期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis 被引量:2
1
作者 Changhui Du Zhenjie Li +9 位作者 Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen 《Food Science and Human Wellness》 SCIE CSCD 2023年第4期1212-1223,共12页
Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we in... Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans. 展开更多
关键词 carnosic acid Inflammatory bowel diseases COLITIS Gut microbiota METABOLITES
下载PDF
A Concise Approach to the Synthesis of Carnosic Acid Type Diterpenes
2
作者 Yu Xin CUI Qiang XIAO Peng Fei TU 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第3期203-204,共2页
10-vinyl-8,11,13-podocatriene 8, which is a modal of Carnosic acid type diterpenes, has been synthesized by an expeditious convergent synthetic approach.
关键词 carnosic acid SYNTHESIS DITERPENES CYCLIZATION ANTI-HIV
下载PDF
Cancer combination therapy with carnosic acid
3
作者 NADIRE OZENVER THOMAS EFFERTH 《BIOCELL》 SCIE 2022年第10期2151-2157,共7页
Carnosic acid(CA)is a natural phenolic diterpene mainly occurring in some species of the Lamiaceae family.Numerous studies described the cytotoxicity of CA towards different types of cancer both in vitro and in vivo.P... Carnosic acid(CA)is a natural phenolic diterpene mainly occurring in some species of the Lamiaceae family.Numerous studies described the cytotoxicity of CA towards different types of cancer both in vitro and in vivo.Particularly,the influence of CA in combination with other drugs,vitamins or natural products through affecting various targets has raised interest.Current experimental in vivo data suggested that CA may cooperate with clinically used anticancer drugs promoting their activity against cancer.From this point of view,CA gained importance,because it may alter pharmacodynamic profiles of various agents in the case of their co-administration,and thereby,act in a potentially synergistic manner,which can provide a basis for potential applications of CA in the management of cancer.In the present review,we give an overview of CA as well as CA co-treatment regimens with a special focus on cancer.In this context,the role of CA as an adjuvant treatment alternative is highlighted. 展开更多
关键词 carnosic acid CANCER Combination therapy Synergism
下载PDF
Synergism between Carnosic Acid and Arsenic Trioxide on Induction of Acute Myeloid Leukemia Cell Apoptosis Is Associated with Modulation of PTEN/Akt Signaling Pathway 被引量:7
4
作者 王冉 丛伟红 +4 位作者 郭刚 李湘新 陈学良 于晓宁 李颢 《Chinese Journal of Integrative Medicine》 SCIE CAS 2012年第12期934-941,共8页
Objective: To investigate the synergistic effects of carnosic acid (CA) with arsenic trioxide (As203) on proliferation and apoptosis in HL-60 human myeloid leukemia cells, and the major cellular signaling pathway... Objective: To investigate the synergistic effects of carnosic acid (CA) with arsenic trioxide (As203) on proliferation and apoptosis in HL-60 human myeloid leukemia cells, and the major cellular signaling pathway involved in these effects. Methods: HL-60 cellular proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTF) analysis. Cell cycle distribution and apoptosis were monitored by flow cytometry. The activation of casepase-9, Bcl-2-associated agonist of cell death (BAD), p-BAD, p27, phosphatase and tensin homolog deleted on chromosome ten (PTEN), Akt, p-Akt was assessed by Western blot analysis. The expression of PTEN mRNA was tested by reverse transcription polymerase chain reaction (RT-PCR) analysis. Results: CA reduced HL-60 cell viability in a dose- and time-dependent manner, and induced G1 arrest and apoptosis. Moreover, CA upregulated PTEN expression, blocked the Akt signaling pathway, subsequently inhibited phosphorylation of BAD, reactivated caspase-9, and elevated levels of p27. CA also augmented these effects of As203. Conclusion: CA might be a novel candidate of the combination therapy for leukemia treatment; these effects were apparently associated with the modulation of PTEN/Akt signaling pathway. 展开更多
关键词 carnosic acid combination therapy acute myeloid leukemia APOPTOSIS PTEN/Akt signalingpathway
原文传递
Dietary carnosic acid and seleno-compounds change concentrations of fatty acids, cholesterol, tocopherols and malondialdehyde in fat and heart of lambs 被引量:1
5
作者 Malgorzata Bialek Marian Czauderna +1 位作者 Kamil Zaworski Katarzyna Krajewska 《Animal Nutrition》 SCIE CSCD 2021年第3期812-822,共11页
