The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（Ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation...The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（Ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation of topological domains within the genome through mediating inter-and intra-chromosomal interactions.In vertebrate,CCCTC-binding factor（CTCF）is the main architectural protein that mediates long-range chromosomal interactions among its DNA binding sites through a process that is stabilized by cohesin （Parelho et al., 2008; Wendt et al., 2008）.展开更多
基金Additional support for EIPC was provided by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR000454supported by the core funding from Temasek Life Sciences Laboratory,Singapore
文摘The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（Ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation of topological domains within the genome through mediating inter-and intra-chromosomal interactions.In vertebrate,CCCTC-binding factor（CTCF）is the main architectural protein that mediates long-range chromosomal interactions among its DNA binding sites through a process that is stabilized by cohesin （Parelho et al., 2008; Wendt et al., 2008）.
