泮托拉唑与金嗓散结胶囊联合显微支撑喉镜下CO2激光治疗声带白斑疗效分析

分析泮托拉唑与金嗓散结胶囊联合显微支撑喉镜下CO2激光治疗声带白斑疗效。方法 连续纳入2019年09月-2021年12月期间110例声带白斑患者,以随机数字表法分为对照组/实验组,45例泮托拉唑与金嗓散结胶囊治疗纳入对照组,65例上述基础上联合显微支撑喉镜下CO2激光治疗纳入实验组。分析其在反流情况、疗效以及临床指征方面的差异。结果 中文版反流症状指数量表(RSI)、中文版反流检查计分量表(RFS)评分方面,基本一致,P>0.05;疗效方面,实验组较对照组的具体情况方面更优,P<0.05;MPT、Jitter、SPL方面,实验组治疗后3个月均优于对照组,P<0.05。;发声情况方面,对照组治疗后2周开始改善,对照组略好于实验组,实验组治疗后3个月时发声明显改善,实验组优于对照组,P<0.05。结论 泮托拉唑与金嗓散结胶囊联合显微支撑喉镜下CO2激光治疗声带白斑患者相对单一药物治疗效果更佳。

甲真菌病的5%盐酸阿莫罗芬擦剂结合CO2激光治疗效果

探索甲真菌病患者接受5%盐酸阿莫罗芬擦剂结合CO2激光治疗的临床效果。方法 选择2022年1月~2023年12月期间在皮肤科接受诊治的甲真菌病患者122例进行研究,根据入院时间先后将此122例甲真菌病患者分为两组,对照组接受5%盐酸阿莫罗芬擦剂治疗,观察组在使用擦剂基础上加用CO2激光治疗,对比分析两组患者的临床疗效、真菌清除率、生活质量、甲真菌病临床评分指数(scoring clinical index of onychomycosis, SCIO)、甲真菌病严重程度指数(onychomycosis severity index, OSI)、康复质量以及不良事件发生率。结果 1.观察组临床疗效为95.08%,对照组临床疗效91.97%,差异有统计学意义(P<0.05);2.观察组真菌完全清除率为90.16%,对照组真菌完全清除率为70.49%,差异有统计学意义(P<0.05);3.观察组生活质量评分更高,差异有统计学意义(P<0.05);4.观察组的SCIO和OSI评分分别为(6.89±1.15)分、(5.62±0.87)分均低于对照组的SCIO评分(8.83±1.36)分、OSI评分(7.84±1.23)分,差异有统计学意义(P<0.05);5.观察组康复质量更好,差异有统计学意义(P<0.05);6.观察组不良事件发生概率更低,差异有统计学意义(P<0.05)。结论 甲真菌病患者接受5%盐酸阿莫罗芬擦剂结合CO2激光治疗临床疗效显著,可积极推广。

重组贻贝粘蛋白水凝胶敷料在点阵CO2激光治疗痤疮凹陷性瘢痕后的疗效和安全性评价

观察点阵CO2激光术后联合重组贻贝粘蛋白水凝胶敷料疗效及安全性。方法 选取2022 年9月—2023年9月来我院皮肤科室治疗痤疮凹陷性瘢痕的患者60例,采用双盲数字法将其平均分为研究组30例和对照组30例,其中对照组患者使用点阵CO2激光治疗,研究组患者在采用点阵CO2激光的基础上联合重组贻贝粘蛋白水凝胶敷料治疗。治疗28d后对两组患者临床疗效、瘢痕皮损、面部红斑量、经表皮水分流失量、临床痤疮瘢痕情况(ECCA评分量表)、面部整体美学效果改善情况(GAIS评分量表)和治疗期间的安全性进行对比。结果 治疗28d后研究组患者的临床总治疗有效率明显高于对照组(93.33% vs 63.33%),差异有统计学意义(P<0.05);治疗后,研究组患者的急性炎症反应半定量评分明显低于对照组(1.53±0.37 vs 2.16±0.28),而平均脱痂时间明显短于对照组(6.34±1.36d vs 8.27±1.86d),差异有统计学意义(P<0.05);治疗后两组患者的ECCA权重评分较治疗前均显著降低,而两组患者的GAIS评分较治疗前显著升高,差异均具有统计学意义(P<0.05),其中研究组患者相较于对照组患者而言ECCA降低更多(15.78±5.28 vs 23.62±6.29),而GAIS升高更多(2.57±0.61 vs 2.13±0.56) ,差异具有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论 重组贻贝粘蛋白水凝胶敷料联合点阵CO2激光治疗痤疮凹陷性瘢痕疗效确切,可减少点阵CO2激光术不良反应,缩短恢复期,提高皮肤屏障功能与美观度。

