Rolling stock manufacturers are finding structural solutions to reduce power required by the vehicles,and the lightweight design of the car body represents a possible solution.Optimization processes and innovative mat...Rolling stock manufacturers are finding structural solutions to reduce power required by the vehicles,and the lightweight design of the car body represents a possible solution.Optimization processes and innovative materials can be combined in order to achieve this goal.In this framework,we propose the redesign and optimization process of the car body roof for a light rail vehicle,introducing a sandwich structure.Bonded joint was used as a fastening system.The project was carried out on a single car of a modern tram platform.This preliminary numerical work was developed in two main steps:redesign of the car body structure and optimization of the innovated system.Objective of the process was the mass reduction of the whole metallic structure,while the constraint condition was imposed on the first frequency of vibration of the system.The effect of introducing a sandwich panel within the roof assembly was evaluated,focusing on the mechanical and dynamic performances of the whole car body.A mass saving of 63%on the optimized components was achieved,corresponding to a 7.6%if compared to the complete car body shell.In addition,a positive increasing of 17.7%on the first frequency of vibration was observed.Encouraging results have been achieved in terms of weight reduction and mechanical behaviour of the innovated car body.展开更多
Creating proper B-spline surface models is a very challenging task for designers in car-body surface design.Due to the tensor-product structure of B-spline surface,some undesirable issues of the redundant control poin...Creating proper B-spline surface models is a very challenging task for designers in car-body surface design.Due to the tensor-product structure of B-spline surface,some undesirable issues of the redundant control points addition,incomplete surface definition and the difficulty of trimming boundary alteration frequently occur,when designing the car-body surface with B-spline surfaces in local-feature-lines construction,full-boundary-merging and visual surface trimming.A more efficient approach is proposed to design the car-body surface by replacing B-spline surface with classical T-spline surface.With the local refinability and multilateral definition offered by Tspline surface,those designing issues related with B-spline surface can be overcomed.Finally,modeling examples of the door,hood and rear-window are given to demonstrate the advantage of T-spline surface over B-spline surface in car-body surface design.展开更多
为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0....为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0.13,压边力为350 k N,拉延筋阻力系数为35%。通过有限元模拟和生产实践验证,证明了该方法的可行的。展开更多
嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其...嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其脱靶效应(on-target off tumor effect);在治疗实体瘤中CAR-T细胞很难达到肿瘤部位,以改善免疫抑制微环境发挥作用;CAR-T细胞在清除肿瘤细胞的同时也会杀伤表达相同靶点的正常细胞;针对除B细胞肿瘤之外的血液肿瘤以及实体瘤而言,CAR-T细胞的有效性还有待提高。本文重点介绍如何通过CAR-T细胞结构的优化使得CAR-T细胞能够精准地识别肿瘤细胞,克服肿瘤的免疫抑制微环境来提高CAR-T细胞治疗恶性肿瘤的有效性;同时使得CAR-T细胞可以被更好地控制,使得CAR-T细胞的安全性更高。展开更多
This paper discusses the basic principle and design m ethod for light distribution of car lamp, introduces an important development: h igh efficient and flexible car lamp with reflecting light distribution-segmente d ...This paper discusses the basic principle and design m ethod for light distribution of car lamp, introduces an important development: h igh efficient and flexible car lamp with reflecting light distribution-segmente d reflector (multi-patch) car lamp, and puts out a design method for segmented reflector based on error analysis. Unlike classical car lamp with refractive lig ht distribution, the method of reflecting light distribution gives car lamp desi gn more flexibility. In the case of guarantying the lightness of car lamp and sa tisfying the standard demand for the light distribution, the design of the exter ior of the car lamp has more freedom. The high gradient of car lamp is more suit able for the demand of streamline of the car exterior. The shape of segmented re flector obtained by theory calculating of car lamp reflecting light distribution is only an ideal shape, which usually has considerable differences with the fin al shape and will influences light distribution. There exist difference between the calculated reflector and manufactured reflector. Owing to light reflecting c haracter, the small diversification of the reflector will reduce the big diver sification of the light distribution shape on light distribution screen in 25 -meter place, so light distribution quality can’t be ensured. To ensure the re flector by light distribution calculation accordance to reflector by practical m anufacture, the error effect of surface shape must be reasonably considered name ly the error effect of manufacture tache. The paper establishes error-analyzing model for segmented reflector according to the analysis of error of making proc ess for segmented reflector. Based on this error-analyzing model and by use of the analyzing software developed for segmented reflector light distribution, it could reasonably consider reflector errors made by manufacturing, such as reflec tor surface spray-painting and plating aluminum, which could give out shapes of reflector patches for segmented reflector well and truly, and direct the plan o f making process efficiently. The method put by the paper has successfully appli ed to develop segmented reflector lamp for several type cars and obtained good e ffect for the factory.展开更多
