Carbopol 934树脂作为清洗材料的应用研究

在对文物进行保护处理过程中,清洗是非常重要工作之一。新的清洗材料、清洗工艺的研究,对文物保护技术的发展具有重要价值。本研究对Carbopol 934树脂应用于纺织品清洗的清洗效果、清洗工艺进行了研究,并对其在纸张和砖石文物上应用的可能性进行了尝试。研究结果表明,Carbopol 934树脂应用在纺织品清洗中具有作用时间长、扩散小的优点;同时应用隔离层能减少残留,达到更好的清洗效果;可有效地用于砖石、纸张和织物上污垢的去除。

Carbopol 934p的亲水膨胀特性及其对曲尼司特缓释片释放行为的影响

目的 :研究Carbopol 934p的凝胶特性及其对曲尼司特缓释片释放行为的影响。方法 :将纯辅料配方和Carbopol 934p为主要辅料的曲尼司特缓释片配方 ,在相同的条件下压片后 ,放入相同的介质中浸泡。采用称重法和体积测量法 ,研究其在不同pH环境、不同浸泡时间的水合度和溶胀度。结果 :辅料片在SGF和SIF中水合速率分别为 1.0 5 3h-1和 2 .75 6h-1,溶胀速率分别为 1.0 33h-1和 2 .45 1h-1,浸泡 5h时溶胀度分别为原有体积的 5 .87倍和 13 .0倍。曲尼司特缓释片在SGF中 ,0 .5h时迅速水合和溶胀 ;而在SIF中 ,5h内随着浸泡时间的增加 ,其重量和体积都缓慢增加 ,5h后重量稍有下降 ,体积基本不变。相同条件下 ,曲尼司特缓释片在人工胃液、人工肠液和梯度pH溶液中 ,10h的释放度分别为 0 .72 %、94.3%和 98.7%。结论 :水凝胶的形成速度和形态与介质的pH关系很大 ;

呋麻鼻用凝胶剂的质量控制

目的 制备呋麻鼻用凝胶剂并建立其质量控制方法。方法 用卡波姆934作为凝胶基质制备呋麻鼻用凝胶剂，采用高效液相色谱法测定呋喃西林和盐酸麻黄碱的含量，对制剂的稳定性进行了考察。结果 呋喃西林在6．25～100μg·ml^-1。浓度范围内线性关系良好（r=0．9998），盐酸麻黄碱在312．5-5000μg·ml^-1。浓度范围内线性关系良好（r=0．9998），平均回收率分别为99．80％和99．95％，制剂质量稳定。结论 该制剂工艺简单，质量可控，稳定性好，可满足临床用药需求。

Formulation and evaluation of herbal gel of Pothos scandens Linn

Objective:To formulate Pothos scandens Linn(P.scandens) leaf extract in to a gel and investigate their burn wound healing activity.Methods:Ethanolic extract of dried leaves of P. scandens were subjected to priliminery phytochemical evaluation and wound healing activities studies.Different gel formulations of ethanolic extract of P.scandens(4%w/v) were prepared using polymers carbopol 934 and carbopol 940 bv varying their concentration.These formulations were evaluated for physical parameters,drug content.pH,viscosity,extrudability.spreadability. primary skin irritation,pharmacological activity and stability.Results:Wound healing studies of ethanolic extract revealed that P.scandens treated animals were found to epithelise in 22 days while the solvent control and the untreated rats epithelise within 35 and 40 days respectively. The formulation with 1.5%w/w carbopol 934 was found to be more promising as it shows better physicochemical characteristics,higher pharmacological activity and stability compared to other formulations.Conclusions:P.scandens alcoholic extract shows significant improvement in burn wound contraction and hence this is a promising candidate in burn wound healing.