NiCo2S4/木材液化物碳气凝胶复合材料的制备及电化学性能

以木材液化物为前驱体原料,经凝胶、碳化、活化法制备的碳气凝胶(CA)为基材,通过两步水热法在其骨架表面原位负载NiCo2S4得到NiCo2S4/木材液化物碳气凝胶(NiCo2S4-CA)复合电极材料。利用扫描电子显微镜(SEM)、氮气吸附-脱附实验、傅里叶红外光谱(FT-IR)、X射线衍射(XRD)、X射线光电子能谱(XPS)等手段来表征NiCo2S4-CA材料的物相结构和表面形貌,通过循环伏安法、恒电流充放电及电化学交流阻抗等测试方法研究其电化学性能,探究其电荷储存机理。结果表明:NiCo2S4纳米颗粒锚定在具有珊瑚网络结构的CA骨架表面,形成丰富的多级孔隙结构。CA的引入有利于NiCo2S4的良好分散,缓解其团聚问题,且不会改变NiCo2S4的晶体结构。NiCo2S4-CA3作为超级电容器电极材料表现出极好的电化学性能,其比容量最大值为1 040.2 F/g(1 A/g),较小的等效电阻为1.01Ω和良好的循环稳定性,经2 000次恒流充放电(10 A/g)循环后,保持着初始比电容的56.61%,优于纯NiCo2S4的47.33%。NiCo2S4-CA3复合材料在20 A/g超大电流密度的电容保持率高达74.34%,远高于纯NiCo2S4的57.65%,电荷储存动力学显示其电化学过程由表面电容控制和扩散控制过程共同作用。该合成工艺简单且成本较低,NiCo2S4-CA3作为超级电容器电极材料在要求高容量、大电流密度领域具有极其广阔的应用前景。

SLCO2A1基因突变致厚皮性骨膜病一例

厚皮性骨膜病是一种罕见的遗传性疾病。本例男性患者,17岁,关节肿胀2年,体格检查发现前额横行皱纹、杵状指、鹦鹉嘴样甲、多发痤疮、毛囊炎,影像学检查提示骨皮质增厚、骨膜增厚、关节炎,高通量测序联合Sanger测序验证发现SLCO2A1基因突变,1个致病[c.941-1G>A(p.?)]的杂合变异和1个疑似致病[c.1286A>G(p.Tyr429Cys)]的杂合变异。对患者父母上述基因位点行遗传追踪,患者母亲携带c.941-1G>A(p.?),患者父亲携带c.1286A>G(p.Tyr429Cys)。给予非甾体抗炎药治疗后症状明显减轻。

Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene:Hypotheses and conundrums

Chronic enteropathy associated with the SLCO2A1 gene(CEAS)is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss.This review explores the potential mechanisms underlying the pathogenesis of CEAS,focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2(PGE2)levels.Studies have suggested that elevated PGE2 levels contribute to mucosal damage,inflammation,and disruption of the intestinal barrier.The effects of PGE2 on macrophage activation and Maxi-Cl channel functionality,as well as its interaction with nonsteroidal anti-inflammatory drugs play crucial roles in the progression of CEAS.Understanding the balance between its protective and pro-inflammatory effects and the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel,targeted therapies.

