组,PCR-RFLP方法检测CRP基因型,并测血清高敏CRP(hs-CRP),logistic回归分析CRP与缺血性脑卒中的关系。结果脑卒中组hs-CRP显著高于对照组(p<0.01),两组CRP基因-717A/G多态性分布无统计学差异(P>0.05)。脑卒中组AA基因型患者hs-CRP浓度显著高于AG+GG基因型[2.30(0.95～3.45)mg/L vs 1.05(0.61～2.12)mg/L,P<0.01],但时照组不同基因型hs-CRP浓度无统计学差异。hs-CRP是老年缺血性脑卒中发生的独立危险因素。结论血清hs-CRP浓度升高与老年脑卒中相关。CRP基因-717A/G多态性与老年缺血性脑卒中无相关性,但与血清hs-CRP浓度有关。展开更多
目的探讨超敏C反应蛋白(hs-CRP)水平在糖尿病患者脑血管意外中的预测价值。方法选择2012年5月～2013年5月宜宾市第二人民医院南区治疗的2型糖尿病合并脑血管意外患者66例为脑血管意外组,选择同时期治疗的2型糖尿病未发生脑血管意外事件...目的探讨超敏C反应蛋白(hs-CRP)水平在糖尿病患者脑血管意外中的预测价值。方法选择2012年5月～2013年5月宜宾市第二人民医院南区治疗的2型糖尿病合并脑血管意外患者66例为脑血管意外组,选择同时期治疗的2型糖尿病未发生脑血管意外事件的患者66例为单纯糖尿病组,同期健康体检者66例为对照组。分别检测并比较三组的空腹血糖(FPG)、口服葡萄糖耐量试验(OGTT)以及hs-CRP浓度情况。结果 1脑血管意外组、单纯糖尿病组FPG值[(8.53±2.03)、(8.62±1.35)mmol/L]、餐后2 h血糖(2 h PG)值[(13.89±2.27)、(14.19±1.86)mmol/L]均高于对照组[(4.01±1.10)、(6.17±1.71)mmol/L],差异均有统计学意义(P<0.05);脑血管意外组、单纯糖尿病组之间FPG值、2 h PG值比较,差异无统计学意义(P>0.05)。2三组间hs-CRP水平及异常比例比较,差异均有统计学意义(F=3.973,χ2=4.730,P<0.05);其中脑血管意外组hs-CRP水平[(12.58±3.53)μg/mL]高于单纯糖尿病组[(4.87±1.94)mg/L]及对照组[(2.03±0.71)mg/L],差异有统计学意义(P<0.05);单纯糖尿病组hsCRP水平高于对照组,差异有统计学意义(P<0.05)。结论 hs-CRP对糖尿病合并脑血管意外具有明显的预测价值,可作为脑血管事件的预测因子。展开更多
目的:探讨血清高敏C反应蛋白(hight-sensitive C-reactive protein,hs-C R P)与脑血管疾病的关系。方法:采用免疫散射速率比浊法,检测60例脑血管疾病患者和25例健康体检对照者血清hs-C R P水平。结果:18例短暂脑缺血发作(TIA)组hs-C R P...目的:探讨血清高敏C反应蛋白(hight-sensitive C-reactive protein,hs-C R P)与脑血管疾病的关系。方法:采用免疫散射速率比浊法,检测60例脑血管疾病患者和25例健康体检对照者血清hs-C R P水平。结果:18例短暂脑缺血发作(TIA)组hs-C R P为(1.94±1.40)m g/L,25例脑梗死组为(15.51±6.91)m g/L,17例脑出血组为(11.95±4.88)m g/L,20例正常对照组为(1.09±0.66)m g/L,脑梗死组、脑出血组与对照组比较血清hs-C R P水平升高,差异均具有显著性(P<0.001);TIA组与对照组比较差异无显著性(P>0.05)。结论:血清hs-C R P水平与脑血管疾病密切相关,可预测脑血管疾病的危险性,并可作为监测病情和预后判断的指标。展开更多
Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the –607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, ...Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the –607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the –607C/A （rs1946518） polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 –137G/C （rs187238） polymorphism and the –13T/C （rs11024595） polymorphism in the 5＇-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele （C homozygotes） was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the –13T/C （rs11024595） polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the –607C/A （rs1946518） polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease.展开更多
