Inhibition of the enzyme COMT （catechol-O-methyltransferase） is an important approach in the treatment of Parkinson＇s disease. A series of potent catechols for COMT may give insight to develop new ways of antiparki...Inhibition of the enzyme COMT （catechol-O-methyltransferase） is an important approach in the treatment of Parkinson＇s disease. A series of potent catechols for COMT may give insight to develop new ways of antiparkinson drug. COMT inhibitors represent a new class of antiparkinson drugs, when they are coadministered with levodopa. Our goal of research is to study the inhibition of catechol-O-methyltransferase by molecular modeling methods. Different molecular modeling tools are used to perform this work （molecular mechanics, molecular dynamics and molecular docking （molegro virtnaldocker））. The results obtained from this work, into which the inhibition of catechol-O-methyltransferase by molecular modeling methods was elucidated, allow us to conclude that different catechols presents a more optimised inhibition of catechol-O-methyltransferase. The results suggest reducing the severity of Parkinson＇s disease.展开更多
Background and Objective:Genetic polymorphism Val158Met of catechol-O-methyltransferase(COMT) may contribute to estrogen-induced carcinogenesis of breast cancer.Soy isoflavones possesses chemical structure similar to ...Background and Objective:Genetic polymorphism Val158Met of catechol-O-methyltransferase(COMT) may contribute to estrogen-induced carcinogenesis of breast cancer.Soy isoflavones possesses chemical structure similar to endogenous estrogen and may promote the carcinogenesis of breast cancer.This study was to investigate the relationship between the polymorphism of COMT,soy isoflavones,and breast cancer in postmenopausal women.Met hods:In total,176 patients newly diagnosed histopathologically with breast cancer were recruited from May 2007 to July 2009,and 176 age-matched cancer-free women as controls were selected from a community-based physical check-up population at the same period.The food-frequency questionnaire was used to collect information on soy food intake.Allelespecific polymerase chain reaction(AS-PCR) was employed to analyze genetic polymorphism Val158Met of COMT.Adjusted odd ratios(aORs) and 95% confidence intervals(95% CI) were estimated by multivariable nonconditional logistic regression.Result s:The proportion of susceptible genotype(COMT-LL) in breast cancer patients was significantly higher than that in the controls.After adjusting selected risk factors,the aOR and 95% CI of COMT-LL were 3.14(1.48-6.66) as compared with those of COMT-HH genotype.The intake of soy isoflavones had a negative correlation with breast cancer in a dose-dependent manner(χ2 = 28.26,P < 0.001).The women with high intake of soy isoflavones(≥ 16.26 mg/d) and carrying susceptible genotype(COMT-LL),as compared with the women carrying the COMT-HH + COMT-HL genotypes and consuming low level of soy isoflavones(< 16.26 mg/d),had no significantly increased risk for breast cancer [aOR(95% CI) = 1.66(0.52-5.24)].Conclusions:In postmenopausal women,carrying COMT-LL genotype may increase the risk for breast cancer,and soy isoflavones intake may protect them from breast cancer.But there may be no interaction between intake of soy isoflavones and COMT-LL genotype.展开更多
Objective To investigate the association between catechol O-methyl transferase（COMT）Val108/158Met polymorphism and P50 sensory gating in patients with schizophrenia.Methods In this study,event-related potentials（ER...Objective To investigate the association between catechol O-methyl transferase（COMT）Val108/158Met polymorphism and P50 sensory gating in patients with schizophrenia.Methods In this study,event-related potentials（ERP）was determined in 139 stable patients with schizophrenia and 165 healthy controls.P50展开更多
文摘Inhibition of the enzyme COMT （catechol-O-methyltransferase） is an important approach in the treatment of Parkinson＇s disease. A series of potent catechols for COMT may give insight to develop new ways of antiparkinson drug. COMT inhibitors represent a new class of antiparkinson drugs, when they are coadministered with levodopa. Our goal of research is to study the inhibition of catechol-O-methyltransferase by molecular modeling methods. Different molecular modeling tools are used to perform this work （molecular mechanics, molecular dynamics and molecular docking （molegro virtnaldocker））. The results obtained from this work, into which the inhibition of catechol-O-methyltransferase by molecular modeling methods was elucidated, allow us to conclude that different catechols presents a more optimised inhibition of catechol-O-methyltransferase. The results suggest reducing the severity of Parkinson＇s disease.
基金This work was supported by the National Natural Science Foundation of China (No.30470577) and "the 10th Five Years Plan" Na-tional Tackle Problem Item (No.2001BA901A49).
文摘Background and Objective:Genetic polymorphism Val158Met of catechol-O-methyltransferase(COMT) may contribute to estrogen-induced carcinogenesis of breast cancer.Soy isoflavones possesses chemical structure similar to endogenous estrogen and may promote the carcinogenesis of breast cancer.This study was to investigate the relationship between the polymorphism of COMT,soy isoflavones,and breast cancer in postmenopausal women.Met hods:In total,176 patients newly diagnosed histopathologically with breast cancer were recruited from May 2007 to July 2009,and 176 age-matched cancer-free women as controls were selected from a community-based physical check-up population at the same period.The food-frequency questionnaire was used to collect information on soy food intake.Allelespecific polymerase chain reaction(AS-PCR) was employed to analyze genetic polymorphism Val158Met of COMT.Adjusted odd ratios(aORs) and 95% confidence intervals(95% CI) were estimated by multivariable nonconditional logistic regression.Result s:The proportion of susceptible genotype(COMT-LL) in breast cancer patients was significantly higher than that in the controls.After adjusting selected risk factors,the aOR and 95% CI of COMT-LL were 3.14(1.48-6.66) as compared with those of COMT-HH genotype.The intake of soy isoflavones had a negative correlation with breast cancer in a dose-dependent manner(χ2 = 28.26,P < 0.001).The women with high intake of soy isoflavones(≥ 16.26 mg/d) and carrying susceptible genotype(COMT-LL),as compared with the women carrying the COMT-HH + COMT-HL genotypes and consuming low level of soy isoflavones(< 16.26 mg/d),had no significantly increased risk for breast cancer [aOR(95% CI) = 1.66(0.52-5.24)].Conclusions:In postmenopausal women,carrying COMT-LL genotype may increase the risk for breast cancer,and soy isoflavones intake may protect them from breast cancer.But there may be no interaction between intake of soy isoflavones and COMT-LL genotype.
文摘Objective To investigate the association between catechol O-methyl transferase（COMT）Val108/158Met polymorphism and P50 sensory gating in patients with schizophrenia.Methods In this study,event-related potentials（ERP）was determined in 139 stable patients with schizophrenia and 165 healthy controls.P50
