Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(201...Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic tumors.We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female.Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 protein.Meanwhile,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT.The results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for cytokeratin.These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.展开更多
目的:探讨卵巢富细胞纤维瘤的临床与病理学特征。方法:收集2008年2月至2017年3月复旦大学附属妇产科医院诊治的24例卵巢富细胞纤维瘤患者的临床病理资料,观察肿瘤组织学特征、免疫表型,并进行随访。结果:24例患者年龄为17~70岁,平均46....目的:探讨卵巢富细胞纤维瘤的临床与病理学特征。方法:收集2008年2月至2017年3月复旦大学附属妇产科医院诊治的24例卵巢富细胞纤维瘤患者的临床病理资料,观察肿瘤组织学特征、免疫表型,并进行随访。结果:24例患者年龄为17~70岁,平均46.5岁。临床症状包括卵巢肿块、下腹胀痛或合并胸腹水。2例患者术前伴CA125显著升高。卵巢富细胞纤维瘤发生于右侧卵巢、左侧卵巢、双侧卵巢分别为13、10、1例。镜下显示肿瘤细胞丰富、无明显异型性。3例患者的肿瘤细胞核分裂象活跃,核分裂象5~7个/10个高倍视野(high power fields,HPF),3例患者的肿瘤中含少量(少于10%)性索成分,4例见黄素化细胞。随访1~109个月,未见复发。结论:卵巢富细胞纤维瘤是纯间质肿瘤,可有核分裂象增多、伴有少量性索成分及黄素化。部分患者合并胸腹水及CA125升高,易误诊为恶性肿瘤。为避免误诊以影响临床诊断和治疗,认识该病具有重要的意义。展开更多
文摘Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic tumors.We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female.Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 protein.Meanwhile,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT.The results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for cytokeratin.These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.
文摘目的:探讨卵巢富细胞纤维瘤的临床与病理学特征。方法:收集2008年2月至2017年3月复旦大学附属妇产科医院诊治的24例卵巢富细胞纤维瘤患者的临床病理资料,观察肿瘤组织学特征、免疫表型,并进行随访。结果:24例患者年龄为17~70岁,平均46.5岁。临床症状包括卵巢肿块、下腹胀痛或合并胸腹水。2例患者术前伴CA125显著升高。卵巢富细胞纤维瘤发生于右侧卵巢、左侧卵巢、双侧卵巢分别为13、10、1例。镜下显示肿瘤细胞丰富、无明显异型性。3例患者的肿瘤细胞核分裂象活跃,核分裂象5~7个/10个高倍视野(high power fields,HPF),3例患者的肿瘤中含少量(少于10%)性索成分,4例见黄素化细胞。随访1~109个月,未见复发。结论:卵巢富细胞纤维瘤是纯间质肿瘤,可有核分裂象增多、伴有少量性索成分及黄素化。部分患者合并胸腹水及CA125升高,易误诊为恶性肿瘤。为避免误诊以影响临床诊断和治疗,认识该病具有重要的意义。
