A novel bacteriohopanoid elucidated as 3fl-hydroxy-35-（cyclohexyl-5′-propan-7′-one）-33-ethyl-34-methyl-bactereohopane （1） has been isolated from the bark of Celtis australis （Ulmaceae） together with three know...A novel bacteriohopanoid elucidated as 3fl-hydroxy-35-（cyclohexyl-5′-propan-7′-one）-33-ethyl-34-methyl-bactereohopane （1） has been isolated from the bark of Celtis australis （Ulmaceae） together with three known compounds apigenin, quercetin and its glucoside. The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.展开更多
Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged prostate.Celtis choseniana Nakai(C.choseniana)is medicinally used to alleviate pain,gastric disease,and lung abscess.In this stu...Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged prostate.Celtis choseniana Nakai(C.choseniana)is medicinally used to alleviate pain,gastric disease,and lung abscess.In this study,the effect of C.choseniana extract on BPH was investigated using testosterone-induced rats.Sprague Dawley rats were divided into five groups:control,BPH(testosterone 5 mg·kg^(−1)),Fina(finasteride 2 mg·kg^(−1)),and C.choseniana(50 and 100 mg·kg^(−1)).After four weeks of TP treatment with finasteride or C.choseniana,prostate weights and DHT levels were measured.In addition,the prostates were histopathologically examined and measured for protein kinase B(Akt)/nuclear factor-κB(NF-κB)/AR signaling,proliferation,apoptosis,and autophagy.Pro-state weight and epithelial thickness were reduced in the C.choseniana groups compared with that in the BPH group.The extract of C.choseniana acted as a 5αreductase inhibitor,reducing DHT levels in the prostate.Furthermore,the extract of C.choseniana blocked the activation of p-Akt,nuclear NF-κB activation and reduced the expression of AR and PSA compared with BPH.Moreover,the ex-pression of Bax,PARP-1,and p53 increased,while the expression of bcl-2 decreased.The present study demonstrated that C.choseni-ana extract alleviated testosterone-induced BPH by suppressing 5αreductase and Akt/NF-κB activation,reducing AR signaling and in-ducing apoptosis and autophagy in the prostate.These results suggested that C.choseniana probably contain potential herbal agents to alleviate BPH.展开更多
Aims Addressing plant responses to water stress is critical to understand the structure of plant communities in water-limited environments and to forecast their resilience to future changes in climate.In a semiarid ag...Aims Addressing plant responses to water stress is critical to understand the structure of plant communities in water-limited environments and to forecast their resilience to future changes in climate.In a semiarid agroforestry system in the Sahelian savannah of Leona(Senegal),we selected nine common tree species and explored their stress-resistance mechanisms.These species represent a variety of life forms and are of high regional socio-economic importance.We hypothesized that different species would show different suites of traits to cope with water stress and expected to identify functional groups differing in strategies to withstand water shortage.Methods Along a dry and a wet season,we monitored four traits reflecting above-and below-ground strategies of resource acquisition such as predawn leaf water potential(ψpd),specific leaf area(SLA),leaf thickness and leaf area index(LAI).We also measured two mor-phological traits:trunk diameter and tree height.LAI andψpd were measured six times during the dry and rainy seasons,and the other traits were measured once.Important Findings We identified two functional classes subdivided into two func-tional groups of each class.The first class included deciduous and semi-deciduous species that generally had large SLA,low leaf thickness and small-to-intermediate inter-seasonal varia-tions inψpd.The second class included evergreen species of two functional groups that differ in SLA,leaf thickness and the mag-nitude of inter-seasonal variations ofψpd throughout the year.The four functional groups identified in this study represent plant strategies differing in their response to changing environmental conditions.展开更多
基金NIPER,Chandigarh for seanning spectra and UGC New Delhi,India[No.33-282/2007(SR)],for financial assistance
文摘A novel bacteriohopanoid elucidated as 3fl-hydroxy-35-（cyclohexyl-5′-propan-7′-one）-33-ethyl-34-methyl-bactereohopane （1） has been isolated from the bark of Celtis australis （Ulmaceae） together with three known compounds apigenin, quercetin and its glucoside. The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.
文摘Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged prostate.Celtis choseniana Nakai(C.choseniana)is medicinally used to alleviate pain,gastric disease,and lung abscess.In this study,the effect of C.choseniana extract on BPH was investigated using testosterone-induced rats.Sprague Dawley rats were divided into five groups:control,BPH(testosterone 5 mg·kg^(−1)),Fina(finasteride 2 mg·kg^(−1)),and C.choseniana(50 and 100 mg·kg^(−1)).After four weeks of TP treatment with finasteride or C.choseniana,prostate weights and DHT levels were measured.In addition,the prostates were histopathologically examined and measured for protein kinase B(Akt)/nuclear factor-κB(NF-κB)/AR signaling,proliferation,apoptosis,and autophagy.Pro-state weight and epithelial thickness were reduced in the C.choseniana groups compared with that in the BPH group.The extract of C.choseniana acted as a 5αreductase inhibitor,reducing DHT levels in the prostate.Furthermore,the extract of C.choseniana blocked the activation of p-Akt,nuclear NF-κB activation and reduced the expression of AR and PSA compared with BPH.Moreover,the ex-pression of Bax,PARP-1,and p53 increased,while the expression of bcl-2 decreased.The present study demonstrated that C.choseni-ana extract alleviated testosterone-induced BPH by suppressing 5αreductase and Akt/NF-κB activation,reducing AR signaling and in-ducing apoptosis and autophagy in the prostate.These results suggested that C.choseniana probably contain potential herbal agents to alleviate BPH.
基金This work was carried out within the FUNCITREE Project,an EU 7FP(contract KBBE-227265)It was also partly funded by the Spanish MICINN(grant CGL2014-59010-R)J.S.D.received a PhD fellowship from the Spanish Agency of International Cooperation for Development(AECID).C.A.is grateful to the Spanish Government for her‘Ramón y Cajal’contract(RYC-2012-12277).
文摘Aims Addressing plant responses to water stress is critical to understand the structure of plant communities in water-limited environments and to forecast their resilience to future changes in climate.In a semiarid agroforestry system in the Sahelian savannah of Leona(Senegal),we selected nine common tree species and explored their stress-resistance mechanisms.These species represent a variety of life forms and are of high regional socio-economic importance.We hypothesized that different species would show different suites of traits to cope with water stress and expected to identify functional groups differing in strategies to withstand water shortage.Methods Along a dry and a wet season,we monitored four traits reflecting above-and below-ground strategies of resource acquisition such as predawn leaf water potential(ψpd),specific leaf area(SLA),leaf thickness and leaf area index(LAI).We also measured two mor-phological traits:trunk diameter and tree height.LAI andψpd were measured six times during the dry and rainy seasons,and the other traits were measured once.Important Findings We identified two functional classes subdivided into two func-tional groups of each class.The first class included deciduous and semi-deciduous species that generally had large SLA,low leaf thickness and small-to-intermediate inter-seasonal varia-tions inψpd.The second class included evergreen species of two functional groups that differ in SLA,leaf thickness and the mag-nitude of inter-seasonal variations ofψpd throughout the year.The four functional groups identified in this study represent plant strategies differing in their response to changing environmental conditions.
