Capillary leak syndrome(CLS)is a rare clinical syndrome associated with significant morbidity and mortality.Intensive care and supportive therapy constitute the mainstay of the treatment,along with judicious use of cr...Capillary leak syndrome(CLS)is a rare clinical syndrome associated with significant morbidity and mortality.Intensive care and supportive therapy constitute the mainstay of the treatment,along with judicious use of crystalloids and colloids such as dextran and starch during the leak phase.The advantages of proning,steroids,and intravenous immunoglobins are worth contemplating in patients with such a presentation.Extracorporeal membrane oxygenation appears to be an excellent strategy to surmount the impediments of the leak and post leak phase of CLS,especially in patients with severe or refractory hypoxemia.展开更多
Capillary leak syndrome(CLS) in critically ill patients is common,and the clinical manifestations of CLS include systemic edema,hypoproteinemia,effective circulating blood volume reduction and blood concentrated.The c...Capillary leak syndrome(CLS) in critically ill patients is common,and the clinical manifestations of CLS include systemic edema,hypoproteinemia,effective circulating blood volume reduction and blood concentrated.The common pathogenesy is sepsis,severe trauma,cardiopulmonary bypass and so on.CLS is divided into leakage period and recovery period usually.Clinical manifestation and treatment in different period are different in each pathophysiologic process.Although the methods of treatment are more,effective treatment measures are in shortage.More therapeutic measures are studied currently which include improvement of endothelial cell function,macromolecular colloidal solution application,continuous blood purification and so on.It is a guiding value to understand the pathological mechanism,clinical manifestations,diagnosis and treatment of the CLS.展开更多
文摘Capillary leak syndrome(CLS)is a rare clinical syndrome associated with significant morbidity and mortality.Intensive care and supportive therapy constitute the mainstay of the treatment,along with judicious use of crystalloids and colloids such as dextran and starch during the leak phase.The advantages of proning,steroids,and intravenous immunoglobins are worth contemplating in patients with such a presentation.Extracorporeal membrane oxygenation appears to be an excellent strategy to surmount the impediments of the leak and post leak phase of CLS,especially in patients with severe or refractory hypoxemia.
基金Medical Research to Anhui Provincial Health Bureau(09A012)
文摘Capillary leak syndrome(CLS) in critically ill patients is common,and the clinical manifestations of CLS include systemic edema,hypoproteinemia,effective circulating blood volume reduction and blood concentrated.The common pathogenesy is sepsis,severe trauma,cardiopulmonary bypass and so on.CLS is divided into leakage period and recovery period usually.Clinical manifestation and treatment in different period are different in each pathophysiologic process.Although the methods of treatment are more,effective treatment measures are in shortage.More therapeutic measures are studied currently which include improvement of endothelial cell function,macromolecular colloidal solution application,continuous blood purification and so on.It is a guiding value to understand the pathological mechanism,clinical manifestations,diagnosis and treatment of the CLS.
