The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-ca...The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns,prognostic value,gene mutations,immune infiltration,correlation analysis,and functional enrichment assessment.Results showed that COPS6 was highly correlated with prognosis,immune cell infiltration level,tumor mutation burden,and microsatellite instability in patients with a range of tumor types.This suggests that COPS6 may be a potential target for cancer treatment.Overall,this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.展开更多
After two weeks of discussions and consultations at the 28 th Conference of the Parties to the United Nations Framework Convention on Climate Change(COP28),states parties finally reached a series of important sustaina...After two weeks of discussions and consultations at the 28 th Conference of the Parties to the United Nations Framework Convention on Climate Change(COP28),states parties finally reached a series of important sustainable development resolutions and voluntary initiatives.In this paper,the possible impact of these resolutions on Taiwan was mainly discussed,and the relevant regulations and policies that the Taiwan government may enact were analyzed.展开更多
The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of...The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of the two protein complexes in terms of their size and amino acid sequences. Eight groups of subunits from the COP9 signalosome and the proteasome lid complex of different organisms are collected from all the databases at the NCBI website. The corresponding subunits of COP9 signalosome and proteasome lid complex share at least 12% amino acid identity and some conserved regions, and the conserved sites spread evenly over the entire length of the subunits, suggesting that the two complexes have a common evolutionary ancestor. Phylogenetic analyses based on the amino acid sequences of the corresponding subunits of two protein complexes indicate that every tree consists of two clades. The subunits from one of the two protein complexes of different organisms are grouped into one of the two clades respectively. The sequences of single-cell organisms are always the basal groups to that of multi-cell animal and plant species. These results imply that the duplication/divergence events of COP9 signalosome and regulatory lid of the proteasome genes have occurred before the divergence of single-cell and multi-cell eukaryotes, and the genes of the two complexes are independently evolved. The analyses of dN/dS correlation show significant Pearson's correlations between 21 and 15 pairs of subunit-encoding sequences within the COP9 signalosome and the proteasome lid complex respectively, suggesting that those subunits pairs might have related functions and interacted with one another, and resulted in co-evolution.展开更多
Photocatalytic water splitting is a promising method for hydrogen production.Numerous efficient photocatalysts have been synthesized and utilized.However,photocatalysts without a noble metal as the co-catalyst have be...Photocatalytic water splitting is a promising method for hydrogen production.Numerous efficient photocatalysts have been synthesized and utilized.However,photocatalysts without a noble metal as the co-catalyst have been rarely reported.Herein,a CoP co-catalyst-modified graphitic-C3N4(g-C3N4/CoP)is investigated for photocatalytic water splitting to produce H2.The g-C3N4/CoP composite is synthesized in two steps.The first step is related to thermal decomposition,and the second step involves an electroless plating technique.The photocatalytic activity for hydrogen evolution reactions of g-C3N4 is distinctly increased by loading the appropriate amount of CoP quantum dots(QDs).Among the as-synthesized samples,the optimized one(g-C3N4/CoP-4%)shows exceptional photocatalytic activity as compared with pristine g-C3N4,generating H2 at a rate of 936μmol g^-1 h^-1,even higher than that of g-C3N4 with 4 wt%Pt(665μmol g^-1 h^-1).The UV-visible and optical absorption behavior confirms that g-C3N4 has an absorption edge at 451 nm,but after being composited with CoP,g-C3N4/CoP-4%has an absorption edge at 497 nm.Furthermore,photoluminescence and photocurrent measurements confirm that loading CoP QDs to pristine g-C3N4 not only enhances the charge separation,but also improves the transfer of photogenerated e--h+pairs,thus improving the photocatalytic performance of the catalyst to generate H2.This work demonstrates a feasible strategy for the synthesis of highly efficient metal phosphide-loaded g-C3N4 for hydrogen generation.展开更多
