Potential of non-Western medicines in chemoradiotherapy for cervical cancer

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’lives.Currently,most treatments are supportive,with no specific treatment options available in Western medicine.Non-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical cancer.Despite these potential benefits,challenges such as limited evidence and restricted application areas persist.While non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

Turning the tide:From cervical cancer's grip to complete response:A case report

BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalities.The case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient outcomes.CASE SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell carcinoma.The tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with CCRT.Despite this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of life.CONCLUSION In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient outcomes.We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.This study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic characteristics.Enrichment analysis identified 128 differentially expressed genes that were enriched in patients with neurological disabilities.Using least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,respectively.Signatures of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%accuracy.Our results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

A possible association between cervical erosion in pregnant women and congenital abnormalities in their children-a population-based case-control study

Objective to study the possible association between erosion of cervix in pregnant women (ECP) and structural birth defects, i.e. congenital abnormalities (CA) in their offspring. Study design: Comparison of cases with CA and all matched controls without any CA born to wo- men with prospectively and medical record ECP in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA). Results: HCC- SCA contained 22,843 cases and 38,151 matched controls, the informative offspring of 40 (0.18%) case mothers and the newborns of 25 control mothers (0.07%) with ECP were compared and the higher risk for total CA (adjusted OR with 95% CI: 2.7, 1.6-4.4) was found explained by the higher risk of 9 cases with hypospadias (OR with 95% CI: 4.5, 2.1-9.7) and 10 cases with car-diovascular CAs (OR with 95% CI: 3.4, 1.6-7.1), particularly with conotruncal CAs. Conclusions: An unexpected possible association of ECP with higher risk for hypospadias and conotrun-cal cardiovascular CAs was found and these findings are considered as signals that need confirmation or

Cervical cancer prevention in China: where are we now, and what's next?

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

Erosion control of Chinese loess using polymer SH and ryegrass

The China Loess Plateau is subjected to severe soil erosion triggered by intense rainfall,resulting in significant harm and losses to both human society and the natural surroundings.In this study,a novel technique for managing loess erosion is introduced,which involves the utilization of a combined polymer SH and ryegrass.A comprehensive series of tests were undertaken,including rainfall erosion tests,disintegration experiments,and scanning electron microscopy examinations,to assess the accumulative sediment yield(ASY),disintegration ratio,and microstructural features of both untreated and treated loess samples.The results showed a significant reduction in ASY with increased dry density of untreated loess.Furthermore,the combined technique effectively controlled erosion,limiting ASY to 266.2 g/cm^(2)in 60 minutes.This was approximately one-sixth,one-ninth,and one-fifteenth of the ASY in SH-treated loess(L-SH),ryegrass-treated loess(L-R),and untreated loess,respectively.It resisted disintegration better than ryegrass alone but slightly less than SH.This improvement was due to the combined effect of SH and ryegrass,which reduced raindrop impact,improved loess microstructure,and boosted ryegrass growth.The innovative technique holds the potential to be applied as a field-scale technique in the Loess Plateau region of China.

Promising outcomes 5 weeks after a surgical cervical shunting procedure to unclog cerebral lymphatic systems in a patient with Alzheimer’s disease

Recently,the glymphatic system has been recognised as an important‘waste solutes transport channel’within the brain.1 Studies have shown that blockage of the glymphatic system leads to increased beta-amyloid deposits,accelerating the onset and progression of Alzheimer’s disease(AD).12 Given that cervical lymph nodes receive cerebrospinal fluid from the brain’s glymphatic system,34 we speculated that decompression of the lymphatic trunk and cervical lymphatic-venous anastomosis(LVA)could facilitate the flow of cerebrospinal fluid in the cranial glymphatic system,potentially accelerating the clearance of harmful beta-amyloid and tau proteins.We collaborated with surgeons who specialise in LVA supermicrosurgery for maxillofacial tumours and lymphoedema to develop a procedure to relieve the blockage of the glymphatic system.This surgery employs supermicrosurgery techniques to create LVA connecting the bilateral cervical,deep lymphatic vessels to the veins,resulting in lymphatic trunk decompression,which allows the lymph fluid in the high-pressure lymphatic vessels to flow into the low-pressure venous system.The goal of the minimally invasive surgery is to enhance the removal of proteins,such as beta-amyloid and tau,from the brain’s lymphatic systems to the maxillofacial lymphatic vessels,unclogging protein blockages within the brain.This extracranial procedure is safer than intracranial approaches.

