Does Caffeine Citrate Administration Decrease Risk of Acute Kidney Injury in Hospitalized Preterm Neonates?

Background: Acute kidney injury (AKI) is a life threatening condition with still high mortality rate in neonates. Early recognition of the risk factors and the rapid effective treatment of the contributing conditions will reduce AKI in the neonatal period. Aim of the Work: To determine association between early caffeine citrate administration and risk of acute kidney injury in hospitalized preterm neonates. Patients and Methods: This study was a prospective study that was conducted at the NICU of El Galaa Teaching Hospital. This study included 100 preterm neonates who were born alive from 32 weeks to 35 weeks of gestation. Results: There was highly statistically significant occurrence of apneaic episode in preterm babies who don’t receive caffeine citrate and consequently decreased incidence of AKI in those babies. Conclusion: We concluded that caffeine citrate administration in preterm babies is associated with reduced incidence of apneaic episode and consequently reduced risk of AKI.