Phase II Clinical Study of Three-Dimensional Printed Coplanar Template Combined with CT-Guided Percutaneous Core Needle Biopsy of Pulmonary Nodules in Elderly Patients

Background: As the population age structure gradually ages, more and more elderly people were found to have pulmonary nodules during physical examinations. Most elderly people had underlying diseases such as heart, lung, brain and blood vessels and cannot tolerate surgery. Computed tomography (CT)-guided percutaneous core needle biopsy (CNB) was the first choice for pathological diagnosis and subsequent targeted drugs, immune drugs or ablation treatment. CT-guided percutaneous CNB requires clinicians with rich CNB experience to ensure high CNB accuracy, but it was easy to cause complications such as pneumothorax and hemorrhage. Three-dimensional (3D) printing coplanar template (PCT) combined with CT-guided percutaneous pulmonary CNB biopsy has been used in clinical practice, but there was no prospective, randomized controlled study. Methods: Elderly patients with lung nodules admitted to the Department of Oncology of our hospital from January 2019 to January 2023 were selected. A total of 225 elderly patients were screened, and 30 patients were included after screening. They were randomly divided into experimental group (Group A: 30 cases) and control group (Group B: 30 cases). Group A was given 3D-PCT combined with CT-guided percutaneous pulmonary CNB biopsy, Group B underwent CT-guided percutaneous pulmonary CNB. The primary outcome measure of this study was the accuracy of diagnostic CNB, and the secondary outcome measures were CNB time, number of CNB needles, number of pathological tissues and complications. Results: The diagnostic accuracy of group A and group B was 96.67% and 76.67%, respectively (P = 0.026). There were statistical differences between group A and group B in average CNB time (P = 0.001), number of CNB (1 vs more than 1, P = 0.029), and pathological tissue obtained by CNB (3 vs 1, P = 0.040). There was no statistical difference in the incidence of pneumothorax and hemorrhage between the two groups (P > 0.05). Conclusions: 3D-PCT combined with CT-guided percutaneous CNB can improve the puncture accuracy of elderly patients, shorten the puncture time, reduce the number of punctures, and increase the amount of puncture pathological tissue, without increasing pneumothorax and hemorrhage complications. We look forward to verifying this in a phase III randomized controlled clinical study. .

Multi-objective strategy to optimize dithering technique for high-quality three-dimensional shape measurement

Dithering optimization techniques can be divided into the phase-optimized technique and the intensity-optimized technique. The problem with the former is the poor sensitivity to various defocusing amounts, and the problem with the latter is that it cannot enhance phase quality directly nor efficiently. In this paper, we present a multi-objective optimization framework for three-dimensional(3D) measurement by utilizing binary defocusing technique. Moreover, a binary patch optimization technique is used to solve the time-consuming issue of genetic algorithm. It is demonstrated that the presented technique consistently obtains significant phase performance improvement under various defocusing amounts.

Evaluating the contribution of satellite measurements to the reconstruction of three-dimensional ocean temperature fields in combination with Argo profiles

Assimilation systems absorb both satellite measurements and Argo observations.This assimilation is essential to diagnose and evaluate the contribution from each type of data to the reconstructed analysis,allowing for better configuration of assimilation parameters.To achieve this,two comparative reconstruction schemes were designed under the optimal interpolation framework.Using a static scheme,an in situ-only field of ocean temperature was derived by correcting climatology with only Argo profiles.Through a dynamic scheme,a synthetic field was first derived from only satellite sea surface height and sea surface temperature measurements through vertical projection,and then a combined field was reconstructed by correcting the synthetic field with in situ profiles.For both schemes,a diagnostic iterative method was performed to optimize the background and observation error covariance statics.The root mean square difference(RMSD)of the in situ-only field,synthetic field and combined field were analyzed toward assimilated observations and independent observations,respectively.The rationale behind the distribution of RMSD was discussed using the following diagnostics:(1)The synthetic field has a smaller RMSD within the global mixed layer and extratropical deep waters,as in the Northwest Pacific Ocean;this is controlled by the explained variance of the vertical surface-underwater regression that reflects the ocean upper mixing and interior baroclinicity.(2)The in situ-only field has a smaller RMSD in the tropical upper layer and at midlatitudes;this is determined by the actual noise-to-signal ratio of ocean temperature.(3)The satellite observations make a more significant contribution to the analysis toward independent observations in the extratropics;this is determined by both the geographical feature of the synthetic field RMSD(smaller at depth in the extratropics)and that of the covariance correlation scales(smaller in the extratropics).