Assessment of soil erosion in the Irga watershed on the eastern edge of the Chota Nagpur Plateau,India

Human activities to improve the quality of life have accelerated the natural rate of soil erosion.In turn,these natural disasters have taken a great impact on humans.Human activities,particularly the conversion of vegetated land into agricultural land and built-up area,stand out as primary contributors to soil erosion.The present study investigated the risk of soil erosion in the Irga watershed located on the eastern fringe of the Chota Nagpur Plateau in Jharkhand,India,which is dominated by sandy loam and sandy clay loam soil with low soil organic carbon(SOC)content.The study used the Revised Universal Soil Loss Equation(RUSLE)and Geographical Information System(GIS)technique to determine the rate of soil erosion.The five parameters(rainfall-runoff erosivity(R)factor,soil erodibility(K)factor,slope length and steepness(LS)factor,cover-management(C)factor,and support practice(P)factor)of the RUSLE were applied to present a more accurate distribution characteristic of soil erosion in the Irga watershed.The result shows that the R factor is positively correlated with rainfall and follows the same distribution pattern as the rainfall.The K factor values in the northern part of the study area are relatively low,while they are relatively high in the southern part.The mean value of the LS factor is 2.74,which is low due to the flat terrain of the Irga watershed.There is a negative linear correlation between Normalized Difference Vegetation Index(NDVI)and the C factor,and the high values of the C factor are observed in places with low NDVI.The mean value of the P factor is 0.210,with a range from 0.000 to 1.000.After calculating all parameters,we obtained the average soil erosion rate of 1.43 t/(hm^(2)•a),with the highest rate reaching as high as 32.71 t/(hm^(2)•a).Therefore,the study area faces a low risk of soil erosion.However,preventative measures are essential to avoid future damage to productive and constructive activities caused by soil erosion.This study also identifies the spatial distribution of soil erosion rate,which will help policy-makers to implement targeted soil erosion control measures.

Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature.Breast metastases are associated with poor prognosis.The following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized treatment.CASE SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node metastases.Cervical biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic disease.She received concurrent cisplatin with external beam radiation therapy.Follow up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic disease.Patient was lost to follow up for six months.She was re-imaged on re-presentation and found to have widely metastatic disease including breast disease.Breast biopsy confirmed programmed death-ligand 1 positive metastatic cervical cancer.The patient received six cycles of carboplatin and paclitaxel with pembrolizumab.Restaging imaging demonstrated response.Patient continued on pembrolizumab with disease control.CONCLUSION Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis challenging.Clinical history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the breast.Overall,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

Numerical simulation on sand sedimentation and erosion characteristics around HDPE sheet sand barrier under different wind angles

For the safety of railroad operations,sand barriers are utilized to mitigate wind-sand disaster effects.These disasters,characterized by multi-directional wind patterns,result in diverse angles among the barriers.In this study,using numerical simulations,we examined the behavior of High Density Polyethylene(HDPE)sheet sand barriers under different wind angles,focusing on flow field distribution,windproof efficiency,and sedimentation erosion dynamics.This study discovered that at a steady wind speed,airflow velocity varies as the angle between the airflow and the HDPE barrier changes.Specifically,a 90°angle results in the widest low-speed airflow area on the barrier’s downwind side.If the airflow is not perpendicular to the barrier,it prompts a lateral airflow movement which decreases as the angle expands.The windproof efficiency correlates directly with this angle but inversely with the wind’s speed.Notably,with a wind angle of 90°,wind speed drops by 81%.The minimum wind speed is found at 5.1H(the sand barrier height)on the barrier’s downwind side.As the angle grows,the barrier’s windproof efficiency improves,extending its protective reach.Sedimentation is most prominent on the barrier’s downwind side,as the wind angle shifts from 30°to 90°,the sand sedimentation area on the barrier’s downwind side enlarges by 14.8H.As the angle grows,sedimentation intensifies,eventually overtakes the forward erosion and enlarges the sedimentation area.

