The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administratio...The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver tissues.In the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ administration.The in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)activation.Treatment with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 expression.Furthermore,other CAR target genes also showed a significant increase in the expression.The up-regulation of murine CAR was observed in the liver tissues of both nude and ICR mice.Subsequent findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator t-BHQ.Inhibition of the ERK1/2 signaling pathway was also observed in vivo.Additionally,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and CAR.In the nude mice,T-AⅢ also inhibited EGFR phosphorylation.These results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.展开更多
Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, a...Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, and the results were optimized according to multiple quality objectives by the grey system theory. With bending angle, bending radius and hight difference along the axis direction as variables, orthogonal FE analyses were conducted and the minimum and maximum wall thicknes ses of the billets with different sizes were obtained. Taking the minimum and maximum wall thick nesses as two references, the correlation coefficient between the data for reference and those for comparison by the grey system theory reduced multi objectives to a single quality objective, and the average correlation level of every billet facilitated the optimization of size parameters for hydroform ing car beam. The trial production showed that the optimization approach satisfied the need of hy droforming car beams.展开更多
On the basis of analyzing the principle of multicarrier code division multiple access (MC-CDMA), an optimized complex wavelet packet based MC-CDMA system (CWP-MC-CDMA) is proposed. The system performances with equal g...On the basis of analyzing the principle of multicarrier code division multiple access (MC-CDMA), an optimized complex wavelet packet based MC-CDMA system (CWP-MC-CDMA) is proposed. The system performances with equal gain combining (EGC) technique and maximum ratio combining (MRC) technique in Nakagami-m fading channels are investigated, respectively; and the corresponding bit error rate (BER) expression is derived. The system can overcome the decrease of spectrum efficiency of discrete Fourier transform (DFT) based conventional MC-CDMA (DFT-MC-CDMA) due to inserting a cyclic prefix (CP). Theoretical analysis and simulation results show that the CWP-MC-CDMA system outperforms DFT-MC-CDMA as well as the real wavelet packet based MC-CDMA (RWP-MC-CDMA) system, and has superior ability to combat multi-path fading and multi-access interference (MAI). Moreover, the BER performance of the proposed system is also superior to that of the conventional MC-CDMA with CP.展开更多
In view of the images collection and processing problems of the smart car camera, the paper introduces a method which deals with field and line synchronization signal separation and binarization processing of the vide...In view of the images collection and processing problems of the smart car camera, the paper introduces a method which deals with field and line synchronization signal separation and binarization processing of the video signal collected from track fields, and which is capable to extract and position black border trajectory images effectively. According to the experiment results of the method, the camera images can be collected and processed effectively, and the accurate image information can be provided for the smart cars to travel along the track. The method has the advantages of being easy to use, strong adaptability, ideal performance and high practical value. On the basis of advantages the method is of high practical value in smart car races.展开更多
In this work, we addressed the inhomogeneity problem in gamma spectrometry caused by hot particles, which are dispersed into environment from large nuclear reactor accidents such as at Chernobyl and Fukushima. Using M...In this work, we addressed the inhomogeneity problem in gamma spectrometry caused by hot particles, which are dispersed into environment from large nuclear reactor accidents such as at Chernobyl and Fukushima. Using Monte Carlo simulation, we have determined the response of a gamma spectrometer to individual and grouped hot particles randomly distributed in a soil matrix of 1-L and 0.6-L sample containers. By exploring the fact that the peak-to-total ratio of efficiencies in gamma spectrometry is an empirical parameter, we derived and verified a power-law relationship between the peak efficiency and peak-to-total ratio. This enabled creation of a novel calibration model which was demonstrated to reduce the bias range and bias standard deviation, caused by measuring hot particles, by several times, as compared with the homogeneous calibration. The new model is independent of the number, location, and distribution of hot particles in the samples. In this work, we demonstrated successful performance of the model for a single-peak <sup>137</sup>Cs radionuclide. An extension to multi-peak radionuclide was also derived.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.82073934,81872937,and 81673513).
文摘The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver tissues.In the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ administration.The in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)activation.Treatment with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 expression.Furthermore,other CAR target genes also showed a significant increase in the expression.The up-regulation of murine CAR was observed in the liver tissues of both nude and ICR mice.Subsequent findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator t-BHQ.Inhibition of the ERK1/2 signaling pathway was also observed in vivo.Additionally,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and CAR.In the nude mice,T-AⅢ also inhibited EGFR phosphorylation.These results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.
基金Supported by the National Key Technology R&D Program of the 11th Five-Year Plan of China(2006BAF04B05)the Natural Science Foundation of Shanxi Province(2010021024-2)
文摘Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, and the results were optimized according to multiple quality objectives by the grey system theory. With bending angle, bending radius and hight difference along the axis direction as variables, orthogonal FE analyses were conducted and the minimum and maximum wall thicknes ses of the billets with different sizes were obtained. Taking the minimum and maximum wall thick nesses as two references, the correlation coefficient between the data for reference and those for comparison by the grey system theory reduced multi objectives to a single quality objective, and the average correlation level of every billet facilitated the optimization of size parameters for hydroform ing car beam. The trial production showed that the optimization approach satisfied the need of hy droforming car beams.
文摘On the basis of analyzing the principle of multicarrier code division multiple access (MC-CDMA), an optimized complex wavelet packet based MC-CDMA system (CWP-MC-CDMA) is proposed. The system performances with equal gain combining (EGC) technique and maximum ratio combining (MRC) technique in Nakagami-m fading channels are investigated, respectively; and the corresponding bit error rate (BER) expression is derived. The system can overcome the decrease of spectrum efficiency of discrete Fourier transform (DFT) based conventional MC-CDMA (DFT-MC-CDMA) due to inserting a cyclic prefix (CP). Theoretical analysis and simulation results show that the CWP-MC-CDMA system outperforms DFT-MC-CDMA as well as the real wavelet packet based MC-CDMA (RWP-MC-CDMA) system, and has superior ability to combat multi-path fading and multi-access interference (MAI). Moreover, the BER performance of the proposed system is also superior to that of the conventional MC-CDMA with CP.
文摘In view of the images collection and processing problems of the smart car camera, the paper introduces a method which deals with field and line synchronization signal separation and binarization processing of the video signal collected from track fields, and which is capable to extract and position black border trajectory images effectively. According to the experiment results of the method, the camera images can be collected and processed effectively, and the accurate image information can be provided for the smart cars to travel along the track. The method has the advantages of being easy to use, strong adaptability, ideal performance and high practical value. On the basis of advantages the method is of high practical value in smart car races.
文摘In this work, we addressed the inhomogeneity problem in gamma spectrometry caused by hot particles, which are dispersed into environment from large nuclear reactor accidents such as at Chernobyl and Fukushima. Using Monte Carlo simulation, we have determined the response of a gamma spectrometer to individual and grouped hot particles randomly distributed in a soil matrix of 1-L and 0.6-L sample containers. By exploring the fact that the peak-to-total ratio of efficiencies in gamma spectrometry is an empirical parameter, we derived and verified a power-law relationship between the peak efficiency and peak-to-total ratio. This enabled creation of a novel calibration model which was demonstrated to reduce the bias range and bias standard deviation, caused by measuring hot particles, by several times, as compared with the homogeneous calibration. The new model is independent of the number, location, and distribution of hot particles in the samples. In this work, we demonstrated successful performance of the model for a single-peak <sup>137</sup>Cs radionuclide. An extension to multi-peak radionuclide was also derived.