Three-Dimensional Measurement and Reconstruction of Fabric Drape Shape

This paper introduces a new method of measuring the three-dimensional drape shape of fabrics with structural light. First, we apply parallel annular structural light to form light and shade alternating contour stripes on the surface of fabrics. We then collect the images of contour stripes using Charge Coupled Device (CCD). Subsequently, we process the images to identify the contour stripes and edges of fabrics, and obtain the fabric contour lines of curved surfaces. Finally, we apply three-dimensional curved surface modeling method based on a network of polar coordinates, and reconstruct the three-dimensional drape shape of fabrics. Experiments show that our method is effective in testing and reconstructing three-dimensional drape shape of fabrics.

A method for phase reconstruction in optical three-dimensional shape measurement

In optical three-dimensional shape measurement, a method of improving the measurement precision for phase reconstruction without phase unwrapping is analyzed in detail. Intensities of any five consecutive pixels that lie in the x-axis direction of the phase domain are given. Partial derivatives of the phase function in the x- and y-axis directions are obtained with a phase-shifting mechanism, the origin of which is analysed. Furthermore, to avoid phase unwrapping in the phase reconstruction, we derive the gradient of the phase function and perform a two-dimensional integral along the x- and y-axis directions. The reconstructed phase can be obtained directly by performing numerical integration, and thus it is of great convenience for phase reconstruction. Finally, the results of numerical simulations and practical experiments verify the correctness of the proposed method.

Digital measurement of bone tumor volume by CT three-dimensional reconstruction technology

Objective To discuss the measurement of bone tumor volume on the basis of three dimensional images segmentation technology. Methods Twenty patients with lacunar bone tumor from Tianjin Hospital and Tongji Hospital were included in the

Development of a toroidal soft x-ray imaging system and application for investigating three-dimensional plasma on J-TEXT

A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.

Volumetric measurement techniques for assessment of cutaneous neurofibromas:A review

Cutaneous neurofibroma(cNF)is a prevalent clinical manifestation of neurofibromatosis type 1,significantly affecting the well-being and quality of life of the affected individuals.The adoption of reliable and reproducible volumetric measurement techniques is essential for precisely evaluating tumor burden and plays a critical role in the development of effective treatments for cNF.This study focuses on widely used volumetric measurement techniques,including vernier calipers,ultrasound,computed tomography,magnetic resonance imaging,and three-dimensional scanning imaging.It outlines the merits and drawbacks of each technique in assessing the cNF load,providing an overview of their current applications and ongoing research advancements in this domain.

Diameters and form of skull base foramen ovale measured by three-dimensional spiral CT thin-slice scan in healthy adults