中国恩施土家族苗族自治州高度近视患者SCO2基因新突变

目的:探讨SCO2(OMIM 604272)基因在恩施土家族苗族自治州高度近视患者中的致病性变异。方法:共招募384例高度近视患者,其中至少一眼球镜度数≤-6.00 D,且眼轴长度≥26.00 mm。应用苯酚-氯仿法从5 mL外周静脉血中提取DNA。通过Sanger测序以鉴定SCO2第2外显子的致病性变异。运用计算机预测软件对检测到的变异进行评估。来自同一地区的288名健康人群作为正常对照。结果:共检测出7个突变位点,分别为4个同义突变(c.201C>T/p.=,c.576C>T/p=,c.633A>C/p.=,c.780T>C/p.=.),2个错义突变(c.187A>G/p.Ile63Val,c.59G>C/p.Arg20Pro)和1个无义突变(c.544C>T/p.Gln182*)。通过PolyPhen2、SIFT和Provean软件预测,两个错义突变没有致病性。新的无义突变(c.544C>T/p.Gln182*)在1000G中未被发现,在288个正常对照中也未被发现。Variant Taster预测该无义突变位点是保守的。结论:新发现的无义突变可能是我们研究的高度近视患者的致病原因。SCO2与高度近视相关,而这批高度近视人群中SCO2基因突变的发生率低至1/384;该无义突变可能是中国恩施土家族苗族自治州高度近视的一种罕见变异。

A Multi-Center Randomized Controlled Study UsingΔP_(CO2)/Ca-v_(O2)as the Target to Guide Early Tissue Hypoperfusion in Sepsis in Plateau Areas

Objective:To explore the value of using the venous-arterial carbon dioxide partial pressure difference and the arterial-venous oxygen content difference ratio(ΔP_(CO2)/Ca-v_(O2))as targets to guide early tissue hypoperfusion in sepsis in plateau areas.Methods:90 sepsis patients admitted to the Third People’s Hospital of Xining and Golmud People’s Hospital from June 2017 to December 2022 were selected as the research subjects,and they were divided into the Scv_(O2)(central venous oxygen saturation)group and theΔP_(CO2)/Ca-v_(O2)group,with 45 cases in each group.The two groups were treated with early shock resuscitation according to different protocols.The hemodynamic characteristics of the two groups of patients before and after resuscitation were observed,and the volume responsiveness was evaluated.The ROC(receiver operating characteristic)curve was used to analyze the significance ofΔP_(CO2)/Ca-v_(O2),Scv_(O2),lactate,lactate clearance,and urine output in evaluating patient prognosis and the correlation betweenΔP_(CO2)/Ca-v_(O2)and the above indicators was explored.Results:Compared with before resuscitation,after fluid resuscitation,the heart rate(HR),mean arterial pressure(MAP),central venous pressure(CVP),cardiac index(CI),lactate,lactate clearance rate,and urine output of the two groups of patients were significantly improved(P<0.05);in terms of therapeutic effect,the 28-day mortality rate,6-hour fluid balance,and lactic acid clearance of theΔP_(CO2)/Ca-v_(O2)group were better than the Scv_(O2)group.The ROC characteristic curve showed that theΔP_(CO2)/Ca-v_(O2)value can effectively predict the prognosis of patients(AUC=0.907,sensitivity was 97%,specificity was 72.4%,and critical value was 1.84).ΔP_(CO2)/Ca-v_(O2)significantly correlated with Scv_(O2),lactic acid,and lactic acid clearance rate.Conclusion:TheΔP_(CO2)/Ca-v_(O2)value can be used to guide fluid resuscitation in early hypoperfusion in sepsis in plateau areas,improve patients’hemodynamics,reduce lactate indicators,and increase urine output.ΔP_(CO2)/Ca-v_(O2)level>1.84 can effectively improve patient prognosis.

