Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers

Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized, and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope （TEM）, dynamic laser scattering analyzer （DLS） and X-ray diffraction （XRD）. The results revealed that the magnetic nanoparticles were cubic shaped and dispersive, with narrow size distribution and average diameter of 11.4 nm. It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution. The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully. A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets. In conclusion, the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carders of targeted-drug in future application.

Fabrication of Poly（y-glutamic acid）-coated Fe3O4 Magnetic Nanoparticles and Their Application in Heavy Metal Removal

In this study, poly（y-glutamic acid）-coated Fe3O4 magnetic nanoparticles （y-PGA/Fe304 MNPs） were successfully fabricated using the co-precipitation method. Fe3O4 MNPs were also prepared for comparison. The av erage size and specific surface area results reveal that 7-PGA/Fe304 MNPs （52.4 nm, 88.41 m2.g-1） have smaller particle size and larger specific surface area_ than Fe3O4 MNPs （62.0 nm, 76.83 mLg-1）. The y-PGA/Fe3O4 MNPs

Surface Organic Modification of Fe_3O_4 Magnetic Nanoparticles

The surface organic modification of Fe3O4 nanoparticles with silane coupling reagent KH570 was studied. The modified and unmodified nanoparticles were characterized by FT-IR, XPS and TEM. The spectra of FT-IR and XPS revealed that KH570 was coated onto the surface of Fe3O4 nanoparticles to get Fe-O- Si bond and an organic coating layer also was formed. Fe3O4 nanoparticles were spheres partly with mean size of 18,8 nm studied by TEM, which was consistent with the result 17.9 nm calculated by Scherrer＇s equation. KH570 was adsorbed on surface and formed chemistry bond to be steric hindrance repulsion which prevented nanoparticles from reuniting. Then glycol-based Fe3O4 magnetic liquids dispersed stably was gained.

Intensification of levofloxacin sono-degradation in a US/H_2O_2 system with Fe_3O_4 magnetic nanoparticles

Fe3O4 magnetic nanoparticles(MNPs) were synthesised, characterised, and used as a peroxidase mimetic to accelerate levofloxacin sono-degradation in an ultrasound(US)/H2O2 system. The Fe3O4 MNPs were in nanometre scale with an average diameter of approximately 12 to 18 nm. The introduction of Fe3O4 MNPs increased levofloxacin sono-degradation in the US/H2O2 system. Experimental parameters, such as Fe3O4 MNP dose, initial solution p H, and H2O2 concentration, were investigated by a one-factor-at-a-time approach. The results showed that Fe3O4 MNPs enhanced levofloxacin removal in the p H range from 4.0 to 9.0. Levofloxacin removal ratio increased with Fe3O4 MNP dose up to 1.0 g·L-1and with H2O2 concentration until reaching the maximum. Moreover, three main intermediate compounds were identified by HPLC with electrospray ionisation tandem mass spectrometry, and a possible degradation pathway was proposed. This study suggests that combination of H2O2, Fe3O4 MNPs and US is a good way to improve the degradation efficiency of antibiotics.

Characteristics of magnetic Fe_3O_4 nanoparticles encapsulated with human serum albumin

Magnetic nanoparticles （Fe304） were prepared by chemical precipitation method using Fe^2＋ and Fe^3＋ salts with sodium hydroxide in the nitrogen atmosphere. Fe3O4 nanoparticles were coated with human serum albumin（HSA） for magnetic resonance imaging as contrast agent. Characteristics of magnetic particles coated or uncoated were carried out using scanning electron microscopy and X-ray diffraction. Zeta potentials, package effects and distributions of colloid particles were measured to confirm the attachment of HSA on magnetic particles. Effects of Fe3O4 nanoparticles coated with HSA on magnetic resonance imaging were investigated with rats. The experimental results show that the adsorption of HSA on magnetic particles is very favorable to dispersing of magnetic Fe3O4 particles, while the sizes of Fe3O4 particles coated are related to the molar ratio of Fe3O4 to HSA. The diameters of the majority of particles coated are less than 100 nm. Fe3O4 nanoparticle coated with HSA has a good biocompatibility and low toxicity. This new contrast agent has some effects on the nuclear magnetic resonance imaging of liver and the lowest dosage is 20μmol/kg for the demands of diagnosis.

