Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)constitute the main subtypes of primary liver cancers(PLCs)as a major cause of cancer-related mortality and incidence.They emerge from varying quan...Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)constitute the main subtypes of primary liver cancers(PLCs)as a major cause of cancer-related mortality and incidence.They emerge from varying quantities and levels of differentiation among major liver cells,comprising hepatocytes,mucin-or non-mucin-producing cholangiocytes,and hepatic progenitor cells(HPCs)with the capability to differentiate into either hepatocytes or cholangiocytes.展开更多
The study of the relationship between trace element and health and disease has attracted more and more interests of scientists. As well known there exist complex interaction between the trace elements, and the trace e...The study of the relationship between trace element and health and disease has attracted more and more interests of scientists. As well known there exist complex interaction between the trace elements, and the trace elements and other substances, so the trace element research must be involved to the com-prehensive effect of multifactors, other than single element. We determined the contents of fifteen trace elements in serum from thirty patients with liver cancer and thirty healthy adults by ICP-AES analysis. The obtained data were analysed statistically by not only routine statistical test bat also multi-variate discrimination analysis, multi-variate stepwise regression and non-linear mapping algorithm. It is hoped that it can provide some valuable informations for investigation on relationship betwecn trace elements and cancer.展开更多
Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include...Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include differences in the spectrum of cancer types, in early detection rates, and in the percentage of cancer patients receiving standardized treatment between China and developed countries.The most important mechanism for improving the curative rate is to improve early detection rates of major cancers in China using novel and affordable technologies that can be operated at home by the patients themselves.This attempt could be helpful in setting up a practical example for other developing countries with limited medical resources and a limited number of healthcare practitioners.展开更多
2023年,《2005—2020年中国国家和分省肿瘤负担趋势:国家死亡监测点数据分析》发布,该文数据覆盖全国31个省市人群的23个特定部位肿瘤的死亡率和人均减寿年数。分析提示,2020年,我国因肿瘤死亡人数为239.78万,死亡率为170.80/10万;各肿...2023年,《2005—2020年中国国家和分省肿瘤负担趋势:国家死亡监测点数据分析》发布,该文数据覆盖全国31个省市人群的23个特定部位肿瘤的死亡率和人均减寿年数。分析提示,2020年,我国因肿瘤死亡人数为239.78万,死亡率为170.80/10万;各肿瘤的死亡人数顺位前10位为肺癌(76.1万)、肝癌(36.77万)、胃癌(29.12万)、结直肠癌(18.24万)、食管癌(17.33万)、胰腺癌(10.04万)、乳腺癌(5.71万)、白血病(5.49万)、脑神经癌(5.42万)、子宫颈癌(4.48万),分别占因肿瘤死亡人数的百分比为32.0%、15.3%、12.1%、7.6%、7.2%、4.2%、2.4%、2.3%、2.3%、1.9%;死亡率分别为54.57/10万、26.19/10万、20.74/10万、13.00/10万、12.34/10万、7.15/10万、4.06/10万、3.91/10万、3.86/10万和3.19/10万。2020年,我国因肿瘤人均减寿年数(average years of life lost,AYLL)为23.60年,比2005年下降了3.74年,其中白血病导致的AYLL为37.35年,较2005年因白血病所致的AYLL 50.71年,降低了13.36年,但仍是导致寿命损失最多的肿瘤,前列腺癌为导致AYLL最少的肿瘤。我国肿瘤谱的构成出现正在向发达国家转变的可能。在发达国家高发的肺癌、乳腺癌和结直肠癌,在中国呈现疾病负担增加趋势。2020年肺癌、乳腺癌和结直肠癌的死亡率在该阶段都上升,较2005年分别上升78.98%,19.41%和47.56%。GLOBOCAN2022提示,2020年我国各肿瘤发病率顺位前10位的为肺癌(40.8/10万)、乳腺癌(33.0/10万)、甲状腺癌(24.6/10万)、肝癌(20.1/10万)、子宫颈癌(15.0/10万)、胃癌(13.8/10万)、前列腺癌(13.7/10万)、食管癌(9.7/10万)、子宫癌(8.7/10万)和卵巢癌(6.8/10万)。中国和美国发病率前10位中有5个癌种重合,其中导致死亡人数首位的均为肺癌。肿瘤疾病谱的改变,让已经获得证实的肿瘤预防和控制措施的推广实施显得更为紧迫。展开更多
