BACKGROUND Aging population is a significant issue in Viet Nam and across the globe.Elderly individuals are at higher risk of chronic kidney disease(CKD),especially those with diabetes.Several studies found that the e...BACKGROUND Aging population is a significant issue in Viet Nam and across the globe.Elderly individuals are at higher risk of chronic kidney disease(CKD),especially those with diabetes.Several studies found that the estimated glomerular filtration rate(eGFR)determined using creatinine-based equations was not as accurate as that determined using cystatin C-based equations.Cystatin C-based equations may be beneficial in elderly patients with an age-associated decline in kidney function.Early determination of eGFR decline and associated factors would aid in appropriate interventions to improve kidney function in elderly patients with diabetes.AIM To determine the utility of cystatin C-based equations in early detection of eGFR decline and to explore factors associated with eGFR decline in elderly patients with diabetes.METHODS This cross-sectional study included 93 participants aged≥60 years evaluated in Can Tho University of Medicine and Pharmacy Hospital between October 2022 and July 2023,including 47 and 46 participants with and without diabetes respectively,according to the American Diabetes Association criteria for diabetes.The kappa coefficient,Student’s t,Mann-Whitney,χ2,Pearson’s correlation,multivariate logistic regression,and multiple linear regression analyses were employed.RESULTS The eGFRs were lower with the cystatin C-based equations than with the creatinine-based equations.Good agreement was found between the Modification of Diet in Renal Disease(MDRD)and CKD Epidemiology Collaboration(CKD-EPI)2021 creatinine-cystatin C equations(kappa=0.66).In the diabetes group,30%of the participants had low eGFR.Both plasma glucose and glycated hemoglobin were associated with an increased risk of eGFR decline(P<0.05)and negatively correlated with eGFR(P=0.001).By multivariate logistic regression,total cholesterol,and exercise were independently associated with low eGFR.By multiple linear regression,higher plasma glucose levels were correlated with lower eGFR(P=0.026,r=-0.366).CONCLUSION Cystatin C-based equations were superior in the early detection of a decline in eGFR,and the MDRD equation may be considered as an alternative to the CKD-EPI 2021 creatinine-cystatin C equation.Exercise,plasma glucose,and total cholesterol were independently associated with eGFR in patients with diabetes.展开更多
In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo [2,1-c][1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-...In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo [2,1-c][1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-bromoethyl) pyrrole-2-carboxylate with silver oxide and its derivatives were obtained by Friedel-Craftes reaction. Nine of 6-acyl derivatives of compound 3 were prepared.展开更多
A mobile C-band dual polarimetric weather radar J type （PCDJ）, which adopts simultaneous transmission and simultaneous reception （STSR） of horizontally and vertically polarized signals, was first developed in Chin...A mobile C-band dual polarimetric weather radar J type （PCDJ）, which adopts simultaneous transmission and simultaneous reception （STSR） of horizontally and vertically polarized signals, was first developed in China in 2008. It was deployed in the radar observation plan in the South China Heavy Rainfall Experiment （SCHeREX） in the summer of 2008 and 2009, as well as in Tropical Western Pacific Ocean Observation Experiments and Research on the Predictability of High Impact Weather Events from 2008 to 2010 in China （TWPOR）. Using the observation data collected in these experiments, the radar systematic error and its sources were analyzed in depth. Meanwhile an algorithm that can smooth differential propagation phase （~Dp） for estimating the high-resolution specific differential phase （KDP） was developed. After attenuation correction of reflectivity in horizontal polarization （ZH） and differential reflectivity （ZDR） of PCDJ radar by means of KDP, the data quality was improved significantly. Using quality-controlled radar data, quantitative rainfall estimation was performed, and the resutls were compared with rain-gauge measurements. A synthetic ZH /KDp-based method was analyzed. The results the traditional ZH-based method when the rain suggest that the synthetic method has the advantage over rate is 〉5 mm h^-1. The more intensive the rain rates, the higher accuracy of the estimation.展开更多
The three title compounds were prepared from 2-phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols via an intramolecular Friedel-Crafts reaction. 2-Phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols were prepared from 2-ph...The three title compounds were prepared from 2-phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols via an intramolecular Friedel-Crafts reaction. 2-Phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols were prepared from 2-phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinones via reduction. The heterocyclic ring system of pyrrolizino[2,1-c]quinoline has not been found in literature.展开更多
In this paper we establish sharp H/51der estimates of harmonic functions on a class of connected post critically finite （p.c.f.） self-similar sets, and show that functions in the domain of Laplacian enjoy the same p...In this paper we establish sharp H/51der estimates of harmonic functions on a class of connected post critically finite （p.c.f.） self-similar sets, and show that functions in the domain of Laplacian enjoy the same property. Some weU-known examples, such as the Sierpinski gasket, the unit interval, the level 3 Sierpinski gasket, the hexagasket, the 3-dimensional Sierpinski gasket, and the Vicsek set are also considered.展开更多
Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9...Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9 were designed and synthesized. They may have antipyretic and analgesic activities.展开更多
文摘BACKGROUND Aging population is a significant issue in Viet Nam and across the globe.Elderly individuals are at higher risk of chronic kidney disease(CKD),especially those with diabetes.Several studies found that the estimated glomerular filtration rate(eGFR)determined using creatinine-based equations was not as accurate as that determined using cystatin C-based equations.Cystatin C-based equations may be beneficial in elderly patients with an age-associated decline in kidney function.Early determination of eGFR decline and associated factors would aid in appropriate interventions to improve kidney function in elderly patients with diabetes.AIM To determine the utility of cystatin C-based equations in early detection of eGFR decline and to explore factors associated with eGFR decline in elderly patients with diabetes.METHODS This cross-sectional study included 93 participants aged≥60 years evaluated in Can Tho University of Medicine and Pharmacy Hospital between October 2022 and July 2023,including 47 and 46 participants with and without diabetes respectively,according to the American Diabetes Association criteria for diabetes.The kappa coefficient,Student’s t,Mann-Whitney,χ2,Pearson’s correlation,multivariate logistic regression,and multiple linear regression analyses were employed.RESULTS The eGFRs were lower with the cystatin C-based equations than with the creatinine-based equations.Good agreement was found between the Modification of Diet in Renal Disease(MDRD)and CKD Epidemiology Collaboration(CKD-EPI)2021 creatinine-cystatin C equations(kappa=0.66).In the diabetes group,30%of the participants had low eGFR.Both plasma glucose and glycated hemoglobin were associated with an increased risk of eGFR decline(P<0.05)and negatively correlated with eGFR(P=0.001).By multivariate logistic regression,total cholesterol,and exercise were independently associated with low eGFR.By multiple linear regression,higher plasma glucose levels were correlated with lower eGFR(P=0.026,r=-0.366).CONCLUSION Cystatin C-based equations were superior in the early detection of a decline in eGFR,and the MDRD equation may be considered as an alternative to the CKD-EPI 2021 creatinine-cystatin C equation.Exercise,plasma glucose,and total cholesterol were independently associated with eGFR in patients with diabetes.
文摘In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo [2,1-c][1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-bromoethyl) pyrrole-2-carboxylate with silver oxide and its derivatives were obtained by Friedel-Craftes reaction. Nine of 6-acyl derivatives of compound 3 were prepared.
基金funded by National Natural Science Foundation of China (Grant Nos. 40975013 and 40975014)Chinese Academy of Meteorological Sciences (CAMS) basic scientific and operational project:Observation and retrieval methods of microphysics and dynamic parameters of cloud and precipitation with multi-wavelength Remote Sensing,SCHeREX and TWPOR
文摘A mobile C-band dual polarimetric weather radar J type （PCDJ）, which adopts simultaneous transmission and simultaneous reception （STSR） of horizontally and vertically polarized signals, was first developed in China in 2008. It was deployed in the radar observation plan in the South China Heavy Rainfall Experiment （SCHeREX） in the summer of 2008 and 2009, as well as in Tropical Western Pacific Ocean Observation Experiments and Research on the Predictability of High Impact Weather Events from 2008 to 2010 in China （TWPOR）. Using the observation data collected in these experiments, the radar systematic error and its sources were analyzed in depth. Meanwhile an algorithm that can smooth differential propagation phase （~Dp） for estimating the high-resolution specific differential phase （KDP） was developed. After attenuation correction of reflectivity in horizontal polarization （ZH） and differential reflectivity （ZDR） of PCDJ radar by means of KDP, the data quality was improved significantly. Using quality-controlled radar data, quantitative rainfall estimation was performed, and the resutls were compared with rain-gauge measurements. A synthetic ZH /KDp-based method was analyzed. The results the traditional ZH-based method when the rain suggest that the synthetic method has the advantage over rate is 〉5 mm h^-1. The more intensive the rain rates, the higher accuracy of the estimation.
文摘The three title compounds were prepared from 2-phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols via an intramolecular Friedel-Crafts reaction. 2-Phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinols were prepared from 2-phenylaminomethyl-3H-1,2-dihydro-1-pyrrolizinones via reduction. The heterocyclic ring system of pyrrolizino[2,1-c]quinoline has not been found in literature.
基金supported by the grants NSFC11201232, 12KJB110008Qing Lan Project, 13KJB110015, 12YJAZH096the Project-sponsored by SRF for ROCS, SEM
文摘In this paper we establish sharp H/51der estimates of harmonic functions on a class of connected post critically finite （p.c.f.） self-similar sets, and show that functions in the domain of Laplacian enjoy the same property. Some weU-known examples, such as the Sierpinski gasket, the unit interval, the level 3 Sierpinski gasket, the hexagasket, the 3-dimensional Sierpinski gasket, and the Vicsek set are also considered.
文摘Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9 were designed and synthesized. They may have antipyretic and analgesic activities.