Modification of Fe_3O_4 Magnetic Nanoparticles by L-dopa or Dopamine as an Enzyme Support

Fe3O4 magnetic nanoparticles were prepared by co-precipitation of Fe^2＋ and Fe^3＋ in an ammonia solution, and its size was about 36 nm measured by an atomic force microscope. Fe3O4 magnetic nanoparticles were modified by L-dopa or dopamine using sonication method. The analysis of FTIR clearly indicated the formation of Fe-O-C bond. Direct immobilization of trypsin （EC： 3.4.21.4） on Fe3O4 magnetic nanoparticles with L-dopa and dopamine spacer was investigated using glutaraldehyde as a coupling agent. No significant changes in the size and magnetic property of the three kinds of magnetic nanoparticles linked with or without trypsin were observed. The existence of the spacer molecule on magnetic nanoparticles could greatly improve the activity and the storage stability of bound trypsin through increasing the flexibility of enzyme and changing the microenvironment on nanoparticles surface compared to the naked magnetic nanoparticles.

Synthesis and Characterization of Superparamagnetic Fe₃O₄@SiO₂Core-Shell Composite Nanoparticles

The Fe3O4@SiO2 composite nanoparticles were obtained from as-synthesized magnetite (Fe3O4) nanoparticles through the modified St?ber method. Then, the Fe3O4 nanoparticles and Fe3O4@SiO2 composite nanoparticles were characterized by means of X-ray diffraction (XRD), Raman spectra, scanning electron microscope (SEM) and vibrating sample magnetometer (VSM). Recently, the studies focus on how to improve the dispersion of composite particle and achieve good magnetic performance. Hence effects of the volume ratio of tetraethyl orthosilicate (TEOS) and magnetite colloid on the structural, morphological and magnetic properties of the composite nanoparticles were systematically investi-gated. The results revealed that the Fe3O4@SiO2 had better thermal stability and dispersion than the magnetite nanoparticles. Furthermore, the particle size and magnetic property of the Fe3O4@SiO2 composite nanoparticles can be adjusted by changing the volume ratio of TEOS and magnetite colloid.

Fe_3O_4 Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

A novel type of Fe3O4 nanoparticles modified glass carbon electrode（Fe3O4/GCE） was constructed and the electrochemical properties of N-（4-nitro-2-phenoxyphenyl）methanesulfonamide（nimesulide） were studied on the Fe3O4/GCE.In 0.4mol/L HAc-NaAc buffer solution（pH=5.0）,the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE.The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide.The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4/GCE,and the sensitivity was increased by ca.3 times.Some experimental conditions were optimized.The linear range between the peak current and the concentration of nimesulide was 2.6×10-6 ＂1.0×10-4mol/L（R=0.993） with a detection limit of 1.3×10-7mol/L.This method has been used to determine the content of nimesulide in medical tablets.The recovery was determined to be 96.9% ＂101.9% by means of standard addition method.The method is comparable to UV-Vis spectrometry.

Static magnetic field-assisted synthesis of Fe3O4 nanoparticles and their adsorption of Mn(Ⅱ) in aqueous solution

A facile method for synthesis of the magnetic Fe_3O_4 nanoparticles was introduced.Magnetic nanoparticles were prepared via co-precipitation method with(PMF) and without(AMF) 0.15 T static magnetic field.The effects of magnetic field on the properties of magnetic nanoparticles were studied by XRD,TEM,SEM,VSM and BET.The results showed that the magnetic field in the co-precipitation reaction process did not result in the phase change of the Fe_3O_4 nanoparticles but improved the crystallinity.The morphology of Fe_3O_4 nanoparticles was varied from random spherical particles to rod-like cluster structure.The VSM results indicated that the saturation magnetization value of the Fe_3O_4 nanoparticles was significantly improved by the magnetic field.The BET of Fe_3O_4nanoparticles prepared with the magnetic field was larger than the control by 23.5%.The batch adsorption experiments of Mn(Ⅱ) on the PMF and AMF Fe_3O_4 nanoparticles showed that the Mn(II) equilibrium capacity was increased with the pH value increased.At pH 8,the Mn(Ⅱ) adsorption capacity for the PMF and AMF Fe_3O_4 was reached at 36.81 and 28.36 mg·g^(-1),respectively.The pseudo-second-order model fitted better the kinetic models and the Freundlich model fitted isotherm model well for both PMF and AMF Fe_3O_4.The results suggested that magnetic nanoparticles prepared by the magnetic field presented a fairly good potential as an adsorbent for an efficient removal of Mn(Ⅱ) from aqueous solution.