As people grow older, their cognitive functions undergo changes which may result in uncomfortable driving situations and even increase the risk of accidents. This research aims to understand the neuropsychological asp...As people grow older, their cognitive functions undergo changes which may result in uncomfortable driving situations and even increase the risk of accidents. This research aims to understand the neuropsychological aspects of healthy aging and their possible relationship <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> changes in motor performance or ability. The research methodology is descriptive and includes a collection of basic studies in the scope of neuroscience, driving tasks, and older driver behavior. The final analysis points to certain changes in the functioning of the cerebral cortex and its connections as being responsible for poor performance in some basic driving tasks, but which can be compensated for by means of adapted mechanisms in motor vehicles. This study may contribute as a methodological tool, to the automobile design process, for the selection of Advanced Driver Assistance Systems (ADAS) or other emerging technologies which can compensate cognitive changes, improve safety, comfort and inclusion of older drivers in the future of automobile interior design. We conclude that in normal aging, people may present some cognitive deficits especially linked to the frontal and parietal lobe, which interfere with the necessary driving skills albeit not with the dangerous ones and can be compensated by technological solutions. The main innovation of this article is related to the bibliographical compilation and critical analysis in terms of identifying the neuropsychological aspects of normal human aging and car driving and its relationship with possible contributions from vehicular technology, as well its consider future trends in automotive interior design that should be analysed with caution in order to users inclusion.</span></span></span>展开更多
The pedestrian protection technology must be used in automotive design if China-made automotives want to compete and grow strong in the world in the future. In this paper, a CAE simulation analysis is made for a domes...The pedestrian protection technology must be used in automotive design if China-made automotives want to compete and grow strong in the world in the future. In this paper, a CAE simulation analysis is made for a domestic sedan car hood to check whether it meet the pedestrian safety protection laws and regulations. Results show that the original car cannot meet the demands of the rules. In order to meet the standards of the pedustrian protection rules, the car hood should undergo structural improvements. Tested again by CAE simulation analysis, the car after a series of improved design can reached the 3-star class EuroNCAP( Euro New Car Assessment Program)standard of the car pedestrian safety protection laws and regulations.展开更多
Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid ...Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid tumors.Different from hematological cancers,solid tumors are characterized by dysregulated blood vessels,dense extracellular matrix,and filled with immunosuppressive signals,which together result in CAR-T cells’insufficient infiltration and rapid dysfunction.The insufficient recognition of tumor cells and tumor heterogeneity eventually causes cancer reoccurrences.In addition,CAR-T therapy also raises safety concerns,including potential cytokine release storm,on-target/off-tumor toxicities,and neuro-system side effects.Here we comprehensively review various targeting aspects,including CAR-T cell design,tumor modulation,and delivery strategy.We believe it is essential to rationally design a combinatory CAR-T therapy via constructing optimized CAR-T cells,directly manipulating tumor tissue microenvironments,and selecting the most suitable delivery strategy to achieve the optimal outcome in both safety and efficacy.展开更多
文摘Rolling stock manufacturers are finding structural solutions to reduce power required by the vehicles,and the lightweight design of the car body represents a possible solution.Optimization processes and innovative materials can be combined in order to achieve this goal.In this framework,we propose the redesign and optimization process of the car body roof for a light rail vehicle,introducing a sandwich structure.Bonded joint was used as a fastening system.The project was carried out on a single car of a modern tram platform.This preliminary numerical work was developed in two main steps:redesign of the car body structure and optimization of the innovated system.Objective of the process was the mass reduction of the whole metallic structure,while the constraint condition was imposed on the first frequency of vibration of the system.The effect of introducing a sandwich panel within the roof assembly was evaluated,focusing on the mechanical and dynamic performances of the whole car body.A mass saving of 63%on the optimized components was achieved,corresponding to a 7.6%if compared to the complete car body shell.In addition,a positive increasing of 17.7%on the first frequency of vibration was observed.Encouraging results have been achieved in terms of weight reduction and mechanical behaviour of the innovated car body.
文摘Creating proper B-spline surface models is a very challenging task for designers in car-body surface design.Due to the tensor-product structure of B-spline surface,some undesirable issues of the redundant control points addition,incomplete surface definition and the difficulty of trimming boundary alteration frequently occur,when designing the car-body surface with B-spline surfaces in local-feature-lines construction,full-boundary-merging and visual surface trimming.A more efficient approach is proposed to design the car-body surface by replacing B-spline surface with classical T-spline surface.With the local refinability and multilateral definition offered by Tspline surface,those designing issues related with B-spline surface can be overcomed.Finally,modeling examples of the door,hood and rear-window are given to demonstrate the advantage of T-spline surface over B-spline surface in car-body surface design.