Co-P precursor was prepared by a mechanical alloying method and then is controlled to synthesis of CoP phase through an annealing method. The optimal conditions of ball milling and annealing temperature are investigat...Co-P precursor was prepared by a mechanical alloying method and then is controlled to synthesis of CoP phase through an annealing method. The optimal conditions of ball milling and annealing temperature are investigated. The CoP exhibits higher electrical conductivity than graphite and cobalt oxide, showing excellent pseudocapacitive properties due its high electrical conductivity which can result in a fast electron transfer in high rate charge-discharge possess. The as-obtained CoP electrode achieves a high specific capacitance of 447.5 Fig at 1 Aug, and displays an excellent rate capability as well as good cycling stability. Besides, the asymmetric supercapacitor (ASC) based on the CoP as the positive electrode and activated carbon (AC) as the negative electrode was assembled and displayed a high rate capability (60% of the capacitance is retained when the current density increased from 1 Aug to 12 Aug), excellent cycling stability (96.7% of the initial capacitance is retained after 5000 cycles), and a superior specific energy of 19 Wh/kg at a power density of 350.8 W/kg. The results, suggest that the CoP electrode materials have a great potential for developing high-performance electrochemical energy storage devices. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.展开更多
Efficient walking is one of the main goals of researches on biped robots. A feasible way is to translate the understanding from human walking into robot walking, for example, an artificial control approach on a human ...Efficient walking is one of the main goals of researches on biped robots. A feasible way is to translate the understanding from human walking into robot walking, for example, an artificial control approach on a human like walking structure. In this paper, a walking pattern based on Center of Pressure （COP） switched and modeled after human walking is introduced firstly. Then, a parameterization method for the proposed walking gait is presented. In view of the complication, a multi-space planning method which divides the whole planning task into three sub-spaces, including simplified model space, work space and joint space, is proposed. Furthermore, a finite-state-based control method is also developed to implement the proposed walking pattern. The state switches of this method are driven by sensor events. For convincing verification, a 2D simulation system with a 9-1ink planar biped robot is developed. The simulation results exhibit an efficient walking gait.展开更多
文摘The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns,prognostic value,gene mutations,immune infiltration,correlation analysis,and functional enrichment assessment.Results showed that COPS6 was highly correlated with prognosis,immune cell infiltration level,tumor mutation burden,and microsatellite instability in patients with a range of tumor types.This suggests that COPS6 may be a potential target for cancer treatment.Overall,this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.
文摘After two weeks of discussions and consultations at the 28 th Conference of the Parties to the United Nations Framework Convention on Climate Change(COP28),states parties finally reached a series of important sustainable development resolutions and voluntary initiatives.In this paper,the possible impact of these resolutions on Taiwan was mainly discussed,and the relevant regulations and policies that the Taiwan government may enact were analyzed.
文摘The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of the two protein complexes in terms of their size and amino acid sequences. Eight groups of subunits from the COP9 signalosome and the proteasome lid complex of different organisms are collected from all the databases at the NCBI website. The corresponding subunits of COP9 signalosome and proteasome lid complex share at least 12% amino acid identity and some conserved regions, and the conserved sites spread evenly over the entire length of the subunits, suggesting that the two complexes have a common evolutionary ancestor. Phylogenetic analyses based on the amino acid sequences of the corresponding subunits of two protein complexes indicate that every tree consists of two clades. The subunits from one of the two protein complexes of different organisms are grouped into one of the two clades respectively. The sequences of single-cell organisms are always the basal groups to that of multi-cell animal and plant species. These results imply that the duplication/divergence events of COP9 signalosome and regulatory lid of the proteasome genes have occurred before the divergence of single-cell and multi-cell eukaryotes, and the genes of the two complexes are independently evolved. The analyses of dN/dS correlation show significant Pearson's correlations between 21 and 15 pairs of subunit-encoding sequences within the COP9 signalosome and the proteasome lid complex respectively, suggesting that those subunits pairs might have related functions and interacted with one another, and resulted in co-evolution.
