Long Range Wide Area Network(LoRaWAN)has been developed to meet the requirements for the enormous device-to-device communication of Inter-net of Things(IoT)networks,which consist of a large number of participating dev...Long Range Wide Area Network(LoRaWAN)has been developed to meet the requirements for the enormous device-to-device communication of Inter-net of Things(IoT)networks,which consist of a large number of participating devices spread over large coverage areas with low data rates and low power con-sumption.It supports communications in both directions,uplink,and downlink directions.However,the downlink communication in the current LoRaWAN raises the bottleneck issue at gateways due to the used gateway selection algo-rithm.This paper proposes a novel gateway selection algorithm based on the duty cycle time-off values for the existing gateways,Duty Cycle Gateway Selection(DCGS),to direct acknowledgment packets as downlink traffic towards the most suitable gateway.Thus,the proposed system avoids subsequent retransmission of previously sent traffic that leads to excessive traffic overloading the network.The proposed system avoids exhausting a gateway duty cycle with downlink traffic by distributing the downlink traffic among available gateways based on the duty cycle time off.DCGS is evaluated using FloRa and INET frameworks in the well-known network simulator OMNeT++.The result shows the superior perfor-mance of the proposed approach over the existing Signal-to-Noise ratio(SNR)based selection mechanism.It clearly indicates that the DCGS maintains a better confirmed packet delivery rate while reducing number of retransmissions,colli-sions,and power consumption.展开更多
The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect...The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.展开更多
This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyua...This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population.展开更多
Improving urban gateway landscape environment helps establish positive images of a city, and helps newcomers form proper recognition of the city. Landscape design of the west gateway in Yulin City was taken for exampl...Improving urban gateway landscape environment helps establish positive images of a city, and helps newcomers form proper recognition of the city. Landscape design of the west gateway in Yulin City was taken for example, its natural ecological environment, historical and humanistic environment and modern man-made environment were investigated, and also macro elements analyzed, such as overall urban planning, historical and cultural background of the city, regional environment features. It was to build the west gateway of Yulin City into a landscape transition area for experiencing culture and history of the city, and appreciating characteristic images of this region, and to improve natural ecological conditions of the local area, realize the sustainable development of regional environment.展开更多
Cloud manufacturing has become a reality. It requires sensing and capturing heterogeneous manufacturing resources and extensive data analysis through the industrial internet. However,the cloud computing and serviceori...Cloud manufacturing has become a reality. It requires sensing and capturing heterogeneous manufacturing resources and extensive data analysis through the industrial internet. However,the cloud computing and serviceoriented architecture are slightly inadequate in dynamic manufacturing resource management. This paper integrates the technology of edge computing and microservice and develops an intelligent edge gateway for internet of thing(IoT)-based manufacturing. Distributed manufacturing resources can be accessed through the edge gateway,and cloud-edge collaboration can be realized. The intelligent edge gateway provides a solution for complex resource ubiquitous perception in current manufacturing scenarios. Finally,a prototype system is developed to verify the effectiveness of the intelligent edge gateway.展开更多
LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity.Under normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking different...LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity.Under normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting proliferation.In addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs.In malignancies,LIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic properties.In this review,we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.展开更多
AIM:To evaluate the effects of LIN28A(human)on high glucose-induced retinal pigmented epithelium(RPE)cell injury and its possible mechanism.METHODS:Diabetic retinopathy model was generated following 48h of exposure to...AIM:To evaluate the effects of LIN28A(human)on high glucose-induced retinal pigmented epithelium(RPE)cell injury and its possible mechanism.METHODS:Diabetic retinopathy model was generated following 48h of exposure to 30 mmol/L high glucose(HG)in ARPE-19 cells.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot tested the expression of the corresponding genes and proteins.Cell viability as well as apoptosis was determined through cell counting kit-8(CCK-8)and flow cytometry assays.Immunofluorescence assay was adopted to evaluate autophagy activity.Caspase 3 activity,oxidative stress markers,and cytokines were appraised adopting their commercial kits,respectively.Finally,ARPE-19 cells were preincubated with EX527,a Sirtuin 1(SIRT1)inhibitor,prior to HG stimulation to validate the regulatory mechanism.RESULTS:LIN28A was downregulated in HG-challenged ARPE-19 cells.LIN28A overexpression greatly inhibited HGinduced ARPE-19 cell viability loss,apoptosis,oxidative damage as well as inflammatory response.Meanwhile,the repressed autophagy and SIRT1 in ARPE-19 cells challenged with HG were elevated after LIN28A overexpression.In addition,treatment of EX527 greatly inhibited the activated autophagy following LIN28A overexpression and partly abolished the protective role of LIN28A against HG-elicited apoptosis,oxidative damage as well as inflammation in ARPE-19 cells.CONCLUSION:LIN28A exerts a protective role against HG-elicited RPE oxidative damage,inflammation,as well as apoptosis via regulating SIRT1/autophagy.展开更多
A typical gateway is analyzed using fully-deformable discrete element method. The fractured zone around the gateway is measured in field. Based on the measurement results and theoretical analysis, a comprehensive supp...A typical gateway is analyzed using fully-deformable discrete element method. The fractured zone around the gateway is measured in field. Based on the measurement results and theoretical analysis, a comprehensive support scheme adopting bolt and steel belt is proposed. Discrete element method is used to assess the bolting scheme, and displacement monitoring in field is also carried out. Having been put into practice, it is proved that the scheme is both successful and rational. According to theoretical analysis and monitoring in field, some important keynotes that should be noticed in gateway bolting practice are presented as well.展开更多
基金supporting this work by Grant Code:(22UQU4331076DSR01).