基于CO2吞吐的页岩油提高采收率技术分析与研究

页岩油作为重要的非常规油气资源,因其储量丰富和分布广泛,逐渐成为能源开发的热点。CO2吞吐技术可以提高页岩油的流动性和采收率,因其显著效果备受关注。本文首先详细探讨了CO2吞吐的机理,包括溶解作用、膨胀作用和置换作用,然后描述了CO2吞吐的工艺流程,包括注气、焖井和生产阶段,并且系统总结了影响CO2吞吐效果的关键因素,如储层温度、注气压力、注气强度、焖井时间和吞吐轮次,对提高页岩油开采效率具有重要的借鉴意义。

内窥镜下CO2激光在喉癌切除术患者中的疗效观察及对生存期的影响研究

本研究旨在评估内窥镜下CO2激光在喉癌切除术患者中的疗效及对生存期的影响。方法 通过回顾性分析,选取了我院2020年8月-2023年8月期间收治的54例喉癌患者,根据手术类型分为观察组(内窥镜下CO2激光手术)和对照组(传统开放性切除术),每组27例,比较了两种手术方法的临床治疗效果、并发症发生情况及生存期。结果 观察组的总有效率显著高于对照组(P<0.05),不良并发症发生率显著低于对照组(P<0.05),但两组患者的三年总生存率无显著差异(P>0.05)。结论 内窥镜下CO2激光手术在提高喉癌切除术的疗效和减少并发症方面表现出优势,但对生存期的影响并无显著差异。

Effects of Anthropogenic CO2 and Thermally-Induced CO2 on Global Warming

Changes in CO2 and temperature are correlated, but it is difficult to observe which is the cause and which is the effect. The release of CO2 dissolved in the ocean into the atmosphere depends on the atmospheric temperature. However, examining the relationship between changes in CO2 caused by other phenomena and temperature is difficult. Studies of soil respiration (Rs) since the late 20th century have shown that CO2 emissions from soil respiration (Rs) are overwhelmingly greater than CO2 emissions from fossil fuel combustion. This is also noted in the IPCC carbon budget assessment. In this paper, the dependences of Rs on temperature, time, latitude, precipitation, seasons, etc., were investigated using the latest NASA database. The changes in temperature and Rs correlated well. There is also a good correlation between Rs and CO2 generation. Therefore, an increase in temperature results in an increase in CO2. On the other hand, there is no evidence other than model calculations that an increase in anthropogenic CO2 is mainly linked to a rise in temperature. The idea that global warming is caused by anthropogenic CO2 production is still a hypothesis. For these reasons, the relationship between global warming and anthropogenic CO2 should be reconsidered based on physical evidence without preconceptions. .

Laboratory Experiments Do Not Support the Greenhouse Effect as Applicable to CO2

The analysis of Greenhouse Effect experiments in the public domain indicated that the lab tests were primarily centered around illustrating the mechanics of conventional greenhouses. They used high-energy visible light (such as sunlight), rather than addressing the Greenhouse Effect, which involves low-energy infrared radiation emitted by the Earth’s surface. Studies with argon, a non-greenhouse gas with similar density to CO2, showed thermal heat transfer as the dominant factor in the temperature profiles, with radiation absorption being undetected. The same conclusion was drawn by another study, which measured infrared back radiation. Experiments using exaggerated CO2 concentrations inadvertently illustrated the principle of the Popper Falsification Test by disproving the Greenhouse Effect applicable to CO2 within the troposphere. A straightforward kitchen test showed that a microwave oven cannot be used as a model for the Greenhouse Effect.

MOF‐derived 1D/3D N‐doped porous carbon for spatially confined electrochemical CO2 reduction to adjustable syngas

Electrochemical reduction of CO_(2)to syngas(CO and H_(2))offers an efficient way to mitigate carbon emissions and store intermittent renewable energy in chemicals.Herein,the hierarchical one‐dimensional/three‐dimensional nitrogen‐doped porous carbon(1D/3D NPC)is prepared by carbonizing the composite of Zn‐MOF‐74 crystals in situ grown on a commercial melamine sponge(MS),for electrochemical CO_(2)reduction reaction(CO_(2)RR).The 1D/3D NPC exhibits a high CO/H_(2)ratio(5.06)and CO yield(31 mmol g^(−1)h^(−1))at−0.55 V,which are 13.7 times and 21.4 times those of 1D porous carbon(derived from Zn‐MOF‐74)and N‐doped carbon(carbonized by MS),respectively.This is attributed to the unique spatial environment of 1D/3D NPC,which increases the adsorption capacity of CO_(2)and promotes electron transfer from the 3D N‐doped carbon framework to 1D carbon,improving the reaction kinetics of CO_(2)RR.Experimental results and charge density difference plots indicate that the active site of CO_(2)RR is the positively charged carbon atom adjacent to graphitic N on 1D carbon and the active site of HER is the pyridinic N on 1D carbon.The presence of pyridinic N and pyrrolic N reduces the number of electron transfer,decreasing the reaction kinetics and the activity of CO_(2)RR.The CO/H_(2)ratio is related to the distribution of N species and the specific surface area,which are determined by the degree of spatial confinement effect.The CO/H_(2)ratios can be regulated by adjusting the carbonization temperature to adjust the degree of spatial confinement effect.Given the low cost of feedstock and easy strategy,1D/3D NPC catalysts have great potential for industrial application.