Magnetic field aligned orderly arrangement of Fe3O4 nanoparticles in CS/PVA/Fe3O4 membranes

The CS/PVA/Fe_3O_4 nanocomposite membranes with chainlike arrangement of Fe_3O_4 nanoparticles are prepared by a magnetic-field-assisted solution casting method. The aim of this work is to investigate the relationship between the microstructure of the magnetic anisotropic CS/PVA/Fe_3O_4 membrane and the evolved macroscopic physicochemical property. With the same doping content, the relative crystallinity of CS/PVA/Fe_3O_4-M is lower than that of CS/PVA/Fe_3O_4.The Fourier transform infrared spectroscopy（FT-TR） measurements indicate that there is no chemical bonding between polymer molecule and Fe_3O_4 nanoparticle. The Fe_3O_4 nanoparticles in CS/PVA/Fe_3O_4 and CS/PVA/Fe_3O_4-M are wrapped by the chains of CS/PVA, which is also confirmed by scanning electron microscopy（SEM） and x-ray diffraction（XRD）analysis. The saturation magnetization value of CS/PVA/Fe_3O_4-M obviously increases compared with that of non-magnetic aligned membrane, meanwhile the transmittance decreases in the UV-visible region. The o-Ps lifetime distribution provides information about the free-volume nanoholes present in the amorphous region. It is suggested that the microstructure of CS/PVA/Fe_3O_4 membrane can be modified in its curing process under a magnetic field, which could affect the magnetic properties and the transmittance of nanocomposite membrane. In brief, a full understanding of the relationship between the microstructure and the macroscopic property of CS/PVA/Fe_3O_4 nanocomposite plays a vital role in exploring and designing the novel multifunctional materials.

Field-variable magnetic domain characterization of individual 10 nm Fe3O4 nanoparticles

The local detection of magnetic domains of isolated 10 nm Fe3O4 magnetic nanoparticles(MNPs) has been achieved by field-variable magnetic force microscopy(MFM) with high spatial resolution.The domain configuration of an individual MNP shows a typical dipolar response.The magnetization reversal of MNP domains is governed by a coherent rotation mechanism, which is consistent with the theoretical results given by micromagnetic calculations.Present results suggest that the field-variable MFM has great potential in providing nanoscale magnetic information on magnetic nanostructures,such as nanoparticles, nanodots, skyrmions, and vortices, with high spatial resolution.This is crucial for the development and application of magnetic nanostructures and devices.

Controllable Synthesis and Magnetic Properties of Monodisperse Fe_3O_4 Nanoparticles

Magnetite （Fe3O4） nanoparticles with different sizes and shapes are synthesized by the thermal decomposition method. Two approaches, non-injection one-pot and hot-injection methods, are designed to investigate the growth mechanism in detail. It is found that the size and shape of nanoparticles are determined by adjusting the precursor concentration and duration time, which can be well explained by the mechanism based on the LaMer model in our synthetic system. The monodisperse Fe3O4 nanoparticles have a mean diameter from 5nm to 16nm, and shape evolution from spherical to triangular and cubic. The magnetic properties are size-dependent, and Fe3O4 nanoparticles in small size about 5 nm exhibit superparamagnetie properties at room temperature and maximum saturation magnetization approaches to 78 emu/g, whereas Fe3O4 nanoparticles develop ferromagnetic properties when the diameter increases to about 16nm.