目的探究正电子发射计算机体层摄影术(PET)/CT联合胸部能谱CT对肺癌及其分型的诊断价值。方法选择2022年7月至2023年8月在皖北煤电集团总医院收治的疑似肺癌患者70例,其中男性55例,女性15例;年龄37~85岁,平均年龄66.34岁;经病理诊断肺...目的探究正电子发射计算机体层摄影术(PET)/CT联合胸部能谱CT对肺癌及其分型的诊断价值。方法选择2022年7月至2023年8月在皖北煤电集团总医院收治的疑似肺癌患者70例,其中男性55例,女性15例;年龄37~85岁,平均年龄66.34岁;经病理诊断肺癌60例,存在淋巴结转移或远处转移19例,无淋巴结转移或远处转移41例。全部病例均接受PET/CT、能谱CT检查,对比两种检查方式单独及联合对肺癌的诊断效能,对比不同肺癌分型的PET/CT、能谱CT检查特征参数,分析两种检查中各参数单独及联合对腺癌、鳞癌的诊断价值。结果经病理诊断10例非肺癌,60例肺癌,其中非小细胞肺癌54例(腺癌31例、鳞癌21例、鳞腺癌2例)、小细胞肺癌6例。PET/CT检查诊断54例肺癌,16例非肺癌;能谱CT诊断51例肺癌,19例非肺癌。PET/CT+能谱CT诊断出62例肺癌,8例非肺癌。PET/CT+能谱CT诊断肺癌的灵敏度、准确度及阴性预测值高于二者单独诊断,漏诊率低于二者单独诊断(P<0.05)。不同肺癌分型PET/CT检查的最大标准化摄取值(SUVmax)差异明显,非小细胞肺癌PET/CT检查的SUVmax比较,腺癌>鳞癌>鳞腺癌(21.61±1.52>13.60±1.39>6.65±1.27)(P<0.05);小细胞肺癌与非小细胞肺癌SUVmax(14.17±1.82 vs 17.94±1.65)比较,差异有显著统计学意义(P<0.001);不同非小细胞肺癌分型能谱CT检查的有效原子系数、钙含量、碘基值、斜率K比较,差异有统计学意义(P<0.05);小细胞肺癌有效原子系数、钙含量、碘基值、斜率K[7.91±0.08、(6.89±1.68)mg/mL、(11.43±0.79)g/L、2.23±0.24]与非小细胞肺癌比较[7.77±0.12、(3.73±1.36)mg/mL、(7.02±1.18)g/L、1.69±0.30],差异有统计学意义(P<0.05);PET/CT、能谱CT检查各参数联合诊断腺癌、鳞癌的曲线下面积分别为0.923、0.939(P<0.05)。结论PET/CT、胸部能谱CT联合应用可提高对肺癌的诊断效能,且PET/CT、能谱CT检查各参数对不同肺癌分型的有较高诊断价值。展开更多
文摘Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)constitute the main subtypes of primary liver cancers(PLCs)as a major cause of cancer-related mortality and incidence.They emerge from varying quantities and levels of differentiation among major liver cells,comprising hepatocytes,mucin-or non-mucin-producing cholangiocytes,and hepatic progenitor cells(HPCs)with the capability to differentiate into either hepatocytes or cholangiocytes.
文摘The study of the relationship between trace element and health and disease has attracted more and more interests of scientists. As well known there exist complex interaction between the trace elements, and the trace elements and other substances, so the trace element research must be involved to the com-prehensive effect of multifactors, other than single element. We determined the contents of fifteen trace elements in serum from thirty patients with liver cancer and thirty healthy adults by ICP-AES analysis. The obtained data were analysed statistically by not only routine statistical test bat also multi-variate discrimination analysis, multi-variate stepwise regression and non-linear mapping algorithm. It is hoped that it can provide some valuable informations for investigation on relationship betwecn trace elements and cancer.
基金supported by grants from the National Natural Science Foundation of China(No.81472386,No.81672872)the National High Technology Research and Development Program of China(863 Program)(No.2012AA02A501)+1 种基金the Science and Technology Planning Project of Guangdong Province,China(No.2014B020212017,No.20148050504004 and No.2015B050501005)the Provincial Natural Science Foundation of Guangdong,China(No.2016A030311011)
文摘Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include differences in the spectrum of cancer types, in early detection rates, and in the percentage of cancer patients receiving standardized treatment between China and developed countries.The most important mechanism for improving the curative rate is to improve early detection rates of major cancers in China using novel and affordable technologies that can be operated at home by the patients themselves.This attempt could be helpful in setting up a practical example for other developing countries with limited medical resources and a limited number of healthcare practitioners.
