Objective To evaluate the effects of Acarbose on incretin level(glucagon-like peptide 1(GLP-1)and gastric inhibitory polypeptide(GIP)of type 2 diabetes mellitus(T2DM)patients after different kinds of glucose load.Meth...Objective To evaluate the effects of Acarbose on incretin level(glucagon-like peptide 1(GLP-1)and gastric inhibitory polypeptide(GIP)of type 2 diabetes mellitus(T2DM)patients after different kinds of glucose load.Methods A total of 32 newly diagnosed T2DM patients were enrolled in this study and randomly divided into展开更多
Given the extreme complexity and diversity of carbohydrates,efficient approaches to the homogeneous oligosaccharide remain limited.Chemical synthesis represents one of the most reliable methods to access homogeneous s...Given the extreme complexity and diversity of carbohydrates,efficient approaches to the homogeneous oligosaccharide remain limited.Chemical synthesis represents one of the most reliable methods to access homogeneous samples,which mainly relies on the key glycosylation reaction.Consistent with enormous efforts to develop leaving groups for establishing robust glycosylation protocols,we herein disclose a structurally novel leaving group of 8-phenylethynyl-1-naphthoate that is able to enable efficient glycosylation reactions under the extremely mild condition of gold(I)-catalysis.Notably,the anomeric naphthoate possesses the unprecedent character of base-stability in sharp contrast to the conventional ester groups at anomeric position of carbohydrates,which endows high compatibility with a variety of chemical transformations.Furthermore,the present glycosylation protocol with 8-phenylethynyl-1-naphthoate as leaving group is able to realize minimally protected glycosylation processes.Mechanistic studies reveal a unique structure of 8-phenylethynyl-1-naphthoate that accounts for the reason for these characteristics.展开更多
文摘Objective To evaluate the effects of Acarbose on incretin level(glucagon-like peptide 1(GLP-1)and gastric inhibitory polypeptide(GIP)of type 2 diabetes mellitus(T2DM)patients after different kinds of glucose load.Methods A total of 32 newly diagnosed T2DM patients were enrolled in this study and randomly divided into
基金the financial support from the National Natural Science Foundation of China(22007080)Zhongshan Science and Technology Bureau(CXTD2022012)+3 种基金Youth Innovation Promotion Association of CAS(2020258)grateful to Hi-Level New R&D Institute(2019B090904008)High-Level Innovative Research Institute(2021B0909050003)from Department of ScienceTechnology of Guangdong Province.Prof.Hongbin Zhang(Yunnan University)is appreciated for the assistance on this project.
文摘Given the extreme complexity and diversity of carbohydrates,efficient approaches to the homogeneous oligosaccharide remain limited.Chemical synthesis represents one of the most reliable methods to access homogeneous samples,which mainly relies on the key glycosylation reaction.Consistent with enormous efforts to develop leaving groups for establishing robust glycosylation protocols,we herein disclose a structurally novel leaving group of 8-phenylethynyl-1-naphthoate that is able to enable efficient glycosylation reactions under the extremely mild condition of gold(I)-catalysis.Notably,the anomeric naphthoate possesses the unprecedent character of base-stability in sharp contrast to the conventional ester groups at anomeric position of carbohydrates,which endows high compatibility with a variety of chemical transformations.Furthermore,the present glycosylation protocol with 8-phenylethynyl-1-naphthoate as leaving group is able to realize minimally protected glycosylation processes.Mechanistic studies reveal a unique structure of 8-phenylethynyl-1-naphthoate that accounts for the reason for these characteristics.