The aim of the current study was to evaluate the impact of carnosic acid(CA),selenised yeast(^(Y)Se)and selenate(^(VI)Se)supplemented to diets,including fish oil(FO)and rapeseed oil(RO),on the content of fatty acids,t... The aim of the current study was to evaluate the impact of carnosic acid(CA),selenised yeast(^(Y)Se)and selenate(^(VI)Se)supplemented to diets,including fish oil(FO)and rapeseed oil(RO),on the content of fatty acids,total cholesterol(TCh),tocopherols and malondialdehyde in the fat located between the thigh muscles and the heart in lambs.Twenty-four male Corriedale lambs were divided into 4 groups of 6 animals.Animals were fed a diet with FO and RO(the control diet)or experimental diets containing RO,FO and CA with/without Se(as^(Y)Se or^(VI)Se).The experimental diets without/with^(Y)Se or^(VI)Se changed concentrations of fatty acids in the fat and heart compared to the control.All experimental diets increased the levels of c11c14C20:2,c5c8c11c14C20:4,c5c8c11c14c17C20:5 and the sums of long-chain polyunsaturated fatty acids(LPUFA)and conjugated linoleic acid isomers in the fat compared to the control.The experimental diet containing^(Y)Se or^(VI)Se increased the content of Se,TCh,c11c14C20:2,c8c11c14C20:3,c5c8c11c14C20:4,c5c8c11c14c17C20:5,c7c10c13c16c19C22:5,c4c7c10c13c16c19C22:6 and the concentration sum of n-3LPUFA,n-6LPUFA and tocopherols in the heart in comparison with the control diet and the diet containing only CA.Experimental diets reduced the concentration of malon-dialdehyde in the fat and heart in comparison with the control diet.Our dietary intervention has great potential for future practical and commercial implementations. 展开更多
关键词 Selenium carnosic acid Fatty acid TOCOPHEROL CHOLESTEROL LAMB
原文传递
Antimicrobial effects of carnosic acid,kaempferol and luteolin on biogenic amine production by spoilage and food-borne pathogenic bacteria
6
作者 Ali Serha Ozkütük 《Food Bioscience》 SCIE 2022年第2期882-889,共8页
Antimicrobial effects of carnosic acid,kaempferol and luteolin on biogenic amine(BA)production by five spoilage(Photobacterium damselae,Proteus mirabilis,Enterobacter cloacea,Pseudomonas luteola and Serratia liquefaci... Antimicrobial effects of carnosic acid,kaempferol and luteolin on biogenic amine(BA)production by five spoilage(Photobacterium damselae,Proteus mirabilis,Enterobacter cloacea,Pseudomonas luteola and Serratia liquefaciens)and five food-borne pathogenic bacteria(Staphylococcus aureus ATCC29213,Enterococcus faecalis ATCC29212,Escherichia coli ATCC25922,Salmonella Paratyphi A NCTC13 and Yersinia enterocolitica NCTC 11175)were investigated.The formation of ammonia(AMN),trimethylamine(TMA)and BAs by all bacterial strains were observed using ornithine decarboxylase broth.BAs,AMN,and TMA were determined by using high performance liquid chromatography(HPLC)method.The results showed that significant differences were observed(P≤0.05)in formation among spoilage and also food-borne bacteria.The impact of phenolic compounds on AMN,TMA and BAs production was dependent on bacterial strains.When total amount of cadaverine(CAD),putrescine(PUT),histamine(HIS)and tyramine(TYR)was considered,the phenolic compounds presented antimicrobial activity against fish spoliage bacteria and food-borne pathogens following the order;kaempferol>carnosic acid>luteolin.These phenolics have potential to be used as food preservatives. 展开更多
关键词 carnosic acid KAEMPFEROL LUTEOLIN Biogenic amine Food-borne pathogens
原文传递
Regulation effects of rosemary(Rosmarinus officinalis Linn) on hepatic lipid metabolism in OA induced NAFLD rats 被引量:5
7
作者 WANG Si-jian CHEN Qian +5 位作者 LIU Meng-yang YU Hai-yang XU Jing-qi WU Jia-qi ZHANG Yi WANG Tao 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期699-700,共2页
OBJECTIVE To highlight the pharmacological effects of rosemary and its active compounds and eluci⁃date its related mechanisms in nonalcoholic fatty liver disease(NAFLD)management both in vitro and in vivo.METHODS In o... OBJECTIVE To highlight the pharmacological effects of rosemary and its active compounds and eluci⁃date its related mechanisms in nonalcoholic fatty liver disease(NAFLD)management both in vitro and in vivo.METHODS In orotic acid induced NAFLD rats model,rats were administrated with 100,200 and 400 mg·kg^-1 rosemary ethanol extract(RO),10,25 and 50 mg·kg^-1 rosemary acid(RA),and 5,10 and 25 mg·kg^-1 carnosic acid(CA)for three weeks respec⁃tively.Sodium oleate induced HepG2 cell model was used to study the regulation effect of rosemary ethanol extract and its main metabolites on fat accumulation.lipid metabolism related gene expression was analyzed by Western blotting and real-time PCR to clarify the specific molecular mechanism of RO,RA and CA in lipid accumulation.RESULTS RO,RA and CA significantly reduced the contents of liver triglyceride(TG),total cholesterol(TC),free fatty acids(FFA)and improved cell hypertrophy,vacuolation,and cell necrosis in liver of orotic acid induced NAFLD model rats.The mecha⁃nism and related pathways of RO and its main metabolites against lipid disorder was related to the up-regulation of the phosphorylation of adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)and inhibition of the sterol regu⁃latory element binding protein-1c(SREBP-1c)cracking into the nuclear,following down-regulation of fatty acid synthesis.CONCLUSION The rosemary has effectively function to regulate lipid metabolism through AMPK/SREBP1c signaling pathway. 展开更多
关键词 rosermary NAFLD rosermary acid carnosic acid AMPK SREBP-1C
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部