文摘2023年,《2005—2020年中国国家和分省肿瘤负担趋势:国家死亡监测点数据分析》发布,该文数据覆盖全国31个省市人群的23个特定部位肿瘤的死亡率和人均减寿年数。分析提示,2020年,我国因肿瘤死亡人数为239.78万,死亡率为170.80/10万;各肿瘤的死亡人数顺位前10位为肺癌(76.1万)、肝癌(36.77万)、胃癌(29.12万)、结直肠癌(18.24万)、食管癌(17.33万)、胰腺癌(10.04万)、乳腺癌(5.71万)、白血病(5.49万)、脑神经癌(5.42万)、子宫颈癌(4.48万),分别占因肿瘤死亡人数的百分比为32.0%、15.3%、12.1%、7.6%、7.2%、4.2%、2.4%、2.3%、2.3%、1.9%;死亡率分别为54.57/10万、26.19/10万、20.74/10万、13.00/10万、12.34/10万、7.15/10万、4.06/10万、3.91/10万、3.86/10万和3.19/10万。2020年,我国因肿瘤人均减寿年数(average years of life lost,AYLL)为23.60年,比2005年下降了3.74年,其中白血病导致的AYLL为37.35年,较2005年因白血病所致的AYLL 50.71年,降低了13.36年,但仍是导致寿命损失最多的肿瘤,前列腺癌为导致AYLL最少的肿瘤。我国肿瘤谱的构成出现正在向发达国家转变的可能。在发达国家高发的肺癌、乳腺癌和结直肠癌,在中国呈现疾病负担增加趋势。2020年肺癌、乳腺癌和结直肠癌的死亡率在该阶段都上升,较2005年分别上升78.98%,19.41%和47.56%。GLOBOCAN2022提示,2020年我国各肿瘤发病率顺位前10位的为肺癌(40.8/10万)、乳腺癌(33.0/10万)、甲状腺癌(24.6/10万)、肝癌(20.1/10万)、子宫颈癌(15.0/10万)、胃癌(13.8/10万)、前列腺癌(13.7/10万)、食管癌(9.7/10万)、子宫癌(8.7/10万)和卵巢癌(6.8/10万)。中国和美国发病率前10位中有5个癌种重合,其中导致死亡人数首位的均为肺癌。肿瘤疾病谱的改变,让已经获得证实的肿瘤预防和控制措施的推广实施显得更为紧迫。
文摘目的探究正电子发射计算机体层摄影术(PET)/CT联合胸部能谱CT对肺癌及其分型的诊断价值。方法选择2022年7月至2023年8月在皖北煤电集团总医院收治的疑似肺癌患者70例,其中男性55例,女性15例;年龄37~85岁,平均年龄66.34岁;经病理诊断肺癌60例,存在淋巴结转移或远处转移19例,无淋巴结转移或远处转移41例。全部病例均接受PET/CT、能谱CT检查,对比两种检查方式单独及联合对肺癌的诊断效能,对比不同肺癌分型的PET/CT、能谱CT检查特征参数,分析两种检查中各参数单独及联合对腺癌、鳞癌的诊断价值。结果经病理诊断10例非肺癌,60例肺癌,其中非小细胞肺癌54例(腺癌31例、鳞癌21例、鳞腺癌2例)、小细胞肺癌6例。PET/CT检查诊断54例肺癌,16例非肺癌;能谱CT诊断51例肺癌,19例非肺癌。PET/CT+能谱CT诊断出62例肺癌,8例非肺癌。PET/CT+能谱CT诊断肺癌的灵敏度、准确度及阴性预测值高于二者单独诊断,漏诊率低于二者单独诊断(P<0.05)。不同肺癌分型PET/CT检查的最大标准化摄取值(SUVmax)差异明显,非小细胞肺癌PET/CT检查的SUVmax比较,腺癌>鳞癌>鳞腺癌(21.61±1.52>13.60±1.39>6.65±1.27)(P<0.05);小细胞肺癌与非小细胞肺癌SUVmax(14.17±1.82 vs 17.94±1.65)比较,差异有显著统计学意义(P<0.001);不同非小细胞肺癌分型能谱CT检查的有效原子系数、钙含量、碘基值、斜率K比较,差异有统计学意义(P<0.05);小细胞肺癌有效原子系数、钙含量、碘基值、斜率K[7.91±0.08、(6.89±1.68)mg/mL、(11.43±0.79)g/L、2.23±0.24]与非小细胞肺癌比较[7.77±0.12、(3.73±1.36)mg/mL、(7.02±1.18)g/L、1.69±0.30],差异有统计学意义(P<0.05);PET/CT、能谱CT检查各参数联合诊断腺癌、鳞癌的曲线下面积分别为0.923、0.939(P<0.05)。结论PET/CT、胸部能谱CT联合应用可提高对肺癌的诊断效能,且PET/CT、能谱CT检查各参数对不同肺癌分型的有较高诊断价值。