文摘为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0.13,压边力为350 k N,拉延筋阻力系数为35%。通过有限元模拟和生产实践验证,证明了该方法的可行的。
文摘嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其脱靶效应(on-target off tumor effect);在治疗实体瘤中CAR-T细胞很难达到肿瘤部位,以改善免疫抑制微环境发挥作用;CAR-T细胞在清除肿瘤细胞的同时也会杀伤表达相同靶点的正常细胞;针对除B细胞肿瘤之外的血液肿瘤以及实体瘤而言,CAR-T细胞的有效性还有待提高。本文重点介绍如何通过CAR-T细胞结构的优化使得CAR-T细胞能够精准地识别肿瘤细胞,克服肿瘤的免疫抑制微环境来提高CAR-T细胞治疗恶性肿瘤的有效性;同时使得CAR-T细胞可以被更好地控制,使得CAR-T细胞的安全性更高。
文摘This paper discusses the basic principle and design m ethod for light distribution of car lamp, introduces an important development: h igh efficient and flexible car lamp with reflecting light distribution-segmente d reflector (multi-patch) car lamp, and puts out a design method for segmented reflector based on error analysis. Unlike classical car lamp with refractive lig ht distribution, the method of reflecting light distribution gives car lamp desi gn more flexibility. In the case of guarantying the lightness of car lamp and sa tisfying the standard demand for the light distribution, the design of the exter ior of the car lamp has more freedom. The high gradient of car lamp is more suit able for the demand of streamline of the car exterior. The shape of segmented re flector obtained by theory calculating of car lamp reflecting light distribution is only an ideal shape, which usually has considerable differences with the fin al shape and will influences light distribution. There exist difference between the calculated reflector and manufactured reflector. Owing to light reflecting c haracter, the small diversification of the reflector will reduce the big diver sification of the light distribution shape on light distribution screen in 25 -meter place, so light distribution quality can’t be ensured. To ensure the re flector by light distribution calculation accordance to reflector by practical m anufacture, the error effect of surface shape must be reasonably considered name ly the error effect of manufacture tache. The paper establishes error-analyzing model for segmented reflector according to the analysis of error of making proc ess for segmented reflector. Based on this error-analyzing model and by use of the analyzing software developed for segmented reflector light distribution, it could reasonably consider reflector errors made by manufacturing, such as reflec tor surface spray-painting and plating aluminum, which could give out shapes of reflector patches for segmented reflector well and truly, and direct the plan o f making process efficiently. The method put by the paper has successfully appli ed to develop segmented reflector lamp for several type cars and obtained good e ffect for the factory.
文摘As people grow older, their cognitive functions undergo changes which may result in uncomfortable driving situations and even increase the risk of accidents. This research aims to understand the neuropsychological aspects of healthy aging and their possible relationship <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> changes in motor performance or ability. The research methodology is descriptive and includes a collection of basic studies in the scope of neuroscience, driving tasks, and older driver behavior. The final analysis points to certain changes in the functioning of the cerebral cortex and its connections as being responsible for poor performance in some basic driving tasks, but which can be compensated for by means of adapted mechanisms in motor vehicles. This study may contribute as a methodological tool, to the automobile design process, for the selection of Advanced Driver Assistance Systems (ADAS) or other emerging technologies which can compensate cognitive changes, improve safety, comfort and inclusion of older drivers in the future of automobile interior design. We conclude that in normal aging, people may present some cognitive deficits especially linked to the frontal and parietal lobe, which interfere with the necessary driving skills albeit not with the dangerous ones and can be compensated by technological solutions. The main innovation of this article is related to the bibliographical compilation and critical analysis in terms of identifying the neuropsychological aspects of normal human aging and car driving and its relationship with possible contributions from vehicular technology, as well its consider future trends in automotive interior design that should be analysed with caution in order to users inclusion.</span></span></span>
文摘The pedestrian protection technology must be used in automotive design if China-made automotives want to compete and grow strong in the world in the future. In this paper, a CAE simulation analysis is made for a domestic sedan car hood to check whether it meet the pedestrian safety protection laws and regulations. Results show that the original car cannot meet the demands of the rules. In order to meet the standards of the pedustrian protection rules, the car hood should undergo structural improvements. Tested again by CAE simulation analysis, the car after a series of improved design can reached the 3-star class EuroNCAP( Euro New Car Assessment Program)standard of the car pedestrian safety protection laws and regulations.
基金support from the National Key R&D Program of China(2021YFA0909900)the National Natural Science Foundation of China(52173142,82072650)+1 种基金the Key Research and Development Program of Zhejiang Province(2021C03121)the grants from the Startup Package of Zhejiang University.
文摘Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid tumors.Different from hematological cancers,solid tumors are characterized by dysregulated blood vessels,dense extracellular matrix,and filled with immunosuppressive signals,which together result in CAR-T cells’insufficient infiltration and rapid dysfunction.The insufficient recognition of tumor cells and tumor heterogeneity eventually causes cancer reoccurrences.In addition,CAR-T therapy also raises safety concerns,including potential cytokine release storm,on-target/off-tumor toxicities,and neuro-system side effects.Here we comprehensively review various targeting aspects,including CAR-T cell design,tumor modulation,and delivery strategy.We believe it is essential to rationally design a combinatory CAR-T therapy via constructing optimized CAR-T cells,directly manipulating tumor tissue microenvironments,and selecting the most suitable delivery strategy to achieve the optimal outcome in both safety and efficacy.