模块间接地故障是H桥级联型电池储能系统(cascaded H bridge based battery energy storage system,CHB-BESS)的易发故障,快速诊断故障位置对减少故障损失至关重要。模块间接地故障的故障特征主要体现在零序电流上,会受到接地过渡电阻...模块间接地故障是H桥级联型电池储能系统(cascaded H bridge based battery energy storage system,CHB-BESS)的易发故障,快速诊断故障位置对减少故障损失至关重要。模块间接地故障的故障特征主要体现在零序电流上,会受到接地过渡电阻的影响。为实现接地过渡电阻不确定情况下,故障模块位置的快速准确鲁棒定位,本工作提出了一种基于损失特征矩阵的快速故障诊断方法。首先,本工作建立了零序等效电路模型;然后,将零序电流模型离散化;接着,提出基于损失特征矩阵的定位方法,该方法使用拓扑矩阵描述故障位置和过渡电阻的遍历信息,基于离散化模型来遍历计算零序电流,将计算结果与测量结果的偏差记录在损失特征矩阵中,通过偏差最优解确定故障位置;其次,本工作证实了故障定位问题作为最优化问题具有最优解唯一性,偏差最优解在接地过渡电阻不确定的情况下可获得准确的故障发生位置;最终,基于最优解唯一性提出了最优化计算的加速方法。实测表明,所提方法的平均定位误差仅为0.2个子模块,在接地过渡电阻较大范围不确定的情况下实现了准确定位,并且所提加速方法显著提高诊断速度。展开更多
Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to...Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.展开更多
文摘模块间接地故障是H桥级联型电池储能系统(cascaded H bridge based battery energy storage system,CHB-BESS)的易发故障,快速诊断故障位置对减少故障损失至关重要。模块间接地故障的故障特征主要体现在零序电流上,会受到接地过渡电阻的影响。为实现接地过渡电阻不确定情况下,故障模块位置的快速准确鲁棒定位,本工作提出了一种基于损失特征矩阵的快速故障诊断方法。首先,本工作建立了零序等效电路模型;然后,将零序电流模型离散化;接着,提出基于损失特征矩阵的定位方法,该方法使用拓扑矩阵描述故障位置和过渡电阻的遍历信息,基于离散化模型来遍历计算零序电流,将计算结果与测量结果的偏差记录在损失特征矩阵中,通过偏差最优解确定故障位置;其次,本工作证实了故障定位问题作为最优化问题具有最优解唯一性,偏差最优解在接地过渡电阻不确定的情况下可获得准确的故障发生位置;最终,基于最优解唯一性提出了最优化计算的加速方法。实测表明,所提方法的平均定位误差仅为0.2个子模块,在接地过渡电阻较大范围不确定的情况下实现了准确定位,并且所提加速方法显著提高诊断速度。
基金supported by the National Key Research and Development Program[2022YFC2603500,2022YFC2603505]Capital Clinical Diagnostic Techniques and Translational Application Projects(Z211100002921059)+2 种基金Capital’s Funds for Health Improvement and Research[2022-1-2172]Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support[XMLX 202127]National Science and Technology Major Project of China[2017ZX10203202-003]。
文摘Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.
