Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT■gait analysis for evaluating hindlimb functional recovery in a widely used an...Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT■gait analysis for evaluating hindlimb functional recovery in a widely used and clinically relevant thoracic contusion/compression spinal cord injury model in rats. Rats were randomly assigned to either a T9 spinal cord injury or sham laminectomy. Locomotion recovery was assessed using the Basso, Beattie, and Bresnahan open field rating scale and the CatWalk XT■gait analysis. To determine the potential bias from weight changes, corrected hindlimb(H) values(divided by the unaffected forelimb(F) values) were calculated. Six weeks after injury, cyst formation, astrogliosis, and the deposition of chondroitin sulfate glycosaminoglycans were assessed by immunohistochemistry staining. Compared with the baseline, a significant spontaneous recovery could be observed in the CatWalk XT■parameters max intensity, mean intensity, max intensity at%, and max contact mean intensity from 4 weeks after injury onwards. Of note, corrected values(H/F) of CatWalk XT■parameters showed a significantly less vulnerability to the weight changes than absolute values, specifically in static parameters. The corrected CatWalk XT■parameters were positively correlated with the Basso, Beattie, and Bresnahan rating scale scores, cyst formation, the immunointensity of astrogliosis and chondroitin sulfate glycosaminoglycan deposition. The CatWalk XT■gait analysis and especially its static parameters, therefore, seem to be highly useful in assessing spontaneous recovery of hindlimb function after severe thoracic spinal cord injury. Because many CatWalk XT■parameters of the hindlimbs seem to be affected by body weight changes, using their corrected values might be a valuable option to improve this dependency.展开更多
A CHINESE debutante attracted most of the limelight at the annual Victoria＇s Secret Fashion Show in New York in November 2011. He Sui, a newcomer to the modeling world, was the focus of many photographers as the dark...A CHINESE debutante attracted most of the limelight at the annual Victoria＇s Secret Fashion Show in New York in November 2011. He Sui, a newcomer to the modeling world, was the focus of many photographers as the dark haired beauty walked down the runway in a mermaid inspired ensemble.展开更多
The line-shape of catwalk of long-span suspension bridge is obtained by using the segmental catenary method to carry out the iterative calculation, where all the bearing cables are considered as one cable, and transve...The line-shape of catwalk of long-span suspension bridge is obtained by using the segmental catenary method to carry out the iterative calculation, where all the bearing cables are considered as one cable, and transversal passages and gantry are treated as nodes which divide the catwalk into several segments. The difference of line-shape and force between catwalk bearing cable and gantry bearing cable is not usually considered, but the line-shape of two kinds of cables is actually inconsistent because of the constraints from gantries. Based on the segmental catenary method, considering the different states of bearing cables (DSB calculation method), fine calculation is carried out. This method is applied to the design of a suspension bridge's catwalk, and is compared with the traditional calculation method. It is obtained that the result is more reasonable and accurate by the coordination calculation method considering different states for two kinds of load-bearing cables, which is worth considering in the process of design and optimization for catwalk.展开更多
文摘Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT■gait analysis for evaluating hindlimb functional recovery in a widely used and clinically relevant thoracic contusion/compression spinal cord injury model in rats. Rats were randomly assigned to either a T9 spinal cord injury or sham laminectomy. Locomotion recovery was assessed using the Basso, Beattie, and Bresnahan open field rating scale and the CatWalk XT■gait analysis. To determine the potential bias from weight changes, corrected hindlimb(H) values(divided by the unaffected forelimb(F) values) were calculated. Six weeks after injury, cyst formation, astrogliosis, and the deposition of chondroitin sulfate glycosaminoglycans were assessed by immunohistochemistry staining. Compared with the baseline, a significant spontaneous recovery could be observed in the CatWalk XT■parameters max intensity, mean intensity, max intensity at%, and max contact mean intensity from 4 weeks after injury onwards. Of note, corrected values(H/F) of CatWalk XT■parameters showed a significantly less vulnerability to the weight changes than absolute values, specifically in static parameters. The corrected CatWalk XT■parameters were positively correlated with the Basso, Beattie, and Bresnahan rating scale scores, cyst formation, the immunointensity of astrogliosis and chondroitin sulfate glycosaminoglycan deposition. The CatWalk XT■gait analysis and especially its static parameters, therefore, seem to be highly useful in assessing spontaneous recovery of hindlimb function after severe thoracic spinal cord injury. Because many CatWalk XT■parameters of the hindlimbs seem to be affected by body weight changes, using their corrected values might be a valuable option to improve this dependency.
文摘A CHINESE debutante attracted most of the limelight at the annual Victoria＇s Secret Fashion Show in New York in November 2011. He Sui, a newcomer to the modeling world, was the focus of many photographers as the dark haired beauty walked down the runway in a mermaid inspired ensemble.
文摘The line-shape of catwalk of long-span suspension bridge is obtained by using the segmental catenary method to carry out the iterative calculation, where all the bearing cables are considered as one cable, and transversal passages and gantry are treated as nodes which divide the catwalk into several segments. The difference of line-shape and force between catwalk bearing cable and gantry bearing cable is not usually considered, but the line-shape of two kinds of cables is actually inconsistent because of the constraints from gantries. Based on the segmental catenary method, considering the different states of bearing cables (DSB calculation method), fine calculation is carried out. This method is applied to the design of a suspension bridge's catwalk, and is compared with the traditional calculation method. It is obtained that the result is more reasonable and accurate by the coordination calculation method considering different states for two kinds of load-bearing cables, which is worth considering in the process of design and optimization for catwalk.
