Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on...Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Proxl and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.展开更多
基金Acknowledgements This study was supported by a grant from the National Natural Science Foundation of China （No. 31400692）.
文摘Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Proxl and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
