Objective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were obs...Objective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT, 东宝肝泰)tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed. Results:The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizingthe ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologicfunctions. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition inliver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered(P < 0. of ) and the effect was better than those in the control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic function.Keywods: Zhiganle capsule; Phlegm--Dampness Stagnation; animal model of fatty liver展开更多
文摘Objective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT, 东宝肝泰)tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed. Results:The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizingthe ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologicfunctions. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition inliver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered(P < 0. of ) and the effect was better than those in the control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic function.Keywods: Zhiganle capsule; Phlegm--Dampness Stagnation; animal model of fatty liver