文摘目的探讨C反应蛋白(CRP)基因-717A/G多态性与老年缺血性脑卒中的关系。方法选择年龄≥60岁的缺血性脑卒中患者196例为脑卒中组,同期健康体检者197例为对照组,PCR-RFLP方法检测CRP基因型,并测血清高敏CRP(hs-CRP),logistic回归分析CRP与缺血性脑卒中的关系。结果脑卒中组hs-CRP显著高于对照组(p<0.01),两组CRP基因-717A/G多态性分布无统计学差异(P>0.05)。脑卒中组AA基因型患者hs-CRP浓度显著高于AG+GG基因型[2.30(0.95～3.45)mg/L vs 1.05(0.61～2.12)mg/L,P<0.01],但时照组不同基因型hs-CRP浓度无统计学差异。hs-CRP是老年缺血性脑卒中发生的独立危险因素。结论血清hs-CRP浓度升高与老年脑卒中相关。CRP基因-717A/G多态性与老年缺血性脑卒中无相关性,但与血清hs-CRP浓度有关。
文摘目的探讨超敏C反应蛋白(hs-CRP)水平在糖尿病患者脑血管意外中的预测价值。方法选择2012年5月～2013年5月宜宾市第二人民医院南区治疗的2型糖尿病合并脑血管意外患者66例为脑血管意外组,选择同时期治疗的2型糖尿病未发生脑血管意外事件的患者66例为单纯糖尿病组,同期健康体检者66例为对照组。分别检测并比较三组的空腹血糖(FPG)、口服葡萄糖耐量试验(OGTT)以及hs-CRP浓度情况。结果 1脑血管意外组、单纯糖尿病组FPG值[(8.53±2.03)、(8.62±1.35)mmol/L]、餐后2 h血糖(2 h PG)值[(13.89±2.27)、(14.19±1.86)mmol/L]均高于对照组[(4.01±1.10)、(6.17±1.71)mmol/L],差异均有统计学意义(P<0.05);脑血管意外组、单纯糖尿病组之间FPG值、2 h PG值比较,差异无统计学意义(P>0.05)。2三组间hs-CRP水平及异常比例比较,差异均有统计学意义(F=3.973,χ2=4.730,P<0.05);其中脑血管意外组hs-CRP水平[(12.58±3.53)μg/mL]高于单纯糖尿病组[(4.87±1.94)mg/L]及对照组[(2.03±0.71)mg/L],差异有统计学意义(P<0.05);单纯糖尿病组hsCRP水平高于对照组,差异有统计学意义(P<0.05)。结论 hs-CRP对糖尿病合并脑血管意外具有明显的预测价值,可作为脑血管事件的预测因子。
文摘目的:探讨血清高敏C反应蛋白(hight-sensitive C-reactive protein,hs-C R P)与脑血管疾病的关系。方法:采用免疫散射速率比浊法,检测60例脑血管疾病患者和25例健康体检对照者血清hs-C R P水平。结果:18例短暂脑缺血发作(TIA)组hs-C R P为(1.94±1.40)m g/L,25例脑梗死组为(15.51±6.91)m g/L,17例脑出血组为(11.95±4.88)m g/L,20例正常对照组为(1.09±0.66)m g/L,脑梗死组、脑出血组与对照组比较血清hs-C R P水平升高,差异均具有显著性(P<0.001);TIA组与对照组比较差异无显著性(P>0.05)。结论:血清hs-C R P水平与脑血管疾病密切相关,可预测脑血管疾病的危险性,并可作为监测病情和预后判断的指标。
文摘Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the –607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the –607C/A （rs1946518） polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 –137G/C （rs187238） polymorphism and the –13T/C （rs11024595） polymorphism in the 5＇-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele （C homozygotes） was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the –13T/C （rs11024595） polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the –607C/A （rs1946518） polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease.
