Gastric cancer is one of the most frequent cancers,and it ranks the third most common cancer in China.The most recently caudal-related homeobox transcription factor 2(CDX2)is expressed in a large number of human gastr...Gastric cancer is one of the most frequent cancers,and it ranks the third most common cancer in China.The most recently caudal-related homeobox transcription factor 2(CDX2)is expressed in a large number of human gastrointestinal cancers.In addition,gastric epithelial cell mutations in CDX2 result in tumor promotion,which is characterized by cellular drug resistance and a high proclivity for developing cancer.A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance.CDX2 appears to forward control regenerating Ⅳand the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.展开更多
基金Supported by The National Natural Science Foundation of China,No.81060201Natural Science Foundation of Guangxi Zhuang Autonomous Region of China,No.2011GXNS-FA018273 and No.2013GXNSFAA019163the Key Health Science Fund of Guangxi Zhuang Autonomous Region of China,No.1298003-2-6
文摘Gastric cancer is one of the most frequent cancers,and it ranks the third most common cancer in China.The most recently caudal-related homeobox transcription factor 2(CDX2)is expressed in a large number of human gastrointestinal cancers.In addition,gastric epithelial cell mutations in CDX2 result in tumor promotion,which is characterized by cellular drug resistance and a high proclivity for developing cancer.A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance.CDX2 appears to forward control regenerating Ⅳand the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.