基金supported by the National Natural Science Foundation of China(51602207)the Doctoral Scientific Research Foundation of Liaoning Province(20170520011)+3 种基金the Program for Liaoning Excellent Talents in Universities(LR2017074)the Open Project Program of the State Key Laboratory of Photocatalysis on Energy and Environment(SKLPEE-201810)Fuzhou University,the Scientific Research Project of the Educational Department of Liaoning Province(LQN201712)Shenyang Excellent Talents in Universities(RC180211)~~
文摘Photocatalytic water splitting is a promising method for hydrogen production.Numerous efficient photocatalysts have been synthesized and utilized.However,photocatalysts without a noble metal as the co-catalyst have been rarely reported.Herein,a CoP co-catalyst-modified graphitic-C3N4(g-C3N4/CoP)is investigated for photocatalytic water splitting to produce H2.The g-C3N4/CoP composite is synthesized in two steps.The first step is related to thermal decomposition,and the second step involves an electroless plating technique.The photocatalytic activity for hydrogen evolution reactions of g-C3N4 is distinctly increased by loading the appropriate amount of CoP quantum dots(QDs).Among the as-synthesized samples,the optimized one(g-C3N4/CoP-4%)shows exceptional photocatalytic activity as compared with pristine g-C3N4,generating H2 at a rate of 936μmol g^-1 h^-1,even higher than that of g-C3N4 with 4 wt%Pt(665μmol g^-1 h^-1).The UV-visible and optical absorption behavior confirms that g-C3N4 has an absorption edge at 451 nm,but after being composited with CoP,g-C3N4/CoP-4%has an absorption edge at 497 nm.Furthermore,photoluminescence and photocurrent measurements confirm that loading CoP QDs to pristine g-C3N4 not only enhances the charge separation,but also improves the transfer of photogenerated e--h+pairs,thus improving the photocatalytic performance of the catalyst to generate H2.This work demonstrates a feasible strategy for the synthesis of highly efficient metal phosphide-loaded g-C3N4 for hydrogen generation.
基金supported by the National Natural Science Foundation of China(no.21403099)the Natural Science Foundation of Gansu Province(no.145RJZA193)fund of the State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals,Lanzhou University of Technology(no.SKLAB02014005)
文摘Co-P precursor was prepared by a mechanical alloying method and then is controlled to synthesis of CoP phase through an annealing method. The optimal conditions of ball milling and annealing temperature are investigated. The CoP exhibits higher electrical conductivity than graphite and cobalt oxide, showing excellent pseudocapacitive properties due its high electrical conductivity which can result in a fast electron transfer in high rate charge-discharge possess. The as-obtained CoP electrode achieves a high specific capacitance of 447.5 Fig at 1 Aug, and displays an excellent rate capability as well as good cycling stability. Besides, the asymmetric supercapacitor (ASC) based on the CoP as the positive electrode and activated carbon (AC) as the negative electrode was assembled and displayed a high rate capability (60% of the capacitance is retained when the current density increased from 1 Aug to 12 Aug), excellent cycling stability (96.7% of the initial capacitance is retained after 5000 cycles), and a superior specific energy of 19 Wh/kg at a power density of 350.8 W/kg. The results, suggest that the CoP electrode materials have a great potential for developing high-performance electrochemical energy storage devices. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.
基金Acknowledgements The work was supported by National Natural Science Foundation of China under grant 50775037 and 51075071.
文摘Efficient walking is one of the main goals of researches on biped robots. A feasible way is to translate the understanding from human walking into robot walking, for example, an artificial control approach on a human like walking structure. In this paper, a walking pattern based on Center of Pressure （COP） switched and modeled after human walking is introduced firstly. Then, a parameterization method for the proposed walking gait is presented. In view of the complication, a multi-space planning method which divides the whole planning task into three sub-spaces, including simplified model space, work space and joint space, is proposed. Furthermore, a finite-state-based control method is also developed to implement the proposed walking pattern. The state switches of this method are driven by sensor events. For convincing verification, a 2D simulation system with a 9-1ink planar biped robot is developed. The simulation results exhibit an efficient walking gait.
