<strong>Background:</strong> Phacoemulsification surgery is the most frequent cataract surgery performed in developed countries because of its effectiveness and safety. However, some degree of endothelial ...<strong>Background:</strong> Phacoemulsification surgery is the most frequent cataract surgery performed in developed countries because of its effectiveness and safety. However, some degree of endothelial loss is inevitable in any type of cataract surgery, including phacoemulsification. Anterior chamber depth (ACD) could be considered as one of important anatomical parameters for preserving endothelial loss from the mechanical and thermal damage that can occur during the procedure. <strong>Purpose:</strong> To evaluate the effects of ACD on endothelial cell density, hexagonality, coefficient variation (CV) and central corneal thickness (CCT) at one and four weeks after phacoemulsification using transversal ultrasound. <strong>Method:</strong> This was a prospective study conducted at Cicendo National Eye Hospital Indonesia from April to August 2018, where we performed phacoemulsification in 148 patients with ACD < 3 mm group, ACD ≥ 3 mm group. Specular microscopy examination was performed prior to phacoemulsification and repeated at one and four weeks after surgery. The changes in endothelial density, percentage of hexagonality, CV and CCT between two groups were evaluated and compared. <strong>Result:</strong> Mean (SD) endothelial density in ACD < 3 mm group and ACD ≥ 3 mm group at 1-week evaluation was 1761.9 (503.3) and 1966.1 (530.6) cells/mm2 respectively, with p value 0.030. At 4-week evaluation, endothelial cell density in ACD < 3 mm group and ACD ≥ 3 mm group was 1537.8 (504.9) and 1798.7 (554.0) cells/mm2 respectively, with p value 0.010. There was no statistical difference regarding hexagonality, CV and CCT between both groups at 1-week and 4-week evaluation. Endothelial density changes percentage also higher in ACD < 3 mm group at 1-week and 4-week evaluation. <strong>Conclusion:</strong> Endothelial cell density in ACD < 3 mm group was significantly lower compared to ACD ≥ 3 mm group at 1-week and 4-week evaluation after phacoemulsification.展开更多
AIM:To investigate the expression profile of miRNA in esophageal squamous cell carcinoma(ESCC).METHODS:The expression profile of miRNA in ESCC tissues was analyzed by miRNA microarray.The expression levels of miR-143 ...AIM:To investigate the expression profile of miRNA in esophageal squamous cell carcinoma(ESCC).METHODS:The expression profile of miRNA in ESCC tissues was analyzed by miRNA microarray.The expression levels of miR-143 and miR-145 in 86 ESCC patients were determined by real-time polymerase chain reaction(PCR) using TaqMan assay.The mobility effect was estimated by wound-healing using esophageal carcinoma cells transfected with miRNA expression plasmids.RESULTS:A set of miRNAs was found to be deregulated in the ESCC tissues,and the expression levels of miR-143 and-145 were significantly decreased in most of the ESCC tissues examined.Both miR-143 and miR-145 expression correlated with tumor invasion depth.The transfection of human esophageal carcinoma cells with miR-143 and miR-145 expression plasmids resulted in a greater inhibition of cell mobility,however,the protein level of the previously reported target of miR-145,FSCN1,did not show any significant downregulation.CONCLUSION:These findings suggest that the deregulation of miRNAs plays an important role in the progression of ESCC.Both miR-143 and miR-145 might act as anti-oncomirs common to ESCC.展开更多
Lithium element has attracted remarkable attraction for energy storage devices, over the past 30 years. Lithium is a light element and exhibits the low atomic number 3, just after hydrogen and helium in the periodic t...Lithium element has attracted remarkable attraction for energy storage devices, over the past 30 years. Lithium is a light element and exhibits the low atomic number 3, just after hydrogen and helium in the periodic table. The lithium atom has a strong tendency to release one electron and constitute a positive charge, as Li<sup> </sup>. Initially, lithium metal was employed as a negative electrode, which released electrons. However, it was observed that its structure changed after the repetition of charge-discharge cycles. To remedy this, the cathode mainly consisted of layer metal oxide and olive, e.g., cobalt oxide, LiFePO<sub>4</sub>, etc., along with some contents of lithium, while the anode was assembled by graphite and silicon, etc. Moreover, the electrolyte was prepared using the lithium salt in a suitable solvent to attain a greater concentration of lithium ions. Owing to the lithium ions’ role, the battery’s name was mentioned as a lithium-ion battery. Herein, the presented work describes the working and operational mechanism of the lithium-ion battery. Further, the lithium-ion batteries’ general view and future prospects have also been elaborated.展开更多