文摘Long Range Wide Area Network(LoRaWAN)has been developed to meet the requirements for the enormous device-to-device communication of Inter-net of Things(IoT)networks,which consist of a large number of participating devices spread over large coverage areas with low data rates and low power con-sumption.It supports communications in both directions,uplink,and downlink directions.However,the downlink communication in the current LoRaWAN raises the bottleneck issue at gateways due to the used gateway selection algo-rithm.This paper proposes a novel gateway selection algorithm based on the duty cycle time-off values for the existing gateways,Duty Cycle Gateway Selection(DCGS),to direct acknowledgment packets as downlink traffic towards the most suitable gateway.Thus,the proposed system avoids subsequent retransmission of previously sent traffic that leads to excessive traffic overloading the network.The proposed system avoids exhausting a gateway duty cycle with downlink traffic by distributing the downlink traffic among available gateways based on the duty cycle time off.DCGS is evaluated using FloRa and INET frameworks in the well-known network simulator OMNeT++.The result shows the superior perfor-mance of the proposed approach over the existing Signal-to-Noise ratio(SNR)based selection mechanism.It clearly indicates that the DCGS maintains a better confirmed packet delivery rate while reducing number of retransmissions,colli-sions,and power consumption.
文摘The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.
文摘This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population.
文摘Improving urban gateway landscape environment helps establish positive images of a city, and helps newcomers form proper recognition of the city. Landscape design of the west gateway in Yulin City was taken for example, its natural ecological environment, historical and humanistic environment and modern man-made environment were investigated, and also macro elements analyzed, such as overall urban planning, historical and cultural background of the city, regional environment features. It was to build the west gateway of Yulin City into a landscape transition area for experiencing culture and history of the city, and appreciating characteristic images of this region, and to improve natural ecological conditions of the local area, realize the sustainable development of regional environment.
基金supported by the National Key Research and Development Program of China (No.2020YFB1710500)the Primary Research & Development Plan of Jiangsu Province(No.BE2021091)。
文摘Cloud manufacturing has become a reality. It requires sensing and capturing heterogeneous manufacturing resources and extensive data analysis through the industrial internet. However,the cloud computing and serviceoriented architecture are slightly inadequate in dynamic manufacturing resource management. This paper integrates the technology of edge computing and microservice and develops an intelligent edge gateway for internet of thing(IoT)-based manufacturing. Distributed manufacturing resources can be accessed through the edge gateway,and cloud-edge collaboration can be realized. The intelligent edge gateway provides a solution for complex resource ubiquitous perception in current manufacturing scenarios. Finally,a prototype system is developed to verify the effectiveness of the intelligent edge gateway.
基金This work was supported by the Fritz Thyssen Foundation(10.21.1.026MN)to L.Meder.
文摘LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity.Under normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting proliferation.In addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs.In malignancies,LIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic properties.In this review,we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.
基金Supported by Medical and Health Science and Technology Project of Zhejiang Province(No.2023KY1356).
文摘AIM:To evaluate the effects of LIN28A(human)on high glucose-induced retinal pigmented epithelium(RPE)cell injury and its possible mechanism.METHODS:Diabetic retinopathy model was generated following 48h of exposure to 30 mmol/L high glucose(HG)in ARPE-19 cells.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot tested the expression of the corresponding genes and proteins.Cell viability as well as apoptosis was determined through cell counting kit-8(CCK-8)and flow cytometry assays.Immunofluorescence assay was adopted to evaluate autophagy activity.Caspase 3 activity,oxidative stress markers,and cytokines were appraised adopting their commercial kits,respectively.Finally,ARPE-19 cells were preincubated with EX527,a Sirtuin 1(SIRT1)inhibitor,prior to HG stimulation to validate the regulatory mechanism.RESULTS:LIN28A was downregulated in HG-challenged ARPE-19 cells.LIN28A overexpression greatly inhibited HGinduced ARPE-19 cell viability loss,apoptosis,oxidative damage as well as inflammatory response.Meanwhile,the repressed autophagy and SIRT1 in ARPE-19 cells challenged with HG were elevated after LIN28A overexpression.In addition,treatment of EX527 greatly inhibited the activated autophagy following LIN28A overexpression and partly abolished the protective role of LIN28A against HG-elicited apoptosis,oxidative damage as well as inflammation in ARPE-19 cells.CONCLUSION:LIN28A exerts a protective role against HG-elicited RPE oxidative damage,inflammation,as well as apoptosis via regulating SIRT1/autophagy.
文摘A typical gateway is analyzed using fully-deformable discrete element method. The fractured zone around the gateway is measured in field. Based on the measurement results and theoretical analysis, a comprehensive support scheme adopting bolt and steel belt is proposed. Discrete element method is used to assess the bolting scheme, and displacement monitoring in field is also carried out. Having been put into practice, it is proved that the scheme is both successful and rational. According to theoretical analysis and monitoring in field, some important keynotes that should be noticed in gateway bolting practice are presented as well.
