The CKLF-like MARVEL transmembrane domain containing(CMTM)family of genes comprises CKLF and CMTM1–8(previously called chemokine-like factor superfamily 1–8,CKLFSF1–8).The CMTM family proteins contain a structurall...The CKLF-like MARVEL transmembrane domain containing(CMTM)family of genes comprises CKLF and CMTM1–8(previously called chemokine-like factor superfamily 1–8,CKLFSF1–8).The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking(MARVEL)domain.Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types.CMTM proteins control critical biological processes in cancer development,including growth factor receptor activation and recycling,cell proliferation,apoptosis,metastasis,and immune evasion.Emergingin vivo andin vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial.This review highlights new findings regarding the roles of CMTM1–8 in cancer,particularly in tumor growth,metastasis,and immune evasion.Additionally,the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.展开更多
基金This study was supported by grants from the National Natural Science Foundation of China(Grant Nos.81670123 and 81670144)from Wuhan University Medical Faculty Innovation Seed Fund Cultivation Project(Grant No.TFZZ2018025).
文摘The CKLF-like MARVEL transmembrane domain containing(CMTM)family of genes comprises CKLF and CMTM1–8(previously called chemokine-like factor superfamily 1–8,CKLFSF1–8).The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking(MARVEL)domain.Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types.CMTM proteins control critical biological processes in cancer development,including growth factor receptor activation and recycling,cell proliferation,apoptosis,metastasis,and immune evasion.Emergingin vivo andin vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial.This review highlights new findings regarding the roles of CMTM1–8 in cancer,particularly in tumor growth,metastasis,and immune evasion.Additionally,the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