文摘<strong>Background:</strong> Phacoemulsification surgery is the most frequent cataract surgery performed in developed countries because of its effectiveness and safety. However, some degree of endothelial loss is inevitable in any type of cataract surgery, including phacoemulsification. Anterior chamber depth (ACD) could be considered as one of important anatomical parameters for preserving endothelial loss from the mechanical and thermal damage that can occur during the procedure. <strong>Purpose:</strong> To evaluate the effects of ACD on endothelial cell density, hexagonality, coefficient variation (CV) and central corneal thickness (CCT) at one and four weeks after phacoemulsification using transversal ultrasound. <strong>Method:</strong> This was a prospective study conducted at Cicendo National Eye Hospital Indonesia from April to August 2018, where we performed phacoemulsification in 148 patients with ACD < 3 mm group, ACD ≥ 3 mm group. Specular microscopy examination was performed prior to phacoemulsification and repeated at one and four weeks after surgery. The changes in endothelial density, percentage of hexagonality, CV and CCT between two groups were evaluated and compared. <strong>Result:</strong> Mean (SD) endothelial density in ACD < 3 mm group and ACD ≥ 3 mm group at 1-week evaluation was 1761.9 (503.3) and 1966.1 (530.6) cells/mm2 respectively, with p value 0.030. At 4-week evaluation, endothelial cell density in ACD < 3 mm group and ACD ≥ 3 mm group was 1537.8 (504.9) and 1798.7 (554.0) cells/mm2 respectively, with p value 0.010. There was no statistical difference regarding hexagonality, CV and CCT between both groups at 1-week and 4-week evaluation. Endothelial density changes percentage also higher in ACD < 3 mm group at 1-week and 4-week evaluation. <strong>Conclusion:</strong> Endothelial cell density in ACD < 3 mm group was significantly lower compared to ACD ≥ 3 mm group at 1-week and 4-week evaluation after phacoemulsification.
基金Supported by Grants from the NSFC-Guangdong Joint Fund,No.U0932001the National Natural Science Foundation of China,No.30900560
文摘AIM:To investigate the expression profile of miRNA in esophageal squamous cell carcinoma(ESCC).METHODS:The expression profile of miRNA in ESCC tissues was analyzed by miRNA microarray.The expression levels of miR-143 and miR-145 in 86 ESCC patients were determined by real-time polymerase chain reaction(PCR) using TaqMan assay.The mobility effect was estimated by wound-healing using esophageal carcinoma cells transfected with miRNA expression plasmids.RESULTS:A set of miRNAs was found to be deregulated in the ESCC tissues,and the expression levels of miR-143 and-145 were significantly decreased in most of the ESCC tissues examined.Both miR-143 and miR-145 expression correlated with tumor invasion depth.The transfection of human esophageal carcinoma cells with miR-143 and miR-145 expression plasmids resulted in a greater inhibition of cell mobility,however,the protein level of the previously reported target of miR-145,FSCN1,did not show any significant downregulation.CONCLUSION:These findings suggest that the deregulation of miRNAs plays an important role in the progression of ESCC.Both miR-143 and miR-145 might act as anti-oncomirs common to ESCC.
文摘Lithium element has attracted remarkable attraction for energy storage devices, over the past 30 years. Lithium is a light element and exhibits the low atomic number 3, just after hydrogen and helium in the periodic table. The lithium atom has a strong tendency to release one electron and constitute a positive charge, as Li<sup> </sup>. Initially, lithium metal was employed as a negative electrode, which released electrons. However, it was observed that its structure changed after the repetition of charge-discharge cycles. To remedy this, the cathode mainly consisted of layer metal oxide and olive, e.g., cobalt oxide, LiFePO<sub>4</sub>, etc., along with some contents of lithium, while the anode was assembled by graphite and silicon, etc. Moreover, the electrolyte was prepared using the lithium salt in a suitable solvent to attain a greater concentration of lithium ions. Owing to the lithium ions’ role, the battery’s name was mentioned as a lithium-ion battery. Herein, the presented work describes the working and operational mechanism of the lithium-ion battery. Further, the lithium-ion batteries’ general view and future prospects have also been elaborated.