Synthesis and characterization of Fe_3O_4 magnetic nanoparticles and their heating effects under radiofrequency capacitive field

Fe3O4 magnetic nanoparticles with diameters varying from 10 to 426 nm were synthesized and characterized.Heating effects of Fe3O4 magnetic nanoparticles under radiofrequency capacitive field(RCF) with frequency of 27.12 MHz and power of 60-150 W were investigated.When the power of RCF is lower than 90 W,temperatures of Fe3O4 magnetic nanoparticles(75-150 mg/mL) can be raised and maximal temperatures are all lower than 50 ℃.When the power of RCF is 90-150 W,temperatures of Fe3O4 magnetic nanoparticles can be quickly raised and are all obviously higher than those of normal saline and distilled water under the same conditions.Temperature of Fe3O4 magnetic nanoparticles can even reach 70.2 ℃ under 150 W RCF.Heating effects of Fe3O4 magnetic nanoparticles are related to RCF power,particle size and particle concentration.

Mesoporous MnSiO3@Fe3O4@C Nanoparticle as p H-responsive T1-T2* Dual-modal Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis

Mesoporous structured MnSiO3@Fe3O4@C nanoparticles(NPs)were prepared via a facile and efficient strategy,with negligible cytotoxicity and minor side efforts.The as-prepared MnSiO3@Fe3O4@C NPs hold great potential in serving as pH-responsive T1-T2^*dual-modal magnetic resonance(MR)imaging contrast agents.The released Mn^2+shortened T1 relaxation time,meanwhile the superparamagnetic Fe3O4 enhanced T2 contrast imaging.The release rate of Mn ions reaches 31.66%under the condition of pH=5.0,which is similar to tumor microenvironment and organelles.Cytotoxicity assays show that MnSiO3@Fe3O4@C NPs have minor toxicity,even at high concentrations.After intravenous injection of MnSiO3@Fe3O4@C NPs,a rapid contrast enhancement in tumors was achieved with a significant enhancement of 132%after 24 h of the administration.Moreover,a significant decreasement of 53.8%was witnessed in T2 MR imaging signal.It demonstrated that MnSiO3@Fe3O4@C NPs can act as both positive and negative MR imaging contrast agents.Besides,owing to the pH-responsive degradation of mesoporous MnSiO3,MnSiO3@Fe3O4@C NPs can also be used as potential drug systems for cancer theranostics.

Analysis of Spectroscopic, Optical and Magnetic Behaviour of PVDF/PMMA Blend Embedded by Magnetite (Fe₃O₄) Nanoparticles

In the present work, magnetite (Fe3O4) nanoparticles have been prepared by a simple chemical method. Polymer nanocomposites based on the blend between poly vinylamine fluoride (PVDF) and (methyl methacrylate) (PMMA) doped with different concentrations of Fe3O4 nanoparticles have been prepared. The structural, optical, and magnetization properties of the nanocomposite samples were studied using suitable techniques. The X-ray study reflected that the cubic spinal structure of pure Fe3O4 crystal. No small peaks or ripples were found in the X-ray spectra, conforming to good dispersion of Fe3O4 within PVDF/PMMA matrices. The FT-IR analysis demonstrated the miscibility between the PVDF and PMMA blend with the interaction between the polymer blend and Fe3O4. The values of the band gap from UV-Vis study were decreased up to 4.21 eV, 3.01 eV for direct and indirect measurements, respectively. The magnetization was measured as a function of the applied magnetic field in the range of −2000 - 2000 Oersted. The curves of the magnetization indicated a paramagnetic behavior of pure Fe3O4 nanoparticles and PVDF/PMMA-Fe3O4 nanocomposites. The values of saturation magnetization for pure Fe3O4 are nearly 75 emu/g, exhibiting a paramagnetic behavior, and it is decreased with the increase of Fe3O4 content.

