Enantioseparation of Racemic Naproxen Esters on Cellulose Tris (4-methylbenzoate) Chiral Stationary Phase

Several kinds of racemic naproxen ester were successfully separated on CTMB chiral stationary phase with hexane-ethanol (98:2, vol./vol.) as the mobile phase. The influence of mobile phase composition and structure of racemic naproxen ester on chiral separation was studied and the chiral recognition mechanism of CTMB was discussed.

Synthesis of Cellulose Tris (4-Methylbenzoate) as Gas Chromatographic Stationary Phase and its Characterization

The cellulose tris (4-methylbenzoate) has been synthesised by the catalytic method and was supported at Gas Chrom Q. The absorption capability of cellulose tris (4-methylbenzoate) used as a gas chromatographic stationary phase was characterized by chromatographic method and the Clausius-Clapeyron equation. However, n-alcohols (C-1-C-8) were successfully separated on the column packed with Gas Chrom Q coated with cellullose tris (4-methylbenzoate).

溶剂效应对手性咪唑衍生物对映异构体与固定相相互作用的影响

采用分子模拟方法研究了两类手性咪唑衍生物的对映异构体与多糖类手性固定相纤维素-三(4-甲基苯甲酸酯)(商品名称为Chiralcel OJ)的相互作用,结果表明,溶剂效应对两者的相互作用有显著影响.在强极性溶剂(溶剂A)条件下,与化合物的S型异构体相比,化合物的R型异构体与固定相间形成的复合物更稳定,即S型先出峰,R型后出峰,与文献报道的拆分实验结果完全吻合;在弱极性溶剂(溶剂B)条件下,两个化合物的R/S型异构体与固定相相结合的结合能差别不大,无法进行有效分离.模拟结果表明,对映体与固定相之间存在远程互相排斥作用,在强极性溶剂作用下,远程静电作用减弱,有利于对对映体与固定相立体相互作用的不同进行区分,从而区分对映异构体.能量分析结果显示,分子间的范德华能,尤其是其中色散能的大小决定了对映体在固定相上是否可有效分离.