Objective:To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana(M.maderaspatana) leaf(CEEM) on deoxycorticosterone acetate(DOCA)-salt hypertensive rats.Methods:A midscapula...Objective:To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana(M.maderaspatana) leaf(CEEM) on deoxycorticosterone acetate(DOCA)-salt hypertensive rats.Methods:A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal artery.The surgical wound was closed using an absorbable suture.After one week recovery period,hypertension was induced by subcutaneous injection of DOCA-salt solution,twice a week,and the rats received a 1%sodium chloride solution as drinking water throughout the experimental period.CEEM or nifedipine was administered orally once a day for 6 weeks.Results:In DOCA-salt hypertensive rats,the level of plasma and tissues of total cholesterol(TC),triglycerides(TG),free fatty acids(FFA) and phospholipids (PL) significantly increased and administration of CEEM significantly reduced these parameters towards normality.Further,the levels of low density lipoprotein-cholesterol(LDL-C) and very low density lipoprotein-cholesterol(VLDL-C) significantly increased while high density lipoprotein-cholesterol (HDL-C) decreased in hypertensive rats and administration of CEEM brought these parameters to normality which proved their antihyperlipidemic action.Histopathology of liver, kidney and heart on DOCA-salt induced rats treated with CEEM showed reduced the damages towards normal histology.Conclusions:These findings provided evidence that CEEM was found to be protecting the liver,kidney and heart against DOCA-salt administration and the protective effect could attribute to its antihyperlipidemic activities.展开更多
文摘针对传统极限学习机易陷入局部最优解的缺点以及环境变化导致光伏出力波动的特点,构建了一种基于自适应噪声完全集成经验模态分解(complete ensemble empirical mode decomposition with adaptive noise,CEEMDAN)算法,结合黑猩猩优化算法优化极限学习机神经网络的光伏出力短期预测模型。首先利用CEEMDAN算法将影响光伏输出功率的关键环境因素序列进行分解,得到数据信号在不同时间尺度的局部特征,降低环境因素序列的非平稳性,然后将各分解子序列和光伏历史数据序列作为黑猩猩算法优化的极限学习机预测模型输入进行预测。最后,选用DKASC Solar Centre光伏电站数据集对不同预测模型进行验证对比。实例仿真结果表明,构建的改进光伏出力预测组合模型的各项指标预测效果更好,且适用不同环境的光伏发电预测。
基金financially supported by UGC-SAP Merit sholarship from the university grants connission
文摘Objective:To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana(M.maderaspatana) leaf(CEEM) on deoxycorticosterone acetate(DOCA)-salt hypertensive rats.Methods:A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal artery.The surgical wound was closed using an absorbable suture.After one week recovery period,hypertension was induced by subcutaneous injection of DOCA-salt solution,twice a week,and the rats received a 1%sodium chloride solution as drinking water throughout the experimental period.CEEM or nifedipine was administered orally once a day for 6 weeks.Results:In DOCA-salt hypertensive rats,the level of plasma and tissues of total cholesterol(TC),triglycerides(TG),free fatty acids(FFA) and phospholipids (PL) significantly increased and administration of CEEM significantly reduced these parameters towards normality.Further,the levels of low density lipoprotein-cholesterol(LDL-C) and very low density lipoprotein-cholesterol(VLDL-C) significantly increased while high density lipoprotein-cholesterol (HDL-C) decreased in hypertensive rats and administration of CEEM brought these parameters to normality which proved their antihyperlipidemic action.Histopathology of liver, kidney and heart on DOCA-salt induced rats treated with CEEM showed reduced the damages towards normal histology.Conclusions:These findings provided evidence that CEEM was found to be protecting the liver,kidney and heart against DOCA-salt administration and the protective effect could attribute to its antihyperlipidemic activities.