MICROSTRIP APPLICATOR FOR TREATMENT OF CERVICAL EROSION AND CERVICAL CONDYLOMA ACUMINATUM

This Paper introduces a microstrip applicator for treatment of cervical erosion and cervical condyloma acuminatum with microwave tissue coagulationmethod. The principle of the applicator,the theoretical calculation of near field distribution of the applicator covered with a lossy dielectric, the experimental resultsfor its performance of the impedance matching and for microwave leakage energyare reported. Finally,the therapeutic method and effects are presented.

Research on the solid particle erosion wear of pipe steel for hydraulic fracturing based on experiments and numerical simulations

Erosion wear is a common failure mode in the oil and gas industry.In the hydraulic fracturing,the fracturing pipes are not only in high-pressure working environment,but also suffer from the impact of the high-speed solid particles in the fracturing fluid.Beneath such complex conditions,the vulnerable components of the pipe system are prone to perforation or even burst accidents,which has become one of the most serious risks at the fracturing site.Unfortunately,it is not yet fully understood the erosion mechanism of pipe steel for hydraulic fracturing.Therefore,this article provides a detailed analysis of the erosion behavior of fracturing pipes under complex working conditions based on experiments and numerical simulations.Firstly,we conducted erosion experiments on AISI 4135 steel for fracturing pipes to investigate the erosion characteristics of the material.The effects of impact angle,flow velocity and applied stress on erosion wear were comprehensively considered.Then a particle impact dynamic model of erosion wear was developed based on the experimental parameters,and the evolution process of particle erosion under different impact angles,impact velocities and applied stress was analyzed.By combining the erosion characteristics,the micro-structure of the eroded area,and the micro-mechanics of erosion damage,the erosion mechanism of pipe steel under fracturing conditions was studied in detail for the first time.Under high-pressure operating conditions,it was demonstrated through experiments and numerical simulations that the size of the micro-defects in the eroded area increased as the applied stress increased,resulting in more severe erosion wear of fracturing pipes.

Effectiveness of Co-Testing in Cervical Cancer Screening Program in Macao SAR

Background: Cervical cancer remains a significant public health concern in Macao SAR despite the implementation of a cervical cancer screening program and HPV vaccination. To improve early detection, Macao SAR introduced HPV DNA testing alongside cytology (co-testing) as the primary screening method in 2019. This study evaluates the effectiveness of co-testing in identifying cervical precancerous lesions (CIN2+) compared to cytology alone. Methods: We conducted a retrospective analysis of women aged 30 - 65 years who participated in the routine cervical cancer screening program in Macao SAR Primary Healthcare Centers from 2019 to 2022. Data from over 70,000 women were analyzed, comparing the detection rates of CIN2+ through co-testing and cytology alone. Women with abnormal cytology or positive HPV results were referred for colposcopy. Results: The introduction of co-testing led to a significant increase in the detection of CIN2+, particularly in women with atypical squamous cells of undetermined significance (ASCUS) or negative for intraepithelial lesion or malignancy (NILM) cytology results. Between 2019 and 2022, the percentage of women with ASCUS/NILM and any high-risk HPV (hrHPV) positive who were diagnosed with CIN2+ after colposcopy were 24%, 13%, 10% and 7.5% respectively. This highlights the ability of co-testing to identify high-risk individuals who would have been missed by cytology alone. Discussion: Our findings demonstrate the effectiveness of co-testing in improving the sensitivity of cervical cancer screening in Macao SAR. The inclusion of HPV DNA testing allows for better risk stratification of women with ASCUS/NILM cytology, leading to more targeted referrals for colposcopy and timely detection of precancerous lesions. The initial high positive rate in 2019 (24%) might be attributed to the small sample size and potentially reflects a backlog of undiagnosed cases prior to co-testing implementation. Conclusion: The implementation of co-testing in Macao SAR’s cervical cancer screening program significantly improves the early detection of precancerous lesions, particularly in women with ambiguous cytology results. This proactive approach contributes to reducing cervical cancer morbidity and mortality and improving women’s health outcomes in Macao SAR.