BACKGROUND： The accurate measurements of various data of the bone diameters of foramen ovale of living person can change the methods of puncturing trigeminal gasserian ganglion via foramen ovale for treating trifacial neuralgia from the experience of puncture operator only to puncture by taking the objective data of measurement as the evidence, which is good for improving the accuracy of puncturing trigeminal ganglion and reducing side effects. OBJECTIVE ： To observe the forms of foramen ovales in healthy adults displayed by volume rendering and multi-planar reconstruction after three-dimensional spiral CT thin-slice scan of skull base, and measure the longitudinal diameter and transverse diameter. DESIGN ： A repetitive observation and measurement SETTINGS ： Department of Neurosurgery and Department of Medical Imaging, Foshan Hospital of Traditional Chinese Medicine. PARTICIPANTS： Fifty healthy adults （100 sides）, who were examined with three-dimensional spiral CT scan, were randomly selected from the Department of Medical Imaging, Foshan Hospital of Traditional Chinese Medicine from January 2005 to January 2006, including 26 males and 24 females, aged 25-68 years with an average of 48 years old. They were all informed and agreed with the examination. METHODS ： The subjects were examined with the Philips 16-slice spiral CT-Mx 8000 IDT CT apparatus （Philips Company, Holland）, the scanning ranged from 2 cm below the canthomeatal line to the level of suprasellar cistem. The width of collimator was 0.75 mm, pitch was 0.663; tube current was 350 mA, voltage was 120 kV, resolution was 512×512 matrix; slice thickness of reconstruction was 1 mm, and interval was 0.5 mm. After the three-dimensional spiral CT thin-slice scan of skull base, the image post-processing techniques including volume rendering and multi-planar reconstruction were applied to observe the forms of foramen ovales, and measure the size, longitudinal diameter and transverse diameter of the foramen ovales. The figures of the foramen ovales were drawn with mouse along the boundary of bone porous margin and soft tissue. According to the indications, the diameters were measured with computer to observe the forms of foramen ovales. MAIN OUTCOME MEASURES ： The longitudinal diameter, transverse diameter and form of foramen ovales were observed. RESULTS： All the 50 healthy adults （100 sides） were involved in the analysis of results. （1） It was observed in the volume rendering images that foramen ovales had four forms of oval shape （77 sides）, kidney shape （12 sides）, round shape （7 sides）, ribbon shape （4 sides）. （2） The longitudinal diameters of left and right foramen ovales were （7.67±1.32） and （7.98±1.45） mm, and the transverse diameters were （4.04±0.83）, （4.09±1.07） mm; There was no obvious difference between left and right longitudinal diameters （t = 1.63, P = 0.11 ）, and left and right transverse diameters were close （t = 0.45, P= 0.65）. CONCLUSION ： The non-invasive techniques of volume rendering and multi-planar reconstruction after three-dimensional spiral CT thin-slice scan can clearly display the formand size of foramen ovale in healthy adults.

A fast and precise three-dimensional measurement system based on multiple parallel line lasers

This paper conducts a trade-off between efficiency and accuracy of three-dimensional(3 D)shape measurement based on the triangulation principle,and introduces a flying and precise 3 D shape measurement method based on multiple parallel line lasers.Firstly,we establish the measurement model of the multiple parallel line lasers system,and introduce the concept that multiple base planes can help to deduce the unified formula of the measurement system and are used in simplifying the process of the calibration.Then,the constraint of the line spatial frequency,which maximizes the measurement efficiency while ensuring accuracy,is determined according to the height distribution of the object.Secondly,the simulation analyzing the variation of the systemic resolution quantitatively under the circumstance of a set of specific parameters is performed,which provides a fundamental thesis for option of the four system parameters.Thirdly,for the application of the precision measurement in the industrial field,additional profiles are acquired to improve the lateral resolution by applying a motor to scan the 3 D surface.Finally,compared with the line laser,the experimental study shows that the present method of obtaining 41220 points per frame improves the measurement efficiency.Furthermore,the accuracy and the process of the calibration are advanced in comparison with the existing multiple-line laser and the structured light makes an accuracy better than 0.22 mm at a distance of 956.02 mm.

Three-Dimensional Velocity Distribution Measurement Using Ultrasonic Velocity Profiler with Developed Transducer

This study describes an ultrasonic velocity profiler that uses a new ultrasonic array transducer with unique 5-element configuration, with all five elements acting as transmitters and four elements as receivers. The receivers are designed to reduce the amount of uncertainty. As the fluid moves through this setup, four Doppler frequencies are obtained. The multi-dimensional velocity information along the measurement line can be reconstructed. The transducer has a compact geometry suitable for a wide range of applications, including narrow flow areas. The transducer’s basic frequency and sound pressure are selected and evaluated to be compatible with the application. First, to confirm the measurement ability, the measurement of the developed system in two-dimensional flow is validated by comparing it to the theoretical data. The uncertainty of measurement was within 15%. Second, the three-dimensional measurement in turbulent and swirling flow is proved experimentally to check the applicability of the proposed technique.