A Review on Technologies for the Use of CO2 as a Working Fluid in Refrigeration and Power Cycles

The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its thermodynamic properties make it a fluid of choice in the efficient use of energy at low and medium temperatures in engine cycles. However, the performance of transcritical CO2 cycles weakens under high temperature and pressure conditions, especially in refrigeration systems;On the other hand, this disadvantage becomes rather interesting in engine cycles where CO2 can be used as an alternative to the organic working fluid in small and medium-sized electrical systems for low quality or waste heat sources. In order to improve the performance of systems operating with CO2 in the field of refrigeration and electricity production, research has made it possible to develop several concepts, of which this article deals with a review of the state of the art, followed by analyzes in-depth and critical of the various developments to the most recent modifications in these fields. Detailed discussions on the performance and technical characteristics of the different evolutions are also highlighted as well as the factors affecting the overall performance of the systems studied. Finally, perspectives on the future development of the use of CO2 in these different cycles are presented.

点阵CO2激光联合牛碱性成纤维生长因子凝胶治疗痤疮凹陷性痤疮瘢痕疗效观察

评价对痤疮患者进行点阵CO2激光联合牛碱性成纤维生长因子凝胶治疗的应用效果。方法 选取我院凹陷性痤疮患者78例,分为两组,对照组进行点阵CO2激光治疗,观察组在对照组的基础上联合牛碱性成纤维生长因子凝胶治疗,对比组间患者的皮损面积改善情况,皮损严重程度评分变化,治疗效果,不良反应,平均误工期和生活质量。结果 观察组患者的皮损面积改善情况,皮损严重程度,治疗效果和生活质量均显著优于对照组(P<0.05),不良反应发生率低于对照组(P<0.05),平均误工期短于对照组(P<0.05)。结论 通过对凹陷性痤疮患者进行点阵CO2激光联合牛碱性成纤维生长因子凝胶治疗,能缩小患者的皮损面积,减轻皮损严重程度,减少不良反应出现,缩短平均误工期,提高生活质量。

CO2 Back-Radiation Sensitivity Studies under Laboratory and Field Conditions

We measured the IR back radiation using a relatively low-cost experimental setup and a test chamber with increasing CO2 concentrations starting with a pure N2 atmosphere against a temperature-controlled black reference background. The results confirm estimations within this work and previous finding about CO2-induced infrared radiation saturation within realistic atmospheric conditions. We used this setup also to study thermal forcing effects with stronger and rare greenhouse gases against a clear night sky. Our results and their interpretation are another indication for having a more critical approach in climate modelling and against monocausal interpretation of climate indices only caused by anthropogenic greenhouse gas emissions. Basic physics combined with measurements and data taken from the literature allow us to conclude that CO2 induced infrared back-radiation must follow an asymptotic logarithmic-like behavior, which is also widely accepted in the climate-change community. The important question of climate sensitivity by doubling current CO2 concentrations is estimated to be below 1˚C. This value is important when the United Nations consider climate change as an existential threat and many governments intend rigorously to reduce net greenhouse gas emissions, led by an ambitious European Union inspired by IPCC assessments is targeting for more than 55% in 2030 and up to 100% in 2050 [1]. But probably they should also listen to experts [2] [3] who found that all these predictions have considerable flaws in basic models, data and impact scenarios.

