To the Editor： A 65-year-old woman with calcinosis, Raynaud＆#39;s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia （CREST） syndrome was admitted to hospital because of progressive dyspnea on e...To the Editor： A 65-year-old woman with calcinosis, Raynaud＆#39;s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia （CREST） syndrome was admitted to hospital because of progressive dyspnea on exertion for about 1 year. In the past, she had been diagnosed as gastroesophageal reflux disease and scleroderma for 10 years. Physical examination showed masked face, Raynaud＇s phenomenon, finger sclerodactyly, and skin telangiectasia on her neck and back [Figure 1a and 1b]. The titer of anticentromere antibody in serum increased to 1： 1000. Analysis of arterial gas on room air revealed the partial pressure of arterial oxygen （PaO2） was 54 mmHg （1 mmHg = 0.133 kPa） and carbon dioxide （PaCO2） was 32 mmHg. Echocardiogram showed severe tricuspid regurgitation and elevated pulmonary arterial pressure of 78 mmHg.展开更多
文摘To the Editor： A 65-year-old woman with calcinosis, Raynaud＆#39;s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia （CREST） syndrome was admitted to hospital because of progressive dyspnea on exertion for about 1 year. In the past, she had been diagnosed as gastroesophageal reflux disease and scleroderma for 10 years. Physical examination showed masked face, Raynaud＇s phenomenon, finger sclerodactyly, and skin telangiectasia on her neck and back [Figure 1a and 1b]. The titer of anticentromere antibody in serum increased to 1： 1000. Analysis of arterial gas on room air revealed the partial pressure of arterial oxygen （PaO2） was 54 mmHg （1 mmHg = 0.133 kPa） and carbon dioxide （PaCO2） was 32 mmHg. Echocardiogram showed severe tricuspid regurgitation and elevated pulmonary arterial pressure of 78 mmHg.