Three-dimensional Imaging of Multi-slice Spiral CT in Bronchial Artery Correlative Study on Blood Supply of Central Lung Cancer and Its Clinical Significance

Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention therapy. Methods: Eighteen patients with central lungcancer underwent MSCT with real time helical thin-slice CT scanning. Three-dimensional bronchialartery reconstruction was done at the console work-station. The space anatomical characters ofbronchial artery were observed through different rotations. Results: For 6 cases, thethree-dimensional images of bronchial artery (33.33%) could exactly show the origins, the routes(lung inner segment and mediatism segment) and the diameters of bronchial arteries. Vision rate ofbronchial arteries was the highest in pulmonary artery stricture and truncation groups, and thevessels' diameter became larger apparently. These characters demonstrated blood supply of this kindof central lung cancer come from bronchial artery. Volume rendering images were the best ones amongthree-dimensional images. Conclusion: Three-dimensional imaging with MSCT in bronchial artery canreveal the anatomical characters of bronchial artery and provide theoretical evidence on bloodsupply and intervention therapy of central lung cancer.

炸药模拟裂纹宽度的CT检测与测量分析

炸药作为武器系统的核心部件,其内部结构质量直接关系到武器系统的可靠性,目前CT技术已被用于炸药试件的内部质量检测与评价研究,特别用于炸药试件内部裂纹的定性与定量分析中。然而选择不同的检测工艺参数会造成CT图像质量的变化,直接影响到后续定量表征的精度。通过在炸药试件表面加工不同宽度的标准尺寸线槽,再将其与相同规格的炸药试件对粘,以实现在炸药试件内部预制标准尺寸裂纹的目的。然后,改变检测参数与工艺条件,得到不同检测参数对试件裂纹宽度测量精度的影响规律,分析讨论了CT测量炸药试件(如尺寸小于10 mm的始发药等)裂纹宽度的最佳检测工艺条件。

增材制造小缺陷的显微CT检测

通过高精度金属增材制造技术设计制造了两组不同类型的缺陷试件,并基于显微CT检测技术和缺陷解剖金相检测方式,研究显微CT对增材制造小缺陷的实际检测能力。试验结果表明,显微CT在体素尺寸5μm下能有效检出尺寸为20μm的人工缺陷;金相检测与CT检测结果基本一致,缺陷尺寸测量差小于10μm;由于部分体积效应的影响,更小尺寸缺陷的尺寸测量结果误差更大。

A comparison of summer precipitation structures over the South China Sea and the East China Sea based on tropical rainfall measurement mission

The three-dimensional structures of summer precipitation over the South China Sea （SCS） and the East China Sea （ECS） are investigated based on tropical rainfall measurement mission （TRMM）. The primary results are as follows. First, both the convective and stratiform precipitation rates in the SCS are much higher than those of the ECS. The contribution of the convective cloud precipitation to the surface precipitation is primarily over the SCS and the ECS with a proportion of about 70%, but the contribution of convective cloud precipitation is slightly larger in the SCS than the ECS. The contribution of stratus precipitation is slightly larger in the ECS than that in the SCS. Second, the content of cloud particles and precipitation particles in the ECS in June was greater than that in the SCS, while in July and August, the content of cloud and precipitation particles in the ECS was less than that in the SCS. Third, the latent heat profile of the ECS is quite different from that of the SCS. In June, the peak values of evaporation and condensation latent heating rates in the ECS are greater than those in the SCS. In July and August, however, the peak values of evaporation and condensation latent heating rates in the ECS are about 0.05°/h less than those in the SCS.