Synthesis of magnetic core–shell structure Fe_3O_4@MCM-41 nanoparticle by vesicles in aqueous solutions

In this study, magnetic core–shell structure Fe3O4@MCM-41 nanoparticles were synthesized with vesicles as soft templates. In the preparation, Fe Cl2 and tetraethy orthosilicate(TEOS) were selected as Fe processor and Si precursor, respectively. Stable vesicles first formed in 0.03 mol·L-11:2 mixture of anionic surfactant sodium dodecyl sulfate and cationic surfactant cetyltrimethyl ammonium bromide. Then, TEOS was added in the vesicle aqueous solution, leading to a highly dispersed solution. After high-temperature calcination, Fe3O4@MCM-41 nanoparticles were obtained. Their structure and morphology were characterized by Saturn Digisizer, transmission electron microscope and vibrating sample magneto-meter. The results indicate that the vesicles are spherical and their size could be tuned between 20 and 50 nm. The average grain diameter of synthesize magnetic core–shell Fe3O4@MCM-41 particles is 100–150 nm and most of them are in elliptical shape. The dispersion of magnetic particles is very good and magnetization values are up to 33.44 emu·g-1, which are superior to that of other Fe3O4 materials reported.

Fabrication and Investigation of the Magnetic Properties of Co and Co3O4 Nanoparticles

The nanoparticles exhibit some novel optical and magnetic properties, which are different from its bulk material. Cobalt oxide has been known as a semi-conductor compound of p type with a Spinel structure. Therefore, they are used as gas sensor and absorbent of solar energy. Furthermore, they are employed as an effective catalyzer in environmental clearing. In the thermal gradation method, carbonyl cobalt Co2(CO)8 is often used as a precursor, though cobalt carbonyl is very toxic and expensive. Magnetic compounds have been among interesting issues for human beings for over 4000 years. In large societies, magnetic compounds including computer disks, credit cards, speakers, coolers, automatic doors, and many other devices can be observed on a daily basis. The structure and morphology of as-prepared Co3O4 nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The TEM images showed that the product nanoparticles consisted of dispersive quasi- spherical particles with a narrow size distribution ranged from 5 to 15 nm and an average size around 10 nm. The magnetic measurements confirmed that the Co3O4 nanoparticles show a little ferromagnetic behavior which could be attributed to the uncompensated surface spins and finite size effects. The ferromagnetic order of the Co3O4 nanoparticles is raised with increasing the decomposition temperature.

磁刺激下Fe_(3)O_(4)@ZIF-8纳米颗粒影响骨髓间充质干细胞的成骨分化

背景:骨髓间充质干细胞在组织工程和骨再生中具有重要作用,然而如何促进骨髓间充质干细胞的成骨分化仍然是一个挑战。目的:探讨磁刺激下Fe_(3)O_(4)@ZIF-8纳米颗粒对骨髓间充质干细胞成骨分化的影响。方法:采用水热法合成沸石咪唑酯骨架(ZIF-8),采用一锅法合成具有磁性的Fe_(3)O_(4)@ZIF-8纳米颗粒(材料制备中分别加入2.5,5,10,20μg的Fe_(3)O_(4)),通过扫描电镜、X射线光电子能谱、X射线衍射、振动样品磁强计检测等对Fe_(3)O_(4)@ZIF-8纳米颗粒进行表征,筛选出合适的材料进行后续实验。提取4周龄SD大鼠骨髓间充质干细胞,分别与不同质量浓度(25,50,75,100,125μg/mL)的Fe_(3)O_(4)@ZIF-8纳米颗粒溶液共培养,CCK-8法检测细胞增殖,筛选出最佳的材料溶液质量浓度;筛选出材料溶液质量浓度后,施加磁刺激(磁场强度分别为0,50,100,150 MT),CCK-8法检测细胞增殖,筛选出最佳的磁场强度与Fe_(3)O_(4)@ZIF-8纳米颗粒,用于骨髓间充质干细胞诱导分化实验。将SD大鼠骨髓间充质干细胞分别与ZIF-8、Fe_(3)O_(4)@ZIF-8、Fe_(3)O_(4)@ZIF-8(磁场干预)纳米颗粒溶液共培养,以单独培养的细胞为空白对照,成脂诱导后进行油红O染色,成骨诱导后进行碱性磷酸酶、茜素红染色与Runx2蛋白质量浓度检测。结果与结论:(1)扫描电镜下可见Fe_(3)O_(4)@ZIF-8纳米颗粒呈现十二面体结构,随着材料中Fe_(3)O_(4)含量的增加,纳米颗粒的粒径增大,选择粒径约250 nm(该粒径下的纳米颗粒功能性及生物安全性较稳定)的Fe_(3)O_(4)@ZIF-8纳米颗粒(材料制备中分别加入5,10μg的Fe_(3)O_(4))进行后续实验。(2)CCK-8检测结果显示,在100MT磁场作用下,50μg/mL的Fe_(3)O_(4)@ZIF-8纳米颗粒(材料制备中加入10μg的Fe_(3)O_(4))能够显著促进骨髓间充质干细胞的增殖,选择该条件下的纳米颗粒进行骨髓间充质干细胞成骨诱导分化实验。(3)成骨诱导后,Fe_(3)O_(4)@ZIF-8(磁场干预)组骨髓间充质干细胞的碱性磷酸酶活性、细胞外基质矿化程度与Runx2蛋白质量浓度均高于其他3组(P<0.05);成脂诱导后,Fe_(3)O_(4)@ZIF-8(磁场干预)组骨髓间充质干细胞的脂滴形成少于其他3组(P<0.05)。(4)结果表明,在特定的磁场条件下Fe_(3)O_(4)@ZIF-8纳米颗粒可以促进骨髓间充质干细胞的成骨分化。

