BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbi...The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbiotic marine microorganisms(n=94).Bibliometric Analysis are conducted in terms of the published trends,subject headings and other aspects.The output of literature in this field has increased rapidly in the past15years.57.4%of the papers were published in the last five years.And the relevance of research topics has increased in recent years.The current research focuses on community diversity,secondary metabolites,biological activities and antibacterial activities.Literature analysis is helpful to understand the overall development trend of overgrowth microorganisms in ocean research.展开更多
To investigate the application of synthetic phenolic antioxidants in marine research by bibliometrics analysis.Papers on the theme of synthetic phenolic antioxidants(N=135)was retrieved from the database of China Nati...To investigate the application of synthetic phenolic antioxidants in marine research by bibliometrics analysis.Papers on the theme of synthetic phenolic antioxidants(N=135)was retrieved from the database of China National Knowledge Infrastructure(CNKI),and the bibliometrics analysis was carried out in terms of article trend and keywords.Results show that the output of literature in this field has grown steadily and rapidly in the past 8 years.64.4%of the papers were published in the past 5 years.The relevance of research topics has increased in recent years.Current researches mainly focus on spatial and temporal distribution characteristics,metabolites and optimized detection methods.The analysis of its metabolites is helpful to understand the development of integrated microorganisms in Marine research.展开更多
目前,DNA甲基化已成为生命科学和医学领域中备受瞩目的研究热点之一,与之相关的文献数量呈现出快速增长的趋势。为深入理解DNA甲基化研究的整体发展历程与趋势,本研究采用文献分析方法,对近30年间Web of Science(WOS)数据库和CNKI数据...目前,DNA甲基化已成为生命科学和医学领域中备受瞩目的研究热点之一,与之相关的文献数量呈现出快速增长的趋势。为深入理解DNA甲基化研究的整体发展历程与趋势,本研究采用文献分析方法,对近30年间Web of Science(WOS)数据库和CNKI数据库中与DNA甲基化相关的文献进行了详细分析,并利用VOSviewer软件进行了可视化处理。检索和分析结果显示,WOS数据库中与DNA甲基化相关文献有21262篇,CNKI数据库有25664篇。在WOS中,美国相关论文数量占有绝对优势,且篇均被引频次和h-指数较高。研究方向主要集中在遗传学、生物化学与分子生物学、肿瘤学这3个方面。关键词主要为“表观遗传学(epigenetics)”、“基因表达(gene-expression)“和”癌症(cancer)”其中基因表达是DNA甲基化研究领域的热点和方向,这些关键词反映了DNA甲基化在这些领域的广泛应用和深入探索。对CNKI数据库分析的结果显示,研究论文主要发表在《癌症》、《中国畜牧兽医》及《畜牧兽医学报》等期刊。本研究通过对WOS和CNKI数据库中DNA甲基化相关文献的深入分析,为后续DNA甲基化领域的研究提供了有价值的信息和参考。展开更多
肌肉生长抑制素(Myostatin,MSTN)作为动物肌肉生长的负调节因子,对提高动物的肌肉量和瘦肉率具有重要意义。该文采用文献计量学方法,以"MSTN/GDF-8/Myostatin"为检索词对2000—2020年期间Web of Science核心合集数据库和CNKI...肌肉生长抑制素(Myostatin,MSTN)作为动物肌肉生长的负调节因子,对提高动物的肌肉量和瘦肉率具有重要意义。该文采用文献计量学方法,以"MSTN/GDF-8/Myostatin"为检索词对2000—2020年期间Web of Science核心合集数据库和CNKI中国学术期刊全文数据库收录的相关论文进行主题检索,并使用Excel 2016、GraphPad Prism 8.4.0和VOS viewer软件对数据进行可视化处理。结果显示,通过Web of Science平台共检索到相关MSTN的SCI论文4404篇,其中中国发表的论文675篇。CNKI中国学术期刊全文数据库内检索出759篇论文。全球关于MSTN的发文量在2000—2020年呈现总体上升的趋势,美国和一些畜牧业发达的国家对MSTN的研究较为深入;中国学者的发文量虽多但其篇均被引频次较低,需从不同维度开展该领域研究并加强机构间合作,提高文章水平,进而缩小差距。目前关于MSTN的研究集中于分子生物学、农学、遗传学、生物技术与微生物学四大领域。对于农学领域提高肉类品质和产量依旧十分重要,因此需要提高对MSTN如何影响肌肉发育及脂肪蓄积方面的认识。本文通过统计分析及可视化处理,为我国科研人员了解MSTN相关的研究动态和研究方向、并以此开展优良品种培育提供信息帮助。展开更多