CO2点阵激光联合他克莫司软膏治疗白癜风的临床效果

探究CO2点阵激光联合他克莫司软膏治疗白癜风的临床效果。方法 选取我院近两年收治的86例白癜风患者(对照组43例实施他克莫司软膏治疗,观察组43例联合实施CO2点阵激光进行治疗),比较两组的治疗效果、色素评分和白斑面积、生活质量评分以及不良反应发生情况。结果 观察组的治疗效果更好,色素评分更高,白斑面积更少,生活质量评分更高,不良反应发生率更低(P<0.05)。结论 对白癜风患者采用CO2点阵激光技术与他克莫司软膏相结合的治疗方案不仅能够在短时间内迅速显现治疗效果,显著改善患者症状,还具有极强的安全性,确保了患者在治疗过程中的安全与舒适。

Capturing CO2 Emissions in the George C. Wallace Tunnel: A Case Study

This paper describes the design of a ventilation system to be paired with a carbon capture system. The ventilation system utilizes the geometry of the George C. Wallace tunnel, located in the City of Mobile, Alabama, USA to capture and redirect emissions to a direct air capture (DAC) device to sequester 25% of the total CO2 mass generated from inside the tunnel. The total CO2 mass rate for the westbound traffic between the week-day hours of 7 a.m. and 6 p.m. has been estimated between 2,300 to 3,000 lbs./hr. By sequestering these emissions, the overall surrounding air quality was shown to be improved to a level that mirrors that from the pre-US industrial era of 270 ppm.

CO2低气压对腔镜乳腺癌切除术后生化功能、并发症影响

探讨二氧化碳低气压对腔镜乳腺癌切除术后生化功能、并发症影响。方法 选取海南医科大学第一附属医院的62例乳腺癌病例,于全身麻醉状态下实施单孔腔镜切除术。将其划分为低压组(即L实验组,压为8mmHg)以及高压组(即H对照组,压为12mmHg)。分别对术前、术后第一天、术后第三天的呼吸循环影响予以记录。结果 对两组术前、术后第一天、术后第三天肝功能的谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)进行检测,结果显示其差异均无统计学意义(P>0.05)。对两组术前、术后第一天、术后第三天肾功能的肌酐(Cr)、尿素氮(BUN)进行检测,其结果比较差异也均无统计学意义(P>0.05)。对两组术前、术后第三天凝血功能的D-二聚体(D-dimer)、纤维蛋白原(FIB)活化进行检测,差异均无统计学意义(P>0.05),然而术后第一天的D-二聚体(D-dimer)存在统计学意义(P<0.05)。两组术后出现恶心呕吐、心律失常比较差异均无统计学意义(P>0.05),但术后皮下气肿有统计学意义(P<0.05)。结论 在平原地区行腔镜乳腺癌切除术,CO2气压越高对呼吸影响越明显。

皮损内注射复方倍他米松序贯CO2点阵激光在增生性瘢痕患者治疗中的应用价值研究

研究增生性瘢痕患者治疗中采用皮损内注射复方倍他米松序贯CO2点阵激光的价值。方法 研究对象:选择我院进行增生性瘢痕治疗的91例患者;研究时间段:2022年2月至2023年11月期间,研究对象抽签法分为随机2组,对照组包含45例,观察组有46例,对照组行皮损内注射复方倍他米松治疗,观察组同时接受CO2点阵激光治疗,评估患者的瘢痕指标、皮肤功能、不良反应发生率和治疗效果指标,对比分析数据结果。结果 观察组瘢痕面积、厚度和VSS评分均小于对照组,观察组角质层含水量大于对照组,表皮水分丢失量和pH值小于对照组,观察组治疗有效率高于对照组,对比差异有统计价值(P<0.05);观察组不良反应发生率与对照组比较,差异没有对比价值P>0.05。结论 皮损内注射复方倍他米松序贯CO2点阵激光治疗增生性瘢痕,既能够改善多项瘢痕指标,同时能够有效恢复皮肤功能,提高治疗效率,且产生的不良反应没有明显增高,可见其在临床中有一定的治疗运用价值,具有临床推广意义。