PREPARATION AND MAGNETORHEOLOGICAL PROPERTIES OF AQUEOUS SUSPENSION BASED ON EMULSION DROPLETS CONTAINING Fe_3O_4 NANOPARTICLES

The Fe3O4 nanoparticles with mean size of 10 nm were prepared by chemical common precipitation . The factors influencing the size and shape of Fe3O4 nanoparticles such as the adding rate of NaOII to the mixed solution and the final pH of the solution were studied . The Fe3O4 based magnetorheological(MR) fluid was formed by adding surfactant . The rheological properties of this MR fluid were studied when the magnetic fields with different direction are applied. It has been found that the MR fluid has the magnetic anisotropy.

Heterogeneous catalytic activation of peroxymonosulfate for efficient degradation of organic pollutants by magnetic Cu^0/Fe_3O_4 submicron composites

Magnetic Cu^0/Fe3O4 submicron composites were prepared using a hydrothermal method and used as heterogeneous catalysts for the activation of peroxymonosulfate（PMS） and the degradation of organic pollutants.The as-prepared magnetic Cu^0/Fe3O4 submicron composites were composed of Cu^0 and Fe3O4 crystals and had an average size of approximately 220 nm.The Cu^0/Fe3O4 composites could efficiently catalyze the activation of PMS to generate singlet oxygen,and thus induced the rapid degradation of rhodamine B,methylene blue,orange Ⅱ,phenol and 4-chlorophenol.The use of0.1 g/L of the Cu^0/Fe3O4 composites induced the complete removal of rhodamine B（20 μmol/L） in15 min,methylene blue（20 μmol/L） in 5 min,orange Ⅱ（20 μmol/L） in 10 min,phenol（0.1mmol/L） in 30 min and 4-chlorophenol（0.1 mmol/L） in 15 min with an initial pH value of 7.0 and a PMS concentration of 0.5 mmol/L.The total organic carbon（TOC） removal higher than 85%for all of these five pollutants was obtained in 30 min when the PMS concentration was 2.5 mmol/L.The rate of degradation was considerably higher than that obtained with Cu^0 or Fe3O4 particles alone.The enhanced catalytic activity of the Cu^0/Fe3O4 composites in the activation of PMS was attributed to the synergistic effect of the Cu^0 and Fe3O4 crystals in the composites.Singlet oxygen was identified as the primary reactive oxygen species responsible for pollutant degradation by electron spin resonance and radical quenching experiments.A possible mechanism for the activation of PMS by Cu^0/Fe3O4 composites is proposed as electron transfer from the organic pollutants to PMS induces the activation of PMS to generate ^1O2,which induces the degradation of the organic pollutants.As a magnetic catalyst,the Cu^0/Fe3O4 composites were easily recovered by magnetic separation,and exhibited excellent stability over five successive degradation cycles.The present study provides a facile and green heterogeneous catalysis method for the oxidative removal of organic pollutants.