All-solid-state batteries(ASSBs)are a class of safer and higher-energy-density materials compared to conventional devices,from which solid-state electrolytes(SSEs)are their essential components.To date,investigations ...All-solid-state batteries(ASSBs)are a class of safer and higher-energy-density materials compared to conventional devices,from which solid-state electrolytes(SSEs)are their essential components.To date,investigations to search for high ion-conducting solid-state electrolytes have attracted broad concern.However,obtaining SSEs with high ionic conductivity is challenging due to the complex structural information and the less-explored structure-performance relationship.To provide a solution to these challenges,developing a database containing typical SSEs from available experimental reports would be a new avenue to understand the structureperformance relationships and find out new design guidelines for reasonable SSEs.Herein,a dynamic experimental database containing>600 materials was developed in a wide range of temperatures(132.40–1261.60 K),including mono-and divalent cations(e.g.,Li^(+),Na^(+),K^(+),Ag^(+),Ca^(2+),Mg^(2+),and Zn^(2+))and various types of anions(e.g.,halide,hydride,sulfide,and oxide).Data-mining was conducted to explore the relationships among different variates(e.g.,transport ion,composition,activation energy,and conductivity).Overall,we expect that this database can provide essential guidelines for the design and development of high-performance SSEs in ASSB applications.This database is dynamically updated,which can be accessed via our open-source online system.展开更多
针对有害生物适应性研究是植物检疫工作的重要基础,明确有害生物在目标地的适生性分布,可提高预测的准确性及决策的科学性。为全面客观的了解国内外物种分布模型的应用领域、发展情况及研究规律,并为从事植物检疫工作研究的学者和决策...针对有害生物适应性研究是植物检疫工作的重要基础,明确有害生物在目标地的适生性分布,可提高预测的准确性及决策的科学性。为全面客观的了解国内外物种分布模型的应用领域、发展情况及研究规律,并为从事植物检疫工作研究的学者和决策者提供数据参考,本研究从文献计量学角度分析了近20年MaxEnt、CLIMEX、GARP三种物种分布模型在Web of Science数据库和CNKI数据库中的文献发展情况,梳理出生态位模型的研究与应用现状和发展脉络,可为研究者从事生态位模型相关研究提供参考依据。展开更多
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
文摘The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbiotic marine microorganisms(n=94).Bibliometric Analysis are conducted in terms of the published trends,subject headings and other aspects.The output of literature in this field has increased rapidly in the past15years.57.4%of the papers were published in the last five years.And the relevance of research topics has increased in recent years.The current research focuses on community diversity,secondary metabolites,biological activities and antibacterial activities.Literature analysis is helpful to understand the overall development trend of overgrowth microorganisms in ocean research.
文摘To investigate the application of synthetic phenolic antioxidants in marine research by bibliometrics analysis.Papers on the theme of synthetic phenolic antioxidants(N=135)was retrieved from the database of China National Knowledge Infrastructure(CNKI),and the bibliometrics analysis was carried out in terms of article trend and keywords.Results show that the output of literature in this field has grown steadily and rapidly in the past 8 years.64.4%of the papers were published in the past 5 years.The relevance of research topics has increased in recent years.Current researches mainly focus on spatial and temporal distribution characteristics,metabolites and optimized detection methods.The analysis of its metabolites is helpful to understand the development of integrated microorganisms in Marine research.