Three-Dimensional Analytical Modeling of Axial-Flux Permanent Magnet Drivers

In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.

Development of a Three-Dimensional Measuring System for Neonates' Head and Facial Morphology

A web camera based multi-camera convergent close-range photogrammetric system is developed to obtain the neonates＇ head and facial morphology. The data will then be used to develop a secure and good-fitting eye-patch protector for neonates, particularly whoa they are exposed to bright lights such as phototherapy light. Measurements obtained by the system are evaluated and validated against data obtained from optical scanning. Results show that the photogrammetric system meets the requirements of measuring accuracy and safety for neonate in the neonatal units.

Multi-Schlieren CT Measurements of Supersonic Microjets from Circular and Square Micro Nozzles

Instantaneous three-dimensional (3D) density distributions of a shock-cell structure of perfectly and imperfectly expanded supersonic microjets escaping into an ambient space are measured. For the 3D observation of supersonic microjets, non-scanning 3D computerized tomography (CT) technique using a 20-directional quantitative schlieren optical system with flashlight source is employed for simultaneous schlieren photography. The 3D density distributions data of the microjets are obtained by 3D-CT reconstruction of the projection’s images using maximum likelihood-expectation maximization. Axisymmetric convergent-divergent (Laval) circular and square micro nozzles with operating nozzle pressure ratio 5.0, 4.5, 4.0, 3.67, and 3.5 have been studied. This study examines perfectly expanded, overexpanded, and underexpanded supersonic microjets issued from micro nozzles with fully expanded jet Mach numbers Mj ranging from 1.47 - 1.71, where the design Mach number is Md = 1.5. A complex phenomenon for free square microjets called axis switching is clearly observed with two types “upright” and “diagonal” of “cross-shaped”. The initial axis-switching is 45° within the first shock-cell range. In addition, from the symmetry and diagonal views of square microjets for the first shock-cells, two different patterns of shock waves are viewed. The shock-cell spacing and supersonic core length for all nozzle pressure ratios are investigated and reported.

EXPERIMENTAL INVESTIGATION FOR THE EFFECT OF ROTATION ON THREE-DIMENSIONAL FLOW FIELD IN FILM-COOLED TURBINE

An experimental investigation of three-dimensional flow field in a film-cooled turbine model is carried out by using particle image velocimeter （PIV） in a low-speed wind tunnel. The effects of different blowing ratios （M=1.5, 2） on the flow field are studied. The experimental results reveal the classical phenomena of the formation of kidney vortex pair and secondary flow in wake region behind the jet hole. And the changes of the kidney vortex pair and the wake at different locations away from the hole on the suction and pressure sides are also studied. Compared with the flow field in stationary cascade, there are centrifugal force and Coriolis force existing in the flow field of rotating turbine, and these forces bring the radial velocity in the jet flow. The effect of rotatien on the flow field of the pressure side is more distinct than that on the suction side from the measured flow fields in Y-Z plane and radial velocity contours. The increase of blowing ratio makes the kidney vortex pair and the secondary flow in the wake region stronger and makes the range of the wake region enlarged.

弥散燃料芯块中核芯颗粒位置信息的CT检测方法

在弥散燃料芯块中,核芯颗粒随机分布在其非金属材料处。采用表征核芯颗粒位置信息的方法评估产品工艺质量,具有重要意义。采用三维CT图像法,通过VG软件拟合芯块的外轮廓,以此来获得芯块的三维坐标,并将核芯颗粒视为夹杂,从而在获得每个核芯颗粒中心坐标的基础上,自动计算出其与相邻核芯颗粒的间距;然后采用微焦CT对弥散燃料芯块进行检测和处理,并采用统计热图方式,直观表征燃料芯块中核芯颗粒的分布均匀性;最后进行了实际燃料芯块相邻核芯颗粒间距的自动测量,验证了该方法的可行性,为进一步开展核芯颗粒分布状况的表征工作奠定了基础。