Internal erosion characteristics and microstructure effects of undisturbed loess

Loess internal erosion caused by preferential flow often leads to serious loess ground collapse,shallow loess landslides,and other geological disasters.However,there is a lack of quantitative evaluation of the internal erodibility of undisturbed loess under the action of preferential flow,and little is known about the correlation between the internal erodibility of loess and its microstructure.In this study,we carried out a series of hole erosion tests(HET)on undisturbed loess samples from 4 typical locations on China's Loess Plateau.The internal erodibility of loess was quantitatively evaluated through an improved HET method,and its association with initial water content,clay content,and initial water head difference was investigated.On the microscopic scale,the microstructure of loess with different clay content was measured by scanning electron microscopy(SEM).The correlation between pore and particle microstructure parameters and loess internal erosion parameters was established based on grey correlation theory.When the initial water content increased from 10%to 36%,the erodibility index increased from 1 to 2.5.When the clay content increased from 8%to 27.95%,the erodibility index increased 3.5 times.The increase of initial water head difference has a positive linear effect on the internal erodibility of loess.The microstructure analysis shows that with the increase of clay content,the microstructure of undisturbed loess changes from a mosaic structure to a cementation structure,which creates favourable conditions for controlling the internal erosion of loess.Through grey correlation analysis,it has been determined that the microstructure of undisturbed loess has a significant correlation with the critical shear stress,and the loess microstructure morphology strongly correlates with the erosion rate.Under normal circumstances,the higher the clay content,the better the erosion resistance,the better the mechanical stability,and the easier to form a stable cave in loess.This study can provide a reference for revealing the cave formation mechanism in the loess area in the future.

Combining neural progenitor cell transplant and rehabilitation for enhanced recovery after cervical spinal cord injury

Efforts to promote recovery of function after human spinal cord injury(SCI) will likely require interventions to rgeting the corticospinal tract(CST) motor system:the most important pathway for voluntary motor control in humans.This system has historically been the most refractory to regenerative efforts after SCI.The "nonregeneration" of the CST changed when robust regeneration of the CST into spared tissue was demonstrated by the inactivation of phosphatase and tensin homolog and delivery of inosine.

Research on Leading Edge Erosion and Aerodynamic Characteristics of Wind Turbine Blade Airfoil

The effects of the erosion present on the leading edge of a wind turbine airfoil(DU 96-W-180)on its aerodynamic performances have been investigated numerically in the framework of a SST k–ωturbulence model based on the Reynolds Averaged Navier-Stokes equations(RANS).The results indicate that when sand-induced holes and small pits are involved as leading edge wear features,they have a minimal influence on the lift and drag coefficients of the airfoil.However,if delamination occurs in the same airfoil region,it significantly impacts the lift and resistance characteristics of the airfoil.Specifically,as the angle of attack grows,there is a significant decrease in the lift coefficient accompanied by a sharp increase in the drag coefficient.As wear intensifies,these effects gradually increase.Moreover,the leading edge wear can exacerbate flow separation near the trailing edge suction surface of the airfoil and cause forward displacement of the separation point.

Erratum to:Influence law of modified glutinous rice-based materials on gravel soil reinforcement and water erosion process

The original online version of this article was revised.The first author is“ZHANG Weng-xiang”in the original article.The first author’s name has been corrected to“ZHANG Wen-xiang”.

Trans-PRK for recurrent epithelial corneal erosion induced by cooking oil accidentally after EVO ICL

Dear Editor,We report a case with trans-photorefractive keratectomy(PRK)for recurrent epithelial corneal erosion caused by cooking oil after EVO-implantable contact lens(ICL)(EVO Visian ICL;STAAR Surgical AG,Switzerland),which should be distinguished from postoperative complications of EVO-ICL.Most corneal burns are classified as chemical and thermal burns,referring to direct contact injury to the cornea.

Retraction:long noncoding RNA ANRIL promotes cervical cancer development by acting as a sponge of miR-186

Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.

Retraction:miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A(INPP5A)

Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.