文摘目前,DNA甲基化已成为生命科学和医学领域中备受瞩目的研究热点之一,与之相关的文献数量呈现出快速增长的趋势。为深入理解DNA甲基化研究的整体发展历程与趋势,本研究采用文献分析方法,对近30年间Web of Science(WOS)数据库和CNKI数据库中与DNA甲基化相关的文献进行了详细分析,并利用VOSviewer软件进行了可视化处理。检索和分析结果显示,WOS数据库中与DNA甲基化相关文献有21262篇,CNKI数据库有25664篇。在WOS中,美国相关论文数量占有绝对优势,且篇均被引频次和h-指数较高。研究方向主要集中在遗传学、生物化学与分子生物学、肿瘤学这3个方面。关键词主要为“表观遗传学(epigenetics)”、“基因表达(gene-expression)“和”癌症(cancer)”其中基因表达是DNA甲基化研究领域的热点和方向,这些关键词反映了DNA甲基化在这些领域的广泛应用和深入探索。对CNKI数据库分析的结果显示,研究论文主要发表在《癌症》、《中国畜牧兽医》及《畜牧兽医学报》等期刊。本研究通过对WOS和CNKI数据库中DNA甲基化相关文献的深入分析,为后续DNA甲基化领域的研究提供了有价值的信息和参考。
文摘肌肉生长抑制素(Myostatin,MSTN)作为动物肌肉生长的负调节因子,对提高动物的肌肉量和瘦肉率具有重要意义。该文采用文献计量学方法,以"MSTN/GDF-8/Myostatin"为检索词对2000—2020年期间Web of Science核心合集数据库和CNKI中国学术期刊全文数据库收录的相关论文进行主题检索,并使用Excel 2016、GraphPad Prism 8.4.0和VOS viewer软件对数据进行可视化处理。结果显示,通过Web of Science平台共检索到相关MSTN的SCI论文4404篇,其中中国发表的论文675篇。CNKI中国学术期刊全文数据库内检索出759篇论文。全球关于MSTN的发文量在2000—2020年呈现总体上升的趋势,美国和一些畜牧业发达的国家对MSTN的研究较为深入;中国学者的发文量虽多但其篇均被引频次较低,需从不同维度开展该领域研究并加强机构间合作,提高文章水平,进而缩小差距。目前关于MSTN的研究集中于分子生物学、农学、遗传学、生物技术与微生物学四大领域。对于农学领域提高肉类品质和产量依旧十分重要,因此需要提高对MSTN如何影响肌肉发育及脂肪蓄积方面的认识。本文通过统计分析及可视化处理,为我国科研人员了解MSTN相关的研究动态和研究方向、并以此开展优良品种培育提供信息帮助。
基金supported by the Ensemble Grant for Early Career Researchers 2022 and the 2023 Ensemble Continuation Grant of Tohoku University,the Hirose Foundation,the Iwatani Naoji Foundation,and the AIMR Fusion Research Grantsupported by JSPS KAKENHI Nos.JP23K13599,JP23K13703,JP22H01803,and JP18H05513+2 种基金the Center for Computational Materials Science,Institute for Materials Research,Tohoku University for the use of MASAMUNEIMR(Nos.202212-SCKXX0204 and 202208-SCKXX-0212)the Institute for Solid State Physics(ISSP)at the University of Tokyo for the use of their supercomputersthe China Scholarship Council(CSC)fund to pursue studies in Japan.
文摘All-solid-state batteries(ASSBs)are a class of safer and higher-energy-density materials compared to conventional devices,from which solid-state electrolytes(SSEs)are their essential components.To date,investigations to search for high ion-conducting solid-state electrolytes have attracted broad concern.However,obtaining SSEs with high ionic conductivity is challenging due to the complex structural information and the less-explored structure-performance relationship.To provide a solution to these challenges,developing a database containing typical SSEs from available experimental reports would be a new avenue to understand the structureperformance relationships and find out new design guidelines for reasonable SSEs.Herein,a dynamic experimental database containing>600 materials was developed in a wide range of temperatures(132.40–1261.60 K),including mono-and divalent cations(e.g.,Li^(+),Na^(+),K^(+),Ag^(+),Ca^(2+),Mg^(2+),and Zn^(2+))and various types of anions(e.g.,halide,hydride,sulfide,and oxide).Data-mining was conducted to explore the relationships among different variates(e.g.,transport ion,composition,activation energy,and conductivity).Overall,we expect that this database can provide essential guidelines for the design and development of high-performance SSEs in ASSB applications.This database is dynamically updated,which can be accessed via our open-source online system.
文摘针对有害生物适应性研究是植物检疫工作的重要基础,明确有害生物在目标地的适生性分布,可提高预测的准确性及决策的科学性。为全面客观的了解国内外物种分布模型的应用领域、发展情况及研究规律,并为从事植物检疫工作研究的学者和决策者提供数据参考,本研究从文献计量学角度分析了近20年MaxEnt、CLIMEX、GARP三种物种分布模型在Web of Science数据库和CNKI数据库中的文献发展情况,梳理出生态位模型的研究与应用现状和发展脉络,可为研究者从事生态位模型相关研究提供参考依据。
