Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity.Methods:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then...Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity.Methods:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then rats received a single dose of CCl4(2.5 mL/kg,50%v/v in liquid paraffin).Biochemical and histopathological assays were performed to assess the effects of the extract on liver function and architecture.Moreover,antioxidant and oxidative markers as well as inflammatory and fibrotic indicators were measured.Results:Pretreatment with Levisticum officinale extract significantly mitigated CCl4-induced damage to liver structure,improved serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,urea,total bilirubin,and total protein,enhanced glutathione content and superoxide dismutase and catalase activities in the liver,as well as decreased plasma and hepatic malondialdehyde levels.Immunohistochemical results demonstrated that the extract reduced Ki-67 andα-SMA expression and Masson’s trichrome staining revealed decreased liver collagen in rats treated with Levisticum officinale extract.Moreover,Levisticum officinale extract markedly decreased the gene expressions of TNF-α,IL-6,TGF-β1,MCP-1,and COX-2.Conclusions:Levisticum officinale extract exerts hepatoprotective effects on CCl4-induced hepatotoxicity through antioxidant,anti-inflammatory,and anti-fibrotic activities.展开更多
“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1...“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。展开更多
“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于199...“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。展开更多
文摘Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity.Methods:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then rats received a single dose of CCl4(2.5 mL/kg,50%v/v in liquid paraffin).Biochemical and histopathological assays were performed to assess the effects of the extract on liver function and architecture.Moreover,antioxidant and oxidative markers as well as inflammatory and fibrotic indicators were measured.Results:Pretreatment with Levisticum officinale extract significantly mitigated CCl4-induced damage to liver structure,improved serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,urea,total bilirubin,and total protein,enhanced glutathione content and superoxide dismutase and catalase activities in the liver,as well as decreased plasma and hepatic malondialdehyde levels.Immunohistochemical results demonstrated that the extract reduced Ki-67 andα-SMA expression and Masson’s trichrome staining revealed decreased liver collagen in rats treated with Levisticum officinale extract.Moreover,Levisticum officinale extract markedly decreased the gene expressions of TNF-α,IL-6,TGF-β1,MCP-1,and COX-2.Conclusions:Levisticum officinale extract exerts hepatoprotective effects on CCl4-induced hepatotoxicity through antioxidant,anti-inflammatory,and anti-fibrotic activities.
文摘“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。